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Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function
Dongmei Wu,Yifu Qiu,Xiang Gao,Xiao-Bing Yuan,Qiwei Zhai
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0021759
Abstract: SIRT1 plays crucial roles in glucose and lipid metabolism, and has various functions in different tissues including brain. The brain-specific SIRT1 knockout mice display defects in somatotropic signaling, memory and synaptic plasticity. And the female mice without SIRT1 in POMC neuron are more sensitive to diet-induced obesity. Here we created transgenic mice overexpressing SIRT1 in striatum and hippocampus under the control of CaMKIIα promoter. These mice, especially females, exhibited increased fat accumulation accompanied by significant upregulation of adipogenic genes in white adipose tissue. Glucose tolerance of the mice was also impaired with decreased Glut4 mRNA levels in muscle. Moreover, the SIRT1 overexpressing mice showed decreased energy expenditure, and concomitantly mitochondria-related genes were decreased in muscle. In addition, these mice showed unusual spontaneous physical activity pattern, decreased activity in open field and rotarod performance. Further studies demonstrated that SIRT1 deacetylated IRS-2, and upregulated phosphorylation level of IRS-2 and ERK1/2 in striatum. Meanwhile, the neurotransmitter signaling in striatum and the expression of endocrine hormones in hypothalamus and serum T3, T4 levels were altered. Taken together, our findings demonstrate that SIRT1 in forebrain regulates lipid/glucose metabolism and motor function.
The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons
Ning Li,Chun-Tao Zhao,Ying Wang,Xiao-Bing Yuan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010596
Abstract: In the murine cerebral cortex, mammalian homologues of the Cux family transcription factors, Cux1 and Cux2, have been identified as restricted molecular markers for the upper layer (II-IV) pyramidal neurons. However, their functions in cortical development are largely unknown. Here we report that increasing the intracellular level of Cux1, but not Cux2, reduced the dendritic complexity of cultured cortical pyramidal neurons. Consistently, reducing the expression of Cux1 promoted the dendritic arborization in these pyramidal neurons. This effect required the existence of the DNA-binding domains, hence the transcriptional passive repression activity of Cux1. Analysis of downstream signals suggested that Cux1 regulates dendrite development primarily through suppressing the expression of the cyclin-dependent kinase inhibitor p27Kip1, and RhoA may mediate the regulation of dendritic complexity by Cux1 and p27. Thus, Cux1 functions as a negative regulator of dendritic complexity for cortical pyramidal neurons.
Review on the ecological effects of N deposition in arid and semi-arid areas
干旱半干旱区氮沉降生态效应研究进展

ZHOU Xiao-Bing,ZHANG Yuan-Ming,
周晓兵
,张元明

生态学报 , 2009,
Abstract: The ecological effect of atmospheric N deposition has become a hot issue along with intensive human activities and global climatic change. N deposition can result in a great change of ecosystem's structure and function, leading to a serial of ecological effects. In this article we reviewed the ecological consequence of N deposition in arid and semi-arid ecosystem as follow: (1) the characteristic of N deposition in arid and semi-arid area is that the nitrogen enters into the N cycle in a form of pulse, impacting other ecological processes. (2) N deposition can increase the mineralization of organic nitrogen and the content of inorganic N in the soil. N cycle can also be affected by other factors. (3) N deposition has a positive effect on the metabolic activity of microbe in soil, and there are still some argues on the effect on microbial biomass. (4) N deposition can influence plant productivity, root growth, although these effects are also regulated by water availability. (5) N deposition can reduce the abundance of endemic species and is benefit to the invasion of exotic species.
A Fast Algorithm for Reduction Based on Skowron Discernibility Matrix
基于Skowron分明矩阵的快速约简算法

WANG Yuan-Zhen,PEI Xiao-Bing,
王元珍
,裴小兵

计算机科学 , 2005,
Abstract: Attribute reduction is one of the basic contents, it is NP-complete problem to calculate all attribute reduc- tions. Based on dividing and conquering thought, the judgement theorem with respect to minimal disjunctive normal form is obtained based on Skowron discernibility matrix, from which an algorithm for all attribute reductions is pre- sented. Theoretical analysis and experimental results show that the algorithm is much more efficient in comparison with those existing algorithm.
A Calculation Method for Relative Reductions of Rough Sets
一种Rough集相对约简的计算方法

PEI Xiao-Bing,WANG Yuan-Zhen,
裴小兵
,王元珍

计算机科学 , 2006,
Abstract: 本文引入邻域分明合取项集概念,讨论了邻域分明合取项集的计算方法。在此基础上,利用约简集 RED_Q(U—{x_o},P)计算约简集 RED_Q(U,P)的思想,给出了相对约简的判定定理,从而提出了一种相对约简的计算方法。由于该方法不用计算分明矩阵的中间环节,节省了空间和时间,提高了运行效率。实验结果表明,该约简算法在效率上较现有的约简算法有一定提高。
Note on color neutral solutions of the $K^0$ condensed color-flavor locked phase
Zhang, Xiao-bing
High Energy Physics - Phenomenology , 2007,
Abstract: In the presence of nonzero strange quark mass $m_s$, we investigate color neutrality in the $K^0$ condensed phase of color-flavor locked quark matter. By treating the $m_s$ effects on both kaon condensate and Fermi-surface phenomenon self-consistently, we develop a new treatment to evaluate color neutral solutions within the model-independent framework. It is pointed out that, in the general sense, the expectation values of gluon fields obtained from dynamics of Goldstone bosons solely are not identified with the factual color chemical potentials.
Study of regenerative medicine in China: demands and clinical translation
Xiao-bing FU
Medical Journal of Chinese People's Liberation Army , 2012,
Abstract: The repair and regeneration of tissue is a well-discussed topic. Over the past 20 years, with the development of genetics, auxology, stem cell biology, and tissue engineering, tissue repair and regeneration have rapidly developed as emerging "Regenerative Medicine". Regenerative medicine has significant market demand in China. Based on national statistics, injury and poisoning patients rank third in afflictions in city hospitals (accounting for 9.13%) and rank second in afflictions in county hospitals (accounting for 14.07%). Totally, approximately one hundred million patients suffered from traumatic, genetic and metabolic diseases in China and demand reparative and regenerative medical treatment each year. The Chinese government and its related departments have always attached great importance and support to the development of regenerative medicine, and the Chinese academic circle is involved in a very wide range of diseases and injuries including regenerative medical theory and technology. Stem cell biology, organ engineering and duplication, tissue engineering research and production have developed rapidly, and great portion of these studies have started to appear in applications, which have aroused extensive concerns in international professional circle. In the next 10 years, the Chinese regenerative medical system will be further improved, in both statute and rules, clinical translation will be further accelerated. Breakthroughs are expected in induced differentiation of stem cells and synchronous repair and regeneration of multiple organs, construction of major organs by tissue engineering, large-scale applications of tissue engineering products, and other aspects.
Effects of curcumin on secretion of adiponectin and interleukin-6 in human adipose tissues: an in vitro study
Xiao-bing QU
Zhong Xi Yi Jie He Xue Bao , 2008,
Abstract: Objective: To investigate the effects of different concentrations of curcumin on secretion of adiponectin (APN) and interleukin-6 (IL-6) in human adipose tissues cultivated in vitro.Methods: Seven male patients with kidney stones were admitted. Abdominal subcutaneous adipose tissue and perirenal adipose tissue were collected from the operating-patients, and were cultivated with different concentrations of curcumin (10 and 100 μg/ml) in vitro. The contents of APN and IL-6 in the culture medium of adipose tissue cells were measured by enzyme-linked immunosorbent assay (ELISA) after they were cultured for 6 and 24 hours.Results: Compared with the blank control group, the content of APN in the adipose tissue culture medium was increased by 100 μg/ml curcumin (P<0.05) after 6-hour culture, and the content of IL-6 was significantly decreased by 100 μg/ml curcumin after 6- and 24-hour culture (P<0.05). Conclusion: 100 μg/ml curcumin can increase APN secretion and decrease IL-6 secretion in human adipose tissues cultivated in vitro
Immunoregulatory function of Radix Glycyrrhizae polysaccharide in tumor-bearing mice
Xiao-bing LI
Zhong Xi Yi Jie He Xue Bao , 2010,
Abstract: Objective: To observe the effects of Radix Glycyrrhizae polysaccharide on regulatory T cells (Treg) in spleen and lymphocyte transformation ratio in tumor-bearing mice so as to explore the mechanisms of its immunoregulatory function.Methods: Fifty BALB/c mice were randomly divided into normal group, untreated group, cyclophosphamide group, Radix Glycyrrhizae polysaccharide group and Radix Glycyrrhizae polysaccharide plus cyclophosphamide group. Except normal group, mice were subcutaneously implanted H22 tumor cells in the right axillary region. After 24 h, mice in normal and untreated group were subcutaneously injected with physiological saline, while mice in the cyclophosphamide group were intraperitoneally injected with cyclophosphamide and mice in Radix Glycyrrhizae polysaccharide group were subcutaneously injected with polysaccharide. Fourteen days later, Treg cells of spleen were detected by flow cytometry and lymphocyte transformation ratio was detected by methyl thiazolyl tetrazolium method. Results: The proportion of Treg cells was significantly higher in the untreated group than in the normal group, and was lower in the Radix Glycyrrhizae polysaccharide group than in the untreated group (P<0.01). Lymphocyte transformation ratio in the Radix Glycyrrhizae polysaccharide group was higher than that in the cyclophosphamide group. There was no interaction between Radix Glycyrrhizae polysaccharide and cyclophosphamide.Conclusion: Radix Glycyrrhizae polysaccharide can regulate the cellular immunity disorders of tumor-bearing mice by decreasing proportion of Treg cells and increasing spleen lymphocyte transformation ratio.
Dephasing time of disordered two-dimensional electron gas in modulated magnetic fields
Xiao-Bing Wang
Physics , 2002, DOI: 10.1103/PhysRevB.65.115303
Abstract: The dephasing time of disordered two-dimensional electron gas in a modulated magnetic field is studied. It is shown that in the weak inhomogeneity limit, the dephasing rate is proportional to the field amplitude, while in strong inhomogeneity limit the dependence is quadratic. It is demonstrated that the origin of the dependence of dephasing time on field amplitude lies in the nature of corresponding single-particle motion. A semiclassical Monte Carlo algorithm is developed to study the dephasing time, which is of qualitative nature but efficient in uncovering the dependence of dephasing time on field amplitude for arbitrarily complicated magnetic-field modulation. Computer simulations support analytical results. The crossover from linear to quadratic dependence is then generalized to the situation with magnetic field modulated periodically in one direction with zero mean, and it is argued that this crossover can be expected for a large class of modulated magnetic fields.
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