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Search Results: 1 - 10 of 173043 matches for " YU Li "
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Selection Advantage Pattern of International Sci-Tech Cooperation and Empirical Analysis  [PDF]
Li Li, Bin Yu
Journal of Service Science and Management (JSSM) , 2011, DOI: 10.4236/jssm.2011.41006
Abstract: Traditional international sci-tech cooperation theories mainly focus on the ability and advantage owned by cooperative parties, and according to which to guide the direction of international science and technology cooperation. Based on the integration of traditional theories of international science and technology cooperation and concrete practice, this paper proposes the selection advantage pattern and matching mechanism, which comprehensively take cooperator advantages, specification of project and change in circumstance into account and will play a guiding role in terms of determining the key country or region with which to prior carry out international science and technology cooperation. This paper also gives an analysis of the current status of industry development in Guangdong province and the research upon competitiveness evaluation of the world's related leading technology, puts forward corresponding countermeasures and suggestions on the science and technology cooperation patterns and approaches in terms of technological level and resources of Guangdong province.
Effect of N’-Acetylindirubin on Proliferation, Apoptosis and Cell Cycle in Acute Myeloid Leukemia HL-60 Cells  [PDF]
Tang Li, Li Yu
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.65015
Abstract:
Acute promyelocytic leukemia (APL) is a severe type of acute leukemia and the prognosis of patients was poor. Indirubin is the active constituent of the traditional Chinese medicine qingdai and an indoline anti-tumor drug. N’-Acetylindirubin is a novel indirubin derivative with better curative effect and less side effect. In this study, the effects of N’-Acetylindirubin on proliferation, apoptosis and cell cycle of acute myeloid leukemia cell line HL-60 was examined. The results demonstrated that N’-Acetylindirubin significantly induced apoptotic cell death in a dose and time-dependent manner and arrested cell cycle in G2/M in HL-60 cells. N’-Acetylindirubin also suppressed cyclin D1. This study suggests that N’-Acetylindirubin may serves as a potential chemopreventive agent for acute promyelocytic leukemia.
EBV-Associated Post-Transplantation B-Cell Lymphoproliferative Disorder in Patient after Allogenic Stem Cell Transplantation  [PDF]
Li Tang, Yu Li
Journal of Biosciences and Medicines (JBM) , 2019, DOI: 10.4236/jbm.2019.75003
Abstract:
Epstein-Barr virus (EBV)-associated B-cell post-transplantation lymphoproliferative disorder (PTLD) is a severe complication following solid-organ transplantation (SOT) and allogeneic hematopoietic stem cell transplantation (HSCT). We present a case of a 15-year-old male developing a monomorphic B-cell PTLD after receiving an allogenic stem cell transplant for acute acute myeloid leukemia. A diagnostic lymph node biopsy revealed monomorphic type, B cell phenotype, associated with Epstein-Barr virus, consistent with post-transplant lymphoproliferative disorder (PTLD). The morbidity and mortality of PTLD are high, and there is no standard protocol for treatment of PTLD. To prevent the occurrence of PTLD and early intervention are important for the prognosis of patients.
Primary Cutaneous Gamma Delta T Cell Lymphoma: A Clinicopathological Analysis  [PDF]
Li Tang, Yu Li
Journal of Biosciences and Medicines (JBM) , 2019, DOI: 10.4236/jbm.2019.75005
Abstract:
Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a very uncommon and extremely aggressive tumor, and is described in the newly re-vised World health organization for research and treatment of cancer classification of cutaneous lymphomas. A 43-year-old male patient presented with a 4 months history of cutaneous lesion over upper lip, without plaque and any constitutional symptom. Histopathological examination of skin biopsy revealed infiltration of atypical lymphocytes with hyperchromatic irregular nuclei. Immunophenotyping pattern of skin biopsy was compatible with PCGD-TLC. It is a highly aggressive tumor resistant to chemotherapy, immunotherapy, and radiation therapy. The GDTCL is characterized by a worse prognosis with a median survival of 15 months. Early diagnosis is essential and aggressive therapy is necessary.
Dynamical Adaptive Particle Swarm Algorithm and Its Application to Optimization of PID Parameters  [PDF]
Jimin Li, Guolin Yu
American Journal of Operations Research (AJOR) , 2012, DOI: 10.4236/ajor.2012.23053
Abstract: Based on a new adaptive Particle Swarm Optimization algorithm with dynamically changing inertia weight (DAPSO), It is used to optimize parameters in PID controller. Compared to conventional PID methods, the simulation shows that this new method makes the optimization perfectly and convergence quickly.
An Innovative Marketing Model Based on AIDA: - A Case from E-bank Campus-marketing by China Construction Bank  [PDF]
Jiangyu Li, Haibo Yu
iBusiness (IB) , 2013, DOI: 10.4236/ib.2013.53B010
Abstract:

In mature marketing, general perception towards AIDA is that most enterprises will lay emphasis directly on value proposition of a product or services, and encourage clients going to each step of AIDA layers, finally to increase the total number of final step, say enlarging the number of actual buying action. However to some extent, the efficiency of such a simple model appears strongly inadequate. Based on AIDA theory and market feature of universities via e-bank at China Construction Bank (CCB) , this paper has introduced a new marketing model which present a new value proposition (new value proposition is attempting to focus on practical-teaching innovation and job competency improvement) to accelerate AIDA marketing activities at university market, the outcome further helps to grow AIDA at bigger market groups. Finding of this paper shows new model greatly improved marketing efficiency of e-bank services from CCB at university market, and it also unfolds a new perspective in marketing of the enterprises.

Regularization and Estimation in Regression with Cluster Variables  [PDF]
Qingzhao Yu, Bin Li
Open Journal of Statistics (OJS) , 2014, DOI: 10.4236/ojs.2014.410077
Abstract: Clustering Lasso, a new regularization method for linear regressions is proposed in the paper. The Clustering Lasso can select variable while keeping the correlation structures among variables. In addition, Clustering Lasso encourages selection of clusters of variables, so that variables having the same mechanism of predicting the response variable will be selected together in the regression model. A real microarray data example and simulation studies show that Clustering Lasso outperforms Lasso in terms of prediction performance, particularly when there is collinearity among variables and/or when the number of predictors is larger than the number of observations. The Clustering Lasso paths can be obtained using any established algorithm for Lasso solution. An algorithm is proposed to construct variable correlation structures and to compute Clustering Lasso paths efficiently.
Reward and Punishment Mechanism in a Vertical Safety Regulation System: A Transferred Prisoner’s Dilemma  [PDF]
Jiachen Li, Lihong Yu
Modern Economy (ME) , 2015, DOI: 10.4236/me.2015.65054
Abstract: Under the current system of safety regulation in China, a lower level in the hierarchical system means more regulatory failure. The mechanism of rewards and punishments has been proven to compensate for regulatory failures according to game theory separately. This study analyzed rewards and punishments simultaneously to strengthen the regulatory power and offset the failure of regulation; examples are provided to facilitate a comparison of the failure possibilities for various degrees of rewards and punishments. In addition, this paper describes the transformation of the behavior of coal enterprises, miners and local governments. Doubling the rewards and punishments was determined to reduce the possibility of failure of local government regulation by 27%; in addition, the probability of safe production in coal mining enterprises increased by 87%, and the willingness of miners to disclose information increased by 50%.
Effect of Legal Sanction for Shareholders’ Expropriation on the Corporate Valuation  [PDF]
Zhigang Yao, Yu Li
Modern Economy (ME) , 2016, DOI: 10.4236/me.2016.78088
Abstract: The purpose of this paper is to study whether the legal sanction by relevant departments for the majority shareholders’ expropriation affects the valuation of the firms or other shareholders’ interests. This study takes the legal sanction by relevant departments for the majority shareholders’ expropriation as external legal environment change events, so whether the return of the listed company shows significant difference during the window before and after the listed company has been sanctioned by the relevant departments for the majority shareholders’ expropriation will be the judgment whether the sanction has any obvious effect on the listed company and the stock market. The study demonstrates that almost all empirical results show that the positive and negative effects don’t pass the significance test, illustrating that the legal sanction system just has limited effect on the corporate governance of the listed company.
Calculation and Empirical Analysis on the Contributions of R&D Spending and Patents to China’s Economic Growth  [PDF]
Jie Li, Yu Jiang
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.66118
Abstract: Based on the national data from 1995 to 2014, we develop an extended C-D production function model alongside with the Solow growth rate equation to investigate contributions of R&D expenditures and patents to China’s GDP respectively. Results indicate that: 1) both R&D expenditures and patents granted are significantly positive correlated with GDP and the growing output elasticity to GDP is in leaps and bounds after 2000 and 2005; 2) comparing to patents granted, R&D expenditures account for a higher share of contribution to economic growth and the both shares show a fluctuating downward trend; 3) the output elasticity of labor is significantly higher than other factors, signaling capital saving technical progress in China. The elasticity coefficient of scientific-technical progress to GDP is small. Nevertheless, its influence is gradually increasing and the intensive economic growth transformation has formed. Some policy implications are distilled after empirical analysis. R&D application, transformation and related incentive mechanism should be improved. Besides, the fields of R&D funding should be adjusted to further coordinate the relationship between the structure of R&D expenditures and the industrial structure.
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