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Search Results: 1 - 10 of 12613 matches for " YH Tian "
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Tat peptide-decorated gelatin-siloxane nanoparticles for delivery of CGRP transgene in treatment of cerebral vasospasm
Tian XH,Wang ZG,Meng H,Wang YH
International Journal of Nanomedicine , 2013,
Abstract: Xin-Hua Tian,1,2 Zhi-Gang Wang,1,2 Han Meng,1,2 Yu-Hua Wang,2 Wei Feng,2 Feng Wei,2 Zhi-Chun Huang,2 Xiao-Ning Lin,2 Lei Ren3,41Xiehe Clinical College of Medicine, Fujian Medical University, Fuzhou, 2Department of Neurosurgery, Zhongshan Hospital, 3Research Center of Biomedical Engineering, Department of Biomaterials, College of Materials, 4State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, People's Republic of ChinaBackground: Gene transfer using a nanoparticle vector is a promising new approach for the safe delivery of therapeutic genes in human disease. The Tat peptide-decorated gelatin-siloxane (Tat-GS) nanoparticle has been demonstrated to be biocompatible as a vector, and to have enhanced gene transfection efficiency compared with the commercial reagent. This study investigated whether intracisternal administration of Tat-GS nanoparticles carrying the calcitonin gene-related peptide (CGRP) gene can attenuate cerebral vasospasm and improve neurological outcomes in a rat model of subarachnoid hemorrhage.Method: A series of gelatin-siloxane nanoparticles with controlled size and surface charge was synthesized by a two-step sol-gel process, and then modified with the Tat peptide. The efficiency of Tat-GS nanoparticle-mediated gene transfer of pLXSN-CGRP was investigated in vitro using brain capillary endothelial cells and in vivo using a double-hemorrhage rat model. For in vivo analysis, we delivered Tat-GS nanoparticles encapsulating pLXSN-CGRP intracisternally using a double-hemorrhage rat model.Results: In vitro, Tat-GS nanoparticles encapsulating pLXSN-CGRP showed 1.71 times higher sustained CGRP expression in endothelial cells than gelatin-siloxane nanoparticles encapsulating pLXSN-CGRP, and 6.92 times higher CGRP expression than naked pLXSN-CGRP. However, there were no significant differences in pLXSN-CGRP entrapment efficiency and cellular uptake between the Tat-GS nanoparticles and gelatin-siloxane nanoparticles. On day 7 of the in vivo experiment, the data indicated better neurological outcomes and reduced vasospasm in the subarachnoid hemorrhage group that received Tat-GS nanoparticles encapsulating pLXSN-CGRP than in the group receiving Tat-GS nanoparticles encapsulating pLXSN alone because of enhanced vasodilatory CGRP expression in cerebrospinal fluid.Conclusion: Overexpression of CGRP attenuated vasospasm and improved neurological outcomes in an experimental rat model of subarachnoid hemorrhage. Tat-GS nanoparticle-mediated CGRP gene delivery could be an innovative strategy for treatment of cerebral
EVOLUTION OF MICROSTRUCTURE OF Sn-Ag-Cu LEAD-FREE FLIP CHIP SOLDER JOINTS DURING AGING PROCESS
YH Tian,CQ Wang,WF Zhou,
Y.H.
,Tian,C.Q.,Wang,W.F.,Zhou

金属学报(英文版) , 2006,
Abstract: Flip chip bonding has become a primary technology that has found application in the chip interconnection process in the electronic manufacturing industry in recent years. The solder joints of the flip chip bonding are small and consist of complicated microstructures such as Sn solution, eutectic mixture, and intermetallic compounds (IMCs), whose mechanical performance is quite different from the original solder bulk. The evolution of microstructure of the flip chip solder joints under thermal aging was analyzed. The results show that with an increase in aging time, coarsening of solder bulk matrix and AuSn4 IMCs occurred within the solder. The IMCs that are formed at the bottom side of the flip chip bond were different from those on the top side during the aging process. (Cu,Ni,Au)6Sn5 were formed at the interfaces of both sides, and large complicated (Au,Ni,Cu)Sn4 IMCs appeared for some time near the bottom interface after aging, but they disappeared again and thus (Cu,Ni,Au)6Sn5 IMC thickness increased considerably. The influence of reflow times during the flip chip bonding (as-bonded condition) on the characteristics of interfacial IMCs was weakened when subjected to the aging process.
Mechanical Properties Of Longitudinal Submerged Arc Welded Steel Pipes Used For Gas Pipeline Of Offshore Oil

ZZ Yang,W Tian,QR Ma,YL Li,JK Li,JZ Gao,HB Zhang,YH Yang,

金属学报(英文版) , 2008,
Abstract: Since the development of offshore oil and gas, increased submarine oil and gas pipelines were installed. All the early steel pipes of submarine pipelines depended on importing because of the strict requirements of comprehensive properties, such as,anti-corrosion, resistance to pressure and so on. To research and develop domestic steel pipes used for the submarine pipeline, the Longitudinal-seam Submerged Arc Welded (LSAW) pipes were made of steel plates cut from leveled hot rolled coils by both the JCOE and UOE (the forming process in which the plate like the letter "J", "C", "O" or "U" shape, then expansion) forming processes. Furthermore, the mechanical properties of the pipe base metal and weld metal were tested, and the results were in accordance with the corresponding pipe specification API SPEC 5L or DNV-OS-F101, which showed that domestic LSAW pipes could be used for submarine oil and gas pipelines.
Generalized -Euler Numbers and Polynomials of Higher Order and Some Theoretic Identities
Kim T,Kim YH
Journal of Inequalities and Applications , 2010,
Abstract: We give a new construction of the -Euler numbers and polynomials of higher order attached to Dirichlet's character . We derive some theoretic identities involving the generalized -Euler numbers and polynomials of higher order.
Peripheral arterial disease: A high risk – but neglected – disease population
Joseph Tomson, Gregory YH Lip
BMC Cardiovascular Disorders , 2005, DOI: 10.1186/1471-2261-5-15
Abstract: Peripheral arterial disease (PAD) results from the narrowing of the blood vessels of the lower limbs, predominantly secondary to atherosclerotic vascular disease leading to compromised blood flow to the lower limbs. Risk factors associated with PAD include typical cardiovascular risk factors, such as older age, cigarette smoking, diabetes mellitus, hypercholesterolemia, and hypertension [1]. PAD is also very common in the western world – based on symptoms of intermittent claudication, PAD has a prevalence of up to 5%, but a higher prevalence is estimated in the general population [1,2]. As with much of cardiovascular disease, PAD can be progressive, which about a third report worsening symptoms and require surgical interventions over 5 to 10 years [3] as well as suffer a higher cardiovascular mortality risk [2-4]. One could argue that compared to the large publicity and public health initiatives on heart attacks and strokes, public recognition on the risks, morbidity and mortality associated with PAD has been relatively neglected.Given that the pathology in PAD arises secondary to atherosclerosis (or atherothrombosis) affecting the vascular tree, PAD would be a very useful, subtle and early indicator of a high risk population. The realisation that the majority of those with PAD remain asymptomatic [4], and that they can be more effectively identified by simple non-invasive techniques warrants new hope for the primary prevention of cardiovascular risk.In their recent article published in BMC Cardiovascular Disorders, Caro et al [5] embark upon estimating the burden of cardiovascular risk in terms of mortality, morbidity and associated risk factors in patients with PAD. Of note, they compared outcomes between the PAD cohort to those with reference populations with a first diagnosis of myocardial infarction and stroke. They report that the mortality rate amongst those with PAD was higher when compared to those who had an index myocardial infarction but lower than those
Blood pressure demographics: nature or nurture ... ... genes or environment?
Joseph Tomson, Gregory YH Lip
BMC Medicine , 2005, DOI: 10.1186/1741-7015-3-3
Abstract: Hypertension is a common problem, with a consistent and continuous risk of cardiovascular disease and stroke associated with rising blood pressure levels [1]. Furthermore, effective treatment of blood pressures has been shown to cause reductions in morbidity and mortality from cardiovascular disease and stroke. The modern management of hypertension is even more complex, with the emergence of newer therapies, ageing populations and new clinical trial evidence, as well as the need for multiple agents to achieve target blood pressures, which are much lower than they used to be in the past [1].The consequences of poor blood pressure control are huge. As high blood pressure is the most important risk factor for cardiovascular disease, it has been calculated that by achieving the target of 140 mmHg, there would be a reduction of 28–44% in stroke and 20–35% in ischaemic heart disease depending on the age. This would prevent approximately 21400 stroke deaths and 41400 ischaemic heart disease deaths each year – and these translate to approximately 42800 strokes and 82800 ischaemic heart diseases saved, making a total of 125600 events saved per year in the United Kingdom alone [2]. Even white coat hypertension is by no means a benign condition [3]. By 2020, the world population would be an estimated 7.8 billion people and hypertension currently is 'estimated' to affect about 1 billion worldwide – this figure will be rising. The growing numbers and the lack of concerted effort to tackle the burden of hypertension makes depressing reading.Nonetheless, what is more intriguing and perhaps still not fully explained, is why some populations seem to have a much higher population prevalence of hypertension as compared to others. For instance, the prevalence and incidence of hypertension differs between the non-westernised and westernised populations. Even within the western world, the Afro-Caribbean or African-American black population has a higher prevalence of hypertension and targ
'Aspirin resistance' or treatment non-compliance: Which is to blame for cardiovascular complications?
Eduard Shantsila, Gregory YH Lip
Journal of Translational Medicine , 2008, DOI: 10.1186/1479-5876-6-47
Abstract: Aspirin is one of the 'cornerstone' drugs in our current management of cardiovascular disorders. The metaanalysis from the Antithrombotic Trialists' Collaboration of 287 randomized trials of antiplatelet therapy in patients at high risk of occlusive vascular events demonstrated a 32% reduction in nonfatal myocardial infarction (MI), nonfatal stroke, and vascular death in patients treated with aspirin [1]. However, despite the prescription of aspirin recurrent vascular events still occur in 10–20% of patients [2]. These, data together with the observations of diminished antiaggregatory response to aspirin in some subjects have provided the basis of the current debate on the existence of so-called "aspirin resistance".'Aspirin resistance' has been defined as either the failure of aspirin to fully inhibit platelet aggregation in the laboratory setting or (clinically) as its inability to prevent cardiovascular events. The problem is important as it potentially implies the need for repeated laboratory tests and/or the replacement of aspirin by other antiplatelet drugs in millions of patients [3].Unfortunately, many of the tests employed to define 'aspirin resistance' lack sufficient sensitivity, specificity, and reproducibility [4]. The prevalence of 'aspirin resistance' as defined by each test varies widely, and furthermore, the value of a single point estimate measure of aspirin resistance is questionable [4,5]. Indeed, the insufficient laboratory suppression of platelet activity may result from reduced enteral absorption of aspirin (e.g. when low doses of enteric-coated aspirin are used), the concomitant administration of other cyclooxygenase-1 inhibitors (e.g. ibuprofen and naproxen), or even increased platelet turnover (e.g. as in infection, inflammation and following major surgery) [6-9]. Polymorphism of genes involved in the thromboxane biosynthetic pathway may also be associated with a modification of the response to aspirin and its clinical efficacy [10]. Partia
Immunocytochemical localization of monoamine oxidase type B in rat liver
YH Huang,M Jiang,BY Fu
European Journal of Histochemistry , 2008, DOI: 10.4081/1181
Abstract: We used an immunohistochemical method to examine the localization of monoamine oxidase type B (MAOB) in rat liver. At the light microscopic level, MAOB was highly expressed in rat liver. It was intense around portal area, and weak around central area. All the hepatocytes examined had MAOB immunoreactivity. For the first time, using a doublelabeling immunofluorescence histochemical method for laser microscopy, we report that no MAOB is found in endothelial cells, hepatic stellate cells, or Kupffer’s cells. When examined under transmission electron microscopy, MAOB was localized to the mitochondrial outer membrane of hepatocytes. No apparent localization of MAOB was found in the rough endoplasmic reticulum, the crystal membrane of mitochondria, the nuclear envelope, or the plasma membrane.
Clinical review: Clinical management of atrial fibrillation – rate control versus rhythm control
Hoong Lim, Ali Hamaad, Gregory YH Lip
Critical Care , 2004, DOI: 10.1186/cc2827
Abstract: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in the community [1]. It is characterized electrocardiographically by irregular fibrillatory waves, usually associated with an irregular ventricular response, which manifests clinically as an irregular pulse. The presence of rapid, uncontrolled AF may be associated with severe symptoms and haemodynamic compromise, necessitating urgent intervention. In addition to its direct haemodynamic effects, AF is associated with a prothrombotic state and is a major risk factor for stroke and thromboembolism [2]. Overall, this arrhythmia also appears to be an independent predictor for death [3].In addition, AF is the most common arrhythmia in postoperative patients [4] (particularly following cardiac surgery [5]) and in critically ill patients [6]. In these patients, as with patients in the community, AF is associated with adverse outcomes [7]. Hence, regardless of the clinical setting, AF identifies patients at substantial risk for morbidity and mortality.Recent guidelines suggested that AF be classifed on the basis of the temporal pattern of the arrhythmia [8]. AF is considered recurrent when a patient develops two or more episodes. These episodes may be paroxysmal if they terminate spontaneously (defined by consensus as 7 days) or persistent if electrical or pharmacological cardioversion is required to terminate the arrhythmia. Successful termination of AF does not alter the classification of persistent AF in these patients. Longstanding AF (defined as over 1 year) that is not successfully terminated by cardioversion, or when cardioversion is not pursued, is classified as permanent.Regardless of the eventual classification, patients with AF should be assessed for symptomatic and haemodynamic compromise, which will guide subsequent management (Fig. 1), identification and correction of associated comorbidities and/or precipitants, and assessment of the patient's thromboembolic risk (Fig. 2) [9].The haemody
Low literacy Chinese patients: how are they affected and how do they cope with health matters? A qualitative study
TP Lam, YH Cheng, YL Chan
BMC Public Health , 2004, DOI: 10.1186/1471-2458-4-14
Abstract: Qualitative study of subjects' opinions using semi-structured group and individual interviews. Thirty-six participants took part in 6 group and 9 individual interviews.Participants' opinions towards low literacy were explored in the interviews. They expressed diverse views on how they perceived low literacy. Some thought they were handicapped by it but others felt it was not a problem. Age, gender, chronic illnesses and their attitudes towards self were found to be major factors affecting their perception. Despite their low literacy, some had their specific ways to overcome the difficulties, for example, drawing symbols to help with the timing of taking the medications. Most of them felt better explanation by the health care workers was most important.It is highly relevant for health care workers to be aware of the low literacy status of their patients and to explain information so that patients understand it.In the 2001 Hong Kong Population Census [1], 8.4% of the population aged 15 and over had either no schooling or only kindergarten level of education. This is particularly so among the females with 12.0% of them belonging to that category versus 4.6% of the males within the same age group. Low literacy is also found to be more common among the older populations. Among the 55 and over, 31.2% had either no schooling or only kindergarten level of education.This shows that a significant number of the population had no or minimal level of education, particularly among the females and the elderly. The latter also tend to suffer from more chronic illnesses. This group of low literacy people are also more likely to belong to the population of the lower socio-economic groups. This group is the major user of Hong Kong's public hospitals and clinics. The ways these people utilise the public health care facilities will have a major impact on the efficiency of the system.Low literacy may be an important barrier to receiving adequate health care, because patients must be able
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