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Search Results: 1 - 10 of 59319 matches for " Y. Meng "
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Swarm Intelligence in Power System Planning  [PDF]
Ke Meng, Z.Y. Dong, Yichen Qiao
International Journal of Clean Coal and Energy (IJCCE) , 2013, DOI: 10.4236/ijcce.2013.22B001
Abstract: Power system planning is one of the essential tasks in the power system operation management, which requires in-depth knowledge of the system under consideration. It can be regarded as a nonlinear, discontinuous, constrained multi objective optimization problem. Although the traditional optimization tools can be used, the modern planning problem requires more advanced optimization tools. In this paper, a survey of state-of-the-art mathematical optimization methods that facilitates power system planning is provided, and the needs of introducing swarm intelligence approaches into power system planning are discussed.
Preparation of an antitumor and antivirus agent: chemical modification of α-MMC and MAP30 from Momordica Charantia L. with covalent conjugation of polyethyelene glycol
Meng Y, Liu S, Li J, Meng Y, Zhao X
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S30631
Abstract: eparation of an antitumor and antivirus agent: chemical modification of α-MMC and MAP30 from Momordica Charantia L. with covalent conjugation of polyethyelene glycol Original Research (2648) Total Article Views Authors: Meng Y, Liu S, Li J, Meng Y, Zhao X Video abstract presented by Yao Meng Views: 52 Published Date June 2012 Volume 2012:7 Pages 3133 - 3142 DOI: http://dx.doi.org/10.2147/IJN.S30631 Received: 07 February 2012 Accepted: 14 April 2012 Published: 28 June 2012 Yao Meng,1,2 Shuangfeng Liu,1 Juan Li,3 Yanfa Meng,3 Xiaojun Zhao2,4 1School of Medical Laboratory Science, Chengdu Medical College, Chengdu, China; 2West China Hospital Laboratory of Nanomedicine and Institute for Nanobiomedical Technology and Membrane Biology, Sichuan University, Chengdu, China; 3Key Laboratory of Bio-resources and Eco-environment Ministry of Education/Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China; 4Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA Background: Alpha-momorcharin (α-MMC) and momordica anti-HIV protein (MAP30) derived from Momordica charantia L. have been confirmed to possess antitumor and antivirus activities due to their RNA-N-glycosidase activity. However, strong immunogenicity and short plasma half-life limit their clinical application. To solve this problem, the two proteins were modified with (mPEG)2-Lys-NHS (20 kDa). Methodology/principal findings: In this article, a novel purification strategy for the two main type I ribosome-inactivating proteins (RIPs), α-MMC and MAP30, was successfully developed for laboratory-scale preparation. Using this dramatic method, 200 mg of α-MMC and about 120 mg of MAP30 was obtained in only one purification process from 200 g of Momordica charantia seeds. The homogeneity and some other properties of the two proteins were assessed by gradient SDS-PAGE, electrospray ionization quadruple mass spectrometry, and N-terminal sequence analysis as well as Western blot. Two polyethylene glycol (PEG)ylated proteins were synthesized and purified. Homogeneous mono-, di-, or tri-PEGylated proteins were characterized by matrix-assisted laser desorption ionization-time of flight mass spectrometry. The analysis of antitumor and antivirus activities indicated that the serial PEGylated RIPs preserved moderate activities on JAR choriocarcinoma cells and herpes simplex virus-1. Furthermore, both PEGylated proteins showed about 60%–70% antitumor and antivirus activities, and at the same time decreased 50%–70% immunogenicity when compared with their unmodified counterparts. Conclusion/significance: α-MMC and MAP30 obtained from this novel purification strategy can meet the requirement of a large amount of samples for research. Their chemical modification can solve the problem of strong immunogenicity and meanwhile preserve moderate activities. All these findings suggest the potential application of
Calibrating the updated overshoot mixing model on eclipsing binary stars: HY Vir, YZ Cas, X2 Hya & VV Crv
Y. Meng,Q. S. Zhang
Physics , 2014, DOI: 10.1088/0004-637X/787/2/127
Abstract: The detached eclipsing binary stars with convective cores provide a good tool to investigate the convective core overshoot. It has been performed on some binary stars to restrict the classical overshoot model which simply extends the boundary of fully mixed region. However, the classical overshoot model is physically unreasonable and inconsistent with the helioseismic investigation. An updated model of the overshoot mixing was established recently. There is a key parameter in the model. In this paper, we use the observations of four eclipsing binary stars, i.e., HY Vir, YZ Cas, $\rm{\chi^2}$ Hya and VV Crv, to investigate the suitable value for the parameter. It is found that the suggested value by the calibrations on eclipsing binary stars is same as the recommended value by other ways. And we have studied the effects of the updated overshoot model on the stellar structure. The diffusion coefficient of the convective/overshoot mixing is very high in the convection zone, then quickly decreases near the convective boundary, and exponentially decreases in the overshoot region. The low value of the diffusion coefficient in the overshoot region leads to weak mixing and the partially mixed overshoot region. The semi-convection, which appears in the standard stellar models of low-mass stars with convective core, is removed by the partial overshoot mixing.
The Breaking of the SU(3)^3 Gauge Group
Meng Y. Wang,Eric D. Carlson
Physics , 1993,
Abstract: We discuss why the SU(3)^3 supersymmetric model with the most general superpotential can naturally break to the standard model if gauge singlets and a discrete symmetry are included. This mechanism does away with the need for fine-tuning in the form of the assumed absence of certain terms in the superpotential. It also automatically guarantees that any abelian discrete phase symmetry of the GUT will survive the symmetry breaking. Such a discrete symmetry, also known as the matter parity, is needed to suppress both proton decay and the flavor changing neutral current (FCNC), and may help solve the hierarchy problem.
Will discrete symmetries help solve the hierarchy problem ?
Meng Y. Wang,Eric D. Carlson
Physics , 1992,
Abstract: We find that massless Higgs doublets at the GUT scale can be the natural result of a discrete symmetry. Such a mechanism does not require elaborate fine tuning or complicated particle content. The same discrete symmetry will also protect against proton decay and flavor changing neutral currents. However, this mechanism always predicts non-minimal standard models. An explicit example of how this mechanism works is also included.
Asymptotics of neutron Cooper pair in weakly bound nuclei
Y. Zhang,M. Matsuo,J. Meng
Physics , 2013, DOI: 10.1103/PhysRevC.90.034313
Abstract: Asymptotic form of neutron Cooper pair penetrating to the exterior of nuclear surface is investigated with the Bogoliubov theory for the superfluid Fermions. Based on a two-particle Schr\"{o}dinger equation governing the Cooper pair wave function and systematic studies for both weakly bound and stable nuclei, the Cooper pair is shown to be spatially correlated even in the asymptotic large distance limit, and the penetration length of the pair condensate is revealed to be universally governed by the two-neutron separation energy $S_{2n}$ and the di-neutron mass $2m$.
Pair correlation of giant halo nuclei in continuum Skyrme-Hartree-Fock-Bogoliubov theory
Y. Zhang,M. Matsuo,J. Meng
Physics , 2012, DOI: 10.1103/PhysRevC.86.054318
Abstract: The giant halos predicted in neutron-rich Zr isotopes with $A=124-138$ are investigated by using the self-consistent continuum Skyrme Hartree-Fock-Bogoliubov approach, in which the asymptotic behavior of continuum quasiparticle states is properly treated by the Green's function method. We study in detail the neutron pair correlation involved in the giant halo by analyzing the asymptotic exponential tail of the neutron pair condensate (pair density) in addition to that of the neutron particle density. The neutron quasiparticle spectra associated with these giant halo nuclei are examined. It is found that the asymptotic exponential tail of the neutron pair condensate is dominated by non-resonant continuum quasiparticle states corresponding to the scattering states with low asymptotic kinetic energy. This is in contrast to the asymptotic tail of the neutron density, whose main contributions arise from the resonant quasiparticle states corresponding to the weakly-bound single-particle orbits and resonance orbits in the Hartree-Fock potential.
Preparation of 10-hydroxycamptothecin-loaded glycyrrhizic acid-conjugated bovine serum albumin nanoparticles for hepatocellular carcinoma-targeted drug delivery
Zu Y,Meng L,Zhao X,Ge Y
International Journal of Nanomedicine , 2013,
Abstract: Yuangang Zu, Li Meng, Xiuhua Zhao, Yunlong Ge, Xinyang Yu, Yin Zhang, Yiping Deng Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, People’s Republic of China Introduction: The livertaxis of glycyrrhizic acid-conjugated bovine serum albumin (GL-BSA) has been reported in the literature. Now, in this paper, we describe a novel type of drug-targeted delivery system containing 10-hydroxycamptothecin (HCPT) with liver tumor targeting. Methods: First, GL was coupled to BSA then HCPT was encapsulated in GL-BSA by high-pressure homogenization emulsification. In the experimental design, the influencing variables on particle size and drug loading efficiency were determined to be BSA concentration, volume ratio of water to organic phase, and speed and speed duration of homogenization as well as homogenization pressure and the number of times homogenized at certain pressures. Particle size plays an important role in screening optimal conditions of nanoparticles preparation. Characteristics of 10-hydroxycamptothecin-loaded glycyrrhizic acid-conjugated bovine serum albumin nanoparticles (GL-BSA-HCPT-NPs), such as the drug encapsulation efficiency, drug loading efficiency, and GL-BSA content were studied. In addition, the morphology of the nanoparticles (NPs) and weight loss rate were determined and Fourier transform infrared spectroscopy, X-ray diffraction spectroscopy, and thermal analysis performed. Results: The average particle size of the sample NPs prepared under optimal conditions was 157.5 nm and the zeta potential was 22.51 ± 0.78 mV; the drug encapsulation efficiency and drug loading efficiency were 93.7% and 10.9%, respectively. The amount of GL coupling to BSA was 98.26 μg/mg. Through physical property study of the samples, we determined that the HCPT had been successfully wrapped in GL-BSA. In vitro drug-release study showed that the nanoparticles could release the drug slowly and continuously. Hemolysis testing showed the safety of GL-BSA as a novel drug delivery system. The targeting properties of GL-BSA-HCPT-NPs were studied in an in vitro cell uptake study and cell proliferation assay. Cells incubated with GL-BSA-HCPT-NPs and labeled with fluorescein isothiocyanate showed more extensive fluorescence spots and stronger fluorescence intensity than samples without GL conjugation. MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to determine the inhibitory rate of the samples. It was found that the inhibitory rate of GL-BSA-HCPT-NPs develops as concentration rises. Furth
A comparative study of the skeletal morphology of the temporo-mandibular joint of children and adults
Meng F,Liu Y,Hu K,Zhao Y
Journal of Postgraduate Medicine , 2008,
Abstract: Background: The skeletal morphology of the temporo-mandibular joint (TMJ) is constantly remodeled. Aims and Objectives: A comparative study was undertaken to determine and characterize the differences in the skeletal morphology of TMJ of children and adults. Materials and Methods: The study was conducted on 30 children cadavers and 30 adult volunteers. Parameters that could reflect TMJ skeletal morphology were measured with a new technology combining helical computed tomography (CT) scan with multi-planar reformation (MPR) imaging. Results: Significant differences between children cadavers and adults were found in the following parameters ( P < 0.05): Condylar axis inclination, smallest area of condylar neck/largest area of condylar process, inclination of anterior slope in inner, middle, and outer one-third of condyle, anteroposterior/mediolateral dimension of condyle, length of anterior slope/posterior slope in inner and middle one-third of condyle, anteroposterior dimension of condyle/glenoid fossa, mediolateral dimension of condyle/glenoid fossa, inclination of anterior slope of glenoid fossa, depth of glenoid fossa, and anteroposterior/mediolateral dimension of glenoid fossa. Conclusion: There are significant differences of TMJ skeletal morphology between children and adults.
Structure, morphology, and mechanical properties of polysiloxane elastomer composites prepared by in situ polymerization of zinc dimethacrylate
Y. Meng,Y. L. Lu,Z. Wei,L. Q. Zhang
eXPRESS Polymer Letters , 2012, DOI: 10.3144/expresspolymlett.2012.94
Abstract: Methyl vinyl silicone rubber/zinc dimethacrylate (VMQ/ZDMA) composites were prepared through in situ polymerization of ZDMA monomers during the peroxide curing. The polymerization conversion of ZDMA and morphology of the VMQ/ZDMA composites were studied. The results showed that most of the ZDMA monomers participated in the in situ polymerization during the cross-linking of the VMQ matrix and uniform nanophases were formed in the composites. The ‘dissolving-diffusion’ model was used to explain the micro-nano transformation of ZDMA. According to the model, a uniform nano-dispersed structure could be obtained through the in situ reaction even though the initial dispersion of ZDMA in the blends was poor. In addition, tensile tests of VMQ/ZDMA composites showed that ZDMA had a significant reinforcement on the mechanical properties of VMQ, and the best mechanical properties were obtained when the amounts of peroxide and ZDMA were 5 and 40 phr, respectively. The gross crosslink density and ionic crosslink density increased as the amount of ZDMA increased, but the covalent crosslink density decreased slightly. These results indicated that the ionic crosslink structure had a significant effect on the mechanical properties of VMQ/ZDMA composites.
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