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Search Results: 1 - 10 of 52723 matches for " Y. Hari Babu "
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Immunomodulatory Effect of Recombinant Chicken Interferon-gamma (rchIFN-γ) on Specific and Non-specific Immune Responses in Chicken Vaccinated Against Newcastle Disease Virus (NDV)
Basavaraj Binjawadagi,Y. Hari Babu,E. Sreekumar
International Journal of Poultry Science , 2009,
Abstract: Present study was undertaken to evaluate the immunomodulatory effect of recombinant chicken interferon -gamma (rchIFN-γ) on specific and non-specific immune responses in chicken vaccinated against Newcastle Disease Virus (NDV). A total of 180 day old layer chicks (BV-300) were divided into three groups. Test Group I (TG-I) (64 chicks) was injected with 5 microgram/chick subcutaneously of rchIFN-γ along with ND vaccinations (LaSota and R2B strains), Test Group II (TG-II) (64 chicks) was injected with same dose and route of rchIFN-γ 6 h after ND vaccinations on both occasions, whereas, third group remained as vaccinated control group (52 chicks). Haemagglutination Inhibition (HI) test and Migration Inhibition (MI) in percentages estimated by Leukocyte Migration Inhibition Test (LMIT) were conducted to evaluate humoral and cell mediated immune responses respectively. Nitroblue Tetrazolium (NBT) reduction assay was conducted to evaluate the non-specific immune response by estimating the Phagocytic Index (PI) in percentages. The test results revealed that, significantly (p< 0.05) increased specific (humoral and cell mediated) and non-specific immune responses were recorded in the groups treated with rchIFN-γ i.e., higher results when given along with the vaccine and highest results when given 6 h after vaccinations. The results advocated that, rchIFN-γ may be used as an immunopotentiator in chicken vaccinated against NDV.
Synthesis, Spectral characterization and antimicrobial activity of 2-(substituted)-2,2-[1,3- dihydro-(3,4-1,2,5-oxadiazolediyl) diaza][5 , 5 -dimethyl-1 , 3 -propanediyl) dioxy] phosphoranes
Y. Hari Babu,A. Uma Ravi Sankar,B. Siva Kumar,C. Suresh Reddy
Organic Communications , 2010,
Abstract: The cyclic oxadiazolediyl dioxachlorophosphine precursor on subsequent reaction with various alcohols underwent halide displacement to give 2-substituted diaza phospholes. These phospholes on oxidative addition with di hydroxy alcohols form corresponding phosphoranes The antimicrobial activities of these compounds were evaluated and they exhibited significant antimicrobial activity.
The Immunomodulatory Role of Calf Thymus Extract on Humoral and Cell Mediated Immune Response in Chicken Vaccinated Against New Castle Disease Virus
B.M. Chandra Naik,Y. Hari Babu,G.S. Mamatha
International Journal of Poultry Science , 2005,
Abstract: The effect of administration of calf thymus extract (CTE) with protein concentration of 1.8mg/ml was studied using two groups of day old layer chicks. Both the groups were vaccinated with ‘F’ and ‘R2B’ strains of New Castle Disease Virus (NDV) vaccines on 7th day and 8th week respectively. One group was administered with 1.8mg of thymic proteins intraperitoneally, one week prior and one week after each vaccination. The other group remained as vaccinated control group. Humoral and cell mediated responses were evaluated 15 days after each vaccination. Intraperitoneal administration of calf thymus extract markedly and significantly increased the antibody titres against NDV, serum globulin level, and percentage of lymphocytes in the blood. In addition thymus extract resulted in definite and significant cellular immunopotentiation.
Design and Evaluation of Delayed and Extended Release Tablets of Mesalamine
NAGARAJU.R,SWAPNA.Y,HARI BABU.R,RAJESH KAZA
Journal of Pharmaceutical Science and Technology , 2010,
Abstract: The present study was focused on optimization of the formulation for the delayed and extendedrelease tablets of mesalamine. Various formulations was prepared by wet granulation technique usingthe polymers, such as HPMCK-100M, HPMC K4M, HPMCE15 and HPMC E5. It was found that the best formulation ML10 showed 98.75 % of drug release at the end of 10 th hour. This way the best formulation was achieved by using the combination of high and low viscous polymers HPMC K4M and HPMC E5 in the ratio of 60:40 was able to prolong the drug release for about 10 hrs in pH 7.5 phosphate buffer. In-vitro drug release studies of mesalamine delayed and extended release tablets showed that, the rate of the drug release follows first order kinetics as indicated straight line with good correlation coefficient for the plot of log percentage drug remaining vs time. The rate of drug release was found to be dissolution control as there was a good correlation coefficient for the plot of Hixon-Crowell cube–root law.
Evaluation of carbamate insecticides as chemotherapeutic agents for cancer
Mohd. Amanullah,Hari Babu
Indian Journal of Cancer , 2011,
Abstract: Background: Cancer chemotherapy has already been in practice by the use of toxins and some of the specific poisonous compounds of cyanide derivatives. Carbamate insecticides inhibit cellular metabolism including energy, protein, and nucleic acid metabolism, thereby, causing cell regression and death. Aim: Preliminary evaluation of three carbamate insecticides, namely, baygon, carbaryl, and carbofuran as chemotherapeutic agents for cancer is undertaken in the present study. Materials and Methods: The toxicity of carbamates on squamous cell carcinoma was assessed in-vitro using dye binding tests. Cells were grown in microtitration ELISA plates, as adherent cultures, for six hours, and then exposed to the drugs for 2, 4, 8, and 12 hours, and finally stained with neutral red, to assess the viable cell number, and with methylene blue for the determination of protein in the monolayer. Optical density was read in an ELISA reader. Statistical Analysis: The data obtained during the experiment was subjected to statistical analysis by using the student ′t′ test. Results: The results indicated that the percentage of the viable cell number reduced with an increase in the time of exposure of the drugs. Exposure of the tumor cells to the drugs for 12 hours detached them completely from the wells, and hence, all the cells were washed out. Exposure of the drugs prior to the establishment of the culture in-vitro resulted in the non-formation of the monolayer in the wells. Conclusions: Among the three drugs studied, the survival percent was least with carbaryl treatment followed by baygon, and with carbofuran treatment it was almost near to control group.
Growth of Strongly Biaxially Aligned MgB2 Thin Films on Sapphire by Post-annealing of Amorphous Precursors
A. Berenov,Z. Lockman,X. Qi,Y. Bugoslavsky,L. F. Cohen,M. -H. Jo,N. A. Stelmashenko,V. N. Tsaneva,M. Kambara,N. Hari Babu,D. A. Cardwell,M. G. Blamire,J. L. MacManus-Driscoll
Physics , 2001, DOI: 10.1063/1.1424070
Abstract: MgB2 thin films were cold-grown on sapphire substrates by pulsed laser deposition (PLD), followed by post-annealing in mixed, reducing gas, Mg-rich, Zr gettered, environments. The films had Tcs in the range 29 K to 34 K, Jcs (20K, H=0) in the range 30 kA/cm2 to 300 kA/cm2, and irreversibility fields at 20 K of 4 T to 6.2 T. An inverse correlation was found between Tc and irreversibility field. The films had grain sizes of 0.1-1 micron and a strong biaxial alignment was observed in the 950C annealed film.
Clinical potential of sodium-glucose cotransporter 2 inhibitors in the management of type 2 diabetes
Kim Y, Babu AR
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy , 2012, DOI: http://dx.doi.org/10.2147/DMSO.S22545
Abstract: ical potential of sodium-glucose cotransporter 2 inhibitors in the management of type 2 diabetes Review (3169) Total Article Views Authors: Kim Y, Babu AR Published Date August 2012 Volume 2012:5 Pages 313 - 327 DOI: http://dx.doi.org/10.2147/DMSO.S22545 Received: 13 April 2012 Accepted: 25 May 2012 Published: 31 August 2012 Yoojin Kim, Ambika R Babu Division of Endocrinology, John Stroger Jr Hospital of Cook County and Rush University, Chicago, IL, USA Background: The kidney plays an important role in glucose metabolism, and has been considered a target for therapeutic intervention. The sodium-glucose cotransporter type 2 (SGLT2) mediates most of the glucose reabsorption from the proximal renal tubule. Inhibition of SGLT2 leads to glucosuria and provides a unique mechanism to lower elevated blood glucose levels in diabetes. The purpose of this review is to explore the physiology of SGLT2 and discuss several SGLT2 inhibitors which have clinical data in patients with type 2 diabetes. Methods: We performed a PubMed search using the terms "SGLT2" and "SGLT2 inhibitor" through April 10, 2012. Published articles, press releases, and abstracts presented at national and international meetings were considered. Results: SGLT2 inhibitors correct a novel pathophysiological defect, have an insulin-independent action, are efficacious with glycosylated hemoglobin reduction ranging from 0.5% to 1.5%, promote weight loss, have a low incidence of hypoglycemia, complement the action of other antidiabetic agents, and can be used at any stage of diabetes. They are generally well tolerated. However, due to side effects, such as repeated urinary tract and genital infections, increased hematocrit, and decreased blood pressure, appropriate patient selection for drug initiation and close monitoring after initiation will be important. Results of ongoing clinical studies of the effect of SGLT2 inhibitors on diabetic complications and cardiovascular safety are crucial to determine the risk-benefit ratio. A recent decision by the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended approval of dapagliflozin for the treatment of type 2 diabetes as an adjunct to diet and exercise, in combination with other glucose-lowering medicinal products, including insulin, and as a monotherapy for metformin-intolerant patients. Clinical research also remains to be carried out on the long-term effects of glucosuria and other potential effects of SGLT2 inhibitors, especially in view of the observed increase in the incidence of bladder and breast cancer. SGLT2 inhibitors represent a promising approach for the treatment of diabetes, and could potentially be an addition to existing therapies.
PCA based image denoising
Y. Murali Mohan Babu
Signal & Image Processing , 2012,
Abstract: Principal component analysis (PCA) is an orthogonal transformation that seeks thedirections of maximum variance in the data and is commonly used to reduce the dimensionality of the data.In image denoising, a compromise has to be found between noise reduction and preserving significantimage details. PCA is a statistical technique for simplifying a dataset by reducing datasets to lowerdimensions. It is a standard technique commonly used for data reduction in statistical pattern recognitionand signal processing. This paper proposes a denoising technique by using a new statistical approach,principal component analysis with local pixel grouping (LPG). This procedure is iterated second time tofurther improve the denoising performance, and the noise level is adaptively adjusted in the second stage.
Clinical potential of sodium-glucose cotransporter 2 inhibitors in the management of type 2 diabetes
Kim Y,Babu AR
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy , 2012,
Abstract: Yoojin Kim, Ambika R BabuDivision of Endocrinology, John Stroger Jr Hospital of Cook County and Rush University, Chicago, IL, USABackground: The kidney plays an important role in glucose metabolism, and has been considered a target for therapeutic intervention. The sodium-glucose cotransporter type 2 (SGLT2) mediates most of the glucose reabsorption from the proximal renal tubule. Inhibition of SGLT2 leads to glucosuria and provides a unique mechanism to lower elevated blood glucose levels in diabetes. The purpose of this review is to explore the physiology of SGLT2 and discuss several SGLT2 inhibitors which have clinical data in patients with type 2 diabetes.Methods: We performed a PubMed search using the terms "SGLT2" and "SGLT2 inhibitor" through April 10, 2012. Published articles, press releases, and abstracts presented at national and international meetings were considered.Results: SGLT2 inhibitors correct a novel pathophysiological defect, have an insulin-independent action, are efficacious with glycosylated hemoglobin reduction ranging from 0.5% to 1.5%, promote weight loss, have a low incidence of hypoglycemia, complement the action of other antidiabetic agents, and can be used at any stage of diabetes. They are generally well tolerated. However, due to side effects, such as repeated urinary tract and genital infections, increased hematocrit, and decreased blood pressure, appropriate patient selection for drug initiation and close monitoring after initiation will be important. Results of ongoing clinical studies of the effect of SGLT2 inhibitors on diabetic complications and cardiovascular safety are crucial to determine the risk-benefit ratio. A recent decision by the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended approval of dapagliflozin for the treatment of type 2 diabetes as an adjunct to diet and exercise, in combination with other glucose-lowering medicinal products, including insulin, and as a monotherapy for metformin-intolerant patients. Clinical research also remains to be carried out on the long-term effects of glucosuria and other potential effects of SGLT2 inhibitors, especially in view of the observed increase in the incidence of bladder and breast cancer. SGLT2 inhibitors represent a promising approach for the treatment of diabetes, and could potentially be an addition to existing therapies.Keywords: sodium-glucose cotransporter type 2, SGLT2, inhibitors, kidney, glucosuria, oral diabetes agent, weight loss
A Regional Climate Study of Heat Waves over the Iberian Peninsula  [PDF]
Hari Prasad Dasari, Isaac Pozo, Francisco Ferri-Yá?ez, Miguel B. Araújo
Atmospheric and Climate Sciences (ACS) , 2014, DOI: 10.4236/acs.2014.45074
Abstract: We present a regional climate simulation for the Iberian Peninsula for a 60-year period (1950-2009) using the WRF-ARW model with a focus on the simulation of summer maximum temperatures and associated extreme heat waves. The WRF model was designed at a 5 km horizontal resolution on a 5-month (May-September) seasonal scale, for every year, during the study period with initial/boundary conditions derived from NCEP 2.5 degree reanalysis. The comparison of simulated mean summer seasonal maximums and mean maximums of June, July, and August months with the corresponding E-OBS data sets indicates that the model is able to characterize the spatial variation of magnitudes of temperature change over the Iberian Peninsula. The mean extreme heat wave conditions during the climate period 1950-2009 are well simulated and match the observations well. The regional scale simulations clearly show the propagation of intense heat waves from the south west to north east of Iberia. The WRF-ARW model also simulated well the general trend of increase in heat waves over most parts of the Iberian Peninsula during the study period 1950-2009. The characteristics of the most severe heat waves years 2003 and 2006 are also well simulated by the model.
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