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Search Results: 1 - 10 of 50489 matches for " Y Balabanova "
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Cross Skin Reactivity to Tyrosine Kinase Inhibitors in a Patient with Chronic Myelogenous Leukemia  [PDF]
V. Broshtilova, M. Balabanova
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.47130
Abstract:

Tyrosine kinase inhibitors (TKI) targeting the bcr-abl protein, c-kit and the platelet-derived growth factor receptors, are significant part of the pathogenic therapy of chronic myelogenous leukemia. A broad spectrum of cutaneous side effects has been described with the clinical use of imatinib mesylate, ranging from various acute rashes to toxic epidermal necrolysis. Herein, a case of cross skin toxicity to TKI in a patient with chronic myelogenous leukemia is presented. In the course of imatinib mesylate therapy the patient developed a grade 4 diffuse lichenoid drug eruption. Six months after switching to nilotinib, hyperpigmented macules and patches spread over his trunk and extremities. To date, few cases of cross skin reactivity to imatinib and nilotinib have been described, none of which showing different clinical phenotypes. Further understanding of the underlying mechanisms and leading to the development of skin rashes from different class of TKI is important to highlight new drug targets and modify the current therapies to a level of maximal efficacy.

The Directly Observed Therapy Short-Course (DOTS) strategy in Samara Oblast, Russian Federation
Y Balabanova, F Drobniewski, I Fedorin, S Zakharova, V Nikolayevskyy, R Atun, R Coker
Respiratory Research , 2006, DOI: 10.1186/1465-9921-7-44
Abstract: The purpose of this study was to implement a DOTS programme in the civilian and prison sectors of Samara Region of Russia, describe the clinical features and outcomes of recruited patients, determine the proportion of individuals in the cohorts who were infected with drug resistant TB, the degree to which resistance was attributed to the Beijing TB strain family and establish risk factors for drug resistance.prospective study2,099 patients were recruited overall. Treatment outcomes were analysed for patients recruited up to the third quarter of 2003 (n = 920). 75.3% of patients were successfully treated. Unsuccessful outcomes occurred in 7.3% of cases; 3.6% of patients died during treatment, with a significantly higher proportion of smear-positive cases dying compared to smear-negative cases. 14.0% were lost and transferred out. A high proportion of new cases (948 sequential culture-proven TB cases) had tuberculosis that was resistant to first-line drugs; (24.9% isoniazid resistant; 20.3% rifampicin resistant; 17.3% multidrug resistant tuberculosis). Molecular epidemiological analysis demonstrated that half of all isolated strains (50.7%; 375/740) belonged to the Beijing family. Drug resistance including MDR TB was strongly associated with infection with the Beijing strain (for MDR TB, 35.2% in Beijing strains versus 9.5% in non-Beijing strains, OR-5.2. Risk factors for multidrug resistant tuberculosis were: being a prisoner (OR 4.4), having a relapse of tuberculosis (OR 3.5), being infected with a Beijing family TB strain (OR 6.5) and having an unsuccessful outcome from treatment (OR 5.0).The implementation of DOTS in Samara, Russia, was feasible and successful. Drug resistant tuberculosis rates in new cases were high and challenge successful outcomes from a conventional DOTS programme alone.Since the 1990s the World Health Organization Directly Observed Therapy Short Course (DOTS) management strategy has become the internationally recommended approach for tubercul
Stereochemical course of hydrolytic reaction catalyzed by alpha-galactosidase from cold adaptable marine bacterium of genus Pseudoalteromonas
Irina Y. Bakunina,Larissa A. Balabanova,Vasiliy A. Golotin,Valeriy A. Rasskazov
Frontiers in Chemistry , 2014, DOI: 10.3389/fchem.2014.00089
Abstract: The recombinant α-galactosidase of the marine bacterium (α-PsGal) was synthesized with the use of the plasmid 40Gal, consisting of plasmid pET-40b (+) (Novagen) and the gene corresponding to the open reading frame of the mature α-galactosidase of marine bacterium Pseudoalteromonas sp. KMM 701, transformed into the Escherichia coli Rosetta(DE3) cells. In order to understand the mechanism of action, the stereochemistry of hydrolysis of 4-nitrophenyl α-D-galactopyranoside (4-NPGP) by α-PsGal was measured by 1H NMR spectroscopy. The kinetics of formation of α- and β-anomer of galactose showed that α-anomer initially formed and accumulated, and then an appreciable amount of β-anomer appeared as a result of mutarotation. The data clearly show that the enzymatic hydrolysis of 4-NPGP proceeds with the retention of anomeric configuration, probably, due to a double displacement mechanism of reaction.
Basic features of agrotourism in Germany
Anna O. Balabanova
European Researcher , 2011,
Abstract: The article concerns basic questions of rural tourism development in Europe and Germany, history of its formation and the form of realization
The Distribution and Substrate Specificity of Extracellular Nuclease Activity in Marine Fungi  [PDF]
Larissa A. Balabanova, Michael V. Pivkin, Valery A. Rasskazov
Open Journal of Marine Science (OJMS) , 2012, DOI: 10.4236/ojms.2012.24022
Abstract: The distribution and specificity of extracellular nucleases produced by marine fungi belonging to eleven genera, namely: Alternaria, Aspergillus, Aureobasidium, Chaetomium, Fusarium, Gliomastix, Humicola, Penicillium, Scopulariopsis, Wardomyces, Periconia, have implied its important function in the organic phosphorus and nitrogen circle in the Ocean. The fungal nucleases of 64 isolates tested were more or less specific for single-stranded DNA with a high preferential specificity towards poly-U substrate with forming of 5’-phosphate mononucleotides. A couple of the nucleases were capable of RNA digesting. The highest level of extracellular nucleolytic ability was observed in Penicillium spp. isolates. The tight correlation found between extracellular nuclease activity and the rate of thymidine uptake by actively growing and sporulating marine fungus Penicillium melinii suggests that this nuclease is required for fulfilling the nucleotide pool of precursors of DNA biosynthesis during transformation of hyphae into the aerial mycelium and conidia in stressful environmental conditions.
An analysis of trends and determinants of health insurance and healthcare utilisation in the Russian population between 2000 and 2004: the 'inverse care law' in action
Francesca Perlman, Dina Balabanova, Martin McKee
BMC Health Services Research , 2009, DOI: 10.1186/1472-6963-9-68
Abstract: Data were from the Russia Longitudinal Monitoring Survey, an annual household panel survey (2000–4) from 38 centres across the Russian Federation. Annual trends in insurance coverage were measured (2000–4). Cross-sectional multivariate analyses of the determinants of health insurance and its relationship with health care utilisation were performed in working-age people (18–59 years) using 2004 data.Between 2000 and 2004, coverage by the compulsory insurance scheme increased from 88% to 94% of adults; however 10% of working-age men remained uninsured. Compulsory health insurance coverage was lower amongst the poor, unemployed, unhealthy and people outside the main cities. The uninsured were less likely to seek medical help for new health problems. 3% of respondents had supplementary (private) insurance, and rising utilisation of private healthcare was greatest amongst the more educated and wealthy.Despite high population insurance coverage, a multiply disadvantaged uninsured minority remains, with low utilisation of health services. Universal insurance could therefore increase access, and potentially contribute to reducing avoidable healthcare-related mortality. Meanwhile, the socioeconomically advantaged are turning increasingly to a growing private sector.The Soviet Union created a health care system that was, at least officially, largely free at the point of use. However, after 1991, the newly independent states faced major challenges in maintaining this system, large parts of which had been linked to major employers that were becoming insolvent. [1] For many, access to health care became difficult, [2] with shortages of equipment and medication. [3] Although Russia may have coped better [4] than some of its neighbours, such as Kyrgyzstan [5] or the southern Caucasus [6] the 1990s were still a time of considerable difficulty. [3] Deaths preventable by timely and effective health care were much more common than in western countries. [7]A system of statutory health
Tinea Faciei – Hypo Diagnosed Facial Dermatoses
Agron Starova,Margareta Balabanova Stefanova,Mihael Skerlev
Macedonian Journal of Medical Sciences , 2010,
Abstract: Background. Tinea faciei is dermatophytoses limited to the nonbearded regions of the face. The objectives of the study are: to assess the frequency of the Tinea faciei patients, the most common causative dermatophytic species and to point out on great diversity of clinical presentation of Tinea faciei. Patients and Methods. The patients with Tinea facie treated in the Mycological Ambulance, Department of Dermatology, Medical Faculty in Skopje, during the period Jun 2007 - Jan 2009 were evaluated. The diagnosis was confirmed by microscopic examination of skin and hair specimens and by culture on Sabouraud’s medium with added chloramphenicol, gentamycin and actidion. Results. Six hundreds patients with dermatophytosis were diagnosed over a time period of twenty months (Jun 2007 – January 2009). The Tinea faciei patients represented 2.2% (13) of all patients with dermatophytosis. Most frequently isolated dermatophytic species are Trichophyton verrucosum (38.46% of all Tinea faciei patients), Microsporum canis (30.77%), Trichophyton rubrum (23.08%) and Trichophyton mentagrophytes var. mentagrophytes (7.69%). The zoophylic dermatophytic species are predominant. All of the Tinea faciei patients are initially misdiagnosed as having other dermatoses.Conclusions. In patients with erythematous lesions of the face, a diagnosis of Tinea faciei should be considered. The variable morphology of Tinea faciei creates a large differential diagnosis. The frequent atypical clinical features and incognito presentations make Tinea faciei a unique and most frequently hypo diagnosed facial dermatoses with often delayed appropriate treatment.
Emergence of Haemophilus influenzae Strains in the Nasopharynx of Children with Tuberculosis
Alina V. Martynova,Larisa A. Balabanova,Alexei Pruschinskyi
Pulmonary Medicine , 2011, DOI: 10.1155/2011/420284
Abstract: Being rigorously studied, epidemiology aspects of Haemophilus influenzae carriage are still remaining unclear. Especially it concerns such a group as children with low immune status and also such group as children with tuberculosis infection. We examined nasopharyngeal tract of children with tuberculosis infection in remission and checked how often these children are carriers of Haemophilus influenzae strains. Also we gained microbiology characteristics of the isolates and defined the clinical significance of H. influenzae carriage in development of opportunistic infections in children with the tuberculosis infection. 1. Introduction Despite improvements in diagnosis, treatment,and preventive measures, tuberculosis remains an important cause of morbidity globally. In the Primorye Region of far east Russia (population 2000.000), the incidence of tuberculosis in 2008 was 105.7 per 100.000 and with a prevalence of 222 per 100.000. For children under 17 years, the incidence of tuberculosis was 36.6 per 100.000. In 2008, there were 108 cases of tuberculosis in??children under 11 years, and 83 cases in children from 11 to 17 years (Federal Morbidity Report, 2009). Mortality increased by 20.7% compared to 2000. In the pediatric population, pulmonary tuberculosis accounted for 90.9% of all tuberculosis in 2008, up from 72.7% in 1999. It was recognized that children treated for tuberculosis were more often ill with other bacterial respiratory tract infections than children without such comorbidity. There are several possible contributing factors to this, for example, impaired immune status, malnutrition, and low??socioeconomical status of their family. However, other important factors could be the regular antimicrobial (antituberculosis) chemotherapy they receive or attendance at the Pediatric Tuberculosis Center for anything between 20 and 180 days, according to the current tuberculosis treatment protocol. As the main focus for such patients is the treatment of tuberculosis, the problem of other bacterial respiratory tract infections could be underestimated. There are some data on the carriage of bacterial respiratory tract pathogens in children with various comorbidities [1–5], but little information on the carriage of H.influenzae in children with tuberculosis or children from closed communities [5, 6]. Aim We aim to study the prevalance of H. influenzae in the??nasopharynx of children with tuberculosis and to assess antimicrobial susceptibility of these bacteria. 2. Materials and Methods We examined 85 children from the Pediatric Tuberculosis Center (Group
Rates of Latent Tuberculosis in Health Care Staff in Russia
Francis Drobniewski ,Yanina Balabanova,Elena Zakamova,Vladyslav Nikolayevskyy,Ivan Fedorin
PLOS Medicine , 2007, DOI: 10.1371/journal.pmed.0040055
Abstract: Background Russia is one of 22 high burden tuberculosis (TB) countries. Identifying individuals, particularly health care workers (HCWs) with latent tuberculosis infection (LTBI), and determining the rate of infection, can assist TB control through chemoprophylaxis and improving institutional cross-infection strategies. The objective of the study was to estimate the prevalence and determine the relative risks and risk factors for infection, within a vertically organised TB service in a country with universal bacille Calmette-Guérin (BCG) vaccination. Methods and Findings We conducted a cross-sectional study to assess the prevalence of and risk factors for LTBI among unexposed students, minimally exposed medical students, primary care health providers, and TB hospital health providers in Samara, Russian Federation. We used a novel in vitro assay (for gamma-interferon [IFN-γ]) release to establish LTBI and a questionnaire to address risk factors. LTBI was seen in 40.8% (107/262) of staff and was significantly higher in doctors and nurses (39.1% [90/230]) than in students (8.7% [32/368]) (relative risk [RR] 4.5; 95% confidence interval [CI] 3.1–6.5) and in TB service versus primary health doctors and nurses: respectively 46.9% (45/96) versus 29.3% (34/116) (RR 1.6; 95% CI 1.1–2.3). There was a gradient of LTBI, proportional to exposure, in medical students, primary health care providers, and TB doctors: respectively, 10.1% (24/238), 25.5% (14/55), and 55% (22/40). LTBI was also high in TB laboratory workers: 11/18 (61.1%). Conclusions IFN-γ assays have a useful role in screening HCWs with a high risk of LTBI and who are BCG vaccinated. TB HCWs were at significantly higher risk of having LTBI. Larger cohort studies are needed to evaluate the individual risks of active TB development in positive individuals and the effectiveness of preventive therapy based on IFN-γ test results.
Reforming sanitary-epidemiological service in Central and Eastern Europe and the former Soviet Union: an exploratory study
George Gotsadze, Ivdity Chikovani, Ketevan Goguadze, Dina Balabanova, Martin McKee
BMC Public Health , 2010, DOI: 10.1186/1471-2458-10-440
Abstract: A review of literature was conducted. A conceptual framework was developed to guide the review, which focused on the two traditional core public health functions of the san-epid system: communicable disease surveillance, prevention and control and environmental health. The review included twenty-two former communist countries in the former Soviet Union (fSU) and in Central and Eastern Europe (CEE).The countries studied fall into two broad groups. Reforms were more extensive in the CEE countries than in the fSU. The CEE countries have moved away from the former centrally managed san-epid system, adopting a variety of models of decentralization. The reformed systems remain mainly funded centrally level, but in some countries there are contributions by local government. In almost all countries, epidemiological surveillance and environmental monitoring remained together under a single organizational umbrella but in a few responsibilities for environmental health have been divided among different ministries.Progress in reform of public health services has varied considerably. There is considerable scope to learn from the differing experiences but also a need for rigorous evaluation of how public health functions are provided.The instigators of the 1917 Russian revolution initially placed a high priority on population health, for sound political reasons; ten million people succumbed to the epidemics of typhus that afflicted Russia from 1918 onwards, threatening the survival of the new regime. The first People's Commissar for Public Health, Nikolai Semashko, who gave his name to the Soviet health care system, created an extensive public health infrastructure, based on a network of sanitary-epidemiological (san-epid) stations, owned by the Ministry of Health, and charged with surveillance and control of threats to health. These threats were interpreted mainly as infectious diseases and control of some forms of environmental pollution (although in both cases always giving pr
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