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Search Results: 1 - 10 of 42428 matches for " Xu Jieshuang "
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Engaging Civil Society Organizations in Adolescent Reproductive Health Policy Process in Mainland of China  [PDF]
Xu Jieshuang, Verhart Noortje, Stephen Pearson, Qian Xu
Chinese Studies (ChnStd) , 2013, DOI: 10.4236/chnstd.2013.23019
Abstract: This paperexploredhow Chinese civil society organizations (CSOs) had been involved in an adolescent reproductive health policy process and its implications for other developing countries with similar political and social contexts. The case study was the 6th cycle of the Country Program on adolescent reproductive health (Jan. 2006-Dec. 2010). It was a multi-phased, retrospective qualitative study in Guangxi autonomous region. Six categories of policy actors including politician, CSO, policy-maker, health manager, development partner and researcher were interviewed, 34 documents were reviewed and 1 participatory stakeholder workshop was held between Jun. 2007 and Apr. 2008. We focused on different CSOs that had been involved in different stages of the policy process, what strategies they had used to interact with the policy process and how they influenced the content and implementation of the policy. Our results showed that new forms of CSOs in China were emerging, with different mechanisms being used to express their voice and influence the policy process. The involvements of CSOs in the adolescent reproductive health policy process also showed how new opportunities were arising in a rapidly changing Chinese political context, but various factors might affect their involvement in policy process. Critical amongst these were the characteristics of the CSOs, the wider political context of the country and the nature of the policy itself.
Rescue of nonsense mutations by amlexanox in human cells
Gonzalez-Hilarion Sara,Beghyn Terence,Jia Jieshuang,Debreuck Nadège
Orphanet Journal of Rare Diseases , 2012, DOI: 10.1186/1750-1172-7-58
Abstract: Background Nonsense mutations are at the origin of many cancers and inherited genetic diseases. The consequence of nonsense mutations is often the absence of mutant gene expression due to the activation of an mRNA surveillance mechanism called nonsense-mediated mRNA decay (NMD). Strategies to rescue the expression of nonsense-containing mRNAs have been developed such as NMD inhibition or nonsense mutation readthrough. Methods Using a dedicated screening system, we sought molecules capable to block NMD. Additionally, 3 cell lines derived from patient cells and harboring a nonsense mutation were used to study the effect of the selected molecule on the level of nonsense-containing mRNAs and the synthesis of proteins from these mutant mRNAs. Results We demonstrate here that amlexanox, a drug used for decades, not only induces an increase in nonsense-containing mRNAs amount in treated cells, but also leads to the synthesis of the full-length protein in an efficient manner. We also demonstrated that these full length proteins are functional. Conclusions As a result of this dual activity, amlexanox may be useful as a therapeutic approach for diseases caused by nonsense mutations.
A Decision Problem of Hotels on Setting Online-Exclusive-Rooms in E-Commerce Age  [PDF]
Liang Xu, Xiaoyan Xu
Journal of Service Science and Management (JSSM) , 2014, DOI: 10.4236/jssm.2014.74029

Due to the rapid development of information technology, customers’ consumption pattern in hotel industry has dramatically changed, and many people book rooms through some professional online platforms. Hotel managers need to redesign their sale channel structures by incorporating online platforms, in order to increase profit. This paper focuses on a revenue maximization problem for a hotel which cooperates with an online platform. Two cooperating forms are investigated and compared. Specifically, one intuitive form is named complete sharing, in which all the hotel rooms are shared with the online platform for booking. The other form is named setting online-exclusive-rooms (OERs), in which the hotel set a fixed quantity of rooms for exclusively booking from the online platform. By building a loss queueing model, this paper finds some properties of the optimal quantity of OERs in the latter form. Factors affecting the selection and how they affect the selection are also investigated.

An Algorithm for Improving Throughput Guarantee of Topology-Transparent MAC Scheduling Strategy  [PDF]
Chaonong Xu
Wireless Sensor Network (WSN) , 2010, DOI: 10.4236/wsn.2010.210096
Abstract: Topology-transparent MAC scheduling strategies nowadays are all based on combinatorial design. To get throughput guarantee, a cover-free set is output as scheduling strategy of network. In this paper, we aim to modify the cover-free set so that better throughput can be guaranteed. At the first step, the redundant slot of the cover-free set is proposed and found to have negative influence on the minimal guaranteed throughput. Second, we prove that any subset of a cover-free set is still a cover-free set after its redundant slots were squashed out. Our algorithm chooses the subset which has the maximal number of redundant slots, squashes all of its redundant slots, and then designates it as the network scheduling strategy. Therefore, better through- put can be guaranteed if the squashed subset is adopted as network scheduling strategy. For any topology- transparent node scheduling strategy, both the increased minimal throughput and decreased maximal transmission delay can be gotten by just using our algorithm as an extra accessory.
Experimental and Numerical Study of the Effect of Surround Protection Technique on the Strain Measurement for Offshore Jacket Platform  [PDF]
Yongjun Xu
Engineering (ENG) , 2011, DOI: 10.4236/eng.2011.35056
Abstract: For strain measurement on offshore jacket platform in deep water, waterproof of strain foil is always an important issue, especially, due to the high pressure in deep water. The waterproof is difficult in two places, one is between the matrix structure and the protection structure, and another is between the lead wires and the protection structure. The surround protection technique discussed in this paper is conventional and ideal, and can be operative for a long time, up to five years. In this method, a metal case and tube is added on the local position, which increases the local rigidity, but the effect on the measurement of strain is not well studied. In this paper, the effect of the surround protection technique on the strain measurement is studied by using numerical and experimental methods, and the results show that the measurement error is well in the range permitted by engineering practice.
Editorial: Special Section on Reinforcement Learning and Approximate Dynamic Programming  [PDF]
Xin Xu
Journal of Intelligent Learning Systems and Applications (JILSA) , 2010, DOI: 10.4236/jilsa.2010.22008
Abstract: .
A Kind of Potential Practical Sensors of Metamaterial in Electromagnetic Flaw Nondestructive Testing  [PDF]
Zhanxian Xu
Engineering (ENG) , 2011, DOI: 10.4236/eng.2011.37090
Abstract: We present a new kind of method of electromagnetic flaw nondestructive testing with coating of metamaterials and simulation near electromagnetic field property for test crack. The simulation of improving a Nondestructive testing (NDT) probe electromagnetic radiant property by Metamatrials (MMs) covering a tiny current element is investigated and analyzed using Ansoft HFSS based on finite element method (FEM), which permittivity and permeability are negative. Electromagnetic model: Ideal MMs ball shell with inner radius of 1 mm and outer radius variation, and the shell’s relative permittivity and relative permeability are all –3.0, dielectric loss tangent and magnetic loss tangent are all 0.1; and exciting current element length is with 0.3 mm, diameter 0.2 mm, value 1 mA at frequency 10 GHz; and simulation is with radiation boundary conditions. The simulating near electromagnetic field variety with ratio of inner radius and out radius, and so near or local field of MMs sensor on a surface crack, as well as comparing near field value of sensor with coating common material are finished. Results can be seen that MMs film sensor near electromagnetic field and radiation properties are obviously better than other two kinds of structures without coating medium and coating with common medium, and Metamaterial may be opened out some new kinds of sensors in electromagnetic flaw nondestructive testing for potential practical applications in future.
Rethinking the China-US Balance of Trade: 1990-2005  [PDF]
Xiaoping Xu
iBusiness (IB) , 2012, DOI: 10.4236/ib.2012.41006
Abstract: Since 1993, American trade deficit with China is expanding and the gap is becoming increasingly bigger. The widening bilateral trade imbalance has caused growing concerns. This paper, by using empirical method and adjusting the data of trade from 1989 to 2005, finds that the causes of the imbalance of China-US trade are as follows: 1) the imbalance of domestic demands of US; 2) the adjustment of American economic structure, and 3) the growing of multinational enterprises. The paper also finds that the imbalance of China-US trade is not as big as it was reported by US; the imbalance of China-US trade is an inevitable result of economic development, and the trade deficit does not necessarily mean a loss of profit. In fact, American investors and consumers have greatly benefited from China-US trade.
Application Study on Multi-Vary Analysis  [PDF]
Xiaomin Xu
Modern Mechanical Engineering (MME) , 2013, DOI: 10.4236/mme.2013.31005

In this article, we studied the bearings made by one company in Shanghai. Through statistical process controlling the quality characteristic of bearings’ diameters and multi-vary analysis is applied to find the key variation factors which have an influence on the quality characteristic of the bearings, the quality level of the bearings of this company is improved.

DNA Circuit System and Charge Transfer Mechanism  [PDF]
Kunming Xu
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510B077

Based on the accurate identification of chemical structures as electric elements, we described charge transport mechanism in a DNA molecule by a stepwiseLCoscillatory circuitry, in which every base pair is a capacitor, every phosphate bridge is an inductor, and every deoxyribose is a charge router. The circuit model agrees with established experimental evidence that has supported super-exchange and hopping mechanisms so far. This alternative charge transport mechanism through both strands of DNA matches the fidelity and reliability of its chemical structure.

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