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Search Results: 1 - 10 of 42530 matches for " Xiu-Rong Hu "
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2-(Cyclohexa-1,4-dienyl)-2-(4-methoxyphenyl)-N,N-dimethylethanaminium chloride
Wei-Jian Lou,Xiu-Rong Hu
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809027627
Abstract: In the title compound, C17H24NO+·Cl , the cyclohexa-1,4-diene ring, which is almost planar, with a maximum deviation of 0.024 (4) from the mean plane, makes a dihedral angle of 66.4 (1)° with the benzene ring. In the crystal, intermolecular N—H...Cl and C—H...Cl hydrogen bonds link the molecules into an infinite chain along the b axis.
Signal transduction mechanism of curcumin in inhibiting the proliferation of bovine lens epithelial cell induced by recombinant human epidermal growth factor
Yan-Hong HU,Xiu-Rong HUANG
Zhong Xi Yi Jie He Xue Bao , 2006,
Abstract: Objective: To investigate the signal transduction mechanism of curcumin in inhibiting the proliferation of bovine lens epithelial cell (LEC) induced by recombinant human epidermal growth factor (rhEGF). Methods: There were three groups in this experiment, which were normal control group, untreated group and curcumin-treated group. Proliferation of LEC was induced by rhEGF (50 μg/L). The concentration of intracellular Ca2+ ([Ca2+]i) in LEC was measured with Fura-2/AM by spectrofluorimetry. The contents of intracellular cAMP and cGMP were assayed by radioimmunoassay.Results: The [Ca2+]i in LEC was obviously increased in the untrated group as compared with that in the normal control group (P<0.01), and the [Ca2+]i in LEC in the curcumin-treated group was highest among three groups (P<0.01). The content of intracellular cAMP in LEC was decreased while the content of intracellular cGMP was obviously increased in the untreated group as compared with those in the normal control group (P<0.01). The content of intracellular cAMP in LEC was higher in the curcumin-treated group than that in the untreated group, while the content of intracellular cGMP was lower than that in the untreated group (P<0.01). Conclusion: The antiproliferation effects of curcumin on LEC may relate to the regulations of multiple processes of signal transduction.
Triamcinolone acetonide acetate
Xiao Lu,Gu-Ping Tang,Jian-Ming Gu,Xiu-Rong Hu
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811000316
Abstract: In the crystal structure of the title compound [systematic name: 2-(4b-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-7,9-dioxapentaleno[2,1-a]phenanthren-6b-yl)-2-oxoethyl acetate], C26H33FO7, the molecules are connected by intermolecular O—H...O hydrogen bonds into an infinite supramolecular chain along the b axis. The molecular framework consists of five condensed rings, including three six-membered rings and two five-membered rings. The cyclohexa-2,5-dienone ring is nearly planar [maximum deviation = 0.013 (3) ], while the cyclohexane rings adopt chair conformations. The two five-membered rings, viz. cyclopentane and 1,3-dioxolane, display envelope conformations.
Eprosartan mesylate, an angiotensin II receptor antagonist
Jing-Jing Qian,Xiu-Rong Hu,Jianming Gu,Su-Xiang Wu
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811006659
Abstract: The title compound, eprosartan mesylate {systematic name: 2-butyl-1-(4-carboxybenzyl)-5-[(E)-2-carboxy-3-(thiophen-2-yl)prop-1-enyl]-1H-imidazol-3-ium methanesulfonate}, C23H25N2O4S+·CH3O3S , one of the angiotensin II-receptor antagonists, is effective in regulating hypertension, induced or exacerbated by angiotensin II, and in the treatment of congestive heart failure, renal failure and glaucoma. In the eprosartan residue, which appears in this crystal in the cationic imidazolium form, the benzene ring plane is almost orthogonal to that of the imidazole ring, making a dihedral angle of 87.89 (2)°. The thiophene ring forms dihedral angles of 66.54 (2) and 67.12 (2)° with the benzene and imidazole rings, respectively. The imidazolium NH group and the H atom of the aromatic carboxyl group participate in hydrogen bonds with the the O atoms of the anion, thus forming centrosymmetric aggregates made up of two cations and two anions each. The second carboxyl group further links the above-mentioned aggregates through a conventional centrosymmetric hydrogen-bonding motif into infinite chains along [011].
Marbofloxacin
Jin Shen,Jing-Jing Qian,Jian-Ming Gu,Xiu-Rong Hu
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812009312
Abstract: In the title compound, [systematic name: 9-fluoro-2,3-dihydro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-7H-pyrido[1,2,3-ij][1,2,4]benzoxadiazine-6-carboxylic acid], C17H19FN4O4, the carbonyl and carboxyl groups are coplanar with the quinoline ring, making a dihedral angle of 2.39 (2)°. The piperazine ring adopts a chair conformation and the oxadiazinane ring displays an envelope conformation with the CH2 group at the flap displaced by 0.650 (2) from the plane through the other five atoms. The molecular structure exhibits an S(6) ring motif, owing to an intramolecular O—H...O hydrogen bond. In the crystal, weak C—H...F hydrogen bonds link molecules into layers parallel to the ab plane.
Bupropion hydrobromide propanol hemisolvate
Min Liu,Xiu-Rong Hu,Jian-Ming Gu,Gu-Ping Tang
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811037093
Abstract: The title compound {systematic name: N-[1-(3-chlorophenyl)-1-oxopropan-2-yl]-tert-butanaminium bromide propanol hemisolvate}, C13H19ClNO+·Br ·0.5C3H8O, crystallizes with two independent bupropion hydrobromide ion pairs and a solvent 1-propanol molecule in the asymmetric unit. In both molecules, the expected proton transfer from HBr to the amino group of the bupropion molecule is observed, and intra- and intermolecular N—H...Br hydrogen-bond interactions are formed. These interactions link the molecules into hydrogen-bond dimers. The side chains of the two cations have slightly different orientations. The 1-propanol solvent molecule is linked to a bromide ion by an O—H...Br hydrogen bond.
Moxifloxacinium chloride monohydrate
Jing-Jing Qian,Jian-Ming Gu,Jin Shen,Xiu-Rong Hu
Acta Crystallographica Section E , 2011, DOI: 10.1107/s160053681103707x
Abstract: The title compound {systematic name: 7-[(1S,6S)-8-aza-2-azoniabicyclo[4.3.0]non-8-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid chloride monohydrate}, C21H25FN3O4+·Cl ·H2O, crystallizes with two moxifloxacinium cations, two chloride ions and two uncoordinated water molecules in the unit cell. The crystal structure has a pseudo-inversion center except for the chloride ions. In both moxifloxacinium cations, the quinoline rings are approximately planar, the maximum atomic deviations being 0.107 (3) and 0.118 (3) . The piperidine rings adopt a chair conformation while the pyrrolidine rings display a half-chair conformation. In the crystal, the carboxyl groups, the protonated piperidyl groups, the uncoordinated water molecule and chloride anions participate in O—H...O, O—H...Cl and N—H...Cl hydrogen bonding; weak intermolecular C—H...O and C—H...Cl hydrogen bonding is also present in the crystal structure.
Memantinium chloride 0.1-hydrate
Wei-Jian Lou,Xiu-Rong Hu,Jian-Ming Gu
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809031791
Abstract: The crystal structure of the title compound, C12H22N+·Cl ·0.1H2O, consists of (3,5-dimethyl-1-adamantyl)ammonium chloride (memantinium chloride) and uncoordinated water molecules. The four six-membered rings of the memantinium cation assume typical chair conformations. The Cl counter-anion links with the memantinium cation via N—H...Cl hydrogen bonding, forming channels where the disordered crystal water molecules are located. The O atom of the water molecule is located on a threefold rotation axis, its two H atoms symmetrically distributed over six sites; the water molecule links with the Cl anions via O—H...Cl hydrogen bonding.
(E)-2-[1-(3-Chloro-4-fluorophenyl)ethylidene]hydrazinecarbothioamide
Xiu-Rong Zhai
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536810051093
Abstract: In the crystal of the title compound, C9H9ClFN3S, the molecules are interconnected by N—H...S and N—H...F hydrogen bonds. There are two different N—H...S hydrogen bond: the stronger one links molecules into infinite chains along the b axis with graph-set motif C(4), while the weaker N—H...S hydrogen bond combines with the previous one into an R22(8) network. Moreover, the chains are linked into layers parallel to (102) by weak N—H...F hydrogen bonds, which form an R22(22) ring motif. In addition, there are also weak π–π interactions between the benzene rings of adjacent molecules [centroid–centroid distance = 3.8997 (15) ].
4-{[2-(2,4-Dinitrophenyl)hydrazinylidene]methyl}phenol ethanol hemisolvate
Xiu-Rong Zhai
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810045782
Abstract: In the title compound, C13H10N4O5·0.5C2H5OH, the two benzene rings form a dihedral angle of 4.29 (9)°. The ethanol solvent molecule was treated as disordered between two orientations related by symmetry (center of inversion), with occupancies fixed at 0.5. The crystal packing, stabilized by intermolecular O—H...O and N—H...O hydrogen bonds and π–π interactions [indicated by the short distance of 3.7299 (7) between the centroids of benzene rings from neighbouring molecules], exhibits short intermolecular O...O contacts of 2.8226 (3) .
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