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Search Results: 1 - 10 of 36737 matches for " XingBin Yan "
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The improvement of the field emission properties from graphene films: Ti transition layer and annealing process
Jun Li,Jiangtao Chen,Baomin Luo,Xingbin Yan
AIP Advances , 2012, DOI: 10.1063/1.3702588
Abstract: Chemical-reduced graphene oxide (rGO) films were deposited on titanium (Ti)-coated silicon substrates by a simple electrophoretic deposition. The rGO films were annealed under argon atmosphere at different temperatures. The morphology and microstructure of the rGO films before and after annealing were characterized using scanning electron microscope, X-ray diffraction and Raman spectroscope. The field emission behaviors from these rGO films were investigated. The results show that, Ti-based transition layer can improve the stability of field emission from the rGO film, and the annealing at appropriate temperature is in favor of the field emission. Particularly, the rGO film displays an unexpected vacuum breakdown phenomenon at a relatively high current density. In addition, it is found that the field emission property of the rGO film is dependent on anode-sample distance and the film exhibits lower turn on field at larger anode-sample distance.
ROS-Dependent Mitochondria Molecular Mechanisms Underlying Antitumor Activity of Pleurotus abalonus Acidic Polysaccharides in Human Breast Cancer MCF-7 Cells
Xiaolong Shi, Yan Zhao, Yadong Jiao, Tengrui Shi, Xingbin Yang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0064266
Abstract: Background A greater reduction in cancer risk associated with mushroom diet rich in fungus polysaccharides is generally accepted. Meanwhile, edible Pleurotus abalonus as a member of Abalone mushroom family is a popular nutritional supplement that purportedly prevents cancer occurrence. However, these anecdotal claims are supported by limited studies describing tumor-inhibitory responses to the promising polysaccharides, and the molecular mechanisms underlying these properties have not yet been elucidated. Methodology/Principal Findings We here fractionated the crude polysaccharide preparation from the fruiting bodies of P. abalonus into three fractions, namely PAP-1, PAP-2 and PAP-3, and tested these fractions for antiproliferative activity in human breast cancer MCF-7 cells. The largest PAP-3, an acidic polysaccharide fraction with a molecular mass of 3.68×105 Da, was the most active in inhibiting MCF-7 cancer cells with an IC50 of 193 μg/mL. The changes in cell normal morphology were observed by DAPI staining and the PAP-3-induced apoptosis was confirmed by annexin V/propidium iodide staining. The apoptosis was involved in mitochondria-mediated pathway including the loss of mitochondrial membrane potential (Δψm), the increase of Bax/Bcl-2 ratio, caspase-9/3 activation, and poly(ADP-ribose) polymerase (PARP) degradation, as well as intracellular ROS production. PAP-3 also induced up-regulation of p53, and cell cycle arrest at the S phase. The incubation of MCF-7 cells with antioxidant superoxide dismutase (SOD) and N-acetylcysteine (NAC) significantly attenuated the ROS generation and apoptosis caused by PAP-3, indicating that intracellular ROS plays a pivotal role in cell death. Conclusions/Significance These findings suggest that the polysaccharides, especially acidic PAP-3, are very important nutritional ingredients responsible for, at least in part, the anticancer health benefits of P. abalonus via ROS-mediated mitochondrial apoptotic pathway. It is a major breakthrough bringing new insight of the potential use of the polysaccharides as health-care food or medicine to provide significant natural defense against human cancer.
Protective Effects of Quercetin and Quercetin-5',8-Disulfonate against Carbon Tetrachloride-Caused Oxidative Liver Injury in Mice
Yanmang Cui,Yong Han,Xingbin Yang,Yanfei Sun,Yan Zhao
Molecules , 2014, DOI: 10.3390/molecules19010291
Abstract: Oxidative stress is one of the major factors in the pathogenesis of liver disease. Quercetin is a plant-based antioxidant traditionally used as a treatment for hepatic injury, but its poor solubility affects its bioavailability. We here report the regulative effects on hepatoprotection and absorption in mice of quercetin sulfation to form quercetin-5',8-disulfonate (QS), a novel synthetic compound. Oral administration of both QS and the parent quercetin at 100, 200 and 500 mg/kg·bw prior to acute CCl 4 oxidative damage in mice, effectively attenuated serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities and hepatic malondialdehyde (MDA) levels ( p < 0.05), and suppressed the CCl 4-induced depletion of glutathione peroxidase (GSH-P x) and total superoxide dismutase (T-SOD). Selective 5',8-sulfation of quercetin increased the hepatoprotective effect, and its relative absorption relative to quercetin ( p < 0.05) as indicated by an improved 24-hour urinary excretion and a decreased fecal excretion determined by HPLC. These results and histopathological observations collectively demonstrate that quercetin sulfation increases its hepatoprotective effects and absorption in mice, and QS has potential as a chemopreventive and chemotherapeutic agent for liver diseases.
Detecting disease-associated genes with confounding variable adjustment and the impact on genomic meta-analysis: With application to major depressive disorder
Xingbin Wang, Yan Lin, Chi Song, Etienne Sibille, George C Tseng
BMC Bioinformatics , 2012, DOI: 10.1186/1471-2105-13-52
Abstract: We applied a random intercept model to account for confounding variables and case-control paired design. A variable selection scheme was developed to determine the effective confounders in each gene. Meta-analysis methods were used to integrate information from five studies and post hoc analyses enhanced biological interpretations. Simulations and application results showed that the adjustment for confounding variables and meta-analysis improved detection of biomarkers and associated pathways.The proposed framework simultaneously considers correction for confounding variables, selection of effective confounders, random effects from paired design and integration by meta-analysis. The approach improved disease-related biomarker and pathway detection, which greatly enhanced understanding of MDD neurobiology. The statistical framework can be applied to similar experimental design encountered in other complex and heterogeneous diseases.Microarray experiment enables researchers to examine the expression of thousands of genes in parallel. Differentially expressed (DE) gene detection is one of the most common analyses in microarray. In such an analysis, genes differentially expressed under multiple conditions are detected and are used for generating further biological hypotheses, developing potential diagnostic tools, or investigating therapeutic targets. The extensive applications of microarray technology have led to an explosion of gene expression profiling studies publicly available. However, the noisy nature of microarray data, together with small sample size in each study, often results in inconsistent biological conclusions [1-3]. Therefore, meta-analysis, a set of statistical techniques to combine multiple studies under related research hypotheses, has been widely applied to microarray analysis to increase the reliability and robustness of results from individual studies. In the literature, three major categories of meta-analysis methods have been applied to genomic
Deposition of bio-mimicking graphene sheets with lotus leaf-like and cell-like structures on the nickel substrate
Juan Yang,XingBin Yan,Ying Wang,BaoMin Luo,LiPing Wang,QunJi Xue
Chinese Science Bulletin , 2012, DOI: 10.1007/s11434-012-5310-0
Abstract: Bio-mimicking graphene films, deposited on textured nickel substrates, were synthesized by the following method: replicating the surface textures of the lotus leaf by polymer duplication, fabricating textured nickel substrates by electroplating on the polymer coated with a Au film, preparing bio-mimicking graphene oxide films on the nickel substrates by vacuum filtration, and electrochemical reduction. By controlling the vacuum filtration, this replica method can not only replicate the lotus leaf structure by a graphene film, but also can achieve a novel cell-like graphene film.
Preparation and cytocompatibility of polylactic acid/hydroxyapatite/graphene oxide nanocomposite fibrous membrane
HaiBin Ma,WenXin Su,ZhiXin Tai,DongFei Sun,XingBin Yan,Bin Liu,QunJi Xue
Chinese Science Bulletin , 2012, DOI: 10.1007/s11434-012-5336-3
Abstract: A series of polylactic acid (PLA) based nanocomposite fibrous membranes, including neat PLA, PLA/hydroxyapatite (HA) and PLA/HA/graphene oxide (GO), were fabricated via electrospinning method. The morphology and composition were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) respectively. The thermal stability was determined by thermogravimetric analysis (TGA). To estimate the cytocompatibility of asprepared PLA/HA/GO fibrous membrane, MC3T3-E1 cells were cultured, and the corresponding cell adhesion and differentiation capability were investigated by fluorescence microscopy, SEM and MTT test. The electrospun ternary PLA/HA/GO membrane exhibited three-dimensional fibrous structure with relatively rough surface morphology, which made itself ideal for cell attachment and proliferation in bone tissue regeneration. The fluorescence microscopy, SEM and MTT test confirmed that the PLA/HA/GO nanocomposite fibrous membrane created a proper environment for the seeding and proliferation of MC3T3-E1 cells.
Effect of annual variation in soil pH on available soil nutrients in pear orchards

Jing Zhao,Yan Dong,Xingbin Xie,Xin Li,Xianxian Zhang,Xiang Shen,

生态学报 , 2011,
Abstract: Soil pH is an important factor affecting the availability of soil nutrients that impact plant growth. Given the susceptibility of soil pH to excessive fertilization and the widespread use of manures, it is essential to examine the influence of soil pH on the distribution and availability of soil nutrients. We sampled and analyzed brown soils from pear orchards in thirteen towns in Wendeng county. Samples were obtained from areas along or between rows of trees at specified distances and depths. The results showed that the soil pH fluctuated from 4.06 to 6.59 in October 2008 and from 4.24 to 7.57 in April 2009. The quantity of soil samples with pH below 5.50 increased by 34.6%. Analysis of the soil pH for samples obtained along the rows of trees showed that the pH decreased as the depth increased (except for the range 5.5 to 6.0); soil pH in the samples obtained between the rows of trees demonstrated different trends. The average organic matter (O.M.) content as well as the N (NH4+) and available P, K, Cu, Zn, Fe, and Mn contents in the samples collected in October 2008 were higher than those observed in April 2009. Conversely, the values for other available nutrients were lower than those in the samples collected in April 2009. The available nutrients and organic matter (O.M.) content in different pH ranges varied. The soil pH was significantly or very significantly correlated with N (NH4+ and NO3-), available K, Cu, Fe, and exchangeable Ca for the October 2008 samples, while a significant or very significant correlation existed between N (NH4+), available P, Zn, exchangeable Ca, and exchangeable Mg for the April 2009 samples. The correlations between soil pH and the amounts of available nutrients and organic matter (O.M.) along the rows of trees in September 2009 were nearly consistent with those between the rows.
Development of an Instructional Model for Online Task-Based Interactive Listening for EFL Learners
Xingbin Tian,Suksan Suppasetseree
English Language Teaching , 2013, DOI: 10.5539/elt.v6n3p30
Abstract: College English in China has shifted from cultivating reading ability to comprehensive communicative abilities with an emphasis on listening and speaking. For this reason, new teaching models should be built on modern information technology. However, little research on developing models for the online teaching of listening skills has been conducted. Thus, the present study aims at developing an instructional model for online task-based interactive listening (OTIL Model) for English as a Foreign Language (EFL) learners and investigating the effects of using OTIL. First, researcher constructed the OTIL Model by analyzing and synthesizing four effective and manageable instructional design models. Subsequently, three experts in the field of instructional systems design and English language teaching evaluated the OTIL Model. Next, two non-English major intact classes at Tongren University, China (TU), were employed in the experiment by using OTIL designed based on the developed OTIL Model. Additionally, the results of the two classes were compared by pre- and post-tests, revealing a significant difference in the post-test score between the experimental and control classes (P=0.000, P?0.05). The results seem to suggest that the OTIL Model can be served to promote students’ listening ability.
汉语致使句的语义推衍:以“使”字句和“把”字句为例
The Semantic Derivation of Chinese Causatives: Evidence from the Shi- and Ba-constructions

吴平,田兴斌
Ping Wu
,Xingbin Tian

- , 2018,
Abstract: 摘要:“使”字句和“把”字句是现代汉语表示致使语义的两个重要句式,二者具有一定的转换关系但又有不同。本文在形式化的事件语义理论框架下,对表示致使义的“使”字句和“把”字句进行了细致的事件结构分析及语义推衍。我们发现,表示致使义的“使”字句和“把”字句,不论句法上表现为单句、从单句向复句转化过程的中间阶段句式,还是复句,在语义上都呈现复合事件结构,其中“使”字句是两个子事件的合取,“把”字句则包含合取加嵌套的复杂事件结构。通过对比两类句式的事件语义结构我们还发现,有可能形成替换关系的是事件致使类的“使”字句和“把”字句,以及个体致使关系类“使”字句与客体指向“把”字句,且第二个原子事件表示完成。二者所表示的语义亦存在细微差异,前者的致事表原因,而后者的致事表外力。
Investigation of Range Profiles from a Simplified Ship on Rough Sea Surface and Its Multipath Imaging Mechanisms
Siyuan He,Fan Zhang,Weidong Hu,Lei Zhuang,Xingbin Ye,Guoqiang Zhu
International Journal of Antennas and Propagation , 2012, DOI: 10.1155/2012/894198
Abstract: The range profiles of a two-dimension (2 D) perfect electric conductor (PEC) ship on a wind-driven rough sea surface are derived by performing an inverse discrete Fourier transform (IDFT) on the wide band backscattered field. The rough sea surface is assuming to be a PEC surface. The back scattered field is computed based on EM numerical simulation when the frequencies are sampled between 100 MHz and 700 MHz. Considering the strong coupling interactions between the ship and sea, the complicated multipath effect to the range profile characteristics is fully analyzed based on the multipath imaging mechanisms. The coupling mechanisms could be explained by means of ray theory prediction and numerical extraction of the coupling currents. The comparison of the range profile locations between ray theory prediction and surface current simulation is implemented and analyzed in this paper. Finally, the influence of different sea states on the radar target signatures has been examined and discussed.
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