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Search Results: 1 - 10 of 42650 matches for " Xiaoxin Xu "
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An Analysis of Practical Teaching System of College of Culture and Media: A Case Study of Sichuan University of Arts and Science  [PDF]
Xiaoxin Jia
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.69020
Abstract: Currently, there are three undergraduate majors in College of Culture and Media of Sichuan University of Arts and Sciences, namely, cultural industry management, broadcasting and hosting, and radio and television director. Those three majors are all applied ones, which require the improvement of practical teaching in the process of major construction and student cultivation. Practical teaching system is under construction in College of Culture and Media, which mainly consists of course practice, project practice, industry practice, social practice and competition practice.
The role of XPC protein deficiency in tobacco smoke-induced DNA hypermethylation of tumor suppressor genes  [PDF]
Gan Wang, Le Wang, Vanitha Bhoopalan, Yue Xi, Deepak K. Bhalla, David Wang, Xiaoxin S. Xu
Open Journal of Genetics (OJGen) , 2013, DOI: 10.4236/ojgen.2013.34032

DNA hypermethylation of tumor suppressor genes has been frequently observed in cancer patients, and therefore, may provide a valuable biomarker for cancer prevention and treatment. DNA hypermethylation may also provide an important mechanism in cancer progression. Lung cancer is strongly associated with exposure to environmental carcinogens, especially tobacco smoke. DNA damage generated by tobacco smoke is believed to play an important role in lung cancer development. XPC is a DNA damage recognition protein required for DNA repair and other DNA damage responses and attenuated XPC protein levels have been detected in many lung cancer patients. We studied the role of XPC protein deficiency in tobacco smoke-caused DNA hypermethylation of important tumor suppressor genes. Using both normal human fibroblasts (NF) and XPC-deficient hu man fibroblasts (XPC), our DNA methylation studies demonstrated that the XPC deficiency caused elevated levels of DNA hypermethylation in both Brca1 and Mlh1 tumor suppressor genes following exposure to tobacco smoke condensate (TSC). The results of our ChIP studies revealed that the XPC deficiency led to an increased binding of DNA methyltransferase 3A (DNMT3A) at the promoter region CpG island-containing sequences of these genes under the TSC treatment; however, this increase was partially diminished with prior treatment with caffeine. The results of our immuno-precipitation (IP) studies demonstrated a protein-protein interaction of the ATR with DNMT3A. Our western blots revealed that the

XPC deficiency caused an increase in TSC-induced ATR phosphorylation at serine 428, an indicator of ATR activation. All these results suggest that XPC deficiency causes an accelerated DNA hypermethylation in important tumor suppressor genes under tobacco smoke exposure and activation of the ATR signaling pathway is involved in this DNA hypermethylation process.

Induction of endogenous γ-globin gene expression with decoy oligonucleotide targeting Oct-1 transcription factor consensus sequence
Xiaoxin S Xu, Xin Hong, Gan Wang
Journal of Hematology & Oncology , 2009, DOI: 10.1186/1756-8722-2-15
Abstract: Human β-hemoglobin disorders, such as sickle cell anemia and β-thalassemia, are relatively common genetic diseases that affect millions of people worldwide. The diseases cause severe clinical symptoms including heart disease, stroke, kidney failure, infection, and other complications. It is well documented that these diseases are caused by mutations in the β-globin gene: a T-to-A mutation at the sixth amino acid codons of the β-globin gene causes sickle cell anemia and various deletions that occur at the β-globin gene lead to β-thalassemia [1]. When γ-globin genes are highly expressed, the presence of high levels of fetal hemoglobin (HbF, α2γ2) in erythrocytes (~20–30%) can compensate for the defective β-globin product and significantly reduce disease symptoms [1]. Therefore, increased expression of the γ-globin genes has important clinical relevance in the treatment of β-globin disorders. However, the γ-globin genes are developmentally regulated and normally expressed at high levels only during the fetal stage of human development [2-5]. In adults, the β-globin gene is predominantly expressed and the adult hemoglobin (HbA, α2β2) consists of over 98% of total hemoglobin whereas the γ-globin genes are expressed at very low levels and the HbF consists of less than 1% of the total hemoglobin. Several strategies have been developed to induce expression of γ-globin genes for the treatment of sickle cell anemia and β-thalassemia [6-9]. However, new strategies still need to be developed so that more effective treatments can be provided for these patients.Oct-1 is a member of the POU family of transcription factors that specifically interacts with the octamer motif ATGCAAAT, a regulatory element that is important for tissue- and cell-specific transcription as well as for the transcription of a number of housekeeping genes [10]. Studies reveal that the promoter region of each of the human γ-globin genes carries three Oct-1 transcription factor consensus sequences, which are
The Impact of Tobacco Taxation Policy on Slim Cigarette Use and the Growing Popularity of Slim Cigarettes in China Since 2014  [PDF]
Xiulan Zhang, Xiaoxin Xu, Mengnan Xu, Teh-wei Hu
Health (Health) , 2019, DOI: 10.4236/health.2019.116059
Abstract: Introduction: In 2016, China became the largest market for slim cigarettes in the world, selling 68.945 billion sticks. The purpose of this study is to examine the impact of China’s 2015 tobacco taxation policy on slim cigarette consumption and the product’s market trends. Methods: Monthly data on the market share of slim cigarettes and their average price between January 2014 and June 2017 were used to show tobacco market trends and to estimate the impact of the 2015 tobacco tax increase on tobacco consumption. Segmented regression analysis was used to estimate the immediate effect of the 2015 tax policy and the time trends in consumption due to the policy change. Findings: After the tobacco tax increase was announced in May 2015, the market share of slim cigarettes initially decreased by 0.2117 (p = 0.067). However, by the third month after the policy change, consumption began to increase, and the market share of slim cigarettes was 1.6 times the normal increase over time. Slim cigarettes gained a 2.02% additional share by the second quarter of 2017 (from 2.58% to 4.60%), controlling for the price difference between slim cigarettes and regular cigarettes. The coefficient of the share and the price ratio (slim cigarettes/regular cigarettes) was ?0.7536 (p = 0.0044), suggesting that slim cigarettes are a substitute for regular cigarettes. Estimates also show that after the tax increase was implemented, consumption of slim cigarettes increased almost three times the normal consumption rate (0.0069 versus 0.0024). Conclusion: The slim cigarette industry in China has grown rapidly in recent years. The 2015 tax increase has had only minimal or short-term impact on reducing the growing popularity of slim cigarettes. Since slim cigarettes are a substitute for regular cigarettes, more empirical research is urgently needed to study the health impacts of slim cigarette use and the impact of tobacco control policies on slim cigarette consumption.
Histone deacetylases (HDACs) in XPC gene silencing and bladder cancer
Xiaoxin S Xu, Le Wang, Judith Abrams, Gan Wang
Journal of Hematology & Oncology , 2011, DOI: 10.1186/1756-8722-4-17
Abstract: Bladder cancer is one of the most common malignancies. Worldwide, more than 350,000 new cases of bladder cancer are diagnosed each year with over 145,000 deaths resulting from the disease [1]. Bladder cancer is strongly associated with exposure to environmental factors. Cigarette smoking is the single most important environmental factor in causing bladder cancer [2]. Exposure to other environmental factors, especially polycyclic aromatic amines, such as aniline, benzidine, and turoline, is also closely correlated with bladder cancer risk [2]. The mechanism by which the exposure to environmental factors causes development of bladder cancer is unknown. It is believed that the exposure to the environment makes the bladder tissue more susceptible to environmental carcinogens and the DNA damage generated by these carcinogens and/or their metabolites causes initiation and progression of bladder cancer.Nucleotide excision repair (NER) is the major DNA repair pathway in repairing bulky DNA damage generated by most environmental carcinogens, including DNA damage generated by cigarette smoking [3-5]. The NER pathway can be further distinguished into the transcription-coupled NER (TCR) and global genome NER (GGR) sub-pathways. The TCR pathway quickly repairs DNA damage in highly transcribed DNA sequences, whereas the GGR pathway repairs DNA damage throughout the entire genome, but at a dramatically decreased rate [6,7]. In TCR, DNA damage is recognized by a stalled transcription event [8,9], whereas in GGR, DNA damage is recognized by XPC, a DNA damage recognition protein [10,11]. The DNA damage recognition signal further recruits several important NER components, including XPA, RPA, TFIIH, XPG, and XPF-ERCC1, to the damage site [4]. The dual incisions made by XPG [12] and XPF-ERCC1 [13,14] generates a 22-24nt single-stranded gap. The DNA polymerases (pol δ and ε) fill the gap using the complementary DNA strand as a template and DNA ligase seals the flanking gaps to complete t
Low-Temperature Reverse Microemulsion Synthesis, Characterization, and Photocatalytic Performance of Nanocrystalline Titanium Dioxide
Zhang Liu,Zicong Jian,Jianzhang Fang,Xiaoxin Xu,Ximiao Zhu,Shuxing Wu
International Journal of Photoenergy , 2012, DOI: 10.1155/2012/702503
Abstract: Nanocrystalline titanium dioxide (TiO2) was synthesized in microemulsions by using cetyltrimethylammonium bromide (CTAB) as surfactant. In order to investigate the crystal transformation and photoactivity at low temperature, the as-prepared precipitates were aged at 65°C or calcined at various temperatures. Analyses using powder X-ray diffraction (XRD) and Fourier transform infrared microscopy (FT-IR) showed that precursors without aging or calcination were noncrystal and adsorbed by surfactant. After aging for 6 h, the amorphous TiO2 began to change into anatase. The obtained catalysts, which were synthesized in microemulsions with weight ratios of n-hexanol/CTAB/water as 6 : 3 : 1 and calcined at 500°C, presented the highest photocatalytic degradation rate on methyl orange (MO), while the catalysts, which were aged at 65°C for 90 h, also exhibited an outstanding photocatalytic performance and a little higher than that of the commercial titania photocatalyst Degussa P25.
Study of altitudinal lapse rates of δ18O in precipitation/river water with seasons on the southeast Tibetan Plateau
XiaoXin Yang,BaiQing Xu,Wei Yang,DongMei Qu,Ping-Nan Lin
Chinese Science Bulletin , 2009, DOI: 10.1007/s11434-009-0496-5
Abstract: Seasonal δ18O variation in water on the southeast Tibetan Plateau has been studied, showing the consistent variation pattern of δ18O with altitude indicative of relevant atmospheric circulation processes. Study shows a similar variation pattern of fixed-site river water δ18O with that of the precipitation δ18O in southeast Tibet. δ18O in regional rivers in southeast Tibet demonstrates a gradual depletion with increasing altitude, though the rates vary seasonally. The most depleted river 18O occurs during the monsoon period, with the lowest δ18O/altitude lapse rate. The river 18O during the westerly period is also depleted, together with low δ18O/altitude lapse rate. The pre-monsoon rivers witness the most enriched 18O with least significant correlation coefficient with the linear regression, whilst the post-monsoon rivers witness the largest δ18O/altitude lapse rate. Different coherence of seasonal δ18O variation with the altitude effect is attributed to different moisture supplies. Though sampling numbers vary with seasons, the δ18O-H linear correlation coefficients all reach the 0.05 confidence level, thus witnessing the variation features of δ18O in seasonal river water due to the influence of atmospheric general circulation and land surface processes revealed from the altitudinal lapse rates.
Production of High Purity Metals: A Review on Zone Refining Process  [PDF]
Xiaoxin Zhang, Semiramis Friedrich, Bernd Friedrich
Journal of Crystallization Process and Technology (JCPT) , 2018, DOI: 10.4236/jcpt.2018.81003
Abstract: Purification is a primary application of zone melting, in which the improvement of efficiency, production yield and minimum achievable impurity level are always the research focus due to the increasing demand for high purity metals. This paper has systematically outlined the whole development of related research on zone refining of metals including basic theories, variants of zone refining, parametric optimization, numerical models, and high purity analytical methods. The collection of this information could be of good value to improve the refining efficiency and the production of high purity metals by zone refining.

Shen Yuehong,Yi Xiaoxin,Xu Fajiang,Li Xingguo,

电子与信息学报 , 2000,
Abstract: In this paper, a new method based the fuzzy pattern recognition and fuzzy cluster techniques for the evaluation of communication equipment/system is proposed. Contrast with fuzzy comprehensive evaluation, the new method is effective for practical applications while it keeps the advantages of fuzzy comprehensive evaluation.
Estimation of attraction domain and exponential convergence rate for high order Hopfield type neural networks

Xu Bingji,Zhou Lun,Liao Xiaoxin,Liu Xinzhi,

电子与信息学报 , 2002,
Abstract: In this paper, the locally exponential stability of equilibrium point for a class of high order Hopfield type neural networks is studied by means of Lyapunov function. Some results about estimation of the attraction domain and exponential convergence rate of the network trajectories to equilibrium point of such networks are obtained.
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