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Search Results: 1 - 10 of 80857 matches for " Xiaoqiu Liu "
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Study on Preparation and Application in Flocculants of Modified Lignin
Haiyin Liu,Xiuyun Yang,Xiaoqiu Liu,Haibo Yao
Modern Applied Science , 2011, DOI: 10.5539/mas.v5n1p205
Abstract: The lignin sulfonate was modified with olefins monomer by the method of radiation graft polymerization, by which a new type of natural polymer flocculants can be made. And results of the flocculation and sedimentation are tested in the furfural wastewater treatment process. Furfural wastewater is a complex composition, whose COD is about 20000mg / L, is difficult to be treated by conventional methods. Our results showed that the kind of flocculants can remove 50 percent COD or more from furfural wastewater after aerating and adjusting pH value to 9.
Horizontal transfer generates genetic variation in an asexual pathogen
Xiaoqiu Huang
PeerJ , 2015, DOI: 10.7717/peerj.650
Abstract: There are major gaps in the understanding of how genetic variation is generated in the asexual pathogen Verticillium dahliae. On the one hand, V. dahliae is a haploid organism that reproduces clonally. On the other hand, single-nucleotide polymorphisms and chromosomal rearrangements were found between V. dahliae strains. Lineage-specific (LS) regions comprising about 5% of the genome are highly variable between V. dahliae strains. Nonetheless, it is unknown whether horizontal gene transfer plays a major role in generating genetic variation in V. dahliae. Here, we analyzed a previously sequenced V. dahliae population of nine strains from various geographical locations and hosts. We found highly homologous elements in LS regions of each strain; LS regions of V. dahliae strain JR2 are much richer in highly homologous elements than the core genome. In addition, we discovered, in LS regions of JR2, several structural forms of nonhomologous recombination, and two or three homologous sequence types of each form, with almost each sequence type present in an LS region of another strain. A large section of one of the forms is known to be horizontally transferred between V. dahliae strains. We unexpectedly found that 350 kilobases of dynamic LS regions were much more conserved than the core genome between V. dahliae and a closely related species (V. albo-atrum), suggesting that these LS regions were horizontally transferred recently. Our results support the view that genetic variation in LS regions is generated by horizontal transfer between strains, and by chromosomal reshuffling reported previously.
Association between Experiences and Representations: Memory, Dreaming, Dementia and Consciousness
Xiaoqiu Huang
Quantitative Biology , 2013,
Abstract: The mechanisms underlying major aspects of the human brain remain a mystery. It is unknown how verbal episodic memory is formed and integrated with sensory episodic memory. There is no consensus on the function and nature of dreaming. Here we present a theory for governing neural activity in the human brain. The theory describes the mechanisms for building memory traces for entities and explains how verbal memory is integrated with sensory memory. We infer that a core function of dreaming is to move charged particles such as calcium ions from the hippocampus to association areas to primary areas. We link a high level of calcium ions concentrations to Alzheimer's disease. We present a more precise definition of consciousness. Our results are a step forward in understanding the function and health of the human brain and provide the public with ways to keep a healthy brain.
Obesity Induced by Neonatal Overfeeding Worsens Airway Hyperresponsiveness and Inflammation
Zehui Ye, Ying Huang, Dan Liu, Xiaoyi Chen, Dongjuan Wang, Daochao Huang, Li Zhao, Xiaoqiu Xiao
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047013
Abstract: Background Obesity is a risk factor for the development of certain respiratory diseases, and neonatal overfeeding results in an early onset of obesity in adulthood. However, the influence of neonatal overfeeding on respiratory diseases has rarely been studied. Therefore, this paper is aimed at investigating the effect of neonatal overfeeding on airway responsiveness and inflammation. Methodology/Principal Findings The neonatal overfeeding was induced by reducing litter size to three pups per litter (small litter, SL) in contrast to the normal litter size with ten pups per litter (NL) on postnatal day 3 (P3) in male ICR mice. On P21, mice were weaned to standard chow diet. Airway responsiveness to methacholine was measured either on P21 or P150. Total and classified inflammatory cells in bronchoalveolar lavage fluid (BALF) were counted, lung inflammatory cells were evaluated through staining with hematoxylin & eosin and F4/80 immunohistochemistry; lung fibrosis was evaluated through staining with Masson and α-SAM immunohistochemistry. Leptin levels in serum were measured by RIA; TNF-α levels in serum and BALF were quantified by ELISA; mRNA levels of TNF-α, CTGF and TGF-β1 in lung tissues were measured using real-time PCR. Mice from SL exhibited accelerated body weight gain, impaired glucose tolerance and hyperleptinemia. Enhanced airway responsiveness to methacholine was observed in SL mice on P150, but not on P21. Pulmonary inflammation was evident in SL mice on P150, as reflected by inflammatory cells especially macrophages around bronchi and interstitium. BALF and serum TNF-α levels and lung TNF-α mRNA expression were significantly increased in SL mice on P150. More collagen accumulated surrounding the bronchi on P150; lung mRNA levels of TGF-β1 and CTGF were also increased on P150. Conclusion In addition to inducing a variety of metabolic defects, neonatal overfeeding enhanced lung inflammation, which may lead to airway remodeling and airway hyperresponsiveness in adulthood.
Translational medicine as a permanent glue and force of clinical medicine and public health: perspectives (1) from 2012 Sino-American symposium on clinical and translational medicine
Jiebai Zhou, Duojiao Wu, Xinqing Liu, Shuoqi Yuan, Xiaoqiu Yang, Xiangdong Wang
Clinical and Translational Medicine , 2012, DOI: 10.1186/2001-1326-1-21
Abstract: Clinical and translational medicine (CTM) has been highly emphasized since Dr. Elias Zerhouni, the former director of the National Institutes of Health, proposed “The NIH Roadmap” in 2003 [1]. CTM is an emerging area comprising multidisciplinary research from basic sciences to medical applications and entails a close collaboration between clinicians and basic scientists across institutes. It is further defined as a two-way road: bench-to-bedside and bedside-to-bench [2], to translate discoveries from the bench into clinical application and/or the translation of clinical findings into the understanding of molecular mechanisms. CTM was emphasized to play a unique and critical role in optimizing new biotechnologies, improving clinical application of new therapeutic concepts, and ultimately improving the quality of life for patients [3]. The emergence of translational science highlights the unifying framework that bridges the continuum of knowledge creation and deployment, converting fundamental discoveries to human application, advancing the information into clinical practice, disseminating best clinical practices into communities and, ultimately, modifying the behavior of populations to improve global health [4].It is of great significance to promote CTM among clinicians, basic researchers, biotechnologists, politicians, ethicists, sociologists, or investors and coordinate these efforts among different countries [5]. CTM as an inter-disciplinary science is developing widely and become a global priority. The 2012 Sino-American Symposium on Clinical and Translational Medicine (SAS-CTM) as one of milestone conferences on CTM was organized by Chinese Academy of Engineering, Chinese Academy of Medical Sciences, The U.S. National Institutes of Health Clinical Center, and GlobalMD Organization. The SAS-CTM was established as a bridge between China and the U.S. to exchange ideas on clinical and translational research, built up the highest level and most influential collaborat
Engaging hospitals to meet tuberculosis control targets in China: using the Internet as a tool to put policy into practice
Wang,Lixia; Liu,Xiaoqiu; Huang,Fei; Hennig,Cornelia; Uplekar,Mukund; Jiang,Shiwen;
Bulletin of the World Health Organization , 2010, DOI: 10.1590/S0042-96862010001200015
Abstract: tuberculosis (tb) services in china are provided through a large network of tb dispensaries. even though hospitals are not as well placed to follow recommended standards of tb care, a significant proportion of people with tb symptoms seek care from hospitals. in spite of having a policy and mandate in place, the ministry of health had little success in encouraging hospitals to refer suspected tb cases to dispensaries. following the epidemic of severe acute respiratory syndrome in 2003, the government set up a nationwide internet-based communicable diseases reporting system. this achieved productive collaboration between hospitals and tb dispensaries. from 2004 to 2007, the percentage of tb suspects and patients needing referral from hospitals who arrived in tb dispensaries increased substantially from 58.7% to 77.8% and the contribution of hospitals to diagnosing sputum smear-positive tb cases doubled from 16.3% to 32.9%. using the internet-based reporting system, hospitals in china contributed to finding about one third of all sputu m smear-positive tb cases and helped meet the global tb control target of detecting 70% of such cases. based on the data available from routine surveillance facilitated by this internet-based system, this paper details the process and outcomes of strengthening collaboration between hospitals and tb dispensaries using the internet as a tool and its potential application to other country settings.
Some General Inequalities for Choquet Integral  [PDF]
Xiuli Yang, Xiaoqiu Song, Leilei Huang
Applied Mathematics (AM) , 2015, DOI: 10.4236/am.2015.614201
Abstract: With the development of fuzzy measure theory, the integral inequalities based on Sugeno integral are extensively investigated. We concern on the inequalities of Choquuet integral. The main purpose of this paper is to prove the H?lder inequality for any arbitrary fuzzy measure-based Choquet integral whenever any two of these integrated functions f, g and h are comonotone, and there are three weights. Then we prove Minkowski inequality and Lyapunov inequality for Choquet integral. Moreover, when any two of these integrated functions f1, f2, , fn are comonotone, we also obtain the Hölder inequality, Minkowski inequality and Lyapunov inequality hold for Choquet integral.
Severe Maternal Hyperglycemia Exacerbates the Development of Insulin Resistance and Fatty Liver in the Offspring on High Fat Diet
Yong Song,Jibin Li,Yong Zhao,Qijuan Zhang,Zhiguo Liu,Jingna Li,Xiaoyi Chen,Zhu Yang,Chao Yu,Xiaoqiu Xiao
Experimental Diabetes Research , 2012, DOI: 10.1155/2012/254976
Abstract: Background. Adverse maternal environments may predispose the offspring to metabolic syndrome in adulthoods, but the underlying mechanism has not been fully understood. Methods. Maternal hyperglycemia was induced by streptozotocin (STZ) injection while control (CON) rats received citrate buffer. Litters were adjusted to eight pups per dam and then weaned to standard diet. Since 13 weeks old, a subset of offspring from STZ and CON dams were switched to high fat diet (HFD) for another 13 weeks. Glucose and insulin tolerance tests (GTT and ITT) and insulin secretion assay were performed; serum levels of lipids and leptin were measured. Hepatic fat accumulation and islet area were evaluated through haematoxylin and eosin staining. Results. STZ offspring exhibited lower survival rate, lower birth weights, and growth inhibition which persisted throughout the study. STZ offspring on HFD showed more severe impairment in GTT and ITT, and more profound hepatic steatosis and more severe hyperlipidemia compared with CON-HFD rats. Conclusions. Offspring from diabetic dams would be prone to exhibit low birth weight and postnatal growth inhibition, but could maintain normal glucose tolerance and insulin sensitivity. HFD accelerates development of insulin resistance in the offspring of diabetic dams mainly via a compensatory response of islets.
THE CONVERGENCE OF A CLASS OF TWO-STEP CONTINUITY RUNGE-KUTTA METHODS FOR SOLVING SINGULAR DELAY DIFFERENTIAL EQUATIONS
一类求解奇异延迟微分方程的两步连续Runge-Kutta方法的收敛性

Leng Xin,Liu Degui,Song Xiaoqiu,Chen Lirong,
冷欣
,刘德贵,宋晓秋,陈丽容

计算数学 , 2006,
Abstract: In this paper, a class of two-step continuity Runge-Kutta(TSCRK) methods for solving delay differential equations where delay lies in the span of the current step is presented. Under certain conditions, we prove the convergence property of the method. Some examples show the efficiency of the method.
Severe Maternal Hyperglycemia Exacerbates the Development of Insulin Resistance and Fatty Liver in the Offspring on High Fat Diet
Yong Song,Jibin Li,Yong Zhao,Qijuan Zhang,Zhiguo Liu,Jingna Li,Xiaoyi Chen,Zhu Yang,Chao Yu,Xiaoqiu Xiao
Journal of Diabetes Research , 2012, DOI: 10.1155/2012/254976
Abstract: Background. Adverse maternal environments may predispose the offspring to metabolic syndrome in adulthoods, but the underlying mechanism has not been fully understood. Methods. Maternal hyperglycemia was induced by streptozotocin (STZ) injection while control (CON) rats received citrate buffer. Litters were adjusted to eight pups per dam and then weaned to standard diet. Since 13 weeks old, a subset of offspring from STZ and CON dams were switched to high fat diet (HFD) for another 13 weeks. Glucose and insulin tolerance tests (GTT and ITT) and insulin secretion assay were performed; serum levels of lipids and leptin were measured. Hepatic fat accumulation and islet area were evaluated through haematoxylin and eosin staining. Results. STZ offspring exhibited lower survival rate, lower birth weights, and growth inhibition which persisted throughout the study. STZ offspring on HFD showed more severe impairment in GTT and ITT, and more profound hepatic steatosis and more severe hyperlipidemia compared with CON-HFD rats. Conclusions. Offspring from diabetic dams would be prone to exhibit low birth weight and postnatal growth inhibition, but could maintain normal glucose tolerance and insulin sensitivity. HFD accelerates development of insulin resistance in the offspring of diabetic dams mainly via a compensatory response of islets. 1. Introduction Metabolic syndrome (MetS) is a clustering of metabolic disorders including hyperglycemia, hypertension, dyslipidemia, overweight, and central obesity, with insulin resistance as the central feature of this syndrome [1]. A global increase in the prevalence of MetS has been found in the last decades due to the worldwide epidemic of obesity [2, 3]. The risk of the MetS depends on genetic susceptibility but is modulated by pre- and postnatal environmental factors. A growing body of evidence suggests that adverse environmental conditions during crucial periods of development may predispose individuals to develop different components of the MetS in adulthood [4]. Of particular note is maternal diabetes, including type 1 and type 2 diabetes and gestational diabetes mellitus (GDM). An overall increasing prevalence of diabetes indicates an emergence of diabetes among childbearing women. During pregnancy, especially during critical window periods for organogenesis and fetal development, unsatisfactory glycemic control is known to increase the incidence of severe obstetrical complications, including preeclampsia, macrosomia, and Caesarean section. Additionally, intrauterine exposure to a hyperglycemic environment predisposes
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