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Search Results: 1 - 10 of 12793 matches for " Xiaoqiang LUO "
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The Subclasses of Characterization on $Pi^*$-Regular Semigroups
Xiaoqiang LUO
Progress in Applied Mathematics , 2013, DOI: 10.3968/j.pam.1925252820130502.643
Abstract: In the paper, we define the equivalence relations on $Pi^*$-regulur semigroups, to show $L^*$, $R^*$, $H^*$, $J^*$-class contains an idempotent with some characterizations.
An Iterative Algorithm to Build Chinese Language Models
Xiaoqiang Luo,Salim Roukos
Computer Science , 1996,
Abstract: We present an iterative procedure to build a Chinese language model (LM). We segment Chinese text into words based on a word-based Chinese language model. However, the construction of a Chinese LM itself requires word boundaries. To get out of the chicken-and-egg problem, we propose an iterative procedure that alternates two operations: segmenting text into words and building an LM. Starting with an initial segmented corpus and an LM based upon it, we use a Viterbi-liek algorithm to segment another set of data. Then, we build an LM based on the second set and use the resulting LM to segment again the first corpus. The alternating procedure provides a self-organized way for the segmenter to detect automatically unseen words and correct segmentation errors. Our preliminary experiment shows that the alternating procedure not only improves the accuracy of our segmentation, but discovers unseen words surprisingly well. The resulting word-based LM has a perplexity of 188 for a general Chinese corpus.
EFFECTS OF δ–FERRITE ON THE MICROSTRUCTURE AND MECHANICAL PROPERTIES IN A TUNGSTEN-ALLOYED 10%Cr ULTRA–SUPERCRITICAL STEEL

HU Xiaoqiang,XIAO Namin,LUO Xinghong,LI Dianzhong,

金属学报 , 2009,
Abstract: The tungsten–alloyed 10%Cr (mass fraction) steel, one of the advanced 9%—12%Cr steels, has been widely considered as a preferred candidate for making key components in ultra–supercritical (USC) steam turbines. Due to large amounts of ferrite former in the steel, the formation temperature of δ–ferrite is lowered down, and therefore δ–ferrite is apt to be produced during hot working. However, understanding of the formation mechanism of δ–ferrite and its influence on the mechanic properties of ultra–supercritical steels is still either ambiguous or conflicting. To clarify this problem, in this paper, the microstructure and morphology of δ–ferrite were investigated by optical microscope, scanning electron microscope and energy dispersive spectrum (EDS) analysis. Also, the mechanical properties including the tensile strength, ductility and impact toughness of the studied steel with various volume fraction of δ–ferrite were tested at room temperature. Experimental results indicate that the transformation mechanism of δ–ferrite is closely dependent on the austenitizing temperature. Extremely small amounts of acicular δ–ferrite preferentially nucleate and grow inside the prior austenite grains, if the austenitizing temperature is just a little higher than the equilibrium transformation point of δ–ferrite. While, as the austenitizing temperature increases further, some polygonal δ–ferrites subsequently form on prior grain boundaries and grow quickly. Meanwhile, the repartitioning of solute elements occurrs between δ–ferrite and prior austenite. Both acicular and polygonal δ–ferrites will damage the impact toughness of the studied steel. And in spite of its few amounts, the detrimental effect of acicular δ–ferrite on the mechanical properties, especially the impact toughness, is more severe than that of polygonal δ–ferrite. Additionally, the tensile strength and the area reduction of the studied steel decrease as the amount of δ–ferrite increases, while the elongation hardly changes with the amount of δ–ferrite increasing. As a conclusion, accurately controlling the austenitizing temperature to prevent from the formation of any δ–ferrite is not only necessary but also very important in obtaining perfect overall mechanical properties.
Twist1 Promotes Gastric Cancer Cell Proliferation through Up-Regulation of FoxM1
Jianxin Qian, Yizhou Luo, Xiaoqiang Gu, Wang Zhan, Xi Wang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0077625
Abstract: Twist-related protein 1 (Twist1), also known as class A basic helix-loop-helix protein 38 (bHLHa38), has been implicated in cell lineage determination and differentiation. Previous studies demonstrate that Twist1 expression is up-regulated in gastric cancer with poor clinical outcomes. Besides, Twist1 is suggested to be involved in progression of human gastric cancer. However, its biological functions remain largely unexplored. In the present study, we show that Twist 1 overexpression leads to a significant up-regulation of FoxM1, which plays a key role in cell cycle progression in gastric cancer cells. In contrast, knockdown of Twist 1 reduces FoxM1 expression, suggesting that FoxM1 might be a direct transcriptional target of Twist 1. At the molecular level, we further reveal that Twist 1 could bind to the promoter region of FoxM1, and subsequently recruit p300 to induce FoxM1 mRNA transcription. Therefore, our results uncover a previous unknown Twist 1/FoxM1 regulatory pathway, which may help to understand the mechanisms of gastric cancer proliferation.
Research on Relevance of Supply Chain and Industry Cluster
Xiaoqiang Han
International Journal of Marketing Studies , 2009, DOI: 10.5539/ijms.v1n2p127
Abstract: Supply chain and industry cluster are the two important ways to enhance the competitiveness of regions or industries. By discussing the differences and links between the two, this paper concludes that industrial cluster and supply chain carry features of compatibility and symbiosis. The combination of the two can effectively increase the competitive advantage of industries so as to enhance regional economic competitiveness.
Salary Management Model of Professional Managers-Based on “Agent and Salary Theory” and “Psychological Contract Theory”
Xiaoqiang Sun
International Journal of Business and Management , 2009, DOI: 10.5539/ijbm.v4n10p194
Abstract: With the foundation of the modern company system, commission-procuration theory becomes the dominant mode of working out the salary management of enterprises. However, many experts from all over the world derived a conclusion that there is little connection between agent and the salary. Psychological contract theory brought new perspective and conception. Meanwhile, the core staff has been washed away due to the intensive change of the organization. To build a long-term relationship and the psychological contract theory between staff and organization plays an extremely vital rule.
Designer Lipid-Like Peptides: A Class of Detergents for Studying Functional Olfactory Receptors Using Commercial Cell-Free Systems
Karolina Corin, Philipp Baaske, Deepali B. Ravel, Junyao Song, Emily Brown, Xiaoqiang Wang, Christoph J. Wienken, Moran Jerabek-Willemsen, Stefan Duhr, Yuan Luo, Dieter Braun, Shuguang Zhang
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0025067
Abstract: A crucial bottleneck in membrane protein studies, particularly G-protein coupled receptors, is the notorious difficulty of finding an optimal detergent that can solubilize them and maintain their stability and function. Here we report rapid production of 12 unique mammalian olfactory receptors using short designer lipid-like peptides as detergents. The peptides were able to solubilize and stabilize each receptor. Circular dichroism showed that the purified olfactory receptors had alpha-helical secondary structures. Microscale thermophoresis suggested that the receptors were functional and bound their odorants. Blot intensity measurements indicated that milligram quantities of each olfactory receptor could be produced with at least one peptide detergent. The peptide detergents' capability was comparable to that of the detergent Brij-35. The ability of 10 peptide detergents to functionally solubilize 12 olfactory receptors demonstrates their usefulness as a new class of detergents for olfactory receptors, and possibly other G-protein coupled receptors and membrane proteins.
Production of a Bioengineered G-Protein Coupled Receptor of Human Formyl Peptide Receptor 3
Xiaoqiang Wang, Shuguang Zhang
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0023076
Abstract: G-protein coupled receptors (GPCRs) participate in a wide range of vital regulations of our physiological actions. They are also of pharmaceutical importance and have become many therapeutic targets for a number of disorders and diseases. Purified GPCR-based approaches including structural study and novel biophysical and biochemical function analyses are increasingly being used in GPCR-directed drug discovery. Before these approaches become routine, however, several hurdles need to be overcome; they include overexpression, solubilization, and purification of large quantities of functional and stable receptors on a regular basis. Here we report milligram production of a human formyl peptide receptor 3 (FPR3). FPR3 comprises a functionally distinct GPCR subfamily that is involved in leukocyte chemotaxis and activation. The bioengineered FPR3 was overexpressed in stable tetracycline-inducible mammalian cell lines (HEK293S). After a systematic detergent screening, fos-choline-14 (FC-14) was selected for subsequent solubilization and purification processes. A two-step purification method, immunoaffinity using anti-rho-tag monoclonal antibody 1D4 and gel filtration, was used to purify the receptors to near homogeneity. Immunofluorescence analysis showed that expressed FPR3 was predominantly displayed on cellular membrane. Secondary structural analysis using circular dichroism showed that the purified FPR3 receptor was correctly folded with >50% α-helix, which is similar to other known GPCR secondary structures. Our method can readily produce milligram quantities of human FPR3, which would facilitate in developing human FPR as therapeutic drug targets.
The Design of Mixed Database in the 4PL Infrastructure
Xiaoqiang Liu,Ning Jiang
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
The Learning Service Bus Based on SOA
Xiaoqiang Liu,Yingpei Wu
Lecture Notes in Engineering and Computer Science , 2008,
Abstract:
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