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Search Results: 1 - 10 of 12331 matches for " Xiaomin Yin "
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Application Study on Multi-Vary Analysis  [PDF]
Xiaomin Xu
Modern Mechanical Engineering (MME) , 2013, DOI: 10.4236/mme.2013.31005
Abstract:

In this article, we studied the bearings made by one company in Shanghai. Through statistical process controlling the quality characteristic of bearings’ diameters and multi-vary analysis is applied to find the key variation factors which have an influence on the quality characteristic of the bearings, the quality level of the bearings of this company is improved.

Novel Understanding of Electron States Architecture and Its Dimensionality in Semiconductors  [PDF]
Xiaomin Ren
Optics and Photonics Journal (OPJ) , 2013, DOI: 10.4236/opj.2013.32B075
Abstract:

Some important insights into the electron-states-architecture (ESA) and its dimensionality (from 3 to 0) in a semiconductor (or generally crystalline) material are obtained. The self-consistency of the set of density of states (DOS) expressions with different dimensionalities is remediated through the clarification and rearrangement of the wave-function boundary conditions for working out the eigenvalues in the wave vector space. The actually too roughly observed and theoretically unpredicted critical points for the dimensionality transitions referring to the integer ones are revealed upon an unusual assumption of the intrinsic energy-level dispersion (ELD). The ELD based quantitative physical model had been established on an immediate instinct at the very beginning and has been properly modified afterwards. The uncertainty regarding the relationship between the de Broglie wavelength of electrons and the dimensionality transitions, seeming somewhat mysterious before, is consequentially eliminated. The effect of the material dimensions on the ELD width is also predicted and has been included in the model. The continuous evolution of the ESA dimensionality is convincingly and comprehensively interpreted and thus the area of the fractional ESA dimensionalities is opened. Another new assumption of the spatial extension shrinkage (SES) closely related to the ELD has also been made and thus the understanding of the behavior of an electron or, in a general sense, a particle has become more comprehensive. This work would manifest itself a new basis for further development of nanoheterostructures (or low dimensional heterostructures including the quantum wells, quantum wires, quantum dots and especially the hetero-dimensional structures). Expected

When “Parents Privilege Competition” Will Not Be an Exclusive Resource?  [PDF]
Xiaomin Guo
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.64004
Abstract:
We describe a common social phenomenon in this article. It is that when children grow up, in addition to their talents and efforts in comparison with their peers, the parental background between children is also an important stake in their competition. Parents’ social status and superior power will result in more social resources and opportunities for children. We call this phenomenon “parents privilege competition”. The root cause of this phenomenon is the serious hardening of the stratum and the poor social mobility in vertical society, which makes it difficult for children to have an equal competitive environment. After analyzing the phenomenon, this article discusses the causes of this phenomenon and the solutions.
Cyclic AMP-Dependent Protein Kinase A Regulates the Alternative Splicing of CaMKIIδ
Qingqing Gu, Nana Jin, Hongzhuan Sheng, Xiaomin Yin, Jianhua Zhu
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0025745
Abstract: Ca2+/calmodulin-dependent protein kinase (CaMK) IIδ is predominantly expressed in the heart. There are three isoforms of CaMKIIδ resulting from the alternative splicing of exons 14, 15, and 16 of its pre-mRNA, which is regulated by the splicing factor SF2/ASF. Inclusion of exons 15 and 16 or of exon 14 generates δA or δB isoform. The exclusion of all three exons gives rise to δC isoform, which is selectively increased in pressure-overload-induced hypertrophy. Overexpression of either δB or δC induces hypertrophy and heart failure, suggesting their specific role in the pathogenesis of hypertrophy and heart failure. It is well known that the β-adrenergic-cyclic AMP-dependent protein kinase A (PKA) pathway is implicated in heart failure. To determine the role of PKA in the alternative splicing of CaMKIIδ, we constructed mini-CaMKIIδ genes and used these genes to investigate the regulation of the alternative splicing of CaMKIIδ by PKA in cultured cells. We found that PKA promoted the exclusion of exons 14, 15, and 16 of CaMKIIδ, resulting in an increase in δC isoform. PKA interacted with and phosphorylated SF2/ASF, and enhanced SF2/ASF's activity to promote the exclusion of exons 14, 15, and 16 of CaMKIIδ, leading to a further increase in the expression of δC isoform. These findings suggest that abnormality in β-adrenergic-PKA signaling may contribute to cardiomyopathy and heart failure through dysregulation in the alternative splicing of CaMKIIδ exons 14, 15, and 16 and up-regulation of CaMKIIδC.
Spatial distribution of ant mounds and effects on soil physical properties in wetlands of the Sanjiang plain, China

Haitao Wu,Donghui Wu,Xianguo Lu,Xiaomin Yin,

生态学报 , 2010,
Abstract:
Data Dependant Learners Ensemble Pruning
Gang Zhang,Jian Yin,Xiaomin He,Lianglun Cheng
Journal of Software , 2012, DOI: 10.4304/jsw.7.4.919-926
Abstract: Ensemble learning aims at combining several slightly different learners to construct stronger learner. Ensemble of a well selected subset of learners would outperform than ensemble of all. However, the well studied accuracy / diversity ensemble pruning framework would lead to over fit of training data, which results a target learner of relatively low generalization ability. We propose to ensemble with base learners trained by both labeled and unlabeled data, by adopting data dependant kernel mapping, which has been proved successful in semi-supervised learning, to get more generalized base learners. We bootstrap both training data and unlabeled data, namely point cloud, to build slight different data set, then construct data dependant kernel. With such kernels data point can be mapped to different feature space which results effective ensemble. We also proof that ensemble of learners trained by both labeled and unlabeled data is of better generalization ability in the meaning of graph Laplacian. Experiments on UCI data repository show the effectiveness of the proposed method.
Effects of Shen-Fu Injection on the Expression of T-Cell-Specific Transcription Factors T-bet/Gata-3 in Porcine Postresuscitation Lung Injury
Wei Gu,ChunSheng Li,WenPeng Yin,XiaoMin Hou
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/464650
Abstract:
Construction and Validation of Self-Management Scale for Undergraduate Students  [PDF]
Gang Xue, Xiaomin Sun
Creative Education (CE) , 2011, DOI: 10.4236/ce.2011.22020
Abstract: This study developed a scale to assess undergraduate students’ self-management ability in daily life. Forty items about self-management on time, goal, emotions and personal relationships were generated for the draft scale. Content review panel deleted seven items. In Study 1, 522 Chinese undergraduate students took the test. Exploratory factor analysis and item analysis on the first half 261 cases deleted 6 items. Confirmatory factor analysis further revised the model and resulted in a two-factor Self-Management Scale, consisting of 21 items. Cross-validation on the second half 261 cases also verified the scale’s structural validity. In Study 2, responses from 374 undergraduate students were used to examine the reliability and criterion-related validity of the scale. The internal consistency reliability of the scale was 0.86. Relationship management showed good criterion-related validity, while the validity of performance management needs further examination.
The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation
Fushan Shi, Lifeng Yang, Mohammed Kouadir, Yang Yang, Jihong Wang, Xiangmei Zhou, Xiaomin Yin, Deming Zhao
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-73
Abstract: The inflammasome components NALP3 and apoptosis-associated speck-like protein (ASC) were knocked down by gene silencing. IL-1β production was assessed using ELISA. The mRNA expression of NALP3, ASC, and pro-inflammatory factors was measured by quantitative PCR. Western blot analysis was used to detect the protein level of NALP3, ASC, caspase-1 and nuclear factor-κB.We found that that PrP106-126-induced IL-1β release depends on NALP3 inflammasome activation, that inflammasome activation is required for the synthesis of pro-inflammatory and chemotactic factors by PrP106-126-activated microglia, that inhibition of NF-κB activation abrogated PrP106-126-induced NALP3 upregulation, and that potassium efflux and production of reactive oxygen species were implicated in PrP106-126-induced NALP3 inflammasome activation in microglia.We conclude that the NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation. To our knowledge, this is the first time that strong evidence for the involvement of NALP3 inflammasome in prion-associated inflammation has been found.Prion diseases, also known as transmissible spongiform encephalopathies, are fatal neurodegenerative disorders, characterized by brain vacuolation, neuronal cell death, and microgliosis [1]. They are caused by the conversion of cellular prion protein (PrPC) into the pathological isoform (PrPSc) through conformational changes. PrPSc is protease-resistant, and has a higher proportion of β-sheet structure in place of the normal α-helix structure [2]. The accumulation of abnormal forms of prion protein (PrPSc) has been shown to be the main causative agent of these diseases [3].The neurotoxic PrP fragment 106–126 (PrP106-126) possesses similar physicochemical and pathogenic properties to PrPSc, in that it forms amyloid fibrils with a high β-sheet content, shows partial proteinase K resistance, and is neurotoxic in vitro. Therefore, PrP106-126 is commonly used as a model for the investigation of
Influence of PrP 106–126 on expression of laminin and fibronectin in astrocyte
YuRong Li,LeLuo Guan,JianMin Yang,XiangMei Zhou,XiaoMin Yin,DeMing Zhao
Chinese Science Bulletin , 2008, DOI: 10.1007/s11434-008-0261-1
Abstract: Astrogliosis is a hallmark of prion disease, but the metabolic alterations of astrocytes remain poorly documented. A synthetic peptide corresponding to amino acid 106–126 of the human prion protein (PrP) has been shown to be toxic to neurons. In this study, the effects of PrP 106–126 on astrocytes were investigated in vitro. The proliferation of astrocytes was significantly (P < 0.05) increased when grown in media conditioned with PrP 106–126 (80 μmol/L) from microglia. The expression of laminin (LN) and fibronectin (FN) was examined at both mRNA and protein levels. The results showed that exposure of astrocytes to PrP 106–126 enhanced the expression of LN and FN. The increase of FN in astrocyte cultures required cytokines previously released by activated microglia. This study reveals the expression of LN and FN affected by PrP106–126.
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