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Search Results: 1 - 10 of 20156 matches for " Xiaofei Chang "
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Study on Mental Health Problems of Students in Petroleum Universities  [PDF]
Xiaofei Zhang
Creative Education (CE) , 2018, DOI: 10.4236/ce.2018.95056
Abstract: College students are valuable talent resources, and are an important reserve force for the great cause of building socialism with Chinese characteristics. University is the transitional stage of puberty to maturity;?the college students are more sensitive to their body and mind, and their psychological state is not fully mature and stable. In the face of complex social environment and fierce?competition for talent, some college students’ mental status presents sub-health?or unhealthy state, and even serious psychological problems. This paper aims to study and solve the problem of college students’?mental health. The research of this thesis is a useful supplement to the research on the mental health of university students in petroleum universities, and it raises the concern of all circles in the society. It is of theoretical and practical significance to further strengthen the mental health education and promote the all-round development of college students.
Imine Resveratrol Analogues: Molecular Design, Nrf2 Activation and SAR Analysis
Chang Li, Xiaofei Xu, Xiu Jun Wang, Yuanjiang Pan
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101455
Abstract: Resveratrol is a natural phenol with protective effects against cancer and inflammation-related diseases. Its mechanism of action involves the activation of nuclear factor E2 p45-related factor 2 (Nrf2), which plays a key role in regulation of genes driven by antioxidant response element (ARE). Inspired by the effect of resveratrol, here we synthesized a series of imine resveratrol analogs (IRAs), evaluated their abilities to activate Nrf2 by using cell based ARE-reporter assay. After the first-round screening, preliminary and quantitative structure-activity relationship (SAR) was analyzed, and the structural features determining Nrf2 activation ability were proposed. Two novel IRAs were designed and subsequently synthesized, namely 2-methoxyl-3,6-dihydroxyl-IRA and 2,3,6-trihydroxyl-IRA. They were proved to be the most potent Nrf2 activators among the IRAs.
Advances in Lung Cancer and Treatment Research  [PDF]
Xiaofei Wang, Baohui Han
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.48A006

With the advances in surgery, chemotherapy, and radiotherapy over the last decades, the treatment strategies of lung cancer has been largely changed. In this review, we summarize recent advances in lung cancer and treatment research. We discuss current clinical management, highlight stage-specific therapy approaches, chemotherapy options for advanced-stage of non-small-cell lung cancer (NSCLC) patients, along with new agents such as epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitors erlotinib and gefitinib, and the anaplastic lymphoma kinase (ALK) inhibitor crizotinib. We also give an outlook into NSCLC disease biology, focuse on the importance of EGFR activating mutations and the role of the tumor-microenvironment. Finally we summarize the new recommendations in treating small-cell-lung cancer (SCLC).

Characteristics Collocation Method of Compressible Miscible Displacement with Dispersion  [PDF]
Ning Ma, Xiaofei Lu
Journal of Applied Mathematics and Physics (JAMP) , 2015, DOI: 10.4236/jamp.2015.31012

The compressible miscible displacement in a porous media is considered in this paper. The problem is a nonlinear system with dispersion in non-periodic space. The concentration is treated by a characteristics collocation method, and the pressure is treated by an orthogonal collocation method. Optimal order estimates are derived.

A Receiver Structure for Frequency-Flat Time-Varying Rayleigh Channels and Performance Analysis  [PDF]
Xiaofei Shao, Harry Leib
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2016, DOI: 10.4236/ijcns.2016.910033
Abstract: This paper proposes a wavelet based receiver structure for frequency-flat time-varying Rayleigh channels, consisting of a receiver front-end followed by a Maximum A-Posteriori (MAP) detector. Discretization of the received continuous time signal using filter banks is an essential stage in the front-end part, where the Fast Haar Transform (FHT) is used to reduce complexity. Analysis of our receiver over slow-fading channels shows that it is optimal for certain modulation schemes. By comparison with literature, it is shown that over such channels our receiver can achieve optimal performance for Time-Orthogonal modulation. Computed and Monte-Carlo simulated performance results over fast time-varying Rayleigh fading channels show that with Minimum Shift Keying (MSK), our receiver using four basis functions (filters) lowers the error floor by more than one order of magnitude with respect to other techniques of comparable complexity. Orthogonal Frequency Shift Keying (FSK) can achieve the same performance as Time-Orthogonal modulation for the slow-fading case, but suffers some degradation over fast-fading channels where it exhibits an error floor. Compared to MSK, however, Orthogonal FSK provides better performance.
A New Method to Digitize DNA Sequence  [PDF]
Xiaofei Xu, Feng Zhu
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.53002
The global description uses composition, transition and distribution to describe an amino acid sequence and has been widely adopted in various fields. Here we integrate it with properties of nucleic acid and form a new method to digitize DNA sequence. Through this method we can use a 39-dimession vector to represent a DNA sequence. We use the exon-1 of β-Globin genes of eight species to verify this method and compare with other methods. A similar result with other method proves that this method is persuading. This method provides a new strategy to digitize DNA sequence and generates DNA sequence descriptor vector. It is different from other methods and this method only produces a 39-dimession vector and not depends on the length of DNA sequence.
The Influence of Intergenerational Succession of Family Business on Its Performance—Taking Enterprise Innovation as a Mediating Variable  [PDF]
Jianjun Yu, Xiaofei Cai
American Journal of Industrial and Business Management (AJIBM) , 2017, DOI: 10.4236/ajibm.2017.76057
Abstract: Intergenerational succession is a critical stage that most Chinese family businesses are in or will be in. Therefore, problems like what influence of intergenerational succession will have on performance of family businesses and what their internal action mechanisms and action paths will be like are worthy to be discussed. Taking 1028 sample data of A-share listed family businesses in Shenzhen and Shanghai during 2010 to 2014 as study objects, the essay discussed direct influence of intergenerational succession on performance of family businesses and mediating effect of enterprise innovation on intergenerational succession and performance of family businesses by use of multiple regressions. Research results indicated that there had a negative correlation between intergenerational succession and performance of family businesses, and between intergenerational succession and enterprise innovation, and moreover, part of mediating effect of enterprise innovation on intergenerational succession and performance of family businesses was obvious. It means that intergenerational succession leads to the decline of performance of family businesses, and one of the mechanisms is that intergenerational succession reduces innovation investment of enterprises. The research results could provide a reference to family businesses in arrangement of innovation strategy and management of enterprise performance in the stage of intergenerational succession.
Adenylate Kinase 3 Sensitizes Cells to Cigarette Smoke Condensate Vapor Induced Cisplatin Resistance
Xiaofei Chang,Rajani Ravi,Vui Pham,Atul Bedi,Aditi Chatterjee,David Sidransky
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020806
Abstract: The major established etiologic risk factor for bladder cancer is cigarette smoking and one of the major antineoplastic agents used for the treatment of advanced bladder cancer is cisplatin. A number of reports have suggested that cancer patients who smoke while receiving treatment have lower rates of response and decreased efficacy of cancer therapies.
A novel scoring schema for peptide identification by searching protein sequence databases using tandem mass spectrometry data
Zhuo Zhang, Shiwei Sun, Xiaopeng Zhu, Suhua Chang, Xiaofei Liu, Chungong Yu, Dongbo Bu, Runsheng Chen
BMC Bioinformatics , 2006, DOI: 10.1186/1471-2105-7-222
Abstract: A novel scoring function is presented, along with criteria to estimate the performance confidence of the function. Through learning the typesof product ions and the probability of generating them, a hypothetic spectrum was generated for each candidate peptide. Then relative entropy was introduced to measure the similarity between the hypothetic and the observed spectra. Based on the extreme value distribution (EVD) theory, a threshold was chosen to distinguish a true peptide assignment from a random one. Tests on a public MS/MS dataset demonstrated that this method performs better than the well-known SEQUEST.A reliable identification of proteins from the spectra promises a more efficient application of tandem mass spectrometry to proteomes with high complexity.A major goal of proteomics is to study biological processes comprehensivelythrough the identification, characterization, and quantification of expressed protein in a cell or a tissue. Recently, tandem mass spectrometry has been shown to be a powerful tool for sensitive high-throughput identification of proteins [1,2]. Following enzymatic digestion of proteins, the resulting peptides are separated in the mass analyzer according to their mass to charge ratio (m/z-value). Peptides with the same m/z value are mostly brokeninto two fragments at a single peptide bond, forming N-terminal ions, i.e. a, b or c-ion and C-terminal ions, i.e., x, y or z-ion. All ions are then detected to generate a MS/MS spectrum (See Figure 1). In a mass spectrum, the intensity of a peak is generally proportional to the frequency of ions with the corresponding m/z-value [3].A number of factors complicate the interpretation of MS/MS data. Neither the peaks corresponding to the a/b/c versus the x/y/z ions, nor the charge states of the ions are known. Some product fragments may be absent because either the fragments are in a neutral state or the precursorion hardly breaks down into these products; and unexplainable peaks may appear as the r
A Tree-Structured Database Machine for Large Relational Database Systems
Meng Liming,Xu Xiaofei,Chang Huiyou,Chen Guangxi,Hu Mingzeng,Li Sheng
计算机科学技术学报 , 1987,
Abstract: This paper proposes a Tree-structured Database Machine (TDM), which is designed forsupporting large relational database systems. The TDM aims at totally improving three levelperformance bottlenecks in relational database systems, i.e.(?) data transfer bottleneck, dataprocessing bottleneck, and multiquery optimization bottleneck. For reducing these bottlenecks,the TDM provides the approaches of data partition and data distribution upon data storages forconcurrent data accesses, the tree-structured multiprocessor architecture for parallel dataprocessing, the technique of tightly-coupled-shared-memory for decreasing data movement,the mechanisms of indices and dictionaries for reducing data transfer from the data storages tothe memory, and so on. These features show that the TDM not only improves the systemperformance, increases the parallelism and the data processing power, but also eliminates theperformance bottlenecks in relational database systems.
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