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Search Results: 1 - 10 of 24271 matches for " XiaoHui Zheng "
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Three-Tier Knowledge Management System Based on .NET  [PDF]
Mingxing Cai, Jintao Zheng, Ping Shi, Xiaohui Li
Journal of Software Engineering and Applications (JSEA) , 2009, DOI: 10.4236/jsea.2009.21006
Abstract: Three-tier knowledge management system based on .NET architecture is designed according to requirement specification, characteristics of and relationship between enterprise electronic archives and knowledge management. This system using three-tier design based on factory pattern has good encapsulation and portability, with clearer and more concise structure. It degrades the costs of system development and maintenance and upgrades system’s high reusability and development efficiency.
Genomic regions with distinct genomic distance conservation in vertebrate genomes
Hong Sun, Geir Skogerb?, Xiaohui Zheng, Wei Liu, Yixue Li
BMC Genomics , 2009, DOI: 10.1186/1471-2164-10-133
Abstract: Among HCE pairs, we found that some consistently preserve highly conserved interval distance among genomes while others have relatively low distance conservation. Using a partition method, we detected two groups of inter-HCE regions (IHRs) with distinct distance conservation pattern in vertebrate genomes: IHR1s that are bordered by HCE pairs with relative small distance variation, and IHR2s with larger distance difference values. Compared to random background, annotated repeat sequences are significantly less frequent in IHR1s than IHR2s, which reflects a correlation between repeat sequences and the length expansion of IHRs. Both groups of IHRs are unexpectedly enriched in human indel (i.e. insertion and deletion) polymorphism-variations than random background. The correlation between the percentage of conserved sequence and human IHR length was stronger for IHR1 than IHR2. Both groups of IHRs are significantly enriched for CpG islands.The data suggest that subsets of HCE pairs may undergo different evolutionary paths in light of their genomic distance conservation, and that sets of genomic regions pertain to HCEs, as well as the region in which HCEs reside, should be treated as integrated domains.Comparative sequence analysis has become an essential component for studying genome function. Genome-wide comparison of human and rodents DNA sequences discovered more than 5,000 ultraconserved elements (UCEs) of absolute identity and >100 bp in length [1], of which 77 percent were located outside annotated exons, and long-range comparison between man and pufferfish also identified high numbers of similar genomic elements [2,3]. A common characteristic of these highly conserved elements is their strong tendency to occur in clusters along the mammalian chromosomes [1-4] with their relative order as conserved as that of protein coding genes [5]. A relative distance difference (RDD) measure was defined to evaluate the genomic distance change ratio of pairs of UCEs found at ad
Evaluation of upper limb muscle fatigue based on surface electromyography
QianXiang Zhou,YuHong Chen,Chao Ma,XiaoHui Zheng
Science China Life Sciences , 2011, DOI: 10.1007/s11427-011-4229-z
Abstract: Fatigue is believed to be a major contributory factor to occupational injuries in machine operators. The development of accurate and usable techniques to measure operator fatigue is therefore important. In this study, we used a novel method based on surface electromyography (sEMG) of the biceps brachii and the Borg scale to evaluate local muscle fatigue in the upper limb after isometric muscle action. Thirteen young males performed isometric actions with the upper limb at different force levels. sEMG activities of the biceps brachii were recorded during the actions. Borg scales were used to evaluate the subjective sensation of local fatigue of the biceps brachii after the actions. sEMG activities were analyzed using the one-third band octave method, and an equation to determine the degree of fatigue was derived based on the relationship between the variable and the Borg scale. The results showed that the relationship could be expressed by a conic curve, and could be used to evaluate muscle fatigue during machine operation.
A Three Step Network Based Approach (TSNBA) to Finding Disease Molecular Signature and Key Regulators: A Case Study of IL-1 and TNF-Alpha Stimulated Inflammation
Jihong Yang, Zheng Li, Xiaohui Fan, Yiyu Cheng
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094360
Abstract: A disease molecular signature is a set of biomolecular features that are prognostic of clinical phenotypes and indicative of underlying pathology. It is of great importance to develop computational approaches for finding more relevant molecular signatures. Based upon the hypothesis that various components in a molecular signature are more likely to share similar patterns, we introduced a novel three step network based approach (TSNBA) to identify the molecular signature and key pathological regulators. Protein-protein interaction (PPI) network and ranking algorithm were integrated in the first step to find pathology related proteins with high accuracy. It was followed by the second step to further screen with co-expression patterns for better pathology enrichment. Context likelihood of relatedness (CLR) algorithm was used in the third step to infer gene regulatory networks and identify key transcription regulators. We applied this approach to study IL-1 (interleukin-1) and TNF-alpha (tumor necrosis factor-alpha) stimulated inflammation. TSNBA identified inflammatory signature with high accuracy and outperformed 5 competing methods namely fold change, degree, interconnectivity, neighborhood score and network propagation based approaches. The best molecular signature, with 80% (40/50) confirmed inflammatory genes, was used to predict inflammation related genes. As a result, 8 out of 10 predicted inflammation genes that were not included in the benchmark Entrez Gene database were validated by literature evidence. Furthermore, 23 of the 32 predicted inflammation regulators were validated by literature evidence. The rest 9 were also validated with TF (transcription factor) binding site analysis. In conclusion, we developed an efficient strategy for disease molecular signature finding and key pathological regulator identification.
The crossing numbers of $K_m\times P_n$ and $K_m\times C_n$
Yuansheng Yang,Baigong Zheng,Xirong Xu,Xiaohui Lin
Computer Science , 2012,
Abstract: The {\it crossing number} of a graph $G$ is the minimum number of pairwise intersections of edges in a drawing of $G$. In this paper, we study the crossing numbers of $K_{m}\times P_n$ and $K_{m}\times C_n$.
The crossing numbers of $K_{n,n}-nK_2$, $K_{n}\times P_2$, $K_{n}\times P_3$ and $K_n\times C_4$
Yuansheng Yang,Baigong Zheng,Xiaohui Lin,Xirong Xu
Computer Science , 2012,
Abstract: The crossing number of a graph $G$ is the minimum number of pairwise intersections of edges among all drawings of $G$. In this paper, we study the crossing number of $K_{n,n}-nK_2$, $K_n\times P_2$, $K_n\times P_3$ and $K_n\times C_4$.
Microstructure and Tribological Properties of Plasma-sprayed Nanostructured Sulfide Coating
Yang XU,Yaohui GUAN,Zhongyu ZHENG,Xiaohui TONG,
Yang
,XU,Yaohui,GUAN,Zhongyu,ZHENG,Xiaohui,TONG

材料科学技术学报 , 2006,
Abstract: The friction and wear properties of plasma-sprayed nanostructured FeS coating were investigated on an MHK-500 friction and wear tester under both oil lubrication and dry friction condition. The microstructure, worn surface morphology and phase composition of the coating were characterized by scanning electron microscopy(SEM)and X-ray diffraction(XRD). It was found that the coating was mainly composed of FeS, a small quantity of Fe1-xS and oxide were also found. The coating was formed by small particles of 50~100 nm in size. The thickness of the coating is approximately 150μm. The friction-reduction and wear-resistance properties of plasma-sprayed nanostructured FeS coating were superior to that of GCr15 steel substrate.Especially under oil lubrication condition, the friction coefficient of nanostructured FeS coating was 50% of that of GCr15 steel, the wear scar widths of the coating were also reduced to nearly 50% of that of GCr15 steel under high load. The failure of the coating was mainly attributed to plastic deformation under both oil lubrication and dry friction condition.
β2-Adrenoceptor affinity chromatography and its application in the screening of the active compounds from Semen Armeniacae Amarum
XiaoHui Zheng,XinFeng Zhao,Rong Yang,ShiXiang Wang,YinMao Wei,JianBin Zheng
Chinese Science Bulletin , 2008, DOI: 10.1007/s11434-007-0510-8
Abstract: β2-Adrenoceptor (β2-AR) was purified from the rabbit lung tissue by sepharose-salbutamol affinity chromatographic column. To prepare the β2-AR stationary phase, β2-AR was evenly immobilized on the surface of macro-pore silica with a mild chemical coupling method through covalent bond. The retention properties of β2-AR stationary phase were characterized by four ligands, salbutamol sulfate, noradrenaline bitartrate, adrenaline hydrochloride and propranolol hydrochloride, to establish the β2-AR affinity chromatography. Then, the method was used to screen the active compounds from the total extracts of Semen Armeniacae Amarum. The results showed that β2-AR on the surface of the stationary phase could keep its original bioactivity and selectivity. Amygdalin retained in the chromatographic column was proved to be the active compound of the total extracts of Semen Armeniacae Amarum. Compared with the existing chromatographic screening approaches, this method showed a good stability and high selectivity. The active compounds which could interact with β2-AR in traditional Chinese medicine (TCM) could be screened efficiently by this method, providing a new way to screen the active compounds in complicated samples such as TCM.
β2-Adrenoceptor affinity chromatography and its application in the screening of the active compounds from Semen Armeniacae Amarum
ZHENG XiaoHui,ZHAO XinFeng,YANG Rong,WANG ShiXiang,WEI YinMao,ZHENG JianBin,

科学通报(英文版) , 2008,
Abstract: β2-Adrenoceptor (β2-AR) was purified from the rabbit lung tissue by sepharose-salbutamol affinity chromatographic column. To prepare the β2-AR stationary phase, β2-AR was evenly immobilized on the surface of macro-pore silica with a mild chemical coupling method through covalent bond. The retention properties of β2-AR stationary phase were characterized by four ligands, salbutamol sulfate, noradrenaline bitartrate, adrenaline hydrochloride and propranolol hydrochloride, to establish the β2-AR affinity chromatography. Then, the method was used to screen the active compounds from the total extracts of Semen Armeniacae Amarum. The results showed that β2-AR on the surface of the stationary phase could keep its original bioactivity and selectivity. Amygdalin retained in the chromatographic column was proved to be the active compound of the total extracts of Semen Armeniacae Amarum. Compared with the existing chromatographic screening approaches, this method showed a good stability and high selectivity. The active compounds which could interact with β2-AR in traditional Chinese medicine (TCM) could be screened efficiently by this method, providing a new way to screen the active compounds in complicated samples such as TCM. Supported by the National Natural Science Foundation of China (Grant No. 20575052) and the Natural Science Foundation of Shaanxi Province, China (Grant Nos. 2006B03 and 2006C220)
Separation and analysis of the soluble trimer of Aβ1–40 and its effects on the rise in intracellular calcium
Separation and analysis of the soluble trimer of Aβ1-40 and its effects on the rise in intracellular calcium

ZHENG Xiaohui,WANG Lijun,ZHANG Lan,HONG Yuankai,HUANG Lixin,SHA Yinlin,
ZHENG
,Xiaohui,WANG,Lijun,ZHANG,Lan,HONG,Yuankai,HUANG,Lixin,SHA,Yinlin

科学通报(英文版) , 2006,
Abstract: The oligomers of Aβ1–40 peptide in PBS buffer solution were analyzed by SEC and native PAGE, and the trimer of Aβ1–40 was also isolated by SEC. In addition, the effects of the soluble Aβ1–40 trimer on intracellular free calcium (Ca2+) balance of hippocampal neurons of postnatal rats were investigated by fluorescence microscopy. The experimental results indicated that Aβ1–40 peptide existed in the form of low molecular weight oligomers in 0.231 mmol/L fresh Aβ1–40 solution (20 mmol/L sodium phosphate buffer, pH 7.4, 0.02% sodium azide) within 24 h and the soluble trimer was the most abundant species. Both the trimeric and the fibrillar Aβ1–40 were able to increase the intracellular Ca2+ concentration, but the Aβ1–40 trimer caused a gradual rise and the potential was also stronger than that of the fibrils at the same concentration. In addition there were different response modes for trimeric and fibrillar Aβ1–40, meaning that there are different mechanisms of increase in intracellular Ca2+ caused by Aβ1–40.
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