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Search Results: 1 - 10 of 104736 matches for " XiaoHong Zhang "
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Optimal Maintenance Modeling for Systems with Multiple Non-Identical Units Using Extended DSSP Method  [PDF]
Xiaohong Zhang, Jianchao Zeng
American Journal of Operations Research (AJOR) , 2016, DOI: 10.4236/ajor.2016.64027
Abstract: In the optimal maintenance modeling, all possible maintenance activities and their corresponding probabilities play a key role in modeling. For a system with multiple non-identical units, its maintenance requirements are very complicated, and it is time-consuming, even omission may occur when enumerating them with various combinations of units and even with different maintenance actions for them. Deterioration state space partition (DSSP) method is an efficient approach to analyze all possible maintenance requirements at each maintenance decision point and deduce their corresponding probabilities for maintenance modeling of multi-unit systems. In this paper, an extended DSSP method is developed for systems with multiple non-identical units considering opportunistic, preventive and corrective maintenance activities for each unit. In this method, different maintenance types are distinguished in each maintenance requirement. A new representation of the possible maintenance requirements and their corresponding probabilities is derived according to the partition results based on the joint probability density function of the maintained system deterioration state. Furthermore, focusing on a two-unit system with a non-periodical inspected condition-based opportunistic preventive-maintenance strategy; a long-term average cost model is established using the proposed method to determine its optimal maintenance parameters jointly, in which “hard failure” and non-negligible maintenance time are considered. Numerical experiments indicate that the extended DSSP method is valid for opportunistic maintenance modeling of multi-unit systems.
Spatio-Temporal Variations of Precipitation Extremes in the Yangtze River Basin (1960-2002), China  [PDF]
Qiang Zhang, Xiaohong Chen, Becker Stefan
Atmospheric and Climate Sciences (ACS) , 2011, DOI: 10.4236/acs.2011.11001
Abstract: Daily precipitation data during 1960-2002 from 150 stations in the Yangtze River basin were analyzed with the help of linear trend analysis. Highest 5-day and 10-day precipitation amount (R5D and R10D) and percentile daily precipitation maxima (prec95p for 95th percentile and prec99p for 99th percentile) were accepted as the precipitation extreme index. The frequency of the R5D and R10D was in downward trend, this phenomenon is more obvious in the middle Yangtze River basin; The stations with total precipitation of R5D and R10D are in significant upward trend (> 95% confidence level) are mostly located in the lower Yangtze River basin and the south-western part of the Yangtze River basin; 2) the spatial distribution of the frequency of total precipitation of the percentile daily precipitation maxima is similar to that of R5D and R10D. However the frequency of prec95p and prec99p is in significant upward trend. The upward trend of total precipitation changes of prec95p and prec99p is more obvious than that of frequency of prec95p and prec99p. The regions dominated by upward trend of frequency/total precipitation of prec95p and prec99p are also the lower Yangtze River basin and south-western part of the Yangtze River basin. Therefore the occurrence probability of the flash floods in the lower Yangtze River basin and south-western part of the Yangtze River basin will be greater.
Regional Evaluations of the Meteorological Drought Characteristics across the Pearl River Basin, China  [PDF]
Qiang Zhang, Mingzhong Xiao, Xiaohong Chen
American Journal of Climate Change (AJCC) , 2012, DOI: 10.4236/ajcc.2012.11005
Abstract: Regional evaluation of drought characteristics provides critical information for water resource management. In this case, this study attempts to analyze the probability behaviors of drought events of a given severity in the Pearl River Basin and to construct severity-area-frequency curves of drought events. Due to possible impacts of complicated topographical properties and diverse climate types within the Pearl River Basin, the entire Pearl River Basin is subdivided into different homogeneous regions. In general, the Pearl River Basin can be categorized into four homogeneous regions, and the severity-area-frequency analysis results for the short-, medium- and long-term drought episodes within each homogeneous regions indicate stressful challenge for the water resource management in the Pearl River Basin due to the fact that severe droughts usually occur over the entire Pearl River Basin. Meanwhile, the Pearl River Delta will face a higher risk of drought when compared to other regions of the Pearl River Basin in terms of the medium-term drought. The Pearl River Basin is highly economically development and is heavily populated, thus impacts of droughts and related resilience resolutions or policies should be taken into account in the formulation of regional sustainable development of water resources and socio-economy within the Pearl River Basin, China.
Basonuclin-Null Mutation Impairs Homeostasis and Wound Repair in Mouse Corneal Epithelium
Xiaohong Zhang, Hung Tseng
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0001087
Abstract: At least two cellular processes are required for corneal epithelium homeostasis and wound repair: cell proliferation and cell-cell adhesion. These processes are delicately balanced to ensure the maintenance of normal epithelial function. During wound healing, these processes must be reprogrammed in coordination to achieve a rapid re-epithelialization. Basonuclin (Bnc1) is a cell-type-specific transcription factor expressed mainly in the proliferative keratinocytes of stratified epithelium (e.g., corneal epithelium, epidermis and esophageal epithelium) and the gametogenic cells in testis and ovary. Our previous work suggested that basonuclin could regulate transcription of ribosomal RNA genes (rDNA) and genes involved in chromatin structure, transcription regulation, cell-cell junction/communication, ion-channels and intracelllular transportation. However, basonuclin's role in keratinocytes has not been demonstrated in vivo. Here we show that basonuclin-null mutation disrupts corneal epithelium homeostasis and delays wound healing by impairing cell proliferation. In basonuclin-null cornea epithelium, RNA polymerase I (Pol I) transcription is perturbed. This perturbation is unique because it affects transcripts from a subset of rDNA. Basonuclin-null mutation also perturbs RNA polymerase II (Pol II) transcripts from genes encoding chromatin structure proteins histone 3 and HMG2, transcription factor Gli2, gap-junction protein connexin 43 and adheren E-cadherin. In most cases, a concerted change in mRNA and protein level is observed. However, for E-cadherin, despite a notable increase in its mRNA level, its protein level was reduced. In conclusion, our study establishes basonuclin as a regulator of corneal epithelium homeostasis and maintenance. Basonuclin likely coordinates functions of a subset of ribosomal RNA genes (rDNA) and a group of protein coding genes in cellular processes critical for the regulation of cell proliferation.
Nose thyself: individuality in the human olfactory genome
Xiaohong Zhang, Stuart Firestein
Genome Biology , 2007, DOI: 10.1186/gb-2007-8-11-230
Abstract: Different people have different noses. Not just on the outside, it turns out, but inside as well. Indeed, there may be more variation in olfactory abilities among humans than in any other sense. We have all had the experience of being in a room where everyone seems to smell some odor, good or bad, that we simply do not perceive, no matter how much we sniff. Detection thresholds - the ability to detect a given odor at a particular concentration - vary over several orders of magnitude of concentration in different people. There are also many cases of selective anosmia, the inability to detect a particular odor, in the human (and mouse) population, and many of these seem to sort along genetic lines. One of the best known is a selective anosmia to isovaleric acid. This is socially important because isovaleric acid is the main noxious component of body odor. About 6% of the human population appears to have this anosmia, and they tend to self identify [1].The high level of variation in the sense of smell may be related to the large family of genes that encode the odor receptors. Odor receptors are G-protein-coupled receptors that are expressed in specialized cilia on the tips of olfactory sensory neurons located in a layer of epithelium at the back of the nasal cavity. The odor receptor genes were first identified in 1991 by Linda Buck and Richard Axel [2], who predicted that they might comprise a very large gene family. We now know that they form the largest gene family known in mammals, numbering more than 1,000 genes [3], or more than 5% of the typical mammalian genome. Even humans, whose sense of smell is thought to be less good than that of many other animals, have some 350 odor receptor genes, comprising more than 1% of the coding genome [4]. For comparison, the next largest family of GPCRs is that of the serotonin receptors, with just 15 members. Given all the genetic material in the odor receptor genes, there are presumably many opportunities for polymorphisms and
HDAC6 and Ovarian Cancer
Joshua Haakenson,Xiaohong Zhang
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14059514
Abstract: The special class IIb histone deacetylase, HDAC6, plays a prominent role in many cellular processes related to cancer, including oncogenesis, the cell stress response, motility, and myriad signaling pathways. Many of the lessons learned from other cancers can be applied to ovarian cancer as well. HDAC6 interacts with diverse proteins such as HSP90, cortactin, tubulin, dynein, p300, Bax, and GRK2 in both the nucleus and cytoplasm to carry out these cancerous functions. Not all pro-cancer interactions of HDAC6 involve deacetylation. The idea of using HDAC6 as a target for cancer treatment continues to expand in recent years, and more potent and specific HDAC6 inhibitors are required to effectively down-regulate the tumor-prone cell signaling pathways responsible for ovarian cancer.
The Definition and Discussion Of Intellectual Capital Conception
Xiaohong Zhang,Sijing Li
International Journal of Business and Management , 2009,
Abstract: The intellectual capital has become the most efficient sources of the modern organization to create wealth, those managers and organizations who own the intellectual capital can occupy the beneficial position in competition. However, there are different comprehension and discussions for the intellectual capital conception in internal and international, which bring the difficulty to the intellectual capital management about creation, evaluate, encourage, audit etc. This thesis studied the conception of the intellectual capital and put forward the new concept about the intellectual capital.
A New Extension of Serrin's Lower Semicontinuity Theorem
Hu Xiaohong,Zhang Shiqing
Mathematics , 2012,
Abstract: In this paper, we present a new extension of the famous Serrin's lower semicontinuity theorem for the variational functional $\int_{\Omega}f(x,u,u')dx$,we prove its lower semicontinuity in $W_{loc}^{1,1}(\Omega)$ with respect to the strong $L_{loc}^{1}$ topology assuming that the integrand $f(x,s,\xi)$ has the usual continuity on all the three variables and the convexity property on the variable $\xi$ and the local absolute continuity on the variable $x$.
Adaptive coordinated control of engine speed and battery charging voltage

Jiangyan ZHANG,Xiaohong JIAO,

控制理论与应用 , 2008,
Abstract: In this paper, the control problem of auxiliary power unit (APU) for hybrid electric vehicles is investigated.An adaptive controller is provided to achieve the coordinated control between the engine speed and the battery charging voltage. The proposed adaptive coordinated control laws for the throttle angle of the engine and the voltage of the powerconverter can guarantee not only the asymptotic tracking performance of the engine speed and the regulation of the battery charging voltage, but also the robust stability of the closed loop system under external load changes. Simulation results are given to verify the performance of the proposed adaptive controller.
An Incidental Detection of Nutcracker Phenomenon in an Adolescent with Transient High Blood Pressure: A Case Report  [PDF]
Min Cai, Haibin Chen, Haixiong Wang, Hong Zhang, Guisheng Feng, Xiaohong Zhang, Jian Chen, Jiyun Du
Case Reports in Clinical Medicine (CRCM) , 2016, DOI: 10.4236/crcm.2016.511060
Abstract: Nutcracker phenomenon (NCP) is caused by a compression of left renal vein between aorta and superior mesenteric artery. The traditional clinical manifestations of nutcracker syndrome is usually accompanied with abdominal pain, hematuria, orthostatic proteinuria, and varicocele formation, however, hypertension is rarely reported as main clinical feature. We describe a male adolescent with manifestation of hypertension who was identified as NCP. Renal ultrasound and computed tomography angiography have provided evidences of left renal vein dilatation, probably due to the compression through the decreased angle between aorta and superior mesenteric artery. There were no other signs for secondary hypertension for the blood levels of renin and aldosterone being between normal limits and urinalysis being negative of hematuria and proteinuria. This patient was conservatively observed without any anti-hypertensive drugs and was asked for appropriately putting on weight. Three months later, the hypertension symptom was alleviated. In conclusion, although there were no established direct pathogenetic links between hypertension and NCP, no other definite etiology was shown to be the cause of this main manifestation. Thus we speculate that the NCP might be the main cause of hypertension in this patient.
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