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Search Results: 1 - 10 of 101773 matches for " Xiao Ling Yu "
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The Phenotypic Conversion of Macrophage Detected by FACS in EAE Mice Treated with or without Fasudil  [PDF]
Chunyun Liu, Yong Xie, Yanhua Li, Jiezhong Yu, Ling Feng, Shaowei Hou, Haifei Zhang, Cungen Ma, Baoguo Xiao
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510B101
Abstract:

We studied the changes of macrophage populations in splenic mononuclear cells of experimental autoimmune ence-phalomyelitis (EAE) mice treated with or without Fasudil. Phenotypic analysis using flow cytometry showed that the levels of TLR4, CD11c and CD40 which represent the type 1 macrophage, were depressed in Fasudil-treated mice. Incontrast, it was observed the expressions of CD200 and CD14 which typify the type 2 macrophage were elevated in Fasudil-treated mice as compared to EAE mice. And we also found that Fasudil at dose of 40 mg/kg alleviated the se-verity of symptom in EAE mice. Based on the evidence that M1 macrophages are neurotoxic and M2 macrophages promote a regenerative growth, indicating that polarization and shifting of macrophages into M2 cells may also play key roles in treatment of EAE.

Lecithin-Linker Microemulsion Gelatin Gels for Extended Drug Delivery
Xiao-Yue Xuan,Yu-Ling Cheng,Edgar Acosta
Pharmaceutics , 2012, DOI: 10.3390/pharmaceutics4010104
Abstract: This article introduces the formulation of alcohol-free, lecithin microemulsion-based gels (MBGs) prepared with gelatin as gelling agent. The influence of oil, water, lecithin and hydrophilic and lipophilic additives (linkers) on the rheological properties and appearance of these gels was systematically explored using ternary phase diagrams. Clear MBGs were obtained in regions of single phase microemulsions (μEs) at room temperature. Increasing the water content in the formulation increased the elastic modulus of the gels, while increasing the oil content had the opposite effect. The hydrophilic additive (PEG-6-caprylic/capric glycerides) was shown to reduce the elastic modulus of gelatin gels, particularly at high temperatures. In contrast to anionic (AOT) μEs, the results suggest that in lecithin (nonionic) μEs, the introduction of gelatin “dehydrates” the μE. Finally, when the transdermal transport of lidocaine formulated in the parent μE and the resulting MBG were compared, only a minor retardation in the loading and release of lidocaine was observed.
(E)-4-(2-Chloro-1-hydroxy-2,6,6-trimethylcyclohexyl)but-3-en-2-one
Shan Liu,Xiao-Yan Yang,Yu-Ling Zhang
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812048544
Abstract: In the title molecule, C13H21ClO2, there is an intramolecular C—H...Cl hydrogen bond. The conformation about the C=C bond is E and the six-membered ring has a chair conformation. In the crystal, molecules are linked by pairs of O—H...O hydrogen bonds, forming inversion dimers, which are consolidated by C—H...O hydrogen bonds. The dimers are linked via C—H.·O hydrogen bonds, forming chains along [100].
A Positive Research on Spatial Agglomeration of China's Cultural Industries
Yuan Xiao-ling,Fan Yu-xian,Qin Jie
Advances in Management and Applied Economics , 2013,
Abstract: On the background of cultural industries development, the study on spatial agglomeration of China's cultural industries has theoretical and practical significance. In this paper, the spatial agglomeration degree of eleven cultural industries of 31 provinces in China is estimated and analyzed from the region and industry by the index of E-G and CR. Using the grey correlation method, the hypothesis that spatial agglomeration of cultural industries may promote the economic growth is tested. And the hypothesis that the per capita GDP, location and abundance of cultural resources are important factors of spatial agglomeration of cultural industries is also tested by the Count Model. Finally, some suggestions are pointed out.
Sequence Characterization of matrix protein (M1) in influenza A viruses (H1, H3 and H5)
Jun Zhang,Xiao Ling Yu,Lei Xu,Fang Zhi Li
Microbiology Research , 2011, DOI: 10.4081/mr.2011.e16
Abstract: This study brings the analysis of amino acid sequences of matrix protein (M1) from the influenza virus A (H1N1, H3N2 and H5N1) during 2007-2208. 741 sequences of M1 were compared, of them, H1N1 388; H3N2 251 and H5N1 102. Even though, the M1 is relatively conserved among the influenza A viruses, we found some variations in the M1 among the viruses, H1N1, H3N2 and H5N1. The nuclear localization signal at amino acid 101 to 105 is RKLKR for H1N1 and H3N2, but for H5N1 is KKLKR. All differences of amino acid in M1 of H1, H3 and H5 were listed. 80 sequences of M1 of H1N1 H3N2 and H5N1 were used for phylogenetic analysis. There is no reasontantment found in the M1 among these subtypes. Further study is needed to study the differences of the function of M1 among H1N1, H3N2 and H5N1. The M1 of H5N1 may contribute to the high pathogenesis to this virus.
Patterns of Positive Selection of the Myogenic Regulatory Factor Gene Family in Vertebrates
Xiao Zhao, Qi Yu, Ling Huang, Qing-Xin Liu
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0092873
Abstract: The functional divergence of transcriptional factors is critical in the evolution of transcriptional regulation. However, the mechanism of functional divergence among these factors remains unclear. Here, we performed an evolutionary analysis for positive selection in members of the myogenic regulatory factor (MRF) gene family of vertebrates. We selected 153 complete vertebrate MRF nucleotide sequences from our analyses, which revealed substantial evidence of positive selection. Here, we show that sites under positive selection were more frequently detected and identified from the genes encoding the myogenic differentiation factors (MyoG and Myf6) than the genes encoding myogenic determination factors (Myf5 and MyoD). Additionally, the functional divergence within the myogenic determination factors or differentiation factors was also under positive selection pressure. The positive selection sites were more frequently detected from MyoG and MyoD than Myf6 and Myf5, respectively. Amino acid residues under positive selection were identified mainly in their transcription activation domains and on the surface of protein three-dimensional structures. These data suggest that the functional gain and divergence of myogenic regulatory factors were driven by distinct positive selection of their transcription activation domains, whereas the function of the DNA binding domains was conserved in evolution. Our study evaluated the mechanism of functional divergence of the transcriptional regulation factors within a family, whereby the functions of their transcription activation domains diverged under positive selection during evolution.
Incompressible Navier-Stokes Equation from Einstein-Maxwell and Gauss-Bonnet-Maxwell Theories
Chao Niu,Yu Tian,Xiao-Ning Wu,Yi Ling
Physics , 2011, DOI: 10.1016/j.physletb.2012.04.029
Abstract: The dual fluid description for a general cutoff surface at radius r=r_c outside the horizon in the charged AdS black brane bulk space-time is investigated, first in the Einstein-Maxwell theory. Under the non-relativistic long-wavelength expansion with parameter \epsilon, the coupled Einstein-Maxwell equations are solved up to O(\epsilon^2). The incompressible Navier-Stokes equation with external force density is obtained as the constraint equation at the cutoff surface. For non-extremal black brane, the viscosity of the dual fluid is determined by the regularity of the metric fluctuation at the horizon, whose ratio to entropy density \eta/s is independent of both the cutoff r_c and the black brane charge. Then, we extend our discussion to the Gauss-Bonnet-Maxwell case, where the incompressible Navier-Stokes equation with external force density is also obtained at a general cutoff surface. In this case, it turns out that the ratio \eta/s is independent of the cutoff r_c but dependent on the charge density of the black brane.
6-Chloro-3-nitro-N-(propan-2-yl)pyridin-2-amine
Xiao-Yu Qing,Yun-Chuang Huang,Ling-Ling Yang,Yong-Mei Xie
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811018083
Abstract: There are two molecules in the asymmetric unit molecule of the title compound, C8H10ClN3O2. Intramolecular N—H...O hydrogen bonds stabilize the molecular structure. There are no classical intermolecular hydrogen bonds in the crystal structure.
Description of a Sulfitobacter Strain and Its Extracellular Cyclodipeptides
Cong Long,Xiao-Ling Lu,Yun Gao,Bing-Hua Jiao,Xiao-Yu Liu
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/393752
Abstract: A marine bacterium M44 was separated from 30?m deep seawater in the East China Sea (26°?28.3′?N 122°?29.0′?E) in 2006. 16S rDNA gene sequence comparison showed that the strain M44 was a member of the genus Sulfitobacter and highly similar to KMM 3554T. A series of experiments demonstrated that this strain M44 had many distinctive characteristics: its cells were gram-negative and mesophilic; its colonies were slightly yellowish, round, convex, and smooth; and it could grow at 10–28°C, pH 6.0–10.0, and in the presence of 0–12.5% (w/v) NaCl; the optimum growth conditions were 25°C and pH 7.0, and the optimum Na+ concentration was 2.5%. In addition, strain M44 contained 18?:?1 ω7c, 11 methyl 18?:?1 ω7c and 16?:?0 fatty acids as major fatty acids, and the genomic DNA G+C content was 58.04?mol%. According to our results of the secondary metabolites, six cyclodipeptides were isolated from the strain M44, which were Cyclo (Val-Leu), Cyclo (Phe-Val), Cyclo (Phe-Leu), Cyclo (Leu-Ile), Cyclo (Phe-Ile), and Cyclo (Trp-Pro). It is the first study of secondary metabolites isolated from this genus. 1. Introduction As marine bacteria live in hypothermic, hyperbaric, and oligotrophic environments that are significantly different from those of terrestrial ones, it is reasonable to suppose that they should have particular physiological and biochemical traits and metabolic pathways. In recent years, there has been more interest in isolation and identification of marine bacteria. Natural products of marine bacteria have been recognized as an important source of novel and biologically active substances [1]. The genus Sulfitobacter was first discovered by Sorokin [2] in 1995. In the next few years, bacteria of this genus were subsequently discovered in marine environments, such as seawater collected in the Mediterranean Sea [3], the East China Sea, Korea [4–6], sea grass collected at the Pacific, and starfish in the South China Sea [7]. Bacteria of this genus were also found in hypersaline Ekho Lake, East Antarctica [8]. Nine species have been identified so far. By now, there are no more research reports on this genus and most of them focused on the physiological and biochemical properties of this genus. To our knowledge, there has been no report on the secondary metabolites of this genus. For the first time, we isolated the metabolites of M44 and elucidated the chemical structure of these compounds by spectral data and MS. The present paper summarized our work about multiphase taxonomic identification and extracellular products composition of a marine Sulfitobacter strain
SVM Based Classification Mapping for User Navigation
Jing-Ling Yuan,Yang Yu,Xuan Xiao,Xiao-Yan Li
International Journal of Distributed Sensor Networks , 2009, DOI: 10.1080/15501320802523955
Abstract: In order to implement active service, a kind of user navigation based on Support Vector Machine (SVM) classification was proposed which solved many traditional problems such as lack of rules and adaptability and so on. Especially, this paper completed a dual classified coordination between user attribute classification and SVM user classification using mapping matrix.
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