Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2020 ( 1 )

2019 ( 243 )

2018 ( 1787 )

2017 ( 1701 )

Custom range...

Search Results: 1 - 10 of 104193 matches for " Xiangning Zhang "
All listed articles are free for downloading (OA Articles)
Page 1 /104193
Display every page Item
Characteristics of South Asia High in Summer in 2010 and Its Relationship with Rainbands in China  [PDF]
Xiangning Cai, Yong Li, Xiakun Zhang, Yuanyuan Bao
Journal of Geoscience and Environment Protection (GEP) , 2017, DOI: 10.4236/gep.2017.57016
Abstract: The characteristics of the South Asia high (SAH) and subtropical westerly jets in the summer of 2010 and their relationship with the changes in rainband in China were analyzed. As shown by the results, the SAH in the upper troposphere extended northward relatively late in June 2010. Correspondingly, the subtropical westerly jets on the north side of the SAH jumped northward comparatively late, thus delaying the formation of a strong divergence field in the upper air over the Yangtze-Huaihe River valley. This was one of the main causes for the late onset of plum rains in the Yangtze-Huaihe River valley. In July, there was a vertical structure consisting of upper-level divergence and low-level convergence near the subtropical westerly jets on the north side of the SAH and in the air stream dispersal area on the northeast side of the eastward-extending SAH, which was the dynamic mechanism bringing about frequent and extremely heavy rainstorms during the plum rain period in this year. The SAH in the upper troposphere affected the subtropical high in the lower stratosphere, and thereby led to changes in the main rainband location in China.
The μ-opioid receptor gene and smoking initiation and nicotine dependence
Lan Zhang, Kenneth S Kendler, Xiangning Chen
Behavioral and Brain Functions , 2006, DOI: 10.1186/1744-9081-2-28
Abstract: Tobacco use is a leading cause of preventable diseases in the world and causes nearly 5 million tobacco-related deaths annually [1]. According to the World Health Organization, 1.3 billion people are smokers and half of the smokers in the world today will die of smoking related diseases [2]. Nicotine is the primary factor responsible for the addictive behaviors. In last two decades, family, twin and adoption studies have implicated that genetic factors strongly influence the behaviors of tobacco use and nicotine dependence [3,4]. In the review by Sullivan and Kendler, they estimated that genetic factors accounted for 56% of the variance in the liability of smoking initiation (SI) and 67% of the variance for progression to nicotine dependence (ND) [4].The μ-opioid receptor encoded by the OPRM1 gene is a key factor contributing to drug addiction [5]. The μ-opioid receptor is a major site of action for endogenous opioid peptides and exogenous opioid drugs. More interestingly, some non-opioid substances including nicotine that have other primary sites of action are likely to induce the release of endogenous opioid peptides, and subsequently activate the μ receptor [5]. For instance, experiments have shown that nicotine causes a release of endogenous opioids in the brains of rat and mouse [6]. Recent studies using inbred and knockout mice strongly suggest that the μ-opioid receptor mediates both the positive and negative reinforcing effects of nicotine. Nicotine-induced antinociception, reward effects and dependence are substantially attenuated in mice lacking the μ-opioid receptor [7,8]. This implies that some aspects of the rewarding valence of nicotine require μ opioid receptors. In humans, opioid receptor antagonist naloxone may reduce the relative reinforcing effects of nicotine, thus it has been used as a smoking cessation drug [9-11]. Lerman and colleagues show that a variant in OPRM1 may predict the treatment responses to clinical nicotine replacement therapy. Sm
Microinvasive Technique for Postoperative Early Bronchial Stump Fistula
Ni ZHANG,Qinzi XU,Xiangning FU
Chinese Journal of Lung Cancer , 2009,
A Case Report of Carina and Right Main Bronchus Resection and Reconstruction with Left Thoracic Incision
Xiangning F,Bo AI,Ni ZHANG,Wei SUN
Chinese Journal of Lung Cancer , 2010,
Comparison Study of Post-operative Pain and Short-term Quality of Life between Uniportal and Three Portal Video-assisted Thoracic Surgery for Radical Lung Cancer Resection
Zhipeng HAO, Yixin CAI, Shengling FU, Ni ZHANG, Xiangning FU
- , 2016, DOI: : 10.3779/j.issn.1009-3419.2016.03.02
Abstract: Background and objective In the recent years, uniportal video-assisted thoracic surgery (uniportal-VATS) is developing rapidly on the basis of traditional three portal VATS and has been applied for radical resection of lung cancer, its superiority on the clinical application compared with traditional VATS is also become the focus of the attention, the aim of this study is to preliminary investigate the effect of uniportal -VATS on post-operative pain and short-term quality of life. Methods Data of 216 patients who underwent uniportal-VATS (n=115) or three portal VATS (3P-VATS)(n=101) for radical resection of non-small cell lung cancer (NSCLC) were analyzed. The clinical and operative data were assessed, visual analogue scale (VAS) was used to evaluate the minimum and maximum pain score (VASmin and VASmax) on the 3rd and 7th post-operative day. Chinese version 4.0 of Functional Assessment of Cancer Treatment-Lung (FACT-L) was applied to evaluate the short-term quality of life preoperatively and 3 months after operation, respectively. Incidence of incision numbness and satisfaction rate of incision appearance were compared between the two groups 3 months after operation. Results Both groups were similar in clinical characteristics, there were no perioperative death in two groups. While the operative time of uniportal-VATS group (157.62±19.50) min was longer than that of the 3P-VATS group [(116.00±17.32) min, P<0.001], the chest tube duration and postoperative hospital stay of uniportal-VATS group [(4.37±1.65) d, (9.87±1.25) d] were both shorter than those of 3P-VATS group [(5.54±1.57) d, (10.43±1.43) d, P=0.020, P=0.004]. No statistically significant difference was reported in VASmin-d3 [(1.98±0.57) vs (2.09±0.59), P=0.148] between the two groups, however, VASmin-d7 and VASmax-d3,d7 were all significantly less in uniportal-VATS group [(1.46±0.29), (3.75±0.54), (2.43±0.53)] than in 3P-VATS group [(1.58±0.30), (3.93±0.51), (2.62±0.62), P=0.003, P=0.011, P=0.018]. FACT-L assessment indicated that the scores of patients’ functional status, emotional status and overall quality of life 3 months after the surgery in uniportal VATS group [(20.94±2.22), (19.88±1.70), (108.09±4.58)] were all higher than those in 3P-VATS group [(20.24±1.92), (19.36±1.67), (106.88±4.17), P=0.014, P=0.024, P=0.045], there were no significant differences between the two groups in physical status, social and family conditions as well as in lung cancer subscale. Compared with 3P-VATS group, the incidence of incision numbness was lower (24.3% vs 38.6%, P=0.024) and satisfaction rate of
A fully integrated multi-standard frequency synthesizer for GNSS receivers with cellular network positioning capability

Li Bin,Fan Xiangning,Li Wei,Zhang Li,Wang Zhigong,
Li Bin
,Fan Xiangning,Li Wei,Zhang Li,Wang Zhigong

半导体学报 , 2013,
Abstract: 本文介绍了一种可支持GPS、Galileo、北斗及TD-SCDMA等标准的全集成混合整数/分数频率合成器的设计。该频率合成器仅采用一个多频段压控振荡器以覆盖所要求的频段,整体结构的设计充分考虑了功耗、面积及相位噪声等性能的折衷。通过切换分频模式以满足各个标准不同的频率精度要求及保持各种工作模式下的锁相环环路带宽。此外,为减少分数分频模式下的分数杂散,采用了一种长输出序列长度、低硬件消耗的多级级联Delta-Sigma调制器。该频率合成器采用0.18um CMOS工艺制造,芯片有效面积为1.48mm2,在1.8V电源电压下,整个频率合成器消耗电流为13.4~16.2mA,测试结果表明,该频率合成器的带内相位噪声小于-80dBc/Hz(100kHz频偏处)而1MHz频偏处相位噪声为-113~-124dBc/Hz,在整数分频模式下参考杂散约为-71dBc,在分数分频模式下分数杂散约为-65dBc。
Tumor suppressor BLU inhibits proliferation of nasopharyngeal carcinoma cells by regulation of cell cycle, c-Jun N-terminal kinase and the cyclin D1 promoter
Xiangning Zhang, Hui Liu, Binbin Li, Peichun Huang, Jianyong Shao, Zhiwei He
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-267
Abstract: BLU was re-expressed in nasopharyngeal carcinoma cells by transfection or viral infection. Clonogenic growth was assayed; cell cycle was analyzed by flow cytometry-based DNA content detection; c-Jun N-terminal kinase (JNK) and cyclin D1 promoter activities were measured by reporter gene assay, and phosphorylation was measured by immunoblotting. The data for each pair of groups were compared with Student t tests.BLU inhibits clonogenic growth of nasopharyngeal carcinoma cells, arrests cell cycle at G1 phase, downregulates JNK and cyclin D1 promoter activities, and inhibits phosphorylation of c-Jun.BLU inhibits growth of nasopharyngeal carcinoma cells by regulation of the JNK-cyclin D1 axis to exert tumor suppression.
Small interference RNA targeting tissue factor inhibits human lung adenocarcinoma growth in vitro and in vivo
Chengcheng Xu, Qi Gui, Wenshu Chen, Leiming Wu, Wei Sun, Ni Zhang, Qinzi Xu, Jianing Wang, Xiangning Fu
Journal of Experimental & Clinical Cancer Research , 2011, DOI: 10.1186/1756-9966-30-63
Abstract: The specific small interfering RNA (siRNA) designed for targeting human TF was transfected into A549 cells. The expression of TF was detected by reverse transcription-PCR and Western blot. Cell proliferation was measured by MTT and clonogenic assays. Cell apoptosis was assessed by flow cytometry. The metastatic potential of A549 cells was determined by wound healing, the mobility and Matrigel invasion assays. Expressions of PI3K/Akt, Erk1/2, VEGF and MMP-2/-9 in transfected cells were detected by Western blot. In vivo, the effect of TF-siRNA on the growth of A549 lung adenocarcinoma xenografts in nude mice was investigated.TF -siRNA significantly reduced the expression of TF in the mRNA and protein levels. The down-regulation of TF in A549 cells resulted in the suppression of cell proliferation, invasion and metastasis and induced cell apoptosis in dose-dependent manner. Erk MAPK, PI3K/Akt pathways as well as VEGF and MMP-2/-9 expressions were inhibited in TF-siRNA transfected cells. Moreover, intratumoral injection of siRNA targeting TF suppressed the tumor growth of A549 cells in vivo model of lung adenocarcinoma.Down-regulation of TF using siRNA could provide a potential approach for gene therapy against lung adenocarcinoma, and the antitumor effects may be associated with inhibition of Erk MAPK, PI3K/Akt pathways.Lung cancer is the leading cause of cancer-related death worldwide [1,2]. Lung adenocarcinoma, accounted for approximately 40% of all lung cancers, is currently one of the most common histological types and its incidence has gradually increased in recent years in many countries [3].Tissue factor (TF), a 47-kDa transmembrane glycoprotein, primarily initiates the coagulation cascade by binding to activated factor VII (FVIIa) [4,5]. Under normal conditions, TF is highly expressed by cells which are not in contact with the blood, such as smooth muscle cells, mesenchymal and epithelial cells. In addition, numerous studies have reported that TF is aberrantly
Advances of Tissue Factor in Lung Cancer
Chengcheng XU,Xiangning FU
Chinese Journal of Lung Cancer , 2010,
Advance of Circulating Tumor Cell in Patients with Lung Cancer
Wei PING,Xiangning FU
Chinese Journal of Lung Cancer , 2011, DOI: 10.3779/j.issn.1009-3419.2011.06.12
Page 1 /104193
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.