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Search Results: 1 - 10 of 5503 matches for " Xavier MIG "
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Dynamic Evaluation of the Venous Pressure During Passive Plantar Flexion and Dorsiflexion Exercises with the RAGodoy Apparatus
Godoy JMP,Godoy MFG,Batigália F,Xavier MIG
Indian Journal of Physical Medicine and Rehabilitation , 2008,
Abstract: Objective: The objective of this case report was to dynamically evaluate pressure changes during passiveexercises using a device that performs plantar flexion and dorsiflexion.Design and setting: The medial vein of the left hallux was punctured using a 0.9 mm x 25 mm angiocatcatheter and this was connected to a DTX Plus TM sensor. With this portable apparatus, pressure variationsare measured at half-second intervals and the data stored in a numerical form. The RAGodoy apparatuswas used to perform passive exercises that stretched and bent the ankle joint.Six evaluations were made and the minimum and maximum pressures during each session were assessed.Main outcome measures and results: In all the sessions, variations in the pressures were obtained with aminimum pressure of 8 mmHg and a maximum of 77 mmHg.Conclusion: The device, named the RAGodoy , creates pressure variations in the venous system, whichassist blood flow in the lower limbs and thus it can be used to avoid venous stasis.
A stability result for parameter identification problems in nonlinear parabolic problems
Stanislaw Migórski
International Journal of Mathematics and Mathematical Sciences , 1995, DOI: 10.1155/s0161171295000020
Abstract: A sequence of identification problems of coefficients in the parabolic equation with nonlinear boundary conditions is considered. The parameter (index of an element of the sequence) appears in the cost functionals as well as boundary data. It is proved that the optimal solutions exist and that under some continuous convergence of the cost functionals and the convergence of the data, the sets of optimal solutions converge in some sense to the set of optimal solutions of the limit problem.
Existence and relaxation results for nonlinear evolution inclusions revisited
S. Migórski
International Journal of Stochastic Analysis , 1995, DOI: 10.1155/s1048953395000141
Abstract: In this paper we confirm the validity of some recent results of Hu, Lakshmikantham, Papageorgiou [4] and Papageorgiou [13] concerning the existence and relaxation for nonlinear evolution inclusions. We fill a gap in the proofs of these results due to the use of incorrect Nagy's compactness embedding theorem.
A counterexample to a compact embedding theorem for functions with values in a Hilbert space
S. Migórski
International Journal of Stochastic Analysis , 1995, DOI: 10.1155/s1048953395000402
A counterexample to a compact embedding theorem for functions with values in a Hilbert space
S. Migórski
International Journal of Stochastic Analysis , 1996, DOI: 10.1155/s1048953396000093
Long-term outcome after coronary stenting
Adnan Kastrati, Donald Hall, Albert Sch?mig
Trials , 2000, DOI: 10.1186/cvm-1-1-048
Abstract: Since the introduction of percutaneous transluminal coronary angioplasty (PTCA), the first use of coronary stenting in clinical practice in 1986 [1] was the major breakthrough in the treatment of patients with coronary artery disease. Coronary stenting was introduced to combat two limitations of conventional PTCA: acute vessel closure and late lumen renarrowing. Now, after 15 years of continuous refinement, stenting has become the dominant percutaneous coronary intervention. Over these years, stent designs, stent delivery systems, stent deployment techniques and adjunctive antithrombotic therapy have all changed dramatically [2].The earliest concern with the use of stenting was its thrombogenicity and potential for disastrous early severe thrombotic complications [3]. Potent anticoagulation therapy with prolonged heparin administration followed by coumarin derivatives only amplified the risk of bleeding complications, without resolving the problem of stent thrombosis [4]. Considerable efforts were then focused on understanding the principal mechanisms of stent thrombosis [5], on technical refinements aimed at improving the immediate lumen gain through high-pressure inflation under the guidance of intravascular ultrasound [6], and on the search for more effective antithrombotic therapies [7].The ISAR (Intracoronary Stenting and Antithrombotic Regimen) trial in 1996 [8] and the other trials that followed in 1998 [9,10] definitively established the role of the combined antiplatelet therapy (ticlopidine plus aspirin) in minimizing the risk of stent thrombosis. The favourable results achieved more recently with newer antiplatelet agents such as glycoprotein IIb/IIIa inhibitors [11] further strengthened the value of the pharmacological approach in the prevention of thrombotic events after stenting. The trials mentioned above were critical in defining stent placement protocols and in guiding future efforts in this field; this became even more apparent after the demonstrate
Advances in Sustainability: Contributions and Outcomes of the 2nd World Sustainability Forum
Sylvie Fl?mig,Marc A. Rosen
Sustainability , 2013, DOI: 10.3390/su5031208
Abstract: After a successful start in 2011, the 2nd World Sustainability Forum (WSF) was held on sciforum.net from 1–30 November 2012. More than 80 papers were presented and over 180 authors contributed to the multidisciplinary conference. The objective of this short report is to sum up the contributions and discussions of the 2nd World Sustainability Forum. It is organized as follows. First, some general information on the Forum is given, then a summary of the contributions to the different sections, as well as providing an overview of the discussions. A final section including an outlook to the 3rd World Sustainability Forum concludes the article.
Identification of the Endogenous Key Substrates of the Human Organic Cation Transporter OCT2 and Their Implication in Function of Dopaminergic Neurons
Dirk Taubert, Gundula Grimberg, Werner Stenzel, Edgar Sch?mig
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0000385
Abstract: Background The etiology of neurodegenerative disorders, such as the accelerated loss of dopaminergic neurons in Parkinson's disease, is unclear. Current hypotheses suggest an abnormal function of the neuronal sodium-dependent dopamine transporter DAT to contribute to cell death in the dopaminergic system, but it has not been investigated whether sodium-independent amine transporters are implicated in the pathogenesis of Parkinson's disease. Methodology/Principal Findings By the use of a novel tandem-mass spectrometry-based substrate search technique, we have shown that the dopaminergic neuromodulators histidyl-proline diketopiperazine (cyclo(his-pro)) and salsolinol were the endogenous key substrates of the sodium-independent organic cation transporter OCT2. Quantitative real-time mRNA expression analysis revealed that OCT2 in contrast to its related transporters was preferentially expressed in the dopaminergic regions of the substantia nigra where it colocalized with DAT and tyrosine hydroxylase. By assessing cell viability with the MTT reduction assay, we found that salsolinol exhibited a selective toxicity toward OCT2-expressing cells that was prevented by cyclo(his-pro). A frequent genetic variant of OCT2 with the amino acid substitution R400C reduced the transport efficiency for the cytoprotective cyclo(his-pro) and thereby increased the susceptibility to salsolinol-induced cell death. Conclusions/Significance Our findings indicate that the OCT2-regulated interplay between cyclo(his-pro) and salsolinol is crucial for nigral cell integrity and that a shift in transport efficiency may impact the risk of Parkinson's disease.
Dynamics of microbial communities during decomposition of litter from pioneering plants in initial soil ecosystems
J. Esperschütz,C. Zimmermann,A. Dümig,G. Welzl
Biogeosciences Discussions , 2012, DOI: 10.5194/bgd-9-14981-2012
Abstract: In initial ecosystems concentrations of all macro- and micronutrients can be considered as extremely low. Plant litter therefore strongly influences the development of a degraders' food web and is an important source for C and N input into soil in such ecosystems. In the present study, a 13C litter decomposition field experiment was performed for 30 weeks in initial soils from a post-mining area near the city of Cottbus (Germany). Two of this regions' dominant but contrasting pioneering plant species (Lotus corniculatus L. and Calamagrostis epigejos L.) were chosen to investigate the effects of litter quality on the litter decomposing microbial food web in initially nutrient-poor substrates. The results clearly indicate the importance of litter quality, mainly the amount of N stored in the litter material and its bioavailability for the degradation process and the development of microbial communities in the detritusphere and bulk soil. Whereas the degradation process of the L. corniculatus litter which had a low C/N ratio was fast and most pronounced changes in the microbial community structure were observed 1–4 weeks after litter addition, the degradation of the C. epigejos litter material was slow and microbial community changes mainly occurred at between 4 and 30 weeks after litter addition to the soil. However for both litter materials a clear indication for the importance of fungi for the degradation process was observed both on the abundance level as well as on the level of 13C incorporation (activity).
Biological soil crusts on initial soils: organic carbon dynamics and chemistry under temperate climatic conditions
A. Dümig,M. Veste,F. Hagedorn,T. Fischer
Biogeosciences Discussions , 2013, DOI: 10.5194/bgd-10-851-2013
Abstract: Numerous studies have been carried out on the community structure and diversity of biological soil crusts (BSCs) as well as their important functions on ecosystem processes. However, the amount of BSC-derived organic carbon (OC) input into soils and its chemical composition under natural conditions has rarely been investigated. In this study, different development stages of algae- and moss-dominated BSCs were investigated on a~natural (<17 yr old BSCs) and experimental sand dune (<4 yr old BSCs) in northeastern Germany. We determined the OC accumulation in BSC-layers and the BSC-derived OC input into the underlying substrates for bulk materials and fractions <63 μm. The chemical composition of OC was characterized by applying solid-state 13C NMR spectroscopy and analysis of the carbohydrate-C signature.14C contents were used to assess the origin and dynamic of OC in BSCs and underlying substrates. Our results indicated a rapid BSC establishment and development from algae- to moss-dominated BSCs within only 4 yr under this temperate climate. The distribution of BSC types was presumably controlled by the surface stability according to the position in the slope. We found no evidence that soil properties influenced the BSC distribution on both sand dunes. 14C contents clearly indicated the existence of two OC pools in BSCs and substrates, recent BSC-derived OC and lignite-derived "old" OC (biologically refractory). The input of recent BSC-derived OC strongly decreased the mean residence time of total OC. The downward translocation of OC into the underlying substrates was only found for moss-dominated BSCs at the natural sand dune which may accelerate soil formation at these spots. BSC-derived OC mainly comprised O-alkyl C (carbohydrate-C) and to a lesser extent also alkyl C and N-alkyl C in varying compositions. Accumulation of alkyl C was only detected in BSCs at the experimental dune which may induce a~lower water solubility of BSC-derived extracellular polymeric substances when compared to BSCs at the natural sand dune indicating that hydrological effects of BSCs on soils depend on the chemical composition of the extracellular polymeric substances.
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