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Search Results: 1 - 10 of 12500 matches for " XY Tian "
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INFLUENCES OF CASTING SPEED AND SEN DEPTH ON FLUID FLOW IN THE FUNNEL TYPE MOLD OF A THIN SLAB CASTER
BW Li,XY Tian,EG Wang,and JC He,
B.W.
,Li,X.Y.,Tian,E.G.,Wang,J.C.,He

金属学报(英文版) , 2007,
Abstract: In recent years, thin slab continuous casting technology has been widely used to improve the quality of the product and to reduce the cost. One of the challenges faced by this technology is to design reasonable flow patterns, which strongly affect the surface and inner properties of the final slab in the mold. With the fixed scales and complex geometrical structures of nozzle and funnel type mold,a series of numerical simulations are made to analyze the flow patterns in melt steel using finite volume method based on structured body fitted coordinate grids. The CFD (computational fluid dynamics) package is validated first using one typical case described in previously published studies,and then it is developed to study the effect of operational parameters on fluid flow in thin slab caster.Two operational parameters, casting speed and SEN (submerged entry nozzle) depth, are mainly considered for numerical analysis. On the basis of present simulations, the reasonable SEN submergence depths corresponding to different casting speeds are suggested according to fluid flow characteristics like, flow jet impingement on the narrow side of the mold, flow speed of the melt steel beneath the meniscus and the recirculation region. This is the first stage of study on the numerical analysis of the whole thin slab casting process with electromagnetic brake.
CATHODIC PROCESS AND WEAR RESISTANCE OF ELECTRODEPOSITED RE-Ni-W-P-SiC COMPOSITE COATING
CATHODIC PROCESS AND WEAR RESISTANCE OF ELECTRO-DEPOSITED RE-Ni-W-P-SiC COMPOSITE COATING

ZC Guo,XY Zhu,RD Xu,

金属学报(英文版) , 2002,
Abstract: Cathodic deposition current density of the composite coatings increases when SiC par-ticles and rare earth (RE) were added in the bath, which is profitable for Ni- W-P alloyto deposit in the cathod, forming Ni-W-P-SiC and RE-Ni-W-P-SiC composite coat-ings. On the contrary, the addition of PTFE in the bath decreases cathodic depositioncurrent density of the coatings. The current density increases a little when the amountof RE is 7-9g/l; however, the current density increases greatly when the amount ofRE is increased to 11-13g/l. But if the amount of RE is raised further, the currentdensity decreases. Hardness and wear resistance of RE-Ni-W-P-SiC composite coat-ing have been studied, and the results show that the hardness and wear resistance ofRE-Ni-W-P-SiC composite coating increase with increasing heat treatment tempera-ture, which reach peak values at 400℃; while the hardness and wear resistance of thecoating decrease with the rise of heat treated temperature continuously.
Comparison of isozyme transformation in maize as a result of insertion of the chitinase gene
Yan,PM; Zhang,HF; Wang,Q; Yan,XY; Sun,Y;
Phyton (Buenos Aires) , 2010,
Abstract: isozymes of peroxidase (pod), catalase (cat), esterase (est) and superoxide dismutase (sod) were analyzed on transgenic maize (with external chitinase gene) and its parent by vertical polyacrylamide gel electrophoresis (page). this study was made using shoots at the fourth leaf stage. results showed that: pod and est were detected in 6 bands. pod-2 and pod-3 were present at the bud and seedling stages. pod-1, pod-4, pod-5 and pod-6 were only present at the seedling stage. pod-6 expressed stronger in the transgenic maize with chitinase than in its parent. est-2 was present only at the bud stage, and its expression in transgenic maize was stronger than that in its parent. est-5 only existed at the seedling stage. est-4 did not exist in the parent maize seedlings and est-1, est-3 and est-6 were present at the bud or seedling stage. four bands were detected for cat. cat-1 and cat-3 were weaker bands than the others. cat-3 in transgenic maize was stronger than in its parent. three bands of sod were detected; sod-1 and sod-2 existed at the bud and seedling stages, but sod-3 was not shown in buds of the parent corn. all data showed that the expression of isozymes in transgenic and parent maize had obvious differences.
Targeting bladder tumor cells in voided urine of Chinese patients with FITC-CSNRDARRC peptide ligand
Jia XY, Yu Q, Zhang ZH, Yang XF
OncoTargets and Therapy , 2012, DOI: http://dx.doi.org/10.2147/OTT.S31368
Abstract: rgeting bladder tumor cells in voided urine of Chinese patients with FITC-CSNRDARRC peptide ligand Original Research (1575) Total Article Views Authors: Jia XY, Yu Q, Zhang ZH, Yang XF Published Date May 2012 Volume 2012:5 Pages 85 - 90 DOI: http://dx.doi.org/10.2147/OTT.S31368 Received: 01 March 2012 Accepted: 27 March 2012 Published: 07 May 2012 Xing-You Jia1, Qi Yu2, Zhe-Hui Zhang3, Xiao-Feng Yang1 1School of the First Clinical Hospital, Shanxi Medical University, Taiyuan, Shanxi, China; 2Department of Information Management, Shanxi Medical University, Taiyuan, Shanxi, China; 3Research Center for Philosophy of Science and Technology, Shanxi University, Taiyuan, Shanxi, China Objective: To study the practicality of the FITC-CSNRDARRC peptide ligand (containing the Cys–Ser–Asn–Arg–Asp–Ala–Arg–Arg–Cys nonapeptide) in diagnosing and monitoring bladder tumors. Materials and methods: Between March 2011 and September 2011, 80 consecutive patients with radiographic abnormalities, localizing hematuria, other symptoms, or signs were studied using the FITC-CSNRDARRC ligand, urinary cytology (UC), and fluorescence in situ hybridization (FISH). The sensitivity and specificity of these three technologies were determined and compared. Cystoscopy and tissue biopsy were taken as the “gold standards” for bladder tumor diagnosis in this study. Results: Twenty-nine out of 80 patients were diagnosed with a bladder tumor via histopathological examination. The FITC-CSNRDARRC ligand was positive in 23 out of 29 bladder tumor patients and produced false negatives in six (20.69%) patients. The UC was positive in six out of 29 bladder tumor patients and produced false negatives in 23 (79.31%) patients. The FISH was positive in 21 out of 29 bladder tumor patients and produced false negatives in eight (27.59%) patients. The overall sensitivity as verified by the FITC-CSNRDARRC ligand was much higher than in UC (79.31% versus 20.69%, P < 0.001) and was slightly higher than in FISH (79.31% versus 72.41%, P = 0.625). The sensitivity of FISH was significantly higher than that of UC (72.41% versus 20.69%, P < 0.001). Sensitivities of the FITC-CSNRDARRC ligand and UC by grade were 58.33% versus 8.3% for low-grade (LG) tumors (P = 0.031) and 94.12% versus 29.41% for high-grade (HG) tumors (P = 0.003), respectively. The advantage was maintained in terms of the detection of invasive tumors between the FITC-CSNRDARRC ligand and UC (90.48% versus 23.81%, P = 0.001) as well as between FISH and UC (85.71% versus 23.81%, P = 0.003). The specificities for the FITC-CSNRDARRC ligand, UC, and FISH were 100%. Conclusion: Results show that the FITC-CSNRDARRC ligand is a promising noninvasive tool for diagnosis and surveillance in patients suspected of having a new bladder tumor.
Expression profiling analyses of porcine MuRF1 gene and its association with muscle production traits
H Shen, MX Liao, SH Zhao, XY Li, B Fan
South African Journal of Animal Science , 2011,
Abstract: Muscle specific RING finger protein-1 (MuRF1) is a member of the muscle specific RING finger protein family, and it is specifically expressed in cardiac and skeletal muscle tissues and is involved in myocyte differentiation, development and morphogenesis. In this study the complete open reading frame (ORF) of the porcine MuRF1 gene consisting of 354 amino acids was obtained and it shared 93% and 90% identity with those of the human and mice, respectively. Using the INRA radiation hybrid panel (IMpRH) technique, the MuRF1 gene was assigned to SSC6q21-26, closely linked to microsatellite markers SW1823 and SW709. The tissue distribution patterns revealed that MuRF1 mRNA was exclusively expressed in cardiac and skeletal muscle tissues. Real-time quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR) results displayed that MuRF1 mRNA was up-regulated in Landrace pigs during the prenatal skeletal muscle development stages. A synonymous T/C single nucleotide polymorphism (SNP) was identified in MuRF1 exon 3 and then a Hin6I PCR - RFLP was developed for SNP genotyping in two pig populations. Association of the genotypes with growth and carcass traits showed that different genotypes of MuRF1 were genetically significantly associated with average daily gain from birth to 90 kg and loin muscle area in one experimental population. The study suggested that the porcine MuRF1 gene might affect muscle growth and development, and could be a potential candidate gene for muscle production traits in the pig.
Triolein-based polycation lipid nanocarrier for efficient gene delivery: characteristics and mechanism
Zhang ZW, Fang XL, Hao JG, Li YJ, Sha XY
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S24720
Abstract: iolein-based polycation lipid nanocarrier for efficient gene delivery: characteristics and mechanism Original Research (2628) Total Article Views Authors: Zhang ZW, Fang XL, Hao JG, Li YJ, Sha XY Published Date October 2011 Volume 2011:6 Pages 2235 - 2244 DOI: http://dx.doi.org/10.2147/IJN.S24720 Zhiwen Zhang1,2, Xiaoling Fang1, Junguo Hao1, Yajuan Li1, Xianyi Sha1 1Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People’s Republic of China; 2Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China Abstract: We proposed to develop a polycation lipid nanocarrier (PLN) with higher transfection efficiency than our previously described polycation nanostrucutred lipid nanocarrier (PNLC). PLN was composed of triolein, cetylated low-molecular-weight polyethylenimine, and dioleoyl phosphatidylethanolamine. The physicochemical properties of PLN and the PLN/DNA complexes (PDC) were characterized. The in vitro transfection was performed in human lung adenocarcinoma (SPC-A1) cells, and the intracellular mechanism was investigated as well. The measurements indicated that PLN and PDC are homogenous nanometer-sized particles with a positive charge. The transfection efficiency of PDC significantly increased with the content of triolein and was higher than that of PNLC and commercial LipofectamineTM 2000. In particular, the transfection of PLN in the presence of 10% serum was more effective than that in its absence. With the help of specific inhibitors of chlorpromazine and filipin, the clathrin-dependent endocytosis pathway was determined to be the main contributor to the successful transfection mediated by PLN in SPC-A1 cells. The captured images verified that the fluorescent PDC was localized in the lysosomes and nuclei after endocytosis. Thus, PLN represents a novel efficient nonviral gene delivery vector.
The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability
Ma YR, Zhao XY, Li J, Shen Q
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S27641
Abstract: omparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability Original Research (2804) Total Article Views Authors: Ma YR, Zhao XY, Li J, Shen Q Published Date February 2012 Volume 2012:7 Pages 559 - 570 DOI: http://dx.doi.org/10.2147/IJN.S27641 Received: 25 October 2011 Accepted: 18 November 2011 Published: 02 February 2012 Yiran Ma, Xinyi Zhao, Jian Li, Qi Shen School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China Abstract: The aim of this research was to increase the oral bioavailability of daidzein by the formulations of poly(lactic-co-glycolic) acid (PLGA) nanoparticles loaded with daidzein. Amongst the various traditional and novel techniques of preparing daidzein-loaded PLGA nanoparticles, daidzein-loaded phospholipid complexes PLGA nanoparticles and daidzein-loaded cyclodextrin inclusion complexes PLGA nanoparticles were selected. The average drug entrapment efficiency, particle size, and zeta potential of daidzein-loaded phospholipid complexes PLGA nanoparticles and daidzein-loaded cyclodextrin inclusion complexes PLGA nanoparticles were 81.9% ± 5%, 309.2 ± 14.0 nm, -32.14 ± 2.53 mV and 83.2% ± 7.2%, 323.2 ± 4.8 nm, -18.73 ± 1.68 mV, respectively. The morphological characterization of nanoparticles was observed with scanning electron microscopy by stereological method and the physicochemical state of nanoparticles was valued by differential scanning calorimetry. The in vitro drug-release profile of both nanoparticle formulations fitted the Weibull dynamic equation. Pharmacokinetic studies demonstrated that after oral administration of daidzein-loaded phospholipid complexes PLGA nanoparticles and daidzein-loaded cyclodextrin inclusion complexes PLGA nanoparticles to rats at a dose of 10 mg/kg, relative bioavailability was enhanced about 5.57- and 8.85-fold, respectively, compared to daidzein suspension as control. These results describe an effective strategy for oral delivery of daidzein-loaded PLGA nanoparticles and might provide a fresh approach to enhancing the bioavailability of drugs with poor lipophilic and poor hydrophilic properties.
Effect and safety of bevacizumab-containing chemotherapy treatment in Chinese patients with metastatic colorectal cancer
Wu Q,Shi Y,Chen L,Xiao XY
OncoTargets and Therapy , 2013,
Abstract: Qian Wu, Yan Shi, Li Chen, Xiaoyi Xiao, Guanghai Dai Department of Multimodality Therapy Oncology, Chinese PLA General Hospital, Beijing, People’s Republic of China Purpose: To review the clinical data and treatment efficacy of bevacizumab in Chinese patients with metastatic colorectal cancer (mCRC). Patients and methods: A total of 96 patients with mCRC treated by chemotherapy plus bevacizumab in the PLA General Hospital between December 2005 and August 2012 were analyzed retrospectively by overall response rate, disease-control rate, progression-free survival (PFS), and overall survival (OS). The tumor responses were assessed by the Response Evaluation Criteria in Solid Tumors guidelines. Results: A total of 96 patients with mCRC were identified. Median age was 53.6 years. Eastern Cooperative Oncology Group performance status was 0–2. By the end of follow-up (August 20, 2012), 54 patients exhibited progression (56.3%), and 39 (40.6%) patients had died. A total of 27 (28.1%) achieved partial response, and 48 patients (50.0%) had stable disease, exhibiting an overall response rate of 28.1% and a disease-control rate of 78.1%. The response rates of the first-line, second-line, and third-line (or later) therapy were 41.7%, 21.9%, and 15.8%, respectively. The median durations of the PFS and OS were 8.13 months and 14.80 months, respectively. The median durations of the PFS were 12.70 months, 8.30 months, and 6.40 months for first-line, second-line, and third-line (or later) therapy, respectively, and the median durations of the OS were 24.03 months, 14.90 months, and 11.03 months for first-line, second-line, and third-line (or later) therapy, respectively. Conclusion: A bevacizumab-containing chemotherapy regimen was well tolerated and effective in Chinese patients with mCRC. Keywords: colorectal cancer, metastasis, Chinese, bevacizumab, efficacy
MicroRNA-141 is downregulated in human renal cell carcinoma and regulates cell survival by targeting CDC25B
Yu XY,Zhang Z,Liu J,Zhan B
OncoTargets and Therapy , 2013,
Abstract: Xiu-yue Yu, Zhe Zhang, Jiao Liu, Bo Zhan, Chui-ze Kong Department of Urology, the First Hospital of China Medical University, Shenyang, People’s Republic of China Background/objective: MicroRNAs (miRNAs) are small noncoding RNAs (ribonucleic acids), approximately 22 nucleotides in length, that function as regulators of gene expression. Dysregulation of miRNAs has been associated with the initiation and progression of oncogenesis in humans. The cell division cycle (CDC)25 phosphatases are important regulators of the cell cycle. Their abnormal expression detected in a number of tumors implies that their dysregulation is involved in malignant transformation. Methods: Using miRNA target prediction software, we found that miR-141 could target the 3′ untranslated region (3′UTR) sequence of CDC25B. To shed light on the role of miR-141 in renal cell carcinogenesis, the expression of miR-141 was examined by real-time polymerase chain reaction (RT-PCR) in renal cell carcinoma and normal tissues. The impact of miR-141 re-expression on 769-P cells was analyzed using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and colony-forming assay. A luciferase reporter assay was applied to prove the functionality of the miR-141 binding site. Results: miR-141 is significantly downregulated in renal cell carcinoma. miR-141 re-expression suppressed cell growth in 769-P cells. Luciferase expression from a reporter vector containing the CDC25B-3'UTR was decreased when this construct was transfected with miR-141 in 769-P cells. The overexpression of miR-141 suppressed the endogenous CDC25B protein level in 769-P cells. Conclusion: For the first time, we demonstrated that CDC25B is a direct target of miR-141 in renal cell carcinoma. The transcriptional loss of miR-141 and the resultant increase in CDC25B expression facilitates increased genomic instability at an early stage of renal cell carcinoma development. Keywords: carcinogenesis, 769-P, target, MicroRNAs, proliferation, luciferase
Targeting bladder tumor cells in voided urine of Chinese patients with FITC-CSNRDARRC peptide ligand
Jia XY,Yu Q,Zhang ZH,Yang XF
OncoTargets and Therapy , 2012,
Abstract: Xing-You Jia1, Qi Yu2, Zhe-Hui Zhang3, Xiao-Feng Yang11School of the First Clinical Hospital, Shanxi Medical University, Taiyuan, Shanxi, China; 2Department of Information Management, Shanxi Medical University, Taiyuan, Shanxi, China; 3Research Center for Philosophy of Science and Technology, Shanxi University, Taiyuan, Shanxi, ChinaObjective: To study the practicality of the FITC-CSNRDARRC peptide ligand (containing the Cys–Ser–Asn–Arg–Asp–Ala–Arg–Arg–Cys nonapeptide) in diagnosing and monitoring bladder tumors.Materials and methods: Between March 2011 and September 2011, 80 consecutive patients with radiographic abnormalities, localizing hematuria, other symptoms, or signs were studied using the FITC-CSNRDARRC ligand, urinary cytology (UC), and fluorescence in situ hybridization (FISH). The sensitivity and specificity of these three technologies were determined and compared. Cystoscopy and tissue biopsy were taken as the “gold standards” for bladder tumor diagnosis in this study.Results: Twenty-nine out of 80 patients were diagnosed with a bladder tumor via histopathological examination. The FITC-CSNRDARRC ligand was positive in 23 out of 29 bladder tumor patients and produced false negatives in six (20.69%) patients. The UC was positive in six out of 29 bladder tumor patients and produced false negatives in 23 (79.31%) patients. The FISH was positive in 21 out of 29 bladder tumor patients and produced false negatives in eight (27.59%) patients. The overall sensitivity as verified by the FITC-CSNRDARRC ligand was much higher than in UC (79.31% versus 20.69%, P < 0.001) and was slightly higher than in FISH (79.31% versus 72.41%, P = 0.625). The sensitivity of FISH was significantly higher than that of UC (72.41% versus 20.69%, P < 0.001). Sensitivities of the FITC-CSNRDARRC ligand and UC by grade were 58.33% versus 8.3% for low-grade (LG) tumors (P = 0.031) and 94.12% versus 29.41% for high-grade (HG) tumors (P = 0.003), respectively. The advantage was maintained in terms of the detection of invasive tumors between the FITC-CSNRDARRC ligand and UC (90.48% versus 23.81%, P = 0.001) as well as between FISH and UC (85.71% versus 23.81%, P = 0.003). The specificities for the FITC-CSNRDARRC ligand, UC, and FISH were 100%.Conclusion: Results show that the FITC-CSNRDARRC ligand is a promising noninvasive tool for diagnosis and surveillance in patients suspected of having a new bladder tumor.Keywords: bladder tumor, tumor-targeting, FITC-CSNRDARRC ligand, fluorescent probe
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