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Search Results: 1 - 10 of 84271 matches for " XU Zhi-ming "
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Expression of Dickkopf-1 and Beta-Catenin Related to the Prognosis of Breast Cancer Patients with Triple Negative Phenotype
Wen-Huan Xu, Zhe-Bin Liu, Chen Yang, Wenxin Qin, Zhi-Ming Shao
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037624
Abstract: Background and Aim We investigated the prognostic importance of dickkopf-1(DKK1) and beta-catenin expression in triple negative breast cancers. Methods The expression of DKK1 and beta-catenin was evaluated in breast cell lines using RT-PCR and western blot. Immunohistochemistry was used to characterize the expression pattern of DKK1 and beta-catenin in 85 triple negative breast cancers and prognostic significance was assessed by Kaplan-Meier analysis and Cox proportional hazards regression modeling. Results The expression of DKK1 was confirmed in hormone-resistant breast cell lines MDA-MB-231, MDA-MB-231-HM and MDA-MB-435. Expression of DKK1 in triple negative breast cancers correlated with cytoplasmic/nuclear beta-catenin (p = 0.000). Elevated expression of DKK1 and cytoplasmic/nuclear beta-catenin in triple negative cancers indicate poor outcome of patients. DKK1 was also a prognostic factor for patients with earlier stage or no lymph node metastasis. Conclusion DKK1 together with beta-catenin might be important prognostic factors in triple negative breast carcinoma. DKK1 might be a valuable biomarker in predicting the prognosis of patients with earlier stage or no lymph node metastasis. It is possible that through further understanding of the role of Wnt/beta-catenin pathway activation, beta-catenin would be a potential therapeutic target for the triple negative breast cancer.
Deadlock Problems in Manufacturing System

XU Gang,WU Zhi-ming,

系统工程理论与实践 , 2004,
Abstract: The definition, characteristic and control policy of deadlock in manufacturing system is introduced. The research achievements in recent ten years are summarized. The research methods are classified according to model method: graph theory, Petri net, automata. The methods are compared with each other. Finally, the problems that need further investigating and possible research directions are pointed.
Deadlock-free scheduling method for automated production cell including buffer

XU Gang,WU Zhi-ming,
徐 刚

控制理论与应用 , 2005,
Abstract: Deadlock must be avoided in a manufacturing system.In this paper,an efficient algorithm for finding an optimal deadlock_free schedules in a Manufacturing System with very limited buffer is presented.First,the deadlock problem and its graph theory representation is introduced.Then based on the effective genetic algorithm (GA) search method,the graph theory is introduced to assure deadlock-free.In order to make the scheduling strategy generated by GA meet the required constrains,a deadlock detection procedure based on graph theory is involved as a condition to select deadlock-free scheduling,or to allocate the buffer.So the feasible scheduling result is obtained while the main performance indicator is guaranteed.Finally,a case is given to demonstrate the effectiveness of this method.
Viral Oncogenes, Noncoding RNAs, and RNA Splicing in Human Tumor Viruses
Zhi-Ming Zheng
International Journal of Biological Sciences , 2010,
Abstract: Viral oncogenes are responsible for oncogenesis resulting from persistent virus infection. Although different human tumor viruses express different viral oncogenes and induce different tumors, their oncoproteins often target similar sets of cellular tumor suppressors or signal pathways to immortalize and/or transform infected cells. Expression of the viral E6 and E7 oncogenes in papillomavirus, E1A and E1B oncogenes in adenovirus, large T and small t antigen in polyomavirus, and Tax oncogene in HTLV-1 are regulated by alternative RNA splicing. However, this regulation is only partially understood. DNA tumor viruses also encode noncoding RNAs, including viral microRNAs, that disturb normal cell functions. Among the determined viral microRNA precursors, EBV encodes 25 from two major clusters (BART and BHRF1), KSHV encodes 12 from a latent region, human polyomavirus MCV produce only one microRNA from the late region antisense to early transcripts, but HPVs appears to produce no viral microRNAs.
Generating superposition and entanglement of squeezed vacuum states
Zhi-Ming Zhang
Physics , 2006,
Abstract: We propose a scheme for generating the superposition and the entanglement of squeezed vacuum states of electromagnetical fields. The scheme involves single-photon source, single photon detector, and cross Kerr nonlinearity. The Kerr nonlinearity required for generating the superposition of squeezed vacuum states is 1/2 of that required for generating the superposition of coherent states. The proposal can also be extended to generate the entanglement states between two coherent states and that between one coherent state and one squeezed vacuum state.
Homotopy theory of presheaves of simplicial groupoids
Zhi-Ming Luo
Mathematics , 2004,
Abstract: We show that the category of presheaves of simplicial groupoids on a site $\mathcal{C}$ is a right proper simplicial model category. We define $G$-torsor of presheaf of 2-groupoids $G$, presheaf of simplicial groups $G$ and presheaf of simplicial groupoids $G$ on a site $\mathcal{C}$ and classify $G$-torsors by the homotopy classes $[\ast, \bar{W}G]$.
Covering groupoids
Zhi-Ming Luo
Mathematics , 2004,
Abstract: Topos properties of the category of covering groupoids over a fixed groupoid are discussed. A classification result for connected covering groupoids over a fixed groupoid analogous to the fundamental theorem of Galois theory is given.
The Lie Group Structure of the $η-ξ$ Space-time and its Physical Significance
Zhi-Ming Gu
Mathematics , 2004,
Abstract: The $\eta-\xi$ space-time is suggested by Gui for the quantum field theory in 1988. This paper consists of two parts. The first part is devoted to the discussion of the global properties of the $\eta-\xi$ space-time. The result contains a proof which asserts that the $\eta-\xi$ space-time is homeomorphic to $\mathbb{C}^{*}\times \mathbb{C}^{*}\times \mathbb{C}^{2}$ by means of two explicit maps, which shows that the $\eta-\xi$ space-time allows a Lie group structure. Thus some transformation groups, one of which is isomorphic to the Lorentz group in two dimensions, can be found. The other part of the paper is the discussion about the embedding of some subspaces in the $\eta-\xi$ space-time. In particular, it is pointed out that the Euclidean space-time and the Minkowskian space-time are linked in a way in the $\eta-\xi$ space-time such that the tilde field appears naturally. In addition some formulae in the $\eta-\xi$ space-time reappear in a more natural way.
Removal of Heavy Metal from Contaminated Soil with Chelating Agents  [PDF]
Wei Jiang, Tao Tao, Zhi-Ming Liao
Open Journal of Soil Science (OJSS) , 2011, DOI: 10.4236/ojss.2011.12010
Abstract: Removal of copper and nickel by the addition of the biodegradable chelating agent, chitosan and ethylenediamine tetraacetic acid (EDTA), was investigated, alongside the reaction of a reference compound sodium citrate for comparison. The artificial-contaminated soils were used in this study. The experiments showed that the extraction ability for copper and nickel from the contaminated soil decreased as follows: chitosan > EDTA > sodium citrate. The pH value of the eluents is the key to control the extraction, especially to chitosan solution. It was evident that the chitosan solution was the most efficient when the pH value was 3 - 3.5, the rate of extraction of copper being 43.36% and of nickel being 37.07%. And the best match of concentration and liquid/solid was 0.3 g/L and 10 mL/g.
Research on Evolution Mechanism of Technological Original Innovation—With Mutation Theory of Respective  [PDF]
Zhi-Ming Zhu, in-Sheng Li, Tao Chen
Journal of Service Science and Management (JSSM) , 2012, DOI: 10.4236/jssm.2012.51004
Abstract: Technical innovation is the power and resource for the sustainable and healthy development of enterprises, and is re- lated to the improvement of social productivity and the establishment and improvement of national innovation system. Technical innovation is the process of the enterprise using the original knowledge and transforming it into new tech- nology. The input and output of knowledge of (i.e., creating new technology) presents S curve, experiencing the stage of imitating type, fusion type and original type, which is subjected to the synergistic action of institutional arrangements factor and its operating factors. Through the analysis of evolution mechanism of different stages of technological inno- vation stages, this paper verifies the rationality and scientific nature of the theoretical assumptions.
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