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EGFR gene copy number as a predictive biomarker for the treatment of metastatic colorectal cancer with anti-EGFR monoclonal antibodies: a meta-analysis
Yang Zu-Yao,Shen Wei-Xi,Hu Xue-Feng,Zheng Da-Yong
Journal of Hematology & Oncology , 2012, DOI: 10.1186/1756-8722-5-52
Abstract: Background Epidermal growth factor receptor gene copy number (EGFR GCN) has been heavily investigated as a potential predictive biomarker for the treatment of metastatic colorectal cancer (mCRC) with anti-EGFR monoclonal antibodies (MAbs). The objective of this study was to systematically review current evidences on this issue. Methods PubMed, EMBASE, The Cochrane Library, Chinese Biomedical Literature Database, Wanfang Data, and the conference abstracts of American Society of Clinical Oncology and European Society of Medical Oncology were comprehensively searched. Studies that reported the objective response rate (ORR), progression-free survival, and/or overall survival of mCRC patients treated with anti-EGFR MAbs, stratified by EGFR GCN status, were included. The effect measures for binary outcome (response) and time-to-event outcomes (progression-free survival and overall survival) were risk difference and hazard ratio, respectively. Statistical heterogeneity among the studies was assessed by the Cochran’s Q-test and the I2 statistic. If appropriate, a quantitative synthesis of data from different studies would be conducted with a random-effects model. Results Nineteen eligible studies were identified. The criteria for increased EGFR GCN (GCN+) were highly inconsistent across different studies. The prevalence of GCN + ranged from 6.9% to 88.9%, and the difference in ORR between patients with GCN + and those with non-increased EGFR GCN (GCN-) varied from 28% to 84%. Because of the significant heterogeneity, no quantitative synthesis of data was performed. There was a general trend towards higher ORR in patients with GCN+. The difference in ORRs between patients with GCN + and those with GCN- was even greater in KRAS wild-type patients, while in KRAS mutated patients the difference often did not exist. Almost all patients with EGFR amplification responded to the treatment. However, the prevalence of EGFR amplification was generally low. Incomplete data on progression-free survival and overall survival seemingly supported the findings on ORR. Conclusions Although increased EGFR GCN is generally associated with a better outcome of anti-EGFR MAbs treatment, especially among patients with wild-type KRAS, the clinical utility of this biomarker for selecting recipients of anti-EGFR MAbs would be severely limited by the heterogeneous scoring system and the poor reproducibility of EGFR GCN enumeration due to technical reasons.
Constraints on the Bulk Lorentz Factors of GRB X-Ray Flares
Shuang-Xi Yi,Xue-Feng Wu,Fa-Yin Wang,Zi-Gao Dai
Physics , 2015, DOI: 10.1088/0004-637X/807/1/92
Abstract: X-ray flares were discovered in the afterglow phase of gamma-ray bursts (GRBs) by the {\em Swift} satellite a decade ago and known as a canonical component in GRB X-ray afterglows. In this paper, we constrain the Lorentz factors of GRB X-ray flares using two different methods. For the first method, we estimate the lower limit on the bulk Lorentz factor with the flare duration and jet break time. In the second method, the upper limit on the Lorentz factor is derived by assuming that the X-ray flare jet has undergone saturated acceleration. We also re-estimate the initial Lorentz factor with GRB afterglow onsets, and find the coefficient of the theoretical Lorentz factor is 1.67 rather than the commonly used 2 for interstellar medium (ISM) and 1.44 for the wind case. We find that the correlation between the limited Lorentz factor and the isotropic radiation energy of X-ray flares in the ISM case is more consistent with that of prompt emission than the wind case in a statistical sense. For a comparison, the lower limit on Lorentz factor is statistically larger than the extrapolation from prompt bursts in the wind case. Our results indicate that X-ray flares and prompt bursts are produced by the same physical mechanism.
Early Afterglows of Gamma-Ray Bursts in a Stratified Medium with a Power-Law Density Distribution
Shuang-Xi Yi,Xue-Feng Wu,Zi-Gao Dai
Physics , 2013, DOI: 10.1088/0004-637X/776/2/120
Abstract: A long-duration gamma-ray burst (GRB) has been widely thought to arise from the collapse of a massive star, and it has been suggested that its ambient medium is a homogenous interstellar medium (ISM) or a stellar wind. There are two shocks when an ultra-relativistic fireball that has been ejected during the prompt gamma-ray emission phase sweeps up the circumburst medium: a reverse shock that propagates into the fireball, and a forward shock that propagates into the ambient medium. In this paper, we investigate the temporal evolution of the dynamics and emission of these two shocks in an environment with a general density distribution of $n\propto R^{-k}$ (where $R$ is the radius) by considering thick-shell and thin-shell cases. A GRB afterglow with one smooth onset peak at early times is understood to result from such external shocks. Thus, we can determine the medium density distribution by fitting the onset peak appearing in the light curve of an early optical afterglow. We apply our model to 19 GRBs, and find that their $k$ values are in the range of 0.4 - 1.4, with a typical value of $k\sim1$, implying that this environment is neither a homogenous interstellar medium with $k=0$ nor a typical stellar wind with $k=2$. This shows that the progenitors of these GRBs might have undergone a new mass-loss evolution.
A method for measuring the density of trapping charges in thin gate oxides
薄栅氧化层中陷阱电荷密度的测量方法

Liu Hong-Xi,Zheng Xue-Feng,Hao Yao,
刘红侠
,郑雪峰,郝跃

物理学报 , 2002,
Abstract: This paper presents an experimental method for measuring the density of trapping charges. This method is based on the dynamic equilibrium equation for the process of trapped charges. We can obtain the density and the location of trapping charges by measuring the high frequency C\|V curve of MOS capacitance before and after stress,and the change of gate voltage under constant current stress. The analytical expression of the density of trapping charges is proposed. The method and the results of parameters extraction are also presented. Experimental results show that this method is convenient and precise.
Generation mechanism of stress induced leakage current in flash memory cell
闪速存储器中应力诱生漏电流的产生机理

Liu Hong-Xi,Zheng Xue-Feng,Hao Yue,
刘红侠
,郑雪峰,郝 跃

物理学报 , 2005,
Abstract: The generation mechanism of stress induced leakage current (SILC) in flash memory cell is studied by experiments. The result shows that the reliability problem under low electronic field stress is mainly caused by carriers charging and discharging inside the oxide, while under high electronic field, the trap-assisted tunneling and positive charge assisted tunneling induced charge variation of floating-gate is the major cause of flash memory cell failure. For both high and low electronic field stresses, the transient current and the steady-state current in SILC are calculated, respectively.
An LMI Approach to Decentralized H
一类不确定关联时滞大系统的分散H∞ 控制器设计—LMI方法(英文)

LIU Hong-xi,XU Bu-gong,ZHU Xue-feng,
刘红霞
,胥布工,朱学峰

控制理论与应用 , 2001,
Abstract: 研究了一类具有N×N个任意未知常时滞和具有范数有界时变不确定的线性连续大系统的分散鲁棒H∞状态反馈控制器设计问题,基于线性矩阵不等式方法得到了一个使该系统存在无记忆H∞状态反馈控制器的充分条件,最后通过一个数值例子来说明分散H∞状态反馈控制器的设计.
Trust Measuring Model Based on Social Factors of Users and their Behavior
基于用户及其行为社会属性的信任测度模型

LU You,HUA Ze,SHENG Hao,XI Xue-feng,
陆 悠
,华 泽,盛 浩,奚雪峰

计算机科学 , 2013,
Abstract: Trust measure is the basis of trust mechanism. Now the trust mechanism is facing the threat that malicious users manipulate the reputation. I}he trust measure model based on the social factors of users and their behavior expands the traditional trust mechanism. It describes and analyses the characters of malicious users and their behavior by the social factor,which reflects the essential of user and behavior. This model also adds the audit process in order to correct the reputation under the attack, so it can guarantee the credibility of trust measure in distributed Environment. Simulation experiments show that this model can effectively react to the reputation manipulation attack by the malicious users.
On the Mechanical Properties of Lead-Free Solder Joints Based on Nanoindentation
基于纳米压痕法无铅焊锡连接各层材料力学性能的研究

XIAO Ge-sheng,YANG Xue-xi,YUAN Guo-zheng,SHU Xue-feng,
肖革胜
,杨雪霞,袁国政,树学峰

实验力学 , 2013,
Abstract: 利用SMT全自动回流焊机和高温恒温试验箱,制备出经2次回流焊时效20天的Sn-0.7Cu/Cu焊点试件。采用纳米压痕法,对其焊点金属间化合物力学性能进行测试。根据Oliver-Pharr算法,利用接触刚度连续测量技术得到该化合物(IMC)的弹性模量及硬度,并与同种工况下的焊料及铜进行对比,发现其硬度明显大于二者。并得到了Sn-0.7Cu焊料、金属间化合物和Cu的室温蠕变速率敏感指数,对三者的蠕变性能做了对比分析,发现Sn-0.7Cu的室温蠕变速率敏感指数明显大于IMC和Cu。
The chaotic vibration of a metal plate with large deflection under a transverse magnetic field
横向磁场中大挠度金属薄板的混沌振动

Xue Chun-Xi,Zhang Shan-Yuan,Shu Xue-Feng,
薛春霞
,张善元,树学锋

物理学报 , 2010,
Abstract: 利用Karman关于板的大挠度理论,考虑涡电流在板中引起的Lorentz力,导出了在横向磁场和横向载荷共同作用下薄板的非线性运动方程.借助Bubnov-Galerkin法将非线性偏微分方程转化为含三次非线性项的常微分方程.在定性分析的基础上,利用次谐轨道的Melnikov函数给出了发生Smale马蹄型混沌运动的阈值条件,进而数值计算了系统的分岔图、相应的相图、Poincaré映射和时程曲线,给出了混沌运动的数字特征.分析结果表明:磁感应强度和外载荷都会影响系统的振动特性.
Morphological Control of Mesoporous Silica in a Base Condition
碱性条件下二氧化硅介孔颗粒的形态控制

LI Zhong-Kai,XI Hong-An,QIAN Xue-Feng,YIN Jie,ZHU Zi-Kang,
李中凯
,席红安,钱雪峰,印杰,朱子康

无机材料学报 , 2003,
Abstract: Mesoporous silica with different morphologies was synthesized in a base medium. The effects of factors such as pH, reaction temperature, concentration of CTAB and EtOH on morphologies of mesoporous silica were studied by means of TEM and XRD. The silica particles with 30-50nm in diameter and well-ordered were synthesized.
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