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Search Results: 1 - 10 of 528 matches for " Wouter Oosterlinck "
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Glucose Tolerance and Left Ventricular Pressure-Volume Relationships in Frequently Used Mouse Strains
Wouter Oosterlinck,Annelies Vanderper,Willem Flameng,Paul Herijgers
Journal of Biomedicine and Biotechnology , 2011, DOI: 10.1155/2011/281312
Abstract: We investigated glucose tolerance and left ventricular contractile performance in 4 frequently used mouse strains (Swiss, C57BL/6J, DBA2, and BalbC) at 24 weeks. Glucose tolerance was tested by measuring blood glucose levels in time after intraperitoneal glucose injection (2 mg/g body weight). Left ventricular contractility was assessed by pressure-conductance analysis. Peak glucose levels and glucose area under the curve were higher (all <.05) in C57BL/6J (418±65 mg/dL and 813±100 mg·h/dL) versus Swiss (237±66 mg/dL and 470±126 mg·h/dL), DBA2 (113±20 mg/dL and 304±49 mg·h/dL, <.01), and BalbC mice (174±55 mg/dL and 416±70 mg·h/dL). Cardiac output was higher (all <.05) in Swiss (14038±4530 μL/min) versus C57BL/6J (10405±2683 μL/min), DBA2 (10438±3251 μL/min), and BalbC mice (8466±3013 μL/min). Load-independent left ventricular contractility assessed as recruitable stroke work (PRSW) was comparable in all strains. In conclusion, glucose tolerance and load-dependent left ventricular performance parameters were different between 4 mice background strains, but PRSW was comparable.
Angiotensin-converting enzyme inhibition and food restriction restore delayed preconditioning in diabetic mice
Gerry Van der Mieren, Ines Nevelsteen, Annelies Vanderper, Wouter Oosterlinck, Willem Flameng, Paul Herijgers
Cardiovascular Diabetology , 2013, DOI: 10.1186/1475-2840-12-36
Abstract: Hypoxic preconditioning was induced in C57Bl6-mice (WT), leptin deficient ob/ob (model for type II diabetes) and double knock-out (DKO) mice with combined leptin and LDL-receptor deficiency (model for metabolic syndrome). Twenty-four hours later, 30 min of regional ischemia was followed by 60 min reperfusion. Left ventricular contractility and infarct size were studied. The effect of 12 weeks food restriction or angiotensin-converting enzyme inhibition (ACE-I) on this was investigated. Differences between groups were analyzed for statistical significance by student's t-test or one-way ANOVA followed by a Fisher's LSD post hoc test. Factorial ANOVA was used to determine the interaction term between preconditioning and treatments, followed by a Fisher's LSD post hoc test. Two-way ANOVA was used to determine the relationship between infarct size and contractility (PRSW). A value of p<0.05 was considered significant.Left ventricular contractility is reduced in ob/ob compared with WT and even further reduced in DKO. ACE-I improved contractility in ob/ob and DKO mice. After ischemia/reperfusion without preconditioning, infarct size was larger in DKO and ob/ob versus WT. Hypoxic preconditioning induced a strong protection in WT and a partial protection in ob/ob mice. The preconditioning potential was lost in DKO. Twelve weeks of food restriction or ACE-I restored the preconditioning potential in DKO and improved it in ob/ob.Delayed preconditioning is restored by food restriction and ACE-I in case of type II diabetes and the metabolic syndrome.
Angiotensin-converting enzyme inhibition and food restriction in diabetic mice do not correct the increased sensitivity for ischemia-reperfusion injury
Gerry Van der Mieren, Ines Nevelsteen, Annelies Vanderper, Wouter Oosterlinck, Willem Flameng, Paul Herijgers
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-89
Abstract: C57Bl6/J wild type (WT) mice, leptin deficient ob/ob (model for type II diabetes) and double knock-out (LDLR-/-;ob/ob, further called DKO) mice with combined leptin and LDL-receptor deficiency (model for metabolic syndrome) were used. The effects of 12?weeks food restriction or ACE-I on infarct size and load-independent left ventricular contractility after 30?min regional cardiac ischemia were investigated. Differences between groups were analyzed for statistical significance by Student’s?t-test or factorial ANOVA followed by a Fisher’s LSD post hoc test.Infarct size was larger in ob/ob and DKO versus WT. Twelve weeks of ACE-I improved pre-ischemic left ventricular contractility in ob/ob and DKO. Twelve weeks of food restriction, with a weight reduction of 35-40%, or ACE-I did not reduce the effect of IR.ACE-I and food restriction do not correct the increased sensitivity for cardiac IR-injury in mouse models of type II diabetes and the metabolic syndrome.The number of patients with diabetes and the metabolic syndrome increases in Western societies and reaches epidemic proportions [1,2]. At present, diabetes affects approximately 250 million people worldwide and by 2025 this is expected to increase to over 380 million, with type II diabetes accounting for 90-95% of them. Prevalence is expected to increase most in Asia and Africa with the majority of patients in 2030 being found there [2]. The prevalence of the metabolic syndrome currently exceeds 20% of individuals who are over 20?years of age and 40% of the population older than 40?years [1]. Heart failure is the leading cause of mortality in people with type II diabetes. The incidence of myocardial infarction in diabetic patients is twice that of the general population [3,4]. They are at increased risk for mortality and post-ischemic complications [3,4]. Infarct size for a given ischemic insult is larger in diabetic mice than in controls [5-7]. This, on top of diabetic cardiomyopathy [8,9], contributes to progressi
Treatment of Bulbar Urethral Strictures. A Review, with Personal Critical Remarks
Willem Oosterlinck
The Scientific World Journal , 2003, DOI: 10.1100/tsw.2003.34
Challenging non-traumatic posterior urethral strictures treated with urethroplasty: a preliminary report
Lumen, Nicolaas;Oosterlinck, Willem;
International braz j urol , 2009, DOI: 10.1590/S1677-55382009000400008
Abstract: introduction: posterior urethral strictures after prostatic radiotherapy or surgery for benign prostatic hyperplasia (bph) refractory to minimal invasive procedures (dilation and/or endoscopic urethrotomy) are challenging to treat. published reports of alternative curative management are extremely rare. this is a preliminary report on the treatment of these difficult strictures by urethroplasty. materials and methods: seven cases were treated: 4 cases occurred after open prostatectomy or transurethral resection of the prostate for bph, one case after external beam irradiation and 2 after brachytherapy. the 4 cases after bph-related surgery were in fact complete obstructions at the bladder neck and the membranous urethra with the prostatic urethra still partially patent. anastomotic repair by perineal route was done in all cases with bladder neck incision in the bph-cases and prostatic apex resection in the radiotherapy cases. results: mean follow-up was 31 months (range: 12-72 months). the operation was successful, with preserved continence, in 3 of the 4 bph-cases and in 2 of the 3 radiotherapy cases. an endoscopic incision was able to treat a short re-stricture in the bph-patient and a longer stricture at the bulbar urethra could be managed with a perineostomy in the radiotherapy-patient. conclusion: posterior non-traumatic strictures refractory to minimal invasive procedures (dilation/endoscopic urethrotomy) can be treated by urethroplasty using an anastomotic repair with a bladder neck incision if necessary.
Increased Cardiac Myocyte PDE5 Levels in Human and Murine Pressure Overload Hypertrophy Contribute to Adverse LV Remodeling
Sara Vandenwijngaert, Peter Pokreisz, Hadewich Hermans, Hilde Gillijns, Marijke Pellens, Noortje A. M. Bax, Giulia Coppiello, Wouter Oosterlinck, Agnes Balogh, Zoltan Papp, Carlijn V. C. Bouten, Jozef Bartunek, Jan D'hooge, Aernout Luttun, Erik Verbeken, Marie Christine Herregods, Paul Herijgers, Kenneth D. Bloch, Stefan Janssens
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058841
Abstract: Background The intracellular second messenger cGMP protects the heart under pathological conditions. We examined expression of phosphodiesterase 5 (PDE5), an enzyme that hydrolyzes cGMP, in human and mouse hearts subjected to sustained left ventricular (LV) pressure overload. We also determined the role of cardiac myocyte-specific PDE5 expression in adverse LV remodeling in mice after transverse aortic constriction (TAC). Methodology/Principal Findings In patients with severe aortic stenosis (AS) undergoing valve replacement, we detected greater myocardial PDE5 expression than in control hearts. We observed robust expression in scattered cardiac myocytes of those AS patients with higher LV filling pressures and BNP serum levels. Following TAC, we detected similar, focal PDE5 expression in cardiac myocytes of C57BL/6NTac mice exhibiting the most pronounced LV remodeling. To examine the effect of cell-specific PDE5 expression, we subjected transgenic mice with cardiac myocyte-specific PDE5 overexpression (PDE5-TG) to TAC. LV hypertrophy and fibrosis were similar as in WT, but PDE5-TG had increased cardiac dimensions, and decreased dP/dtmax and dP/dtmin with prolonged tau (P<0.05 for all). Greater cardiac dysfunction in PDE5-TG was associated with reduced myocardial cGMP and SERCA2 levels, and higher passive force in cardiac myocytes in vitro. Conclusions/Significance Myocardial PDE5 expression is increased in the hearts of humans and mice with chronic pressure overload. Increased cardiac myocyte-specific PDE5 expression is a molecular hallmark in hypertrophic hearts with contractile failure, and represents an important therapeutic target.
Locked patellar dislocation: a case report
Frederick Michels, Nicole Pouliart, Dirk Oosterlinck
Journal of Medical Case Reports , 2008, DOI: 10.1186/1752-1947-2-371
Abstract: A 16-year-old girl of Hispanic origin sustained a sudden dislocation of the patella while she was dancing. Pre-operative computed tomography revealed a patellar dislocation with rotation around the vertical axis with the patella wedged on the side of the lateral condyle. Closed reduction failed. Open reduction was needed and the torn structures were repaired. At 1-year follow-up, she had a good functional outcome and reported no recurrence of dislocation.This case report shows that some patellar dislocations may be irreducible with the closed technique. Computed tomography is valuable in case of doubt. If an open reduction is needed, the medial ligamentous structures should be repaired.Acute patellar dislocation is a relatively common problem and most likely caused by indirect trauma (gymnastics, dancing, etc.). About 10% of acute dislocations are the result of a direct blow to the medial side. The most common dislocation is laterally in the coronal plane. Sometimes spontaneous reduction occurs, but if not, closed reduction can easily be done. In this paper, we report a very uncommon type of locked dislocation which required an open reduction.A 16-year-old girl of Hispanic origin sustained a sudden dislocation of the patella while she was dancing. There was no direct trauma involved, but just an awkward movement. Past history was unremarkable and revealed no predisposing factors (previous trauma or significant joint laxity).On physical examination, the knee was locked in extension with the patella located laterally. There was tenderness around the patellar region. A general laxity of ligaments was observed and she was moderately obese. A laterally dislocated patella was seen on plain radiographs (Figure 1).Closed reduction without anaesthesia was unsuccessful. A computed tomography (CT) scan revealed a laterally dislocated patella with the articular surface facing laterally and the lateral border of the patella directed anteriorly (Figure 2).Another attempt at close
Ontogenetic pattern change in amphibians: the case of Salamandra corsica
Wouter Beukema
Acta Herpetologica , 2011,
Abstract: Ontogenetic, post-metamorphic pattern development is a rarely studied topic in amphibian science. As there are indications that the pattern of Salamandra corsica might expand over time, digital image analyses were applied in order to measure several phenotypical variables which were related to the snout vent length. Results show a significant increase of patches which change to irregular shapes while SVL increases. Digital image analysis is identified as a suitable tool to explore pattern shape and change in general, while the documented pattern development in S. corsica might be one of the first quantified cases of post-metamorphic ontogenetic pattern change in amphibians.
Rereading: Theory of the Partisan
Wouter Werner
Amsterdam Law Forum , 2009,
The Fate of Complex Languages: Classical Arabic and Old Norse in the Age of Globalisation
Wouter Kusters
Nordlyd : Troms? University Working Papers on Language & Linguistics / Institutt for Spr?k og Litteratur, Universitetet i Troms? , 2003,
Abstract: I discuss the effects of globalisation on verbal inflection in two language groups, Arabic and Scandinavian. With the term ‘globalisation’ I do not only refer to most recent world history, but also to earlier expansions of empires, cultures and languages. I compare the social and cultural situation and the verbal inflection of Classical Arabic and Old Norse with those of modern Arabic and Scandinavian varieties. The hypothesis that factors of the historical social dimension influence variables of verbal inflection is confirmed for these cases. It was found that the more second language learning takes place, the more internal dialect contact and migrations occur, and the less prestige a language has, the more transparent and economic the verbal inflection becomes. On the other hand, tight small communities with strong language traditions and few second language learners are found to be the best environment for inflectional complexities. When such small communities expand, and when the earlier ‘ethnic’ language becomes a tool for smoother communication, restructuring takes place. In Arabic and Scandinavian this restructuring is sensitive to phonological changes, and appears to be almost ‘natural’. Other evidence from cases like Quechua and Swahili indicate that simplification is morphologically and semantically driven and needs favorable social circumstances to take place. This strongly suggests that simplification has some universal characteristics, like the tendency towards more economy and transparency, but is also dependent on language particular morphological structure.
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