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Search Results: 1 - 10 of 15266 matches for " William Tam "
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Iridium-catalyzed intramolecular [4 + 2] cycloadditions of alkynyl halides
Andrew Tigchelaar,William Tam
Beilstein Journal of Organic Chemistry , 2012, DOI: 10.3762/bjoc.8.201
Abstract: Iridium-catalyzed intramolecular [4 + 2] cycloadditions of diene-tethered alkynyl halides were investigated by using [IrCl(cod)]2 as catalyst, and dppe was found to be the most suitable phosphine ligand for the reaction. No oxidative insertion of the iridium into the carbon–halide bond was observed, and the reactions proceeded to provide the halogenated cycloadducts in good yield (75–94%). These results are the first examples of cycloadditions of alkynyl halides using an iridium catalyst.
Tetra-tert-butyl 13,14-dioxapentacyclo[8.2.1.14,7.02,9.03,8]tetradeca-5,11-diene-5,6,11,12-tetracarboxylate
Alan J. Lough,Kelsey Jack,William Tam
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812039220
Abstract: The stereochemistry of the title compound, C32H44O10, at the cyclobutane ring is cis-anti-cis. The molecule lies across an inversion center. In the crystal, weak C—H...O hydrogen bonds connect molecules into chains along [100], forming R22(6) rings.
Tetramethyl 1,4-dimethyl-13,14-dioxapentacyclo[8.2.1.14,7.02,9.03,8]tetradeca-5,11-diene-5,6,11,12-tetracarboxylate
Alan J. Lough,Kelsey Jack,William Tam
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812039219
Abstract: In the title compound, C22H24O14, the relative stereochemistry at the cyclobutane ring is cis-anti-cis and the methyl groups in the bicyclic rings are syn to each other. The two carboxylate groups attached to the same —C=C— bond are disordered over two sets of sites in a 0.603 (2):0.397 (2) ratio. In the crystal, weak C—H...O hydrogen bonds connect molecules into C(12) chains along [001] incorporating R222(10) rings.
Hexamethyl 13,14-dioxapentacyclo[8.2.1.14,7.02,9.03,8]tetradeca-5,11-diene-1,4,5,6,11,12-hexacarboxylate
Alan J. Lough,Kelsey Jack,William Tam
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812039232
Abstract: In the title compound, C24H24O14, the stereochemistry at the cyclobutane ring is cis-anti-cis and the –COOMe groups in the bicyclic rings are syn to each other. The molecule lies on a twofold rotation axis. In the crystal, weak C—H...O hydrogen bonds connect molecules into chains along [001], forming R22(10) rings.
tert-Butyl N-hydroxy-N-[(1S*,2R*)-2-(1-naphthyl)cyclopent-3-en-1-yl]carbamate
Alan J. Lough,Ben P. Machin,William Tam
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809020315
Abstract: The relative stereochemistry of the title compound, C20H23NO3, was established by X-ray analysis. The asymmetric unit contains two independent molecules. In the crystal structure, each type of molecule forms a centrosymmetric dimer via pairs of intermolecular O—H...O hydrogen bonds, resulting in an R22(10) loop in each case.
(1S,2S,4R)-7-tert-Butoxybicyclo[2.2.1]hept-5-en-2-yl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate
Alan J. Lough,David A. Petrone,William Tam
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811024238
Abstract: In the title molecule, C25H30O4, the napthalene ring system is slightly bowed, with a dihedral angle of 4.37 (13)° between the two benzene rings.
Real-time histology with the endocytoscope
Rajvinder Singh, Swee Lin Chen Yi Mei, William Tam, Devinder Raju, Andrew Ruszkiewicz
World Journal of Gastroenterology , 2010,
Abstract: Endoscopic Imaging has progressed tremendously over the last few decades. Novel imaging technologies such as high-resolution and high-magnification white light endoscopy, narrow band imaging, optimal band imaging, autoflourescence imaging and optical coherence tomography not only aid the endoscopist in detecting malignant or pre-malignant lesions but also assist in predicting histology. Recently, the introduction of Endocytoscopy (EC) and Confocal Endomicroscopy has taken us into a new realm of diagnostic endoscopy. With the ability to magnify up to 1000 ×, cellular structures can be visualized in real-time. This advance in technology could potentially lead to a paradigm shift negating the need to obtain biopsies. EC is, however, still in the early stages of development and further research needs to be carried out before it can be accepted as standard practice. This review will focus on the diagnostic utility of the Endocytoscope.
Bilateral Radial Ulnar Synostosis and Vertebral Anomalies in a Child with a De Novo 16p13.3 Interstitial Deletion
Allison Tam,Kit Shan Lee,Sansan Lee,William Burkhalter,Lucio U. Pascua,Thomas P. Slavin
Case Reports in Genetics , 2013, DOI: 10.1155/2013/149085
Abstract: We describe an 8-year-old boy with developmental delay, clinical bilateral radial ulnar synostosis, Klippel-Feil anomaly, and other vertebral deformities who was found to have a de novo deletion of 114.5kb at 16p13.3. The deletion contains five genes and three miRNAs. The genes are E4F1, DNASE1L2, ECI1, RNPS1, and ABCA3; miRNAs are MIR3677, MIR940, and MIR4717. The specific deletion has never been previously reported. We describe the phenotype of the boy and review the genes in the deleted region. None of the regulatory elements have any known linkage to skeletal formation and/or maintenance. We believe this deletion is causative given that it was de novo and that this patient cannot be easily explained as having any other specific recognizable pattern of human malformation. 1. Introduction Many of the reports on chromosome 16p13.3 gene deletions are in relation to the Rubinstein-Taybi syndrome, alpha thalassemia mental retardation, polycystic kidney disease, and familial Mediterranean fever. Chromosome 16p13.3 gene deletions associated with the Rubinstein-Taybi syndrome are discussed in depth in articles by Wallerstein et al. and Hennekam et al., respectively [1, 2]. We report a child with developmental delay, bilateral radial ulnar synostosis, Klippel-Feil anomaly, and other vertebral deformities with a de novo interstitial deletion of 114.5?kb on chromosome 16p found using chromosomal microarray. The deleted region contains five genes and three miRNAs of unclear clinical significance. We are not aware of reports of gene deletions that overlap with the 114.5kb deletion described here. The purpose of this paper is to describe our patient’s unique phenotype and discuss the possible genotype-phenotype correlations of the deleted region. 2. Clinical Report Past medical history was significant for term birth with complication of preeclampsia of unknown etiology. He had no neonatal complications. His birth weight was 7 lbs 3?oz. Family history was unremarkable for skeletal disorders. Younger full sibling sister was healthy without issues. The patient had a history of developmental delay and was in an early intervention program in California. He walked around age 2, spoke at age 3, and had phrases around age 4. He also was not toilet trained until age 4. Neurodevelopmental assessment at the age of 8 years showed a Wechsler Intelligence Scale for Children Fourth Edition (WISC IV) verbal comprehension of 89, working memory of 80, perceptional reasoning of 96, processing speed of 83, and low average full scale IQ of 84. He had a history of two febrile seizures,
TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus
Ruth E. Watkinson?,William A. McEwan?,Jerry C. H. Tam,Marina Vaysburd?,Leo C. James
PLOS Pathogens , 2015, DOI: 10.1371/journal.ppat.1005253
Abstract: Encapsidation is a strategy almost universally employed by viruses to protect their genomes from degradation and from innate immune sensors. We show that TRIM21, which targets antibody-opsonized virions for proteasomal destruction, circumvents this protection, enabling the rapid detection and degradation of viral genomes before their replication. TRIM21 triggers an initial wave of cytokine transcription that is antibody, rather than pathogen, driven. This early response is augmented by a second transcriptional program, determined by the nature of the infecting virus. In this second response, TRIM21-induced exposure of the viral genome promotes sensing of DNA and RNA viruses by cGAS and RIG-I. This mechanism allows early detection of an infection event and drives an inflammatory response in mice within hours of viral challenge.
Astronomy and Computing: a New Journal for the Astronomical Computing Community
Alberto Accomazzi,Tamás Budavári,Christopher Fluke,Norman Gray,Robert G Mann,William O'Mullane,Andreas Wicenec,Michael Wise
Physics , 2012,
Abstract: We introduce \emph{Astronomy and Computing}, a new journal for the growing population of people working in the domain where astronomy overlaps with computer science and information technology. The journal aims to provide a new communication channel within that community, which is not well served by current journals, and to help secure recognition of its true importance within modern astronomy. In this inaugural editorial, we describe the rationale for creating the journal, outline its scope and ambitions, and seek input from the community in defining in detail how the journal should work towards its high-level goals.
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