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Search Results: 1 - 10 of 14258 matches for " William Sugar "
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Second Life in Education: The Case of Commercial Online Virtual Reality Applied to Teaching and Learning
Abbie Brown,William Sugar
Themes in Science and Technology Education , 2009,
Abstract: Second Life is a three-dimensional, multi-user virtual environment that has attracted particularattention for its instructional potential in professional development and higher educationsettings. This article describes Second Life in general and explores the benefits and challengesof using it for teaching and learning.
Examining the Anatomy of a Screencast: Uncovering Common Elements and Instructional Strategies
William Sugar,Abbie Brown,Kenneth Luterbach
International Review of Research in Open and Distance Learning , 2010,
Abstract: The researchers engaged in cooperative inquiry in order to explore screencasts as online instructional tools. In total, each researcher analyzed 37 screencasts, which provided over two hours of instruction. The content area of these screencasts concentrated on teaching specific computing procedures (e.g., how to install web server software or how to add a table in a word processor). The researchers analyzed their own self-produced screencasts as well as those that were professionally produced. Analyses of the screencasts led the researchers to discover common structural components (i.e., bumpers, screen movement, and narration) and common instructional strategies (i.e., provide overview, describe procedure, present concept, focus attention, and elaborate content). By synthesizing the common structure and common instructional strategies, the researchers offer a framework for considering the role of screencasts as online instructional tools. To introduce a practical application of the framework, the researchers created a screencasting checklist, which may be used by online instructors and instructional designers to develop and assess their own screencasts. This initial work invites additional research and development in order to refine the screencasting framework and checklist.
Self-regulating genes. Exact steady state solution by using Poisson Representation
Istvan P. Sugar,Istvan Simon
Quantitative Biology , 2013, DOI: 10.2478/s11534-014-0497-0
Abstract: Systems biology studies the structure and behavior of complex gene regulatory networks. One of its aims is to develop a quantitative understanding of the modular components that constitute such networks. The self-regulating gene is a type of auto regulatory genetic modules which appears in over 40% of known transcription factors in E. coli. In this work, using the technique of Poisson Representation, we are able to provide exact steady state solutions for this feedback model. By using the methods of synthetic biology (P.E.M. Purnick and Weiss, R., Nature Reviews, Molecular Cell Biology, 2009, 10: 410-422) one can build the system itself from modules like this.
Is There an Association between Advanced Paternal Age and Endophenotype Deficit Levels in Schizophrenia?
Debby Tsuang, Michelle Esterberg, David Braff, Monica Calkins, Kristin Cadenhead, Dorcas Dobie, Robert Freedman, Michael F. Green, Tiffany Greenwood, Raquel Gur, Ruben Gur, William Horan, Laura C. Lazzeroni, Gregory A. Light, Steven P. Millard, Ann Olincy, Keith Nuechterlein, Larry Seidman, Larry Siever, Jeremy Silverman, William Stone, Joyce Sprock, Catherine Sugar, Neal Swerdlow, Ming Tsuang, Bruce Turetsky, Allen Radant
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088379
Abstract: The children of older fathers have increased risks of developing schizophrenia spectrum disorders, and among those who develop these disorders, those with older fathers present with more severe clinical symptoms. However, the influence of advanced paternal age on other important domains related to schizophrenia, such as quantitative endophenotype deficit levels, remains unknown. This study investigated the associations between paternal age and level of endophenotypic impairment in a well-characterized family-based sample from the Consortium on the Genetics of Schizophrenia (COGS). All families included at least one affected subject and one unaffected sibling. Subjects met criteria for schizophrenia (probands; n = 293) or were unaffected first-degree siblings of those probands (n = 382). Paternal age at the time of subjects’ birth was documented. Subjects completed a comprehensive clinical assessment and a battery of tests that measured 16 endophenotypes. After controlling for covariates, potential paternal age–endophenotype associations were analyzed using one model that included probands alone and a second model that included both probands and unaffected siblings. Endophenotype deficits in the Identical Pairs version of the 4-digit Continuous Performance Test and in the Penn Computerized Neurocognitive Battery verbal memory test showed significant associations with paternal age. However, after correcting for multiple comparisons, no endophenotype was significantly associated with paternal age. These findings suggest that factors other than advanced paternal age at birth may account for endophenotypic deficit levels in schizophrenia.
Improved flavor symmetry in Kogut-Susskind fermion actions
K. Orginos,R. Sugar,D. Toussaint
Physics , 1999, DOI: 10.1016/S0920-5632(00)91832-2
Abstract: We study improved Kogut-Susskind fermion actions focusing on flavor symmetry restoration. Several variants of fat actions suitable for dynamical simulations are considered, including an action with no tree level order a-squared errors. The spectrum of all the pions is computed and used as a measure of flavor symmetry violation. Finally, the Naik term is introduced to restore rotational symmetry.
Variants of fattening and flavor symmetry restoration
Kostas Orginos,R. L. Sugar,Doug Toussaint
Physics , 1999, DOI: 10.1103/PhysRevD.60.054503
Abstract: We study the effects of different "fat link" actions for Kogut-Susskind quarks on flavor symmetry breaking. Our method is mostly empirical - we compute the pion spectrum with different valence quark actions on common sets of sample lattices. Different actions are compared, as best we can, at equivalent physical points. We find significant reductions in flavor symmetry breaking relative to the conventional or to the "link plus staple" actions, with a reasonable cost in computer time. We also develop and test a scheme for approximate unitarization of the fat links. While our tests have concentrated on the valence quark action, our results will be useful in designing simulations with dynamical quarks.
Does Cluster Membership Enhance Financial Performance?  [PDF]
William Ruland
iBusiness (IB) , 2013, DOI: 10.4236/ib.2013.51001

This paper reports upon the profitability of firms that locate their headquarters in same-industry geographic concentrations or clusters and those that opt to maintain headquarters in other locations. While the preponderance of the theoretical and descriptive literature emphasizes the potential benefits associated with clustering, some papers suggest that clustering should not be beneficial, at least for particular types of firms in particular circumstances. This empirical study, which examines a sample of more than 4000 Compustat firms from 86 different industries, compares the profitability of firms in industry clusters and firms in other locations. The sample is partitioned into small and large firms to account for expected differences in profitability, in general, and the possible differential impact of geographic clustering. The results show that for smaller firms, the profitability of cluster members tends to be considerably lower than for firms that opt not to join clusters. For the subsample of larger firms, the results are mixed depending upon the measure of profitability. The results imply that smaller firms should carefully evaluate the decision to locate in industry clusters.

Why do we yawn?  [PDF]
William Burke
Health (Health) , 2013, DOI: 10.4236/health.2013.510213

The biomedical hypothesis proposed here is that the immediate trigger for a yawn is a restricted collapse of a few alveoli in the lungs. The extent of this alveolar collapse may be too small for it to be detected by current X-ray technology, but this technology is continually improving and may soon be good enough to test the hypothesis. In support of the hypothesis, it is shown that yawning can be inhibited by deep breaths of air, nitrogen or carbogen, thus showing that yawning is not triggered by lack of oxygen or by excess carbon dioxide, leaving alveolar collapse as the most likely possibility. A more extensive form of alveolar collapse is termed atelectasis and this involves a serious state of hypoxia which, if deepened or prolonged, can be fatal. Therefore, if the hypothesis is correct, yawning may prevent the development of atelectasis and save lives. This paper is not concerned with other indirect ways in which yawning may be induced, nor with the mechanism and neural circuitry of the yawn, nor with social aspects of yawning, only with the immediate trigger. My aim is to get better evidence for the hypothesis put forward here and also to study the behaviour of the pulmonary alveoli in normal respiration.

The Ionic Composition of Nasal Fluid and Its Function  [PDF]
William Burke
Health (Health) , 2014, DOI: 10.4236/health.2014.68093
Abstract: The aim of the experiments reported here is to increase our understanding of the function of the nasal fluid. It is generally accepted that the nasal fluid assists in the humidification of the inspired air. It also assists in the capture of inspired particles such as pollen, preventing them getting lodged in the lungs. It is also known to contain antibacterial substances which keep the nose, nasopharynx and respiratory passages relatively free of infection. There are other features of the nasal fluid that are not understood. In cold weather, is it the fluid that collects in the nostrils pure water or nasal fluid? Why does nasal fluid have an exceptionally high potassium concentration? Does nasal fluid secreted during the common cold have the same composition as at other times? My objectives are to try to answer these questions. My method is to collect my nasal fluid in several different ways and have the ionic composition of each determined accurately. My findings are that nasal fluid is similar in composition however it is secreted. In cold weather, if expiration is via the nose, the nasal fluid is diluted by condensed water. The high concentration of potassium in the nasal fluid is not a way of controlling the level of potassium in the body but I suggest that it may assist in maintaining the antibacterial property of the nasal fluid.
Coherence Modified for Sensitivity to Relative Phase of Real Band-Limited Time Series  [PDF]
William Menke
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.517261
Abstract: As is well known, coherence does not distinguish the relative phase of a pair of real, sinusoidal time series; the coherence between them is always unity. This behavior can limit the applicability of coherence analysis in the special case where the time series are band-limited (nearly-monoch- romatic) and where sensitivity to phase differences is advantageous. We propose a simple mod-ification to the usual formula for coherence in which the cross-spectrum is replaced by its real part. The resulting quantity behaves similarly to coherence, except that it is sensitive to relative phase when the signals being compared are strongly band-limited. Furthermore, it has a useful interpretation in terms of the zero-lag cross-correlation of real band-passed versions of the time series.
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