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Search Results: 1 - 10 of 481253 matches for " Wilkinson Paul A "
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Conceptualization about internalizing problems in children and adolescents
Ciência & Saúde Coletiva , 2009, DOI: 10.1590/S1413-81232009000200007
Abstract: this review will discuss the concept of internalizing disorders. it will describe the two main types of internalizing disorder: depressive and anxiety disorders. it will discuss how they have much in common, but that there are also key differences. the review will use data from modern studies of symptom factor analysis, aetiology, treatment and prognosis to illustrate the commonalities and differences. it will conclude by trying to answer where internalizing disorders should be placed in future diagnostic classification schemes.
CerealsDB 2.0: an integrated resource for plant breeders and scientists
Wilkinson Paul A,Winfield Mark O,Barker Gary LA,Allen Alexandra M
BMC Bioinformatics , 2012, DOI: 10.1186/1471-2105-13-219
Abstract: Background Food security is an issue that has come under renewed scrutiny amidst concerns that substantial yield increases in cereal crops are required to feed the world’s booming population. Wheat is of fundamental importance in this regard being one of the three most important crops for both human consumption and livestock feed; however, increase in crop yields have not kept pace with the demands of a growing world population. In order to address this issue, plant breeders require new molecular tools to help them identify genes for important agronomic traits that can be introduced into elite varieties. Studies of the genome using next-generation sequencing enable the identification of molecular markers such as single nucleotide polymorphisms that may be used by breeders to identify and follow genes when breeding new varieties. The development and application of next-generation sequencing technologies has made the characterisation of SNP markers in wheat relatively cheap and straightforward. There is a growing need for the widespread dissemination of this information to plant breeders. Description CerealsDB is an online resource containing a range of genomic datasets for wheat (Triticum aestivum) that will assist plant breeders and scientists to select the most appropriate markers for marker assisted selection. CerealsDB includes a database which currently contains in excess of 100,000 putative varietal SNPs, of which several thousand have been experimentally validated. In addition, CerealsDB contains databases for DArT markers and EST sequences, and links to a draft genome sequence for the wheat variety Chinese Spring. Conclusion CerealsDB is an open access website that is rapidly becoming an invaluable resource within the wheat research and plant breeding communities.
Impairment of IFN-Gamma Response to Synthetic Peptides of Mycobacterium tuberculosis in a 7-Day Whole Blood Assay
Hannah Priyadarshini Gideon, Melissa Shea Hamilton, Kathryn Wood, Dominique Pepper, Tolu Oni, Ronnett Seldon, Claire Banwell, Paul R. Langford, Robert J. Wilkinson, Katalin A. Wilkinson
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071351
Abstract: Studies on Mycobacterium tuberculosis (MTB) antigens are of interest in order to improve vaccine efficacy and to define biomarkers for diagnosis and treatment monitoring. The methodologies used for these investigations differ greatly between laboratories and discordant results are common. The IFN-gamma response to two well characterized MTB antigens ESAT-6 and CFP-10, in the form of recombinant proteins and synthetic peptides, was evaluated in HIV-1 uninfected persons in both long-term (7 day) and 24 hour, commercially available QuantiFERON TB Gold in Tube (QFT-GIT), whole blood assays. Our findings showed differences in the IFN-gamma response between 24 hour and 7 day cultures, with recombinant proteins inducing a significantly higher response than the peptide pools in 7 day whole blood assays. The activity of peptides and recombinant proteins did not differ in 24 hour whole blood or peripheral blood mononuclear cell (PBMC) based assays, nor in the ELISpot assay. Further analysis by SELDI-TOF mass spectrometry showed that the peptides are degraded over the course of 7 days of incubation in whole blood whilst the recombinant proteins remain intact. This study therefore demonstrates that screening antigenic candidates as synthetic peptides in long-term whole blood assays may underestimate immunogenicity.
Profiles of family-focused adverse experiences through childhood and early adolescence: The ROOTS project a community investigation of adolescent mental health
Valerie J Dunn, Rosemary A Abbott, Tim J Croudace, Paul Wilkinson, Peter B Jones, Joe Herbert, Ian M Goodyer
BMC Psychiatry , 2011, DOI: 10.1186/1471-244x-11-109
Abstract: Primary carers of 1143 randomly recruited 14-year olds in Cambridgeshire and Suffolk, UK were interviewed using the Cambridge Early Experiences Interview (CAMEEI) to assess family-focused adversities. Adversities were recorded retrospectively in three time periods (early and later childhood and early adolescence). Latent Class Analysis (LCA) grouped individuals into adversity classes for each time period and longitudinally. Adolescents were interviewed to generate lifetime DSM-IV diagnoses using the K-SADS-PL. The associations between adversity class and diagnoses were explored.LCA generated a 4-class model for each time period and longitudinally. In early childhood 69% were allocated to a low adversity class; a moderate adversity class (19%) showed elevated rates of family loss, mild or moderate family discord, financial difficulties, maternal psychiatric illness and higher risk for paternal atypical parenting; a severe class (6%) experienced higher rates on all indicators and almost exclusively accounted for incidents of child abuse; a fourth class, characterised by atypical parenting from both parents, accounted for the remaining 7%. Class membership was fairly stable (~ 55%) over time with escape from any adversity by 14 years being uncommon. Compared to those in the low class, the odds ratio for reported psychopathology in adolescents in the severe class ranged from 8 for disruptive behaviour disorders through to 4.8 for depressions and 2.0 for anxiety disorders. Only in the low adversity class did significantly more females than males report psychopathology.Family adversities in the early years occur as multiple rather than single experiences. Although some children escape adversity, for many this negative family environment persists over the first 15 years of life. Different profiles of family risk may be associated with specific mental disorders in young people. Sex differences in psychopathologies may be most pronounced in those exposed to low levels of fam
Salivary gland proteins of the human malaria vector, Anopheles dirus B (Diptera: Culicidae)
Jariyapan, Narissara;Choochote, Wej;Jitpakdi, Atchariya;Harnnoi, Thasaneeya;Siriyasatein, Padet;Wilkinson, Mark C.;Junkum, Anuluck;Bates, Paul A.;
Revista do Instituto de Medicina Tropical de S?o Paulo , 2007, DOI: 10.1590/S0036-46652007000100002
Abstract: salivary gland proteins of the human malaria vector, anopheles dirus b were determined and analyzed. the amount of salivary gland proteins in mosquitoes aged between 3 - 10 days was approximately 1.08 ± 0.04 μg/female and 0.1 ± 0.05 μg/male. the salivary glands of both sexes displayed the same morphological organization as that of other anopheline mosquitoes. in females, apyrase accumulated in the distal regions, whereas alpha-glucosidase was found in the proximal region of the lateral lobes. this differential distribution of the analyzed enzymes reflects specialization of different regions for sugar and blood feeding. sds-page analysis revealed that at least seven major proteins were found in the female salivary glands, of which each morphological region contained different major proteins. similar electrophoretic protein profiles were detected comparing unfed and blood-fed mosquitoes, suggesting that there is no specific protein induced by blood. two-dimensional polyacrylamide gel analysis showed the most abundant salivary gland protein, with a molecular mass of approximately 35 kilodaltons and an isoelectric point of approximately 4.0. these results provide basic information that would lead to further study on the role of salivary proteins of an. dirus b in disease transmission and hematophagy.
An examination of recovery planning for forest-dwelling woodland caribou (Rangifer tarandus caribou) in Ontario, Canada
Christopher J. A. Wilkinson
Rangifer , 2008,
Abstract: Ontario’s population of forest-dwelling woodland caribou is listed both federally and provincially as a species at risk. It is estimated that 20 000 woodland caribou remain in Ontario, of which approximately one quarter inhabit the boreal forest and are described as the sedentary forest-dwelling population. This paper examines the recovery strategy for this population developed by the Ministry of Natural Resources, as well as discussing the implications of provincial forestry policy on woodland caribou management. Commercial timber harvesting will likely soon be allowed in parts of the northern third of the province, in which woodland caribou habitat currently is relatively unimpaired by industrial development. Abstract in Norwegian / Sammendrag: Planlegging for bevaring av skogs kotypen av Rangifer tarandus caribou i Ontario, Canada Skogsvillreinen av skogs kotypen i Ontario er vurdert som s rbar b de f deralt og p provinsniv . Av provinsens rundt 20 000 skogsvillrein h rer omtrent en fjerdepart til den stasjon re skogsboende skogs koypen. Artikkelen ser p bevaringsstrategien som er utarbeidet av naturressursdepartementet i Ontario for denne spesielle bestanden og diskuterer konsekvensene for villreinen av provinsens skogpolitikk. Kommersiell hogst vil mest sannsynlig og snart bli tillatt i deler av Ontarios nordlige tredel der skogvillreinens leveomr der er relativt up virket av industriell virksomhet.
High dose rate (HDR) brachytherapy quality assurance: a practical guide
Wilkinson D.A.
Biomedical Imaging and Intervention Journal , 2006, DOI: 10.2349/biij.2.2.e34
The effects of cognitive-behavioural therapy on mood-related ruminative response style in depressed adolescents
Wilkinson Paul O,Goodyer Ian M
Child and Adolescent Psychiatry and Mental Health , 2008, DOI: 10.1186/1753-2000-2-3
Abstract: Background A mood-related ruminative response style increases the risk of onset and persistence of depression. This preliminary study investigated whether, in depressed adolescents, cognitive-behaviour therapy reduces mood-related ruminative response style. Whether specific factors within the rumination scale were differentially affected by CBT is also reported. Methods 26 depressed adolescents were randomised to receiving serotonin-specific reuptake inhibitor antidepressants (SSRI) plus psychosocial treatment as usual or SSRI and psychosocial treatment as usual plus CBT. Ruminative response style and depressive symptoms were measured at baseline and after 30 weeks of treatment, with the Responses to Depression Questionnaire and Mood and Feelings Questionnaire. Results There were significantly greater reductions in ruminations in the CBT group compared to the non-CBT group (p = .002). There was no significant difference in the reduction in self-reported depressive symptoms between the groups. Rumination was reduced to levels of never-depressed controls in adolescents who had recovered from depression and received CBT. There were greater falls in the CBT group in the more pathological 'brooding' factor of rumination. Conclusion These findings suggest that adding CBT to SSRI medication in the presence of active clinical care causes a greater reduction in mood-related ruminative response style in depressed adolescents. This may reduce the risk of future relapse. Trial registration Current Controlled Trials ISRCNT83809224.
Distribution of Oscillator Strengths for Recombination of Localised Excitons in Two Dimensions
Michael Wilkinson,Paul N. Walker,Kaumba Chinyama
Physics , 1996, DOI: 10.1016/S0960-0779(97)00014-3
Abstract: We investigate the distribution of oscillator strengths for the recombination of excitons in a two dimensional sample, trapped in local minima of the confinement potential: the results are derived from a statistical topographic model of the potential. The predicted distribution of oscillator strengths is very different from the Porter-Thomas disribution which usually characterises disordered systems, and is notable for the fact that small oscillator strengths are extremely rare.
Genome-Wide Analysis Reveals Loci Encoding Anti-Macrophage Factors in the Human Pathogen Burkholderia pseudomallei K96243
Andrea J. Dowling,Paul A. Wilkinson,Matthew T. G. Holden,Michael A. Quail,Stephen D. Bentley,Julia Reger,Nicholas R. Waterfield,Richard W. Titball,Richard H. ffrench-Constant
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0015693
Abstract: Burkholderia pseudomallei is an important human pathogen whose infection biology is still poorly understood. The bacterium is endemic to tropical regions, including South East Asia and Northern Australia, where it causes melioidosis, a serious disease associated with both high mortality and antibiotic resistance. B. pseudomallei is a Gram-negative facultative intracellular pathogen that is able to replicate in macrophages. However despite the critical nature of its interaction with macrophages, few anti-macrophage factors have been characterized to date. Here we perform a genome-wide gain of function screen of B. pseudomallei strain K96243 to identify loci encoding factors with anti-macrophage activity. We identify a total of 113 such loci scattered across both chromosomes, with positive gene clusters encoding transporters and secretion systems, enzymes/toxins, secondary metabolite, biofilm, adhesion and signal response related factors. Further phenotypic analysis of four of these regions shows that the encoded factors cause striking cellular phenotypes relevant to infection biology, including apoptosis, formation of actin ‘tails’ and multi-nucleation within treated macrophages. The detailed analysis of the remaining host of loci will facilitate genetic dissection of the interaction of this important pathogen with host macrophages and thus further elucidate this critical part of its infection cycle.
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