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Internet-Based Support and Coaching for Adolescents and Young Adults with Neuropsychiatric Disorders—The Implementation of an Intervention from an Organizational Perspective  [PDF]
Nanna Gillberg, Elisabet Wentz
Health (Health) , 2017, DOI: 10.4236/health.2017.91006
Abstract: There is a documented and often unmet need for interventions aimed at supporting young people with attention-deficit/hyperactivity disorder (ADHD) and/or autism spectrum disorder (ASD) in their transition between adolescence and adulthood. Difficulties with social interaction, initiation difficulties, and impairments in executive function can complicate visits at a clinic, i.e. traditional treatment, for individuals with neuropsychiatric disorders (NPD). A model for internet-based support and coaching aimed at young people with ASD and/or ADHD was developed and tested at three treatment sites in western Sweden. The implementation was analyzed against an inventory according to which implementations are more likely to be successful if an intervention: 1) has advantages compared to other existing methods, 2) matches the individual and organizational values, norms and work practices of its recipients, 3) is perceived as easy to use, and 4) is adaptable to local conditions and the recipients’ needs. Data were collected through group interviews with professionals involved in the implementation of the intervention. The implementation of the intervention showed promising results on measures such as access, delivery/quality of healthcare services, and equality of distribution of healthcare services. The identified impediments to successful implementation related to a wide range of factors and levels, including the design of the intervention, technical issues, attitudes of staff, organizational culture, and organizational structure at the implementation sites in terms of patient stock, work division, and resource allocation. The results are consistent with previous studies that stress the need for multi-component implementation strategies.
Feasibility of observing Hanbury Brown and Twiss phase
Tina Wentz,Prasenjit Saha
Physics , 2014, DOI: 10.1093/mnras/stu2206
Abstract: The interferometers of Hanbury Brown and collaborators in the 1950s and 60s, and their modern descendants now being developed (intensity interferometers) measure the spatial power spectrum of the source from intensity correlations at two points. The quantum optical theory of the Hanbury Brown and Twiss (HBT) effect shows that more is possible, in particular the phase information can be recovered by correlating intensities at three points (bispectrum). In this paper we argue that such 3 point measurements are possible for bright stars such as Sirius and Betelgeuse using off the shelf single photon counters with collecting areas of the order of 100m2. It seems possible to map individual features on the stellar surface. Simple diameter measurements would be possible with amateur class telescopes.
Experiences of rejection by mental health patients— A qualitative study  [PDF]
Bertil Lundberg, Pia Lundqvist, Lars Hansson, Elisabet Wentz, Bengt Sivberg
Health (Health) , 2013, DOI: 10.4236/health.2013.510211
Abstract:

Background and aim: People suffering from mental illness and their experiences of attitudes towards them are rarely investigated from the perspective of the individual. The aim was to gain an understanding of how a group of mental health patients experienced social relationships in personal settings as well as in society. Method: Open interviews with twenty-five mental health patients were conducted and analysed with a qualitative content analysis. Result: The essence of the result was that mental health patients’ experiences are still not taken enough into account, neither by mental health professionals nor by their social networks. This was underpinned by four core categories: Patients’ experience of deteriorated and reduced social contacts due to various degrees of acceptance and knowledge of people in general; service users reported on difficulties with social contacts in general, with family relationships, relationships with friends and workmates and with employers; reduced life opportunities were expressed, including violated self-image and poor coping competence and, ambivalent experiences of contact with the mental health services were reported. Conclusion and clinical implication: The present study contributes to the understanding of mental health patients’ experiences of professional services and of their social networks. This knowledge may strengthen the implications of patient-centred care essential for the outcome of the care.

The Role of miRNAs as Key Regulators in the Neoplastic Microenvironment
K. K. Wentz-Hunter,J. A. Potashkin
Molecular Biology International , 2011, DOI: 10.4061/2011/839872
Abstract: The neoplastic microenvironment has been recognized to play a critical role in the development of cancer. Although a large body of evidence has established the importance of the cancer microenvironment, the manners of crosstalk between it and the cancer cells still remains unclear. Emerging mechanisms of communication include microRNAs (miRNAs). miRNAs are small noncoding RNA molecules that are involved in the posttranscriptional regulation of mRNA. Both intracellular and circulating miRNAs are differentially expressed in cancer and some of these alterations have been correlated with clinical patient outcomes. The role of miRNAs in the tumor microenvironment has only recently become a focus of research, however. In this paper, we discuss the influence of miRNAs on the tumor microenvironment as it relates to cancer progression. We conclude that miRNAs are a critical component in understanding invasion and metastasis of cancer cells. 1. Introduction The belief that cancer cells are the sole dictators of their proliferative, invasive and migratory abilities has been revised. In its place is the view that the six hallmarks of cancer cells, namely self-sufficiency in growth signals, insensitivity to antigrowth signals and self-renewal, evasion of apoptosis, limitless replication potential, angiogenesis, invasion and metastasis, result from heterotypic signaling of cancer cells with its microenvironment [1]. Carcinoma progression and prognosis are dependent on the interaction of cancer epithelial cells with, and the recruitment of, tumor stroma, immune cells, and vascular networks as well as the alteration of the extracellular matrix [ECM] components (reviewed in [2–4]). How do cancer cells influence normal cells to abandon their homeostatic activities and instead support the neoplastic nature of the tumor? Obviously, there must be some method of communication between the cancer cells and their microenvironment. The dynamic crosstalk between cancer cells and normal cells in the microenvironment is a crucial point in the progression of disease. One manner of cell-cell communication is through the secretion of molecules and paracrine signaling. Molecules of secretion are no longer limited to cytokines, chemokines, growth factors, and other protein molecules but now include miRNA species. MiRNAs are pleiotropic regulators of gene expression that regulate various normal cellular processes as well as play a role in disease progression, especially cancer. Some intracellular and circulating miRNA species are dysregulated in cancer, leading to altered expression that
Teaching Sustainable Design Using BIM and Project-Based Energy Simulations
Zhigang Shen,Wayne Jensen,Timothy Wentz,Bruce Fischer
Education Sciences , 2012, DOI: 10.3390/educsci2030136
Abstract: The cross-disciplinary nature of energy-efficient building design has created many challenges for architecture, engineering and construction instructors. One of the technical challenges in teaching sustainable building design is enabling students to quantitatively understand how different building designs affect a building’s energy performance. Concept based instructional methods fall short in evaluating the impact of different design choices on a buildings’ energy consumption. Building Information Modeling (BIM) with energy performance software provides a feasible tool to evaluate building design parameters. One notable advantage of this tool is its ability to couple 3D visualization of the structure with energy performance analysis without requiring detailed mathematical and thermodynamic calculations. Project-based Learning (PBL) utilizing BIM tools coupled with energy analysis software was incorporated into a senior level undergraduate class. Student perceptions and feedback were analyzed to gauge the effectiveness of these techniques as instructional tools. The findings indicated that BIM-PBL can be used to effectively teach energy-efficient building design and construction.
Systematic review of prognostic models in traumatic brain injury
Pablo Perel, Phil Edwards, Reinhard Wentz, Ian Roberts
BMC Medical Informatics and Decision Making , 2006, DOI: 10.1186/1472-6947-6-38
Abstract: Studies that combine at least two variables to predict any outcome in patients with TBI were searched in PUBMED and EMBASE. Two reviewers independently examined titles, abstracts and assessed whether each met the pre-defined inclusion criteria.A total of 53 reports including 102 models were identified. Almost half (47%) were derived from adult patients. Three quarters of the models included less than 500 patients. Most of the models (93%) were from high income countries populations. Logistic regression was the most common analytical strategy to derived models (47%). In relation to the quality of the derivation models (n:66), only 15% reported less than 10% pf loss to follow-up, 68% did not justify the rationale to include the predictors, 11% conducted an external validation and only 19% of the logistic models presented the results in a clinically user-friendly wayPrognostic models are frequently published but they are developed from small samples of patients, their methodological quality is poor and they are rarely validated on external populations. Furthermore, they are not clinically practical as they are not presented to physicians in a user-friendly way. Finally because only a few are developed using populations from low and middle income countries, where most of trauma occurs, the generalizability to these setting is limited.Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Every year, an estimated 1.5 million people die and hundreds of millions require emergency treatment after a TBI. Fatality rates and disability rates vary depending on the severity and mechanisms of the TBI but unfavourable outcomes (death, vegetative state and severe disability) following TBI can be higher than 20%[1,2].Physicians routinely make diagnostic and therapeutic decisions based on the patient's prognosis. Furthermore, prognostic information is also important in the counselling of patients and relatives in this critical scenario. Nevertheless in gen
Gauging differential health among the sexes at Windover (8Br246) using the Western Hemisphere Health Index
Wentz, Rachel K;Tucker, Bryan;Krigbaum, John;Doran, Glen H;
Memórias do Instituto Oswaldo Cruz , 2006, DOI: 10.1590/S0074-02762006001000014
Abstract: assessment of intrapopulation human health provides information concerning social structure, division of labor, and lifestyle. differential health among the sexes can provide clues to social roles, resource acquisition and status within prehistoric populations. windover (8br246) is an archaic mortuary pond located in eastern central florida. its occupation spans over 500 years and dates to 7000 years bp. over 168 well-preserved individuals were excavated, providing a glimpse into life during florida's archaic. through the application of the western hemisphere health index, we find that males within the group experienced better overall health than females. males outscore females in quality of life, percent of maximum scores, stature, anemia, dental disease, and infection. females out-score males in enamel hypoplasia and degenerative joint disease. causative factors for observed differential health are examined and include activity levels, sexual division of labor, access to resources, and the physiological demands of childbearing.
Neuroendocrine and squamous colonic composite carcinoma: Case report with molecular analysis
Sabrina C Wentz,Cindy Vnencak-Jones,William V Chopp
World Journal of Gastroenterology , 2011, DOI: 10.3748/wjg.v17.i42.4729
Abstract: Composite colorectal carcinomas are rare. There are a modest number of cases in the medical literature, with even fewer cases describing composite carcinoma with neuroendocrine and squamous components. There are to our knowledge no reports of composite carcinoma molecular alterations. We present a case of composite carcinoma of the splenic flexure in a 33 year-old Caucasian male to investigate the presence and prognostic significance of molecular alterations in rare colonic carcinoma subtypes. Formalin-fixed paraffin-embedded (FFPE) tissue was hematoxylin and eosin- and mucicarmine-stained according to protocol, and immuno-stained with cytokeratin (CK)7, CK20, CDX2, AE1/AE3, chromogranin-A and synaptophysin. DNA was extracted from FFPE tissues and molecular analyses were performed according to lab-developed methods, followed by capillary electrophoresis. Hematoxylin and eosin staining showed admixed neuroendocrine and keratinized squamous cells. Positive nuclear CDX2 expression confirmed intestinal derivation. CK7 and CK20 were negative. Neuroendocrine cells stained positively for synaptophysin and AE1/AE3 and negatively for chromogranin and mucicarmine. Hepatic metastases showed a similar immunohistochemical profile. Molecular analysis revealed a G13D KRAS mutation. BRAF mutational testing was negative and microsatellite instability was not detected. The patient had rapid disease progression on chemotherapy and died 60 d after presentation. Although the G13D KRAS mutation normally predicts an intermediate outcome, the aggressive tumor behavior suggests other modifying factors in rare types of colonic carcinomas.
Influência da infus o transcervical de plasma seminal ou de estrógeno na concep o, no ciclo estral e na ovula o de porcas
Stahlberg R.,Bortolozzo F.P.,Wentz I.,Nagae R.
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2001,
Abstract: O objetivo deste trabalho foi o de avaliar o desempenho reprodutivo de 211 porcas da linhagem Camborough 22a , de diferentes ordens de parto, submetidas à infus o transcervical de plasma seminal ou de estrógeno no início do estro. Após o desmame, elas foram examinadas duas vezes ao dia para a detec o do estro, na presen a de um macho sexualmente maduro, e da ovula o, com auxílio da ultra-sonografia transcutanea. No início do estro as fêmeas receberam aleatoriamente uma infus o transcervical de plasma seminal, de estrógeno ou permaneceram como grupo-controle. Todas as fêmeas foram inseminadas no turno seguinte à detec o do estro, recebendo no máximo três insemina es com intervalos de 8 a 16h. No grupo-controle as fêmeas de primeiro parto ovularam mais precocemente que as fêmeas com maior número de partos (P<0,05). Os tratamentos n o influenciaram a dura o do estro e o momento da ovula o. O número total de leit es nascidos n o diferiu entre os tratamentos.
A hipertermia durante o estro pode afetar o desempenho reprodutivo de fêmeas suínas
Wentz Ivo,Bortolozzo Fernando Pandolfo,Brandt Guilherme,Heck Augusto
Ciência Rural , 2001,
Abstract: O objetivo deste estudo foi avaliar o efeito da hipertermia no dia da insemina o artificial (IA) até o 13o dia de gesta o, sobre o desempenho reprodutivo de leitoas e porcas. No experimento 1, as 488 fêmeas foram divididas em dois grupos de acordo com a temperatura retal no dia da primeira insemina o artificial (IA), respectivamente, G1 = £39,5oC (normotermia) e G2 = >39,5oC (hipertermia). As fêmeas com hipertermia apresentaram taxas de retorno ao estro (TRE) maiores e taxas de parto (TP) e tamanho de leitegada (TL) menores (p<0,05), quando comparadas às fêmeas com normotermia. No experimento 2, as 764 fêmeas foram classificadas em quatro grupos, respectivamente, G1 = hipertermia no dia da IA; G2 = hipertermia em um dos primeiros 4 dias após a IA; G3 = hipertermia em pelo menos um dia nos dois períodos anteriores e G4 = hipertermia do 10o ao 13o dia de gesta o. Fêmeas com hipertermia no dia da primeira IA e no período inicial de gesta o apresentaram maior TRE e menor TP no G1 e G2 (p£ 0,01) e o TL foi menor (p<0,01) nos grupos G1, G2 e G3, quando comparado às fêmeas com normotermia. Na fase de liga o embrio-maternal (G4), n o foram observadas diferen as entre as fêmeas com normotermia e hipertermia. O experimento 3, no qual foram acompanhadas 102 leitoas, das quais 88 foram abatidas aos 29-34 dias de gesta o, mostrou uma maior taxa de retorno ao estro (TRE) (p£ 0,01) e menor taxa de prenhez (TPr) (p£ 0,05), além de um menor número médio de embri es viáveis (NEV) e menor taxa de sobrevivência embrionária (SE) (p<0,05), nas leitoas com hipertermia. Com base nesses resultados, pode-se concluir que fêmeas com hipertermia no dia da IA e nos primeiros quatro dias após, podem apresentar prejuízos para o desempenho reprodutivo.
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