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Search Results: 1 - 10 of 16486 matches for " Wenhui Qi "
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Orbital Stability of Solitary Waves for Generalized Klein-Gordon-Schrodinger Equations  [PDF]
Wenhui Qi, Guoguang Lin
Applied Mathematics (AM) , 2011, DOI: 10.4236/am.2011.28139
Abstract: This paper concerns the orbital stability for exact solitary waves of the Generalized Klein-Gordon-Schrod-inger equations. Since the abstract results of Grillakis et al[1-2] can not be applied directly, we can extend the abstract stability theory and use the detailed spectral analysis to obtain the stability of the solitary waves.
Cooperative Advertising in a Two-Stage Supply Chain with Network Externalities  [PDF]
Wenhui Li
American Journal of Industrial and Business Management (AJIBM) , 2019, DOI: 10.4236/ajibm.2019.94069
A two-stage game is developed with network externalities where, besides pricing decisions, the retailer and manufacturer can determine their advertising investments and advertising participation rates for each stage. In addition to the full cooperation advertising model, three part cooperation advertising models are established. We develop propositions and insights from the comparison of these models. Our main findings are as follows: 1) the equilibrium solutions critically depend on the effects of network externalities; 2) the optimal choice in a two-stage game is to achieve full cooperation; and 3) a second-best choice for the manufacturer is to share the retailer’s advertising in the first stage. Our research results have guiding significance for supply chain member’s decision-making in local advertising practice.
ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion
Hailing Li, Wenhui Peng, Weixia Jian, Yuanmin Li, Qi Li, Weiming Li, Yawei Xu
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-65
Abstract: HUVECs were stimulated with high glucose (HG) or HG?+?fasudil in different concentration or different time. Monocyte-endothelial cell adhesion was determined using fluorescence-labeled monocytes. The mRNA and protein expression of VCAM-1 and MCP-1 were measured using real-time PCR and western blot. The protein levels of RhoA, ROCKI and p-MYPT were determined using western blot analysis. ELISA was employed to measure the expression of soluble VCAM-1 and MCP-1 in cell supernatants and human serum samples.Fasudil significantly suppressed HG-induced adhesion of THP-1 to HUVECs. Fasudil reduced Rho/ROCK activity (as indicated by lower p-MYPT/MYPT ratio), and prevented HG induced increases in VCAM-1 and MCP-1 mRNA and protein levels. Fasudil also decreased MCP-1 concentration in HUVEC supernatants, but increased sVCAM-1 shedding into the media. In human diabetic subjects, 2?weeks of fasudil treatment significantly decreased serum MCP-1 level from 27.9?±?10.6?pg/ml to 13.8?±?7.0?pg/ml (P?<?0.05), while sVCAM-1 increased from 23.2?±?7.5?ng/ml to 39.7?±?5.6?ng/ml after fasudil treatment (P?<?0.05).Treatment with the Rho/ROCK pathway inhibitor fasudil attenuated HG-induced monocyte-endothelial cell adhesion, possibly by reducing endothelial expression of VCAM-1 and MCP-1. These results suggest inhibition of Rho/ROCK signaling may have therapeutic potential in preventing diabetes associated vascular inflammation and atherogenesis.Macrovascular complications including atherosclerosis are the leading causes of morbidity and mortality in patients with diabetes mellitus [1]. The underlying mechanisms of vascular impairment in diabetes are not precisely defined. A potential contribution to atherogenesis in diabetes is increased adhesion of circulating monocytes to the vessel wall, which is believed to be exacerbated by hyperglycemia. Transmigration of monocytes into the subendothelial space and subsequent transformation into macrophage-derived foam cells are key events in atherogen
Stochastic Finite Element for Structural Vibration
Mo Wenhui
Mathematical Problems in Engineering , 2010, DOI: 10.1155/2010/584863
Abstract: This paper proposes a new method of calculating stochastic field. It is an improvement of the midpoint method of stochastic field. The vibration equation of a system is transformed to a static problem by using the Newmark method and the Taylor expansion is extended for the structural vibration analysis with uncertain factors. In order to develop computational efficiency and allow for efficient storage, the Conjugate Gradient method (CG) is also employed. An example is given, respectively, and calculated results are compared to validate the proposed methods.
Control of Free-floating Space Robotic Manipulators base on Neural Network
Zhang Wenhui
International Journal of Computer Science Issues , 2012,
Abstract: For problems of trajectory tracking of the free-floating space robot model with uncertainties in task space, neural networks adaptive control strategy is put forward by this paper. Because the non-linear system model can not be obtained accurately, neural network is used to directly identify all parts of the system parameters through GL matrix and its multiplication operator ".". Robust controller is designed to eliminate the approximation errors of neural network and external disturbances. The control strategy neither requires an estimate of inverse dynamic model, nor calculates the inverse Jacobin matrix. Global asymptotic stability based on Lyapunov theory is proved by the paper. Simulation results show that higher control precision is achieved. The control strategy has great value in engineering applications.
Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism
Qian Zhang,Xinhua Xiao,Kai Feng,Tong Wang,Wenhui Li,Tao Yuan,Xiaofang Sun,Qi Sun,Hongding Xiang,Heng Wang
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/924851
Abstract: Berberine is known to improve glucose and lipid metabolism disorders, but the mechanism is still under investigation. In this paper, we explored the effects of berberine on the weight, glucose levels, lipid metabolism, and serum insulin of KKAy mice and investigated its possible glucose and lipid-regulating mechanism. We randomly divided KKAy mice into two groups: berberine group (treated with 250 mg/kg/d berberine) and control group. Fasting blood glucose (FBG), weight, total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c), and fasting serum insulin were measured in both groups. The oral glucose tolerance test (OGTT) was performed. RT2 PCR array gene expression analysis was performed using skeletal muscle of KKAy mice. Our data demonstrated that berberine significantly decreased FBG, area under the curve (AUC), fasting serum insulin (FINS), homeostasis model assessment insulin resistance (HOMA-IR) index, TC, and TG, compared with those of control group. RT2 profiler PCR array analysis showed that berberine upregulated the expression of glucose transporter 4 (GLUT4), mitogen-activated protein kinase 14 (MAPK14), MAPK8(c-jun N-terminal kinase, JNK), peroxisome proliferator-activated receptor (PPAR), uncoupling protein 2 (UCP2), and hepatic nuclear factor 4(HNF4), whereas it downregulated the expression of PPAR, CCAAT/enhancer-binding protein (CEBP), PPAR coactivator 1(PGC 1), and resistin. These results suggest that berberine moderates glucose and lipid metabolism through a multipathway mechanism that includes AMP-activated protein kinase-(AMPK-) p38 MAPK-GLUT4, JNK pathway, and PPAR pathway.
Neo-sex chromosomes in the black muntjac recapitulate incipient evolution of mammalian sex chromosomes
Qi Zhou, Jun Wang, Ling Huang, Wenhui Nie, Jinhuan Wang, Yan Liu, Xiangyi Zhao, Fengtang Yang, Wen Wang
Genome Biology , 2008, DOI: 10.1186/gb-2008-9-6-r98
Abstract: We studied the intriguing case of black muntjac, in which a recent X-autosome fusion and a subsequent large autosomal inversion within just the past 0.5 million years have led to inheritance patterns identical to the traditional X-Y (neo-sex chromosomes). We compared patterns of genome evolution in 35-kilobase noncoding regions and 23 gene pairs on the homologous neo-sex chromosomes. We found that neo-Y alleles have accumulated more mutations, comprising a wide variety of mutation types, which indicates cessation of recombination and is consistent with an ongoing neo-Y degeneration process. Putative deleterious mutations were observed in coding regions of eight investigated genes as well as cis-regulatory regions of two housekeeping genes. In vivo assays characterized a neo-Y insertion in the promoter of the CLTC gene that causes a significant reduction in allelic expression. A neo-Y-linked deletion in the 3'-untranslated region of gene SNX22 abolished a microRNA target site. Finally, expression analyses revealed complex patterns of expression divergence between neo-Y and neo-X alleles.The nascent neo-sex chromosome system of black muntjacs is a valuable model in which to study the evolution of sex chromosomes in mammals. Our results illustrate the degeneration scenarios in various genomic regions. Of particular importance, we report - for the first time - that regulatory mutations were probably able to accelerate the degeneration process of Y and contribute to further evolution of dosage compensation.It is believed that in human and other eutherian mammals, the heteromorphic sex chromosomes evolved from a pair of ordinary autosomes between 166 and 148 million years ago [1-4]. After the birth of the sex-determining gene, extensive recombination suppression evolved between proto-X and proto-Y to prevent the sexual reversal along the entirety of the chromosome pair, with the exception of a short 'pseudoautosomal region' (PAR) [5]. Theoretical models predict that proto
Chromosome 9p21.3 polymorphism in a Chinese Han population is associated with angiographic coronary plaque progression in non-diabetic but not in type 2 diabetic patients
Wei Wang, Wenhui Peng, Xianling Zhang, Lin Lu, Ruiyan Zhang, Qi Zhang, Lingjie Wang, Qiujing Chen, Weifeng Shen
Cardiovascular Diabetology , 2010, DOI: 10.1186/1475-2840-9-33
Abstract: Genotyping and quantitative coronary angiography (QCA) were performed in 2046 Chinese Han patients (1012 diabetic cases) undergoing coronary angiography; 430 of them received repeat angiographic studies at 1-year follow-up.CC genotype at rs1333049 on chromosome 9p21.3 was associated with CAD (unadjusted OR 1.524, p = 0.001 and adjusted OR 1.859, p = 0.005, respectively). However, CC genotype had no magnified association with CAD in diabetic patients (OR 1.275, p = 0.150) compared with non-diabetic counterparts (OR 1.446, p = 0.020) after adjusting for conventional risk factors. During angiographic follow-up, non-diabetic patients (n = 280) had significant decrease in minimal lumen diameter and increase in percent diameter stenosis among the three genotypes (p = 0.005 and p = 0.038, respectively), demonstrating that CC or GC genotype carriers had a more severe plaque progression than GG genotype carriers. In patients with type 2 diabetes (n = 150), although plaque progression was more severe than that in non-diabetic counterparts, no relations existed between plaque progression and genotypes. Rs1333049 was an independent determinant of plaque progression for non-diabetic (OR 3.468, p = 0.004 and OR 4.339, p = 0.002 for GC and CC genotype, respectively) but not for diabetic patients (OR 0.529, p = 0.077 and 0R 0.878, p = 0.644 for GC and CC genotype, respectively).This study demonstrates a significant association of homozygous CC genotype of rs1333049 on chromosome 9p21.3 with CAD in Chinese Han population. Rs1333049 polymorphism is an independent determinant for coronary plaque progression in non-diabetic but not in type 2 diabetic patients.Recent genome-wide scanning has implicated chromosome 9p21.3 as a novel locus conferring susceptibility to coronary artery disease (CAD), myocardial infarction and cardiac death [1-5], which is independent of traditional risk factors including gender, age, obesity, smoking, hypertension and hyperlipidemia [6,7]. Several studies sh
Hepatitis D Virus Infection of Mice Expressing Human Sodium Taurocholate Co-transporting Polypeptide
Wenhui He?,Bijie Ren?,Fengfeng Mao?,Zhiyi Jing?,Yunfei Li?,Yang Liu?,Bo Peng?,Huan Yan?,Yonghe Qi,Yinyan Sun
PLOS Pathogens , 2015, DOI: 10.1371/journal.ppat.1004840
Abstract: Hepatitis D virus (HDV) is the smallest virus known to infect human. About 15 million people worldwide are infected by HDV among those 240 million infected by its helper hepatitis B virus (HBV). Viral hepatitis D is considered as one of the most severe forms of human viral hepatitis. No specific antivirals are currently available to treat HDV infection and antivirals against HBV do not ameliorate hepatitis D. Liver sodium taurocholate co-transporting polypeptide (NTCP) was recently identified as a common entry receptor for HDV and HBV in cell cultures. Here we show HDV can infect mice expressing human NTCP (hNTCP-Tg). Antibodies against critical regions of HBV envelope proteins blocked HDV infection in the hNTCP-Tg mice. The infection was acute yet HDV genome replication occurred efficiently, evident by the presence of antigenome RNA and edited RNA species specifying large delta antigen in the livers of infected mice. The resolution of HDV infection appears not dependent on adaptive immune response, but might be facilitated by innate immunity. Liver RNA-seq analyses of HDV infected hNTCP-Tg and type I interferon receptor 1 (IFNα/βR1) null hNTCP-Tg mice indicated that in addition to induction of type I IFN response, HDV infection was also associated with up-regulation of novel cellular genes that may modulate HDV infection. Our work has thus proved the concept that NTCP is a functional receptor for HDV infection in vivo and established a convenient small animal model for investigation of HDV pathogenesis and evaluation of antiviral therapeutics against the early steps of infection for this important human pathogen.
The Clinical Anatomy of the Cavernous Sinus  [PDF]
Pengfei Zhang, Huanjiu Xi, Wenhui Li
Forensic Medicine and Anatomy Research (FMAR) , 2015, DOI: 10.4236/fmar.2015.32012
Abstract: Introduction: The cavernous sinus (CS) is a very important concept because it is not only interesting to anatomical theory but also useful to clinical medicine, especially in the field of surgery. This paper described the microsurgical anatomy of the CS with special attention to its concept that the CS was really venous sinus or plexus. Materials and Methods: Fifty CSs from 25 Chinese adult cadaver heads fixed in 10% methanal, whose artery and vein were injected with red and blue latex, respectively, dissected stepwise under the operating microscope. Results: Asymmetric and nonintegral blue latex distributed in the cavity of the CS to form a retina with various diameters and repeatedly diverged and converged were observed under the surgical microscope with magnification 5 - 25, after the lateral wall of the CS was opened by maxillary approach. Measurement of sinus included length, diameter and triangular structure of the CS. It is very important to understand the microsurgical anatomy of the CS for neurosurgeons. Conclusion: The CS was venous plexus rather than sinus. The lateral wall of the sinus had two layers, and the lateral cavity of the sinus really did exist even though it was very small. The triangles where maxillary approach passed were more important for neurosurgeons.
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