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Search Results: 1 - 10 of 1057 matches for " Weil AJ "
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High molecular weight hyaluronan for treatment of chronic shoulder pain associated with glenohumeral arthritis
Weil AJ
Medical Devices: Evidence and Research , 2011, DOI: http://dx.doi.org/10.2147/MDER.S22423
Abstract: h molecular weight hyaluronan for treatment of chronic shoulder pain associated with glenohumeral arthritis Original Research (2226) Total Article Views Authors: Weil AJ Published Date July 2011 Volume 2011:4 Pages 99 - 105 DOI: http://dx.doi.org/10.2147/MDER.S22423 Arnold J Weil Non-Surgical Orthopedics PC, Marietta, GA, USA Background: There is insufficient evidence to determine whether intra-articular injections may be effective for treatment of glenohumeral osteoarthritis. Euflexxa (high molecular weight hyaluronate), a bioengineered high molecular weight hyaluronan, has been shown to be a safe and effective treatment for patients with knee osteoarthritis. There is also support for the use of hyaluronate injection for the treatment of chronic shoulder pain associated with osteoarthritis or rotator cuff damage. This small-scale exploratory study was conducted to evaluate the safety and efficacy of high molecular weight hyaluronate for the treatment of chronic shoulder pain associated with osteoarthritis. Methods: Subjects with glenohumeral osteoarthritis and chronic pain (n = 27) received one injection per week for 3 weeks of high molecular weight hyaluronate and were assessed for changes in pain (100 mm visual analog scale [VAS]), range of motion, and the subject’s and physician’s global assessment over 26 weeks. Subjects were also assessed for pain, stiffness, and physical functioning using the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Finally, responses were evaluated using modified Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT)-Osteoarthritis Research Society International (OARSI) Proposition D criteria. Safety was assessed by recording adverse events. Results: High molecular weight hyaluronate significantly improved pain (VAS, WOMAC), range of motion, stiffness, and physical functioning scores; 77.8% of subjects were rated as having an OMERACT-OARSI Proposition D high response. There were no serious adverse events, and none were considered to be related to treatment. Conclusion: Treatment with high molecular weight hyaluronate improves pain, stiffness, and range of motion, and may have an acceptable safety and tolerability profile. A randomized, double-blind, placebo-controlled clinical trial may be warranted to investigate further the efficacy and safety of intra-articular high molecular weight hyaluronate for treatment of chronic shoulder pain in patients with glenohumeral osteoarthritis.
High molecular weight hyaluronan for treatment of chronic shoulder pain associated with glenohumeral arthritis
Weil AJ
Medical Devices: Evidence and Research , 2011,
Abstract: Arnold J WeilNon-Surgical Orthopedics PC, Marietta, GA, USABackground: There is insufficient evidence to determine whether intra-articular injections may be effective for treatment of glenohumeral osteoarthritis. Euflexxa (high molecular weight hyaluronate), a bioengineered high molecular weight hyaluronan, has been shown to be a safe and effective treatment for patients with knee osteoarthritis. There is also support for the use of hyaluronate injection for the treatment of chronic shoulder pain associated with osteoarthritis or rotator cuff damage. This small-scale exploratory study was conducted to evaluate the safety and efficacy of high molecular weight hyaluronate for the treatment of chronic shoulder pain associated with osteoarthritis.Methods: Subjects with glenohumeral osteoarthritis and chronic pain (n = 27) received one injection per week for 3 weeks of high molecular weight hyaluronate and were assessed for changes in pain (100 mm visual analog scale [VAS]), range of motion, and the subject’s and physician’s global assessment over 26 weeks. Subjects were also assessed for pain, stiffness, and physical functioning using the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Finally, responses were evaluated using modified Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT)-Osteoarthritis Research Society International (OARSI) Proposition D criteria. Safety was assessed by recording adverse events.Results: High molecular weight hyaluronate significantly improved pain (VAS, WOMAC), range of motion, stiffness, and physical functioning scores; 77.8% of subjects were rated as having an OMERACT-OARSI Proposition D high response. There were no serious adverse events, and none were considered to be related to treatment.Conclusion: Treatment with high molecular weight hyaluronate improves pain, stiffness, and range of motion, and may have an acceptable safety and tolerability profile. A randomized, double-blind, placebo-controlled clinical trial may be warranted to investigate further the efficacy and safety of intra-articular high molecular weight hyaluronate for treatment of chronic shoulder pain in patients with glenohumeral osteoarthritis.Keywords: Euflexxa , hyaluronan, osteoarthritis, pain, range of motion, shoulder
Glioblastoma Multiforme-Treating a Deadly Tumor with Both Strands of RNA.
Weil
PLOS Medicine , 2005,
Abstract:
Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data
Sabine Fredersdorf, Christian Thumann, Wolfram H Zimmermann, Roland Vetter, Tobias Graf, Andreas Luchner, Günter AJ Riegger, Heribert Schunkert, Thomas Eschenhagen, Joachim Weil
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-57
Abstract: Zucker Diabetic Fatty rats treated with or without insulin (ZDF?±?Ins, n?=?13) and lean littermates (controls, n?=?7) were sacrificed at the age of 19?weeks. ZDF?+?Ins (n?=?6) were treated with insulin for the last 6?weeks of life. Gene expression of Ca2+ ATPase in the cardiac sarcoplasmatic reticulum (SERCA2a, further abbreviated as SERCA) and phospholamban (PLB) were determined by northern blotting. Ca2+ transport of the sarcoplasmatic reticulum (SR) was assessed by oxalate-facilitated 45Ca-uptake in left ventricular homogenates. In addition, isolated neonatal cardiomyocytes were stimulated in cell culture with insulin, glucose or triiodthyronine (T3, positive control). mRNA expression of SERCA and PLB were measured by Taqman PCR. Furthermore, effects of insulin treatment on force of contraction and relaxation were evaluated by cardiomyocytes grown in a three-dimensional collagen matrix (engineered heart tissue, EHT) stimulated for 5?days by insulin. By western blot phosphorylations status of Akt was determed and the influence of wortmannin.SERCA levels increased in both ZDF and ZDF?+?Ins compared to control (control 100?±?6.2 vs. ZDF 152?±?26.6* vs. ZDF?+?Ins 212?±?18.5*# % of control, *p?<?0.05 vs. control, #p?<?0.05 vs. ZDF) whereas PLB was significantly decreased in ZDF and ZDF?+?Ins (control 100?±?2.8 vs. ZDF 76.3?±?13.5* vs. ZDF?+?Ins 79.4?±?12.9* % of control, *p?<?0.05 vs control). The increase in the SERCA/PLB ratio in ZDF and ZDF?±?Ins was accompanied by enhanced Ca2+ uptake to the SR (control 1.58?±?0.1 vs. ZDF 1.85?±?0.06* vs. ZDF?+?Ins 2.03?±?0.1* μg/mg/min, *p?<?0.05 vs. control). Interestingly, there was a significant correlation between Ca2+ uptake and SERCA2a expression. As shown by in-vitro experiments, the effect of insulin on SERCA2a mRNA expression seemed to have a direct effect on cardiomyocytes. Furthermore, long-term treatment of engineered heart tissue with insulin increased the SERCA/PLB ratio and accelerated relaxation time. Akt was sign
Partial pressure of end-tidal carbon dioxide predicts successful cardiopulmonary resuscitation in the field
Max Weil
Critical Care , 2008, DOI: 10.1186/cc7090
Abstract: In their report on 737 patients who sustained out-of-hospital cardiac arrest, collected over an interval of 9 years in a well-organized emergency medical system, Kolar and colleagues confirmed that the measurement of end-tidal carbon dioxide tension (PetCO2) is predictive of the outcomes of cardiopulmonary resuscitation [1]. The authors provide impressive data supporting the conclusion that, in their population, failure to increase PetCO2 to levels exceeding 14 mmHg (1.5 kPa) after 20 minutes of attempted resuscitation served as a reliable guide for terminating unsuccessful cardiopulmonary resuscitation. The population studied, however, differed in some respects from the majority of earlier demographic reports that the authors cited with hospital survival <3%. More than 53% survived. The majority of instances of cardiac arrest reported by them was witnessed, and as many as one-third of victims received bystander cardiopulmonary resuscitation – favoring improved outcomes. Fatal outcomes, as anticipated, were associated with a doubling of the response time of professional rescuers, presumably in the absence of bystander utilization of automated external defibrillators, especially since a majority of survivors had shockable ventricular fibrillation or ventricular tachycardia.As the authors pinpoint, PetCO2 has evolved into a technically facile and singularly useful monitor to guide cardiopulmonary resuscitation. PetCO2 provides an indirect measurement of the cardiac output generated by chest compression and thereby guides the effectiveness of the procedure, including chest compression, to achieve better outcomes. It also allows uninterrupted chest compression because it promptly signals the return of spontaneous circulation [2]. PetCO2 is likely to promptly identify asphyxia, in contrast to primary cardiac causes of arrest as previously reported by one of the present authors [3]. PetCO2 measurement during cardiopulmonary resuscitation may not require routine endotrache
A normose informacional
Weil, Pierre;
Ciência da Informa??o , 2000, DOI: 10.1590/S0100-19652000000200008
Abstract: although recognizing the great contribution computer science has been giving to the humanity, the author calls the public'c attention to pathological and lethat aspects of some applications by several technologies. the author argues that there is something that he calls informational normosis which shows up under two forms: informatosis and cibernosis. after having defined the criteria of diagnosis of a normesis he demonstrates with several concrete examples these pathological and lethal aspects of computer science and suggests what he calls normotherapy.
Diversidad y abundancia relativa de corales, octocorales y esponjas en el Parque Nacional Jaragua, República Dominicana
Weil,Ernesto;
Revista de Biología Tropical , 2006,
Abstract: diversity and relative abundance of corals, octocorals and sponges at jaragua national park, dominican republic. the jaragua national park is located in a remote area to the sw coast of the dominican republic. fishing and mining are the major human activities. the main reef formations of the park include: (a) long bank reefs (spur and groove) growing as bands over the platform and running in a sw-nw direction at 12-25 m depth, (b) well developed, deep, fringing reefs at the platform edge (drop-off) areas which could extend from 10 to 45 m depth, and (c) small patch reefs and poorly developed coral-octocoral-sponge-algal communities in shallow platforms near shore, rocky bottoms, and over the submerged walls of the uplifted reef. nine reef localities were surveyed between cabo beata and bahia honda using scuba diving to inventory the diversity and relative abundance of scleractinian corals, octocorals and sponges. fringing reefs were surveyed starting at the bottom (30 m) and swimming in a zig-zag pattern (50 m on each side) to shallower areas. bank reefs were surveyed by swimming in zig-zag across the spur-groove formation along 500 m. sponges were the most diverse group with 83 species in 50 genera followed by the scleractinian corals with 56 species in 26 genera and the octocorals with 47 species in 15 genera. new records included eight coral species, 29 octocoral species and 59 sponges. the diversity, species composition and abundance of particular groups varied across the different localities. northern reefs within the park and the los frailes island offshore had the highest live cover, relative abundance and diversity for the three groups. in general, the jaragua national park had the highest diversity of corals, octocorals and sponges reported for the dominican republic and rank amongst the highest reported for the northern caribbean. it is recommended that the area be protected and that fishing activities be regulated or eliminated altogether. rev. biol. trop
[Cu2(HF2)(H2O)8][AlF6]·2H2O
Matthias Weil
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809009702
Abstract: The title compound, octaaqua(hydrogendifluorido)dicopper(II) hexafluoridoaluminate dihydrate, was obtained under hydrothermal conditions. The structure is isotypic with that of the analogous FeIII compound, [Cu2(HF2)(H2O)8][FeF6]·2H2O. The coordination sphere of the CuII atom is formed by one F and three water O atoms at short distances < 2 and is augmented by two additional water O atoms at significantly longer distances, leading to a considerably distorted octahedral environment. By edge-sharing, these octahedra form dimeric [Cu2(HF2)(H2O)8]3+ units that are bonded to [AlF6]3 anions (overline{1} symmetry) and to crystal lattice water molecules via hydrogen bonds. Besides F—H...F interactions between the dimeric cationic units, O—H...F and O—H...O hydrogen bonds (both in part bifurcated) are observed.
The cyclo-tetraphosphate Cd2P4O12, a member of the isotypic series M2P4O12 (M = Mg, Mn, Fe, Co, Ni, Cu)
Matthias Weil
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810040195
Abstract: The title compound, Cd2P4O12, dicadmium cyclo-tetraphosphate, crystallizes isotypically with the members of the series MII2P4O12, where M = Mg, Mn, Fe, Co, Ni or Cu. Two CdO6 octahedra, one with 2 and one with overline{1} symmetry, share corners with the centrosymmetric P4O124 ring anion that is built up from four corner-sharing PO4 tetrahedra. The isolated ring anions are arranged in layers parallel to (10overline{1}) with the CdO6 octahedra situated between these layers. The main difference between the individual MII2P4O12 structures pertains to the different sizes of the MO6 octahedra whereas the geometric parameters of all cyclo-P4O124 anions are very similar.
NaSr(AsO4)(H2O)9: the (Sr,As) analogue of nabaphite and nastrophite
Matthias Weil
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809040355
Abstract: The crystal structure of the title compound, sodium strontium orthoarsenate(V) nonahydrate, is isotypic with NaSr(PO4)(H2O)9 and the minerals nabaphite [NaBa(PO4)(H2O)9] and nastrophite [Na(Sr,Ba)(PO4)(H2O)9]. The Na and Sr atoms are located on threefold rotation axes and are in the centres of slightly distorted Na(H2O)6 octahedra and Sr(H2O)9 tricapped trigonal prisms, respectively. A framework structure is established via edge-sharing of these polyhedra. Disordered AsO4 tetrahedra (with threefold symmetry) are situated in the interstitial space of the framework. Although reasonable H-atom positions of the water molecules were not established, close O...O contacts between the disordered AsO4 tetrahedra and the water molecules suggest strong O—H...O hydrogen bonding.
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