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Search Results: 1 - 10 of 175811 matches for " Wang Yu-Fan "
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Dynamic Behavior of Multi-agent Systems with Distributed Sampled Control

YU Hong-Wang,ZHENG Yu-Fan,

自动化学报 , 2012,
Abstract: This paper devotes to the study of coordinated control and dynamical behavior of multi-agent systems in digital communication network by means of graph theory, matrix analysis, and control theory. It is assumed that each agent of the system is described by a sampling dynamical system and is able to obtain the information of location coordinates of its neighbors by remote sensors. The system behavior depends on a linear distributed protocol in digital communication network. Thus, the whole multi-agent system can be considered as a hybrid dynamic system. Our results show that the multi-agent systems under consideration may appear three different dynamical behaviors, i.e., asymptotical aggregation, periodic oscillation, and divergence of agents. The dynamical behavior of the system depends not only on the algebraic characterization of the network topology but also on the dynamics of agents, as well as the sampling time period. Moreover, we give some algebraic criteria relevant to the system behavior. Examples show the effectiveness of our results.
In vitro and in vivo targeted delivery of IL-10 interfering RNA by JC virus-like particles
Meng-Ing Chou, Yu-Fan Hsieh, Meilin Wang, Jinghua Chang, Deching Chang, Moncef Zouali, Gregory J Tsay
Journal of Biomedical Science , 2010, DOI: 10.1186/1423-0127-17-51
Abstract: JCV VLPs were generated by recombinant JCV VP1 protein in yeast expression system. DNA fragment containing IL-10 shRNA was packaged into VLPs by osmotic shock.In RAW 264.7 cells, IL-10 shRNA was found to reduce IL-10 expression by 85 to 89%, as compared with VLPs alone. IL-10 shRNA did not cross-react with TNF-alpha mRNA or influence the expression of TNF-alpha. In BALB/c mice IL-10 shRNA could reduce 95% of IL-10 secretion. Surprisingly, it also down regulated TNF-alpha expression.We show for the first time that JCV VLPs empty capsids are competent vectors to deliver RNAi and are nontoxic to cells, suggesting that JCV VLPs is an efficient agent to deliver RNAi in both murine macrophage cells and BALB/c mice. This system provides an efficient means for delivering the RNAi for gene therapy purposes.Transfection of RNA interference (RNAi) into living cells is a major technique in studying the biological function of genes and for their potential treatment of human diseases. There are considerable excitements about its potential therapeutic applications in human diseases [1-3]. RNAi offers the prospects of higher specificity, lower immunogenicity, and greater disease modification than current antibody therapies for systemic autoimmune diseases (AID) such as systemic lupus erythematosus (SLE). The major challenge in turning RNAi into an effective therapeutic strategy is the delivery system.JC virus (JCV), a human polyomavirus, belongs to the polyomaviridae. The JC virion contains three capsid proteins (VP1, VP2 and VP3) and a viral mini chromosome. VP1 is the major capsid protein constituting approximately 75% of the total proteins. Chang et al. [4] found that JCV VP1 could be transported into the nucleus and self-assembled to form capsid-like particles (VLPs) similar to the natural empty capsid without the involvement of the viral minor capsid proteins, VP2 and VP3. JCV VLPs can be generated by recombinant JCV VP1 protein in yeast expression. The recombinant VLPs were d
Global dynamic-behavior of a group of swarms in directed communication network

YU Hong-wang,ZHENG Yu-fan,ZHANG Bao-shan,

控制理论与应用 , 2011,
Abstract: This paper investigates global dynamic-behavior of a group of swarms in directed network by means of graph theory, matrix analysis and control theory. The swarms consist of many identical dynamical agents and each agent is stable in the sense of Lyapunov when it is disconnected from other agents. Each agent communicates the biased position information with its neighbors. When each dynamical agent employs a linear distributed protocol in communication network, the global dynamic-behaviors of swarms not only depend on the dynamic equations of agents, but also on the algebraic characteristics associated with the network topology. Moreover, algebraic criteria are developed for the agents to achieve gradual aggregation, periodical stability or divergence in trajectories. Finally, the simulation example shows the desired result.
Progress of adipocyte plasma membrane associated protein

HUANG Jing-jing
, MA Yu-hang, WANG Yu-fan

- , 2017, DOI: 10.3969/j.issn.1674-8115.2017.11.017
Abstract: 脂肪细胞膜相关蛋白(APMAP)是一种新型整合膜蛋白,在人体内多种组织器官中表达,能够促进前脂肪细胞向成熟脂肪细 胞分化,从而维持脂肪细胞的正常生理代谢功能,并在脂肪细胞分化的过程中发挥着重要作用。目前,研究表明 APMAP 与人体内炎 症反应的发生发展密切相关,与妊娠期糖尿病等多种疾病有关。该文对 APMAP 的结构和功能进行总结,综述近年来关于 APMAP 的 研究进展。
: Adipocyte plasma membrane associated protein (APMAP) is a novel integral membrane protein, widely expressed in many organizations in humans. It promotes the differentiation of preadipocytes to mature adipocytes, so as to maintain normal physiological metabolism function in adipocytes, and plays a major role in adipocytes differentiation. Nowadays, some progress has been made in its role of inflammation and consequently in pathogenesis of gestational diabetes mellitus and other diseases. This paper gives a brief review about the structure and function of APMAP and sums up progress of the current studies
Stabilization of nonlinear discrete-time systems with communication constraints

WANG Ge-xi,WANG Zhi-ming,ZHENG Yu-fan,

控制理论与应用 , 2009,
Abstract: The stabilization is studied for a class of nonlinear discrete-time systems with communication constraint. A sufficient condition for the stabilization is presented in terms of linear matrix inequalities. A stabilizing coder-decodercontroller is then developed and the requirement for the channel capacity is also derived. In addition, a corollary of the system observability is deduced for zero input. Finally, an example is given to illustrate the efficiency and feasibility of the proposed approach.
A Novel Missense Mutation in the Connexin30 Causes Nonsyndromic Hearing Loss
Wen-Hung Wang, Yu-Fan Liu, Ching-Chyuan Su, Mao-Chang Su, Shuan-Yow Li, Jiann-Jou Yang
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021473
Abstract: Dysfunctional gap junctions caused by GJB2 (CX26) and GJB6 (CX30) mutations are implicated in nearly half of nonsyndromic hearing loss cases. A recent study identified a heterozygous mutation, c.119C>T (p.A40V), in the GJB6 gene of patients with nonsyndromic hearing loss. However, the functional role of the mutation in hearing loss remains unclear. In this study, analyses of cell biology indicated that a p.A40V missense mutation of CX30 causes CX30 protein accumulation in the Golgi body rather than in the cytoplasmic membrane. The tet-on protein expression system was used for further study of mutant proteins in CX30 and CX30A40V co-expressions and in CX26 and CX30A40V co-expressions. The p.A40V missense mutation exerted a dominant negative effect on both normal CX30 and CX26, which impaired gap junction formation. Moreover, computer-assisted modeling suggested that this p.A40V mutation affects the intra molecular interaction in the hydrophobic core of Trp44, which significantly alters the efficiency of gap junction formation. These findings suggest that the p.A40V mutation in CX30 causes autosomal-dominant nonsyndromic hearing loss. These data provide a novel molecular explanation for the role of GJB6 in hearing loss.
Impacts of CA9 Gene Polymorphisms on Urothelial Cell Carcinoma Susceptibility and Clinicopathologic Characteristics in Taiwan
Shian-Shiang Wang, Yu-Fan Liu, Yen-Chuan Ou, Chuan-Shu Chen, Jian-Ri Li, Shun-Fa Yang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0082804
Abstract: Background Carbonic anhydrase 9 (CA9) is reportedly overexpressed in several types of carcinomas and is generally considered a marker of malignancy. The current study explored the effect of CA9 gene polymorphisms on the susceptibility of developing urothelial cell carcinoma (UCC) and the clinicopathological status. Methodology and Principal Findings A total of 442 participants, including 221 healthy people and 221 patients with UCC, were recruited for this study. Four single-nucleotide polymorphisms (SNPs) of the CA9 gene were assessed by a real-time PCR with the TaqMan assay. After adjusting for other co-variants, the individuals carrying at least one A allele at CA9 rs1048638 had a 2.303-fold risk of developing UCC than did wild-type (CC) carriers. Furthermore, UCC patients who carried at least one A allele at rs1048638 had a higher invasive stage risk (p< 0.05) than did patients carrying the wild-type allele. Moreover, among the UCC patients with smoker, people with at least one A allele of CA9 polymorphisms (rs1048638) had a 4.75-fold (95% CI = 1.204–18.746) increased risk of invasive cancer. Conclusion The rs1048638 polymorphic genotypes of CA9 might contribute to the prediction of susceptibility to and pathological development of UCC. This is the first study to provide insight into risk factors associated with CA9 variants in carcinogenesis of UCC in Taiwan.
Long-term effects of gestational diabetes mellitus on mothers and offspring and strategies of postpartum follow up

, ZHAO Li, FANG Fang, ZHEN Qin, YAN Shuai, WANG Yu-fan

- , 2016, DOI: 10.3969/j.issn.1674-8115.2016.09.022
Abstract: 妊娠期糖尿病(GDM)是指妊娠期间发生的或首次发现的任何程度的糖代谢异常,不包括孕前已诊断或已患糖尿病的患者。GDM不仅增加孕产期母婴不良事件,而且其对母子的影响并未随着妊娠的结束而终止,GDM可使母亲2型糖尿病、心血管疾病、代谢综合征及抑郁症的发病率升高,增加子代糖代谢异常、高血压、肥胖的发生风险,而有效的产后随访及干预能降低这些风险。该文就GDM对母亲和子代的远期影响以及GDM患者母子产后随访的策略和方法作一综述。
: Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance that is first identified during pregnancy, excluding diabetic patients diagnosed before pregnancy. GDM not only can cause adverse events in mother and infant during pregnancy, but also has long-term effects after pregnancy. GDM can increase the prevalence of type 2 diabetes, cardiovascular disease, metabolic syndrome, and depression in mothers and elevates risks of abnormal glucose metabolism, hypertension, and obesity in offspring. Effective postpartum follow up and intervention can reduce those risks. This article reviews long term effects of GDM on mothers and offspring and strategies and methods of postpartum follow up
Immunological and Regenerative Aspects of Hepatic Mast Cells in Liver Allograft Rejection and Tolerance
Toshiaki Nakano, Chia-Yun Lai, Shigeru Goto, Li-Wen Hsu, Seiji Kawamoto, Kazuhisa Ono, Kuang-Den Chen, Chih-Che Lin, King-Wah Chiu, Chih-Chi Wang, Yu-Fan Cheng, Chao-Long Chen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037202
Abstract: The precise roles of mast cells in liver allograft rejection and tolerance are still unknown. This study aimed to explore the roles of mast cells in immune regulation and liver regeneration for tolerance induction by using rat models of orthotopic liver transplantation (OLT). Stem cell factor (SCF) and its receptor c-Kit, which are critical to the migration and development of not only stem cells but also mast cells, significantly increased in the tolerogenic livers as compared with rejected livers. The significant elevation of mast cell tryptase, high-affinity IgE receptor, and histamine suggested the activation of mast cells in liver allografts at the tolerogenic phase after OLT. Immunohistochemical analysis using confocal microscope clearly showed colocalization of mast cells, Foxp3+ Tregs, γδ T cells, and recipient-derived hepatic progenitor cells with higher expression of SCF, IL-9, IL-10, TGF-β1, and IL-17 related to immunoregulation and liver regeneration in the donor grafts of a tolerogenic OLT model. Cross-talk among mast cells and other cells was evaluated by in vitro studies demonstrating that syngeneic bone marrow?derived mast cells (BMMCs) co-cultured with na?ve splenocytes or primary hepatocytes significantly increased the population of splenic γδ T cells by mitogen stimulation or by mast cell degranulation, and also significantly induced the hepatocyte proliferation, respectively. Our results suggested that mast cells in the donor grafts may play important roles in the induction/maintenance of immune tolerance and liver regeneration resulting in the replacement of hepatic cells from donor to recipient.
White Matter Abnormalities Correlating with Memory and Depression in Heroin Users under Methadone Maintenance Treatment
Wei-Che Lin, Kun-Hsien Chou, Chien-Chih Chen, Chu-Chung Huang, Hsiu-Ling Chen, Cheng-Hsien Lu, Shau-Hsuan Li, Ya-Ling Wang, Yu-Fan Cheng, Ching-Po Lin
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033809
Abstract: Methadone maintenance treatment (MMT) has elevated rates of co-morbid memory deficit and depression that are associated with higher relapse rates for substance abuse. White matter (WM) disruption in MMT patients have been reported but their impact on these co-morbidities is unknown. This study aimed to investigate changes in WM integrity of MMT subjects using diffusion tensor image (DTI), and their relationship with history of heroin and methadone use in treated opiate-dependent individuals. The association between WM integrity changes from direct group comparisons and the severity of memory deficit and depression was also investigated. Differences in WM integrity between 35 MMT patients and 23 healthy controls were evaluated using DTI with tract-based spatial statistical analysis. Differences in DTI indices correlated with diminished memory function, Beck Depression Inventory, duration of heroin use and MMT, and dose of heroin and methadone administration. Changes in WM integrity were found in several WM regions, including the temporal and frontal lobes, pons, cerebellum, and cingulum bundles. The duration of MMT was associated with declining DTI indices in the superior longitudinal fasciculus and para-hippocampus. MMT patients had more memory and emotional deficits than healthy subjects. Worse scores in both depression and memory functions were associated with altered WM integrity in the superior longitudinal fasciculus, para-hippocampus, and middle cerebellar peduncle in MMT. Patients on MMT also had significant WM differences in the reward circuit and in depression- and memory-associated regions. Correlations among decreased DTI indices, disease severity, and accumulation effects of methadone suggest that WM alterations may be involved in the psychopathology and pathophysiology of co-morbidities in MMT.
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