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Search Results: 1 - 10 of 120133 matches for " Wang Yitao "
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Yitao Li,Zhiguo Wang
Acta Crystallographica Section E , 2008, DOI: 10.1107/s1600536807068249
Abstract: The molecule of the title compound, C31H16F6N2O4, consists of two phthalimide units linked by a [bis(trifluoromethyl)methylene]di-p-phenylene bridge, with the two halves of the molecule related to each other by a twofold rotation axis. The dihedral angle between the planes of the two central benzene rings is 70.5 (3)°. The terminal isoindole groups are approximately planar, with a maximum r.m.s. deviation of 0.006 from the mean plane, and they form dihedral angles of 46.03 (3)° to the attached benzene rings. Intermolecular C—H...O hydrogen bonds link neighboring molecules into chains along the c axis.
Glucose Metabolism in Breast Cancer and its Implication in Cancer Therapy  [PDF]
Ning Li, Wen Tan, Jing Li, Ping Li, Simon Lee, Yitao Wang, Yuewen Gong
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.22022
Abstract: It is well known that malignant cells have accelerated glucose uptake and metabolism in order to maintain their fast proliferation rates. With the increased influx of glucose into cancer cells, glycolysis is facilitated through a coordinated regulation of metabolic enzymes and pyruvate consumption. Shiftting from mitochondrial oxidative phosphorylation to glycolysis and other pathways such as pentose phosphate pathway (PPP) and de novo fatty acid synthesis in the breast tumor provides not only energy but also the materials needed for cell proliferation. Glucose augmentation in tumor cells can be due to the elevated level of glucose transporter (GLUT) proteins, such as the over-expression of GLUT1 and expression of GLUT5 in breast cancers. Moreover, other factors such as hypoxia-inducible factor-1 (HIF-1), estrogen and growth factors are important modulators of glucose metabolism in the progression of breast carcinomas. Therapies targeting at the glycolytic pathway, fatty acid synthesis and GLUTs expression are currently being investigated. Restoring tumor cells to its normal glucose metabolic state would endow tumor specific and accessible treatment that targets glucose metabolism.
Molecular Identification of Chinese Materia Medica and Its Adulterants Using ITS2 and psbA-trnH Barcodes: A Case Study on Rhizoma Menispermi  [PDF]
Pei Yang, Xiwen Li, Hong Zhou, Hao Hu, Hui Zhang, Wei Sun, Yitao Wang, Hui Yao
Chinese Medicine (CM) , 2014, DOI: 10.4236/cm.2014.54023
Abstract: Rhizoma Menispermi, derived from the rhizoma of Menispermum dauricum DC., is one of the most popular Chinese medicines. However Rhizoma Menispermi is often illegally mixed with other species in the herbal market, including Aristolochia mollissimae Hance, which is toxic to the kidneys and potentially carcinogenic. The use of DNA barcoding to authenticate herbs has improved the management and safety of traditional medicines. In this paper, 49 samples belonging to five species, including 34 samples of M. dauricum, from different locations and herb markets in China were collected and identified using DNA barcoding. The sequences of all 34 samples of Rhizoma Menispermi are highly consistent, with only one site variation in internal transcribed spacer 2 (ITS2) of nuclear ribosomal DNA and no variations in the psbA-trnH region. The intra-specific genetic distance is much smaller than inter-specific one. Phylogenetic analysis shows that both sequences allow the successful identification of all species. Nearest distance and BLAST1 methods for the ITS2 and psbA-trnH regions indicate 100% identification efficiency. Our research shows that DNA barcoding can effectively distinguish Rhizoma Menispermi from its adulterants from both commercial and original samples, which provides a new and reliable way to monitor commercial herbs and to manage the modern medicine market.
Nanotechnologies for Curcumin: An Ancient Puzzler Meets Modern Solutions
Shengpeng Wang,Miao Tan,Zhangfeng Zhong,Meiwan Chen,Yitao Wang
Journal of Nanomaterials , 2011, DOI: 10.1155/2011/723178
Abstract: Curcumin, a low-molecular-weight natural polyphenol mainly found in the plant Curcuma longa (turmeric), is widely used as a food colorant and as a potential protective agent against several chronic diseases including cancer, HIV-infection, neurological, cardiovascular, and skin diseases. Moreover, evidences from long-term use process and preclinical trials have demonstrated low toxicity of curcumin, even at relatively high doses. However, it has been well known that the application of curcumin was limited owing to its water insolubility, instability, and poor bioavailability. For decades, many attempts have been made to compensate for these disadvantages, with the development of improved delivery platforms as the feasible approaches. The past ten years witnessed the encouraging progress in the use of nanoscale drug delivery systems on curcumin such as loading curcumin into liposomes or nanoparticles, forming self-microemulsifying drug delivery systems (SMEDDS), cyclodextrin inclusions, and solid dispersions, as well as the latest reported technologies such as nadodisks and nanotubes. This paper summarizes the recent works on the design and development of nanoscale delivery systems of curcumin, with the goal of harnessing the true difficulties of this multifunctional agent in the clinical arena. 1. Introduction Curcumin (Figure 1), an active constituent mainly derived from Curcuma longa (turmeric), is a natural yellow-orange polyphenol which has been used for its medicinal benefits for centuries [1, 2]. Curcumin was firstly extracted in impure form in 1815, then in 1870 the pure crystalline state was prepared. Almost three decades later, its composition was finally elucidated as 1, 6-heptadiene-3, 5-dione-1, 7-bis-(4-hydroxy-3-methoxyphenyl)-(1E, 6E) [3–6]. In China, curcumin has been used as a part of herbal medicine for centuries to alleviate throbbing pain in the chest and hypochondriac region, mass in abdomen, and pain of the shoulder due to win-cold or traumatic injuries. The accumulating of experimental and clinical evidences indicates that curcumin has a variety of pharmacological activities, such as antitumor, antiinflammatory, antivirus, antioxidation, anti-HIV, and low toxicity [7–11]. Figure 1: Chemical structure of curcumin. However, good things never come easy. Applicational advancement of curcumin has been hindered by its water insolubility, degradation at alkaline pH, and photodegradation and thus extremely low bioavailability in both vascular and oral administration [12, 13]. Therefore, many approaches have been investigated, including
Recent advances in nanoparticle formulation of oleanolic acid
Meiwan Chen, Zhangfeng Zhong, Wen Tan, Shengpeng Wang, Yitao Wang
Chinese Medicine , 2011, DOI: 10.1186/1749-8546-6-20
Abstract: Oleanolic acid (OA), a naturally occurring pentacyclic triterpenoid extracted from the leaves and roots of Olea europaea, Viscum album L., Aralia chinensis L. and over 120 other plant species [1], is chemically known as 3β-hydroxy-olea-12-en-28-oic acid [2] (Figure 1). OA exhibits many biological activities such as anti-inflammatory, antitumor, antiviral, hepatoprotective and anti-hyperlipidemic effects. OA has been used in Chinese medicine to treat liver disorders for over 20 years [2]. Conventional formulations of OA are tablets and capsules [3]; however, OA's poor aqueous solubility and low bioavailability in vivo make it necessary to develop new formulations for clinical applications.Derived from nanotechnology, nanoparticulate delivery system provides an innovative approach to drug delivery [4-7]; nanoparticulate technique reduces particles to nanometer ranges, thus reducing the dose and reactive nature of the molecule [8]. Various nanoparticulate drug delivery systems have been explored, such as nanoparticles, nanospheres, nanocapsules, solid lipid nanoparticles (SLN), self-emulsifying drug delivery systems (SEDDS) and submicron/nanoemulsions [9][10]. Compared to conventional dosage forms, nanoparticulate drug delivery system has many advantages, namely enhancement of solubility and stability, protection from toxicity, enrichment of pharmacological activities, improvement of tissue macrophage distribution, bioavailability and sustained delivery, protection from physical and chemical degradation [7,11].This article reviews recent advances in nanoparticulate formulation of OA.Solid lipid nanoparticles (SLN), which remain solid at room temperature, have emerged as a new pharmaceutical delivery system or formulation to modify the release profile for many drugs [12]. SLN has characteristics of drug carriers such as lipophilicity, hydrophilicity as well as low bio-toxicity. Main advantages of SLN include: controlling drug release, targeting with reduced toxicity, in
Organic compositions of lacustrine source rocks in Jiyang super-depression and its implication to petroleum geology
Linye Zhang,Yitao Song,Guangli Wang,Difan Huang
Chinese Science Bulletin , 2006, DOI: 10.1007/s11434-006-0573-y
Abstract: The compositions of organic matter in four immature source rocks from Tertiary strata of Jiyang super-depression, the most typical continental rift subsidence basin in East China, have been studied by different extracting methods with CHCl3, MAC and CS2/NMP, respectively. The results suggest that there are great differences among the chemical compositions of organic matter in the source rocks derived from different depositional environments. About 79% of all the organic matter exists by non-covalent bond in the Es4 source rocks which were deposited under the saline lacustrine, indicating that its organic matter is not the real kerogen, but mainly composed of soluble organic matter which is easy to generate hydrocarbon at lower temperature. This is why the immature oils were derived from Es4 source rocks in Dongying depression. In contrast, around 60% of organic matter exists by covalent bond in Es3 source rocks which were deposited under the deep brackish-fresh lacustrine, showing that Es3 source rocks are mainly composed of kerogen producing mature hydrocarbon at higher temperature. The thermal simulation experiments, upon the remaining solid source rocks which were sequentially extracted by the three solvents, have been carried out. The chloroform extracts from the simulation product have been compared with the other three solvent extracts gained at room temperature. It is obvious that remarkable odd/even predominance (OEP) is mainly the characteristic of soluble organic matter; phytane mostly exists in the soluble organic matter by means of non-covalent bonds and characteristics of soluble organic matter are similar to these in immature oils produced in Jiyang super-depression.
Construction of antisense RNA expression vectors and correction of splicing defect in human β-globin gene (IVS-2-654 C→T mutant) in HeLa cells
Lan Gong,Xiaofeng Gu,Min Wang,Shuzheng Huang,Yitao Zeng
Science China Life Sciences , 1998, DOI: 10.1007/BF02882712
Abstract: The antisense fragments, which were available inin vitro system, were cloned into the mammalian expression vector pcDNA3, and were transfected into H654 cells, a mammalian cell line stably expressing the thalassaemic (IVS-2-654 C→T) human β-globin gene. In these transfected cells, the level of correctly spliced β-globin mRNA in total β-globin mRNA (β/(β + β*)) was improved from 0.07 (0 d) to 0.22 (3 d), and this effect persisted for up to 15 d post transfection. All the results demonstrated that antisense RNAs were able to be transcribed from the antisense fragment expression vectors stably and effectively suppressed aberrant splicing pattern of the mutated β-globin gene (IVS-2-654 C→T) and restored correct splicing pathway. This work provided a novel approach with potential clinical significance to gene therapy of this kind of splicing mutants including β-thalassaemia (IVS-2-654 C→T) by antisense RNAs.
Hydrocarbons pyrolysed from nannoplanktonic algae: An experimental organism system for study on the origin of petroleum and natural gas
Qingyu Wu,Ruiyong Wang,Junbiao Dai,Yitao Song,Yoshihiro Shiraiwa
Chinese Science Bulletin , 1999, DOI: 10.1007/BF02909724
Qualitative and quantitative relationships between affinity constants from model study and real adsorption data
YiTao Qiao,PingLin Li,JianXin Zhao,Wei Wang,Zhi Yuan
Chinese Science Bulletin , 2010, DOI: 10.1007/s11434-010-4060-0
Abstract: Linear polymers bearing the same functional groups as their corresponding adsorbents could be used as models to study the adsorption behaviors. However, the relationships between the data from model study and real adsorption have not been fully interpreted. In this work, three adsorbent (CP1-Zn2+, CP2-Zn2+ and CP3-Zn2+) and their corresponding linear models (P1-Zn2+, P2-Zn2+ and P3-Zn2+) were synthesized. The affinity constants (K a) between these models and target peptide DFLAE (DE5) were obtained by isothermal titration calorimetry (ITC). Adsorption capacities and adsorption affinities were carried out by static adsorption and adsorption isotherm. The qualitative and quantitative relationships between affinity constants from model study and the real adsorption data were explored. This study was significant to bridge the model study with the real adsorption.
Provision and Usage of Medical Services by Community Pharmacy: A Comparative Study of New York, Macao and Zhuhai (China)
Shuai GE,Cheong Kuan-long,Hao HU,Yitao WANG
Canadian Social Science , 2012, DOI: 10.3968/j.css.1923669720120806.1030
Abstract: Community pharmacies around the world are redefining their roles by experimenting to provide medical services directly to consumers. The aim of this study was to investigate the medical services provided by community pharmacies and consumers’ usage of these medical services. This study was carried out through semi-structured interviews with both community pharmacists and their consumers in New York, Macao and Zhuhai. Community pharmacists reported information about provision of medical services, and consumers provided information about their usage of medical services at community pharmacies accordingly. Through analysis of interview materials it showed that community pharmacies mainly provided free medical examination, reference books and booklet of drug information. Some community pharmacies provided health care lecture and founded own website for medicine information. But touch-screen computer querying system and telephone health care service had not been provided. Additionally the consumers’ usage of medical services at community pharmacy is obviously lower than provision by community pharmacy. The provision level of medical services by community pharmacy was relatively low and the types of medical services were relatively narrow. There was an obvious gap between provision of medical services by community pharmacies and usage of such services by consumers. The position of community pharmacy in national health system and capability of community pharmacy have impact on the medical services of community pharmacies. Key words: Community pharmacy; Medical services; Comparative study; New York; Macao; Zhuhai (China)
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