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Search Results: 1 - 10 of 120038 matches for " Wang Yaoli "
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Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice
Wang Yaoli,Bai Chunxue,Wang Guansong,Wang Diane
Genetic Vaccines and Therapy , 2010, DOI: 10.1186/1479-0556-8-2
Abstract: Background Allergen-induced imbalance of specific T regulatory (Treg) cells and T helper 2 cells plays a decisive role in the development of immune response against allergens. Objective To evaluate effects and potential mechanisms of DNA vaccine containing ovalbumin (OVA) and Fc fusion on allergic airway inflammation. Methods Bronchoalveolar lavage (BAL) levels of inflammatory mediators and leukocyte infiltration, expression of CD11c+CD80+ and CD11c+CD86+ co-stimulatory molecules in spleen dendritic cells (DCs), circulating CD4+ and CD8+ T cells, Foxp3+ in spleen CD4+ T cells and spleen CD4+ T cells were measured in OVA-sensitized and challenged animals pretreated with pcDNA, OVA-pcDNA, Fc-pcDNA, and OVA-Fc-pcDNA. Results OVA-Sensitized and challenged mice developed airway inflammation and Th2 responses, and decreased the proliferation of peripheral CD4+and CD8+ T cells and the number of spleen Foxp3+ Treg. Those changes with increased INF-γ production and reduced OVA-specific IgE production were protected by the pretreatment with OVA-Fc-pcDNA. Conclusion DNA vaccine encoding both Fc and OVA showed more effective than DNA vaccine encoding Fc or OVA alone, through the balance of DCs and Treg.
Regulatory effects of the JAK3/STAT1 pathway on the release of secreted phospholipase A2-IIA in microvascular endothelial cells of the injured brain
Guansong Wang, Pin Qian, Zhi Xu, Jiqiang Zhang, Yaoli Wang, Saiyu Cheng, Wenqin Cai, Guisheng Qian, Changzheng Wang, Mark A DeCoster
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-170
Abstract: Supernatants were collected from primary cultures of BMVECs. The release of sPLA2-IIA, and the expression of inducible nitric oxide synthase (iNOS), phospho-JAK3, phospho-STAT1, total JAK3 and STAT1, β-actin, and bovine serum albumin (BSA) were analyzed by Western blot or ELISA. NO production was calculated by the Griess reaction. sPLA2 enzyme activity was measured with a fluorometric assay. Specific inhibitors of NO (L-NAME and aminoguanidine, AG), JAK3 (WHI-P154,WHI), STAT1 (fludarabine, Flu), and STAT1 siRNA were used to determine the involvement of these molecules in the LPS-induced release of sPLA2-IIA from BMVECs. Nuclear STAT1 activation was tested with the EMSA method. The monolayer permeability of BMVECs was measured with a diffusion assay using biotinylated BSA.Treatment of BMVECs with LPS increased the release of sPLA2-IIA and nitrite into the cell culture medium up to 24?h. Pretreatment with an NO donor, sodium nitroprusside, decreased LPS-induced sPLA2-IIA release and sPLA2 enzyme activity, and enhanced the expression of iNOS and nitrite generation after LPS treatment. Pretreatment with L-NAME, AG, WHI-P154, or Flu notably reduced the expression of iNOS and nitrite, but increased sPLA2-IIA protein levels and sPLA2 enzyme activity. In addition, pretreatment of the cells with STAT1 siRNA inhibited the phosphorylation of STAT1, iNOS expression, and nitrite production, and enhanced the release of sPLA2-IIA. Pretreatment with the specific inhibitors of NOS, JAK2, and STAT3 decreased the permeability of BMVECs. In contrast, inhibition of sPLA2-IIA release increased cell permeability. These results suggest that sPLA2-IIA expression is regulated by the NO-JAK3-STAT1 pathway. Importantly, sPLA2-IIA augmentation could protect the LPS-induced permeability of BMVECs.Our results demonstrate the important action of sPLA2-IIA in the permeability of microvascular endothelial cells during brain inflammatory events. The sPLA2 and NO pathways can be potential targets for
Femtosecond laser-induced damage in dielectrics
ufeng Peng,Yaoli Wei,Zhenlong Lv
Optica Applicata , 2004,
Abstract: We present a new method to investigate the ablation phenomenon by a 100 fs, 1053 nm Gaussian laser pulse in fused silica and describe the different mechanisms of ablation in long pulse and ultrashort pulse lasers. A modified rate equation is used to numerically calculate damage in dielectrics. In addition, we examine the respective role of ionization and avalanche ionization in femtosecond laser-induced damage. We find that present results are in quantitative agreement with those of earlier study.
Software Industry Cluster be Disagreement on Theory and Practice  [PDF]
Yang Wang, Luqian Wang
Intelligent Information Management (IIM) , 2010, DOI: 10.4236/iim.2010.210069
Abstract: In the view of traditional industry cluster theory, it is easy to copy the software industry cluster pattern, or it is easy to copy another Silicon Valley, due to low reliability of the resources and the guidance factors of locations in software industry. But it is much more difficult to copy a Silicon Valley mode practically than imaginatively and the difficulties of bringing up and supporting high-tech initiatives is more than theoretic anticipation. In China, the software companies have just gathered together geographically and therefore no initiative center can be formed. All these above signify that software industry cluster is distinct from the traditional industry clusters, but the cognition of the reasons of software industry cluster is not clear yet. Furthermore, reasonable explanations of the bewilderment in the economical practice of software industry cluster are urgently needed.
The Economic Growth Effect of Logistics Industry FDI Analysis  [PDF]
Yang Wang, Luqian Wang
iBusiness (IB) , 2010, DOI: 10.4236/ib.2010.24049
Abstract: Based on the direction of the international FDI changed, from manufacturing to service industries, we should concern about the influence of the introduction of China’s logistics industry FDI to the national economy. The paper sets up regression model to examine logistics FDI and GDP in two aspects of time series and growth rate, we find that the logistics FDI reaches a high correlation with GDP, and logistics FDI is one of the major driving forces of economic development. Therefore, China should expand the introduction of logistics FDI, improve the quality of foreign investment, develop the positive economic growth effect of logistics FDI and promote the change of China’s economic growth pattern to ensure the development of China’s economy.
The Predictive Effects of Online Communication on Well-Being among Chinese Adolescents  [PDF]
Jinliang Wang, Haizhen Wang
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.24056
Abstract: Based on theories and previous studies on online communication, we proposed two hypotheses to better under- stand the effects of online communication on subjective well-being with a sample of Chinese adolescents (n = 190). The results of liner regression analysis found that online communication was positively related to adoles- cents’ subjective well-being. For boys, the coefficient of determination of online communication on subjective well-being was .143, and for girls the coefficient of determination was .040, indicating that boys benefit more from online communication than do girls.
The Impact of Radical Prostatectomy on the Survival of Patients with Carcinosarcoma of the Prostate  [PDF]
Jue Wang, Fenwei Wang
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.24064
Abstract: Background: The objective of this study was to evaluate the impact of radical prostatectomy on carcinosarcoma of the prostate. Methods: Patients diagnosed with carcinosarcoma of the prostate from 1977 through 2007 were identified in the Surveillance, Epidemiology, and End Results (SEER) database. Outcomes were examined with Kaplan-Meier survival analysis and Cox models. The association between clinical and demographic characteristics and survival of carcinosarcoma of the prostate was examined. Results: A total of fifty-four cases of histology confirmed carcinosarcoma of the prostate were identified. Median age of the patients was 74 years (range 28 - 94). Of the patients with a known tumor stage, all but one patient had a locally advanced or distant stage; all of the patients with known histology grade had poorly or undifferentiated histology. Twenty (37%) patients underwent transurethral resection only and Fourteen (25.9%) patients underwent radical prostatectomy. Eight (14%) patients received radiation therapy in combination with surgery. The median cancer specific survival was 16 months (95% CI 0 - 32 months). 1-, 3-, and 5- year cancer specific survival rate were 55.1%, 32.3% and 21.1%. In a multivariate analysis, radical prostatectomy was found to be a significant prognostic factor for cancer-specific survival. Conclusions: Carcinosarcoma of the prostate commonly occurs in older patients and associated with aggressive disease and poor prognosis. Radical prostatectomy is the only treatment modality that significantly improves survival. Emphasis on early diagnosis and detection and multimodality therapy of this disease is needed to improve the outcome for patients with this malignancy.
A Research on the Relationship between FDI and Jiangsu’s Regional Economy Disparity  [PDF]
Baoqian Wang, Cheng Wang
Technology and Investment (TI) , 2012, DOI: 10.4236/ti.2012.33018
Abstract: Through reading and summarizing relevant articles, the authors analyze two different kinds of effects that FDI influence the regional economy. Location and digesting ability reflects such non-equilibrium. By using regression analysis, the authors discover, in south Jiangsu, which the unit FDI increase contributes most to the GDP development, with middle and north Jiangsu lagging behind. The regression coefficient is 1.198, 0.429 and 0.572 respectively. Considering the index of digestion ability, unit FDI increase and unit GDP contribution rate still share strong relevant relationship. However, the coefficients change. The effects that FDI stimulate GDP growth are weakened, been made up by the endogenous ability. The granger test shows that in south Jiangsu, there exists a cycle of accumulative effect, namely both the FDI increase and the GDP growth do well with each other. However, in the rest of Jiangsu province, such effect is not obvious. Considering the elements of location and digesting ability, this paper offers tactics for Jiangsu for a better coordinate of future development.
Causes of and Remedies for Chinglish in Chinese College Students’ Writings  [PDF]
Ping Wang, Weiping Wang
Open Journal of Modern Linguistics (OJML) , 2012, DOI: 10.4236/ojml.2012.22009
Abstract: Based on Interlanguage Theory and other theories, this study examines data from samples of Chinese college students’ writings and interviews with the students to explore the causes of and remedies for Chinglish (a term used to refer English with Chinese characteristics). It claims that Chinglish is mainly caused by syntactic transfer from Chinese, the influence of Chinese thought patterns, inadequate exposure to authentic English and insufficient practice in English writing. The interviews with the students showed that the proportion of L1 thinking decreased with the writer’s L2 development. The recommended remedies for Chinglish include raising students’ awareness of distinctions between English and Chinese, increasing their exposure to authentic English and practice in English writing, and adjusting their thought patterns.
An Entanglement Criterion for States in Infinite Dimensional Bipartite Quantum Systems  [PDF]
Yinzhu Wang, Danxia Wang
Journal of Quantum Information Science (JQIS) , 2012, DOI: 10.4236/jqis.2012.23013
Abstract: In this paper, an entanglement criterion for states in infinite dimensional bipartite quantum systems is presented. We generalize some of separability criterion that was recently introduced by Wu and Anandan in (Phys. Lett. A, 2002, 297, 4-8) to infinite dimensional bipartite quantum systems. In addition, we give an example aimed to illustrate the application of the theorem.
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