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Development of a floating multiple unit controlled-release system for mosapride
Senthil Kumaran K,Manjunath S,Wamorkar Vinay
Asian Journal of Pharmaceutics , 2010,
Abstract: Floating beads are often used for controlled drug release as they have a gastroretentive property without affecting the gastric emptying rate. In the present study mosapride-controlled release beads were prepared with the help of the ionotropic gelation method, using sodium alginate containing KHCO 3 as the gas-forming agent. The physical characterization of the mosapride beads was examined by SEM. The results showed that the shape and texture of the beads were uniform before and after dissolution. The percentage of mosapride drug entrapment efficiency ranged from 97.4 ± 0.08 to 99.1 ± 0.04. The percentage of mosapride content from the beads was determined by high-performance liquid chromatography (HPLC) and ranged from 97.9 ± 0.08 to 99.6 ± 0.01. The in-vitro percentage release of mosapride from the beads at the end of 14 hours ranged from 90.0 ± 0.2 to 99.5 ± 0.12. The formulated beads in formulations 1 and 3 were sealed in vials and kept for 90 days at 40°C / 75% RH. After 90 days of exposure the percentage drug content was found to be 99.2 ± 0.04. The Floating beads designed for the gastroretentive dosage form could be suitable for controlled drug delivery.
Reverse-phase high performance liquid chromatographic determination of Tizanidine and Valdecoxib in tablets
Ramaa C,Deshpande D,Shirode A,Wamorkar V
Indian Journal of Pharmaceutical Sciences , 2006,
Abstract: A simple, reproducible and efficient reverse-phase high performance liquid chromatographic (HPLC) method was developed for simultaneous determination of tizanidine and valdecoxib from their pharmaceutical dosage forms. Separation was done by using mobile phase of composition ammonium acetate buffer (0.1 M): methanol: acetonitrile in the ratio of 50:30:20 v/v. Quantitation was achieved with UV detection at 232 nm based on peak area, with linear calibration curves at concentration ranges from 1-100 μg/ml for tizanidine and valdecoxib respectively. The method has successfully been applied to pharmaceutical dosage forms. No chromatographic interference from the tablet excipients was found. The method was validated using ICH guidelines and was found to be highly precise, accurate and robust.
Time-Frequency Analysis of Asymmetric Triaxial Galaxy Model Including Effect of Spherical Dark Halo Component  [PDF]
Beena R. Gupta, Vinay Kumar
International Journal of Astronomy and Astrophysics (IJAA) , 2015, DOI: 10.4236/ijaa.2015.52014
Abstract: A method of time-frequency analysis (TFA) based on wavelets is applied to study the phase space structure of three-dimensional asymmetric triaxial galaxy enclosed by spherical dark halo component. The investigation is carried out in the presence and absence of dark halo component. Time-frequency analysis is based on the extraction of instantaneous frequency from the phase of the continuous wavelet transform. This method is comparatively fast and reliable. This method can differentiate periodic from quasi-periodic, chaotic sticky from chaotic non-sticky, ordered from chaotic and also, it can accurately determine the time interval of the resonance trapping and transitions too. Apart from that, the phenomenon of transient chaos can be explained with the help of time-frequency analysis. Comparison with the method of total angular momentum (denoted as Ltot) proposed recently is also presented.
Smartphone Based Fall Detection and Logic Testing Application Using Android SDK  [PDF]
Vinay Kumar Suryadevara, Maher Rizkalla
Journal of Biomedical Science and Engineering (JBiSE) , 2015, DOI: 10.4236/jbise.2015.89057
Abstract: Smart systems aimed at detecting the fall of a person have increased significantly due to recent technological advances and availability of modular electronics. This work presents the use of embedded accelerometer and gyroscope in mobile phones to accurately detect and classify the type of fall a person is experiencing before suffering an impact. Early classification of fall type helps in optimizing the algorithm of the fall detection. User acceptance, feasibility and the limitations in the accuracy of the existing devices have also been considered in this study. High efficiency and low power approaches were emphasized with wireless capability that enhanced the system performance for variety of applications. There is a need of reducing the time for analyzing the smart algorithms designed. It is also emphasized that this application will be a good platform that can be used to test various algorithms and multiple sensors at a time with ease and obtain data analysis in a short period.
In Vitro Model Systems to Investigate Drug Resistance Mechanisms in Pancreatic Cancer Cells  [PDF]
Eric Romney, Vinay J. Nagaraj
Advances in Biological Chemistry (ABC) , 2015, DOI: 10.4236/abc.2015.57026
Abstract: With a 5-year survival rate of less than 6%, the diagnosis of pancreatic cancer is devastating news for any patient. Gemcitabine, the most commonly used chemotherapy drug, only improves survival by approximately 1.5 months. A major obstacle to the treatment of pancreatic cancer with gemcitabine is the development of drug resistance. To better understand the precise mechanisms by which patient tumor cells gain resistance to gemcitabine, a cell culture model system that more accurately reflects the development of drug resistance in vivo is required. In this study, cultured pancreatic adenocarcinoma BxPC-3 cells were subjected to two different treatment regimens. The first method—termed pulse method—involves periodically treating separate cultures of BxPC-3 cells with constant predetermined doses of gemcitabine. The second treatment regimen—termed incremental method—consists of treating BxPC-3 cells with increasing doses of gemcitabine from 10 to 100 nM. While all treated cells showed enhanced resistance to gemcitabine, low-dose pulse treatments were sufficient to produce highly drug-resistant cells as evidenced by higher IC50 measurements. Pulse treatments also resulted in slower growth rates and increased doubling time of the drug-resistant cells. Morphological changes indicate cellular abnormalities linked to likely epithelial-to-mesenchymal transition and drug resistance. Our preliminary results indicate that the pulse method may better simulate resistance observed in patients undergoing chemotherapy and may serve as a superior model to investigate drug-resistance. This model can also help with identification of appropriate markers that determine the presence of drug-resistant cells and help clinicians adjust treatment strategies to improve outcomes for patients suffering from pancreatic cancer.
Mathematics Is Science: A Topic Revisited in Context of FCS of India
Vinay Kumar
International Journal of Modern Education and Computer Science , 2012,
Abstract: Mathematics is universally accepted as mother of all science. Despite that, Department of Personnel and Training (DOPT) has recently issued a circular mentioning that a person having master degree in mathematics cannot be considered for the post of scientists. The open question of ‘Is mathematics a science?’ is revisited in this paper under the new perspective to explore scientific practices that sans mathematics arrived knocking, challenging basic understanding of precision and practical sense that makes science. Considering the fact that in India, most crucial policy decisions at a higher level of abstraction in every conceivable arena of our national life are taken by either GOM (Group of Ministers) or GOS (Group of Secretaries), apprehension raises a basic query 'Who decides?' Some decision causes much unexpected consequence, which is noticed when it takes its toll and becomes virtually irreversible. This recent decision of Flexible Complementing Scheme (FCS), wherein mathematics is not considered as science, has potential to damage the very scientific culture and practices in India. This paper is an attempt to place mathematics in its right perspective and to highlight the damage that this decision might do. The paper also suggests ways to control the damage.
Study And Design of NANU-Modified- Register : An Innovative Approach
Vinay Aggarwal
International Journal on Theoretical and Applied Research in Mechanical Engineering , 2012,
Abstract: The N-M-Register is new, pre-eminent electronic device which store the suitable information after fetching the amount of data entered and assemble in an excellent manner. Its versatile ability makes it more dominating in several applications such as data-storage device, calculator, time/alarm machine, etc. which not only reduces the paper work, even contribute in quick and fast calculations resulting in save of human precious time.
Web sites on adverse drug reactions and drug interactions
Gopalani Vinay
Indian Journal of Dermatology, Venereology and Leprology , 2005,
Abstract:
Full text access to journals on the net
Gopalani Vinay
Indian Journal of Dermatology, Venereology and Leprology , 2005,
Abstract:
Psoriasis websites
Gopalani Vinay
Indian Journal of Dermatology, Venereology and Leprology , 2004,
Abstract:
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