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Search Results: 1 - 10 of 7243 matches for " Walter Fries "
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Inflammatory bowel disease-associated spondyloarthropathies
Walter Fries
World Journal of Gastroenterology , 2009,
Abstract: This issue presents a symposium held in Messina talking about inflammatory bowel disease (IBD) and associated spondyloarthropathies. The topic covers epidemiology and clinical manifestations of IBD-related arthropathies, common genetic and immunologic features, combined therapies for gut and joint inflammation, and future biologic therapies etc. I believe this series of articles will deeply facilitate understanding of and the approach to IBD and associated arthropathies.
Clinical features and epidemiology of spondyloarthritides associated with inflammatory bowel disease
Carlo Salvarani, Walter Fries
World Journal of Gastroenterology , 2009,
Abstract: Inflammation of axial and/or peripheral joints is one of the most frequent extra-intestinal manifestations complicating the clinical course and therapeutic approach in inflammatory bowel diseases (IBD). The frequency of these complications seems to be similar for both diseases, Crohn’s disease and ulcerative colitis. Arthritis associated with IBD belongs to the category of spondyloarthropathies. Axial involvement ranges from isolated inflammatory back pain to ankylosing spondylitis, whereas peripheral arthritis is noted in pauciarticular and in polyarticular disease. Asymptomatic radiological involvement of the sacroiliac joints is reported to occur in up to 50% of patients. Other musculoskeletal manifestations such as buttock pain, dactylitis, calcaneal enthesitis, and thoracic pain are frequently underdiagnosed and, consequently, are not treated appropriately. Several diagnostic approaches and criteria have been proposed over the past 40 years in an attempt to correctly classify and diagnose such manifestations. The correct recognition of spondylarthropathies needs an integrated multidisciplinary approach in order to identify common therapeutic strategies, especially in the era of the new biologic therapies.
Levantamento Gravimétrico na Regi o de Franca - SP e Delfinópolis - MG, no Reconhecimento e Delimita o de Fei es Estruturais (Zonas de Sutura)
Maximilian Fries,Walter Malagutti Filho,Norberto Morales,Jo?o Carlos Dourado
Geologia USP : Série Científica , 2007,
Abstract: Este trabalho apresenta o resultado do levantamento geofísico realizado no nordeste do estado de S o Paulo e sudoeste doestado de Minas Gerais em uma área de 80 por 97,5 km localizada a sudoeste do Brasil. O mapa da anomalia Bouguerassociado a estudos geológicos e estruturais permite identificar basicamente três grandes domínios gravimétricos relacionadosao arranjo estrutural e compartimenta o crustal (blocos crustais delimitados por grandes descontinuidades) na área. Essasdescontinuidades foram interpretadas em estudos anteriores como zonas de geosuturas localizadas abaixo dos sedimentos daBacia sedimentar do Paraná e possuem um prolongamento no embasamento Pré – Cambriano. As descontinuidades denominadasde Alterosa e Ribeir o Preto s o classificadas como sendo suturas colisionais do tipo - A compondo um arranjo dejun o tríplice. S o reconhecidas no mapa da anomalia Bouguer duas anomalias lineares e os limites entre os blocos crustaisou paleo-placas Brasília e S o Paulo. A zona de sutura de Alterosa possui uma dire o preferencial NW-SE e na dire o NESWencontra-se a zona de sutura de Ribeir o Preto. O mapa da anomalia Bouguer gerado fornece subsídios e informa es paranovos conceitos e teorias de modelos tect nicos propostos.
Infliximab and Etanercept Are Equally Effective in Reducing Enterocyte APOPTOSIS in Experimental Colitis
Walter Fries, Carmelo Muja, Carmela Crisafulli, Giuseppe Costantino, Giuseppe Longo, Salvatore Cuzzocrea, Emanuela Mazzon
International Journal of Medical Sciences , 2008,
Abstract: Loss of epithelial barrier integrity is considered an early step in the pathogenesis of Crohn's disease (CD), and the rate of enterocyte apoptosis is one of the determinants of the intestinal barrier function. Tumor necrosis factor-α (TNF-α), one of the major proinflammatory mediators in CD, is one of the extrinsic signals which initiate apoptosis of enterocytes. The aim of this study was to investigate the early effects of experimental colitis on enterocyte apoptosis, and the effects of two anti-TNF treatments, infliximab (IFX) and etanercept (ETC). In addition, the importance of receptor I for TNF was tested in TNFR-1-/- mice. Circulating TNF-α levels were effectively reduced by IFX and ETC (p<0.01, both) at 3 and 6 h. Apoptosis of the ileal enterocytes, assessed by TUNEL staining, staining for Fas-ligand, and bax, increased at 3 and 6h. These alterations were prevented by both anti-TNF strategies, and in TNFR-1-/- animals. The anti-apoptotic protein Bcl-2 was expressed in the ileal epithelium under control conditions, but was suppressed in DNB-colitis. Expression of Bcl-2 was maintained in both anti-TNF treatments and TNFR-1-/- mice. DNB colitis induced a very early, rapid increase of enterocyte apoptosis. Both anti-TNF strategies, IFX and ETC, were equally effective in suppressing enterocyte apoptosis, most likely by inactivation of circulating TNF-α.
Uncovering Hypercoagulability in Sepsis Using ROTEM Thromboelastometry: A Case Series
Günter Luckner, Viktoria D. Mayr, Dietmar R. Fries, Petra Innerhofer, Stefan Jochberger, Walter R. HasibederMartin W. Dünser
The Open Critical Care Medicine Journal , 2008, DOI: 10.2174/1874828700801010001]
Abstract: This case series presents three patients with sepsis/septic shock in whom standard coagulation tests (international normalized ratio, activated partial thromboplastin time, fibrinogen, antithrombin, thrombocytes) and ROTEM thromboelastometry (InTEM, ExTEM, FibTEM) were simultaneously performed. Although all patients showed significantly prolonged plasmatic coagulation times with a putatively increased risk of bleeding, ROTEM thromboelastometry revealed normal clotting times and even signs of hypercoagulability. Therefore, no coagulation active therapy was performed in any patient, not even before invasive procedures or major surgical interventions. No bleeding occurred in any study patient during surgery or the subsequent stay on the intensive care unit. These observations suggest that some critically ill patients with sepsis and abnormal standard coagulation tests may in fact have hypercoagulability. ROTEM thromboelastometry can add important information in these patients and enable that blood products are used targeted and only for substitution of relevant deficencies. Future studies are necessary to validate these preliminary findings.
Gerinnungsmanagement der peripartalen Massivblutung
Fries D
Speculum - Zeitschrift für Gyn?kologie und Geburtshilfe , 2010,
M. van der Beek, A.A.J. Scheffers, De muntslag ten tijde van Koning Willem I. Ontwerp en productie van de Nederlandse munten 1814-1839, A. A. J. Scheffers, ed.
W. Fries
BMGN : Low Countries Historical Review , 1998,
P. Bange, Geloof, moraal en intellect in de middeleeuwen. Voordrachten gehouden tijdens het symposium t.g.v. het tien-jarig bestaan van het Nijmeegs Centrum voor middeleeuwse studies, 10 en 11 december 1993
W. Fries
BMGN : Low Countries Historical Review , 1997,
J. van Damme, Laevinus Torrentius. Tweede bisschop van Antwerpen
W. Fries
BMGN : Low Countries Historical Review , 1997,
H. Würzner, K. Kr hnke, Deutsche Literatur im Exil in den Niederlanden 1933-1940
W. Fries
BMGN : Low Countries Historical Review , 1996,
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