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High performance thin layer chromatographic method for simultaneous estimation of ibuprofen and pseudoephedrine hydrochloride
Chitlange S,Sakarkar D,Wankhede S,Wadodkar S
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: High performance thin layer chromatographic method is developed for simultaneous estimation of ibuprofen and pseudoephedrine hydrochloride in tablets. Silica gel 60F 254 plates were used as stationary phase and t.butanol: ethyl acetate: glacial acetic acid: water (7:4:2:2 v/v) as mobile phase. Wavelength selected for analysis was 254 nm. Percent estimation of ibuprofen and pseudoephedrine hydrochloride was found to be 99.56% and 98.77%, respectively. Percent recovery for both the drugs was found in the range of 98.27% to 100.91%, respectively.
PHYSICOCHEMICAL CHARECTARIZATION OF VANGA BHASMA
Lagad C. E.,Sawant R. S.,Tayade A. N.,Wadodkar D. S.
International Research Journal of Pharmacy , 2013,
Abstract: Bhasma is very effective when prepared by appropriate method and used in accurate therapeutic dose. Vanga Bhasma [VB]is being used in genitor-urinary disorders since long in Ayurveda. The pharmaceutical processing of VB was performed by four steps i.e. Samanya Shodhana, Vishesh Shodhana, Jarana&Marana.To assure the quality of bhasma,rasa shastra quality control tests like rekhapurna, varitara, Niruttha, etc., were used. After the bhasma complied with these tests, the bhasma was analyzed [Physcicochemical characterization] using ICP-AES, X-ray Diffraction (XRD) revealed that Vanga bhasma contains major compound SnO2and Thermo Gravimetric analysis (TGA) with DTA showed no weight loss and no physical or chemical changes so it can be an alternative and supportive to Niruttha Pariksha. It may be concluded that raw Vanga is a Simple compound which gets converted into a mixture of complex compounds after the particular process of marana.
PREPARATION OF RASASINDURA BY MODIFIED PORTABLE VALUKAYANTRA VIS-à-VIS TRADITIONAL METHOD
Manish S. Bhoyar,C.E. Lagad,D.S. Wadodkar
International Journal of Research in Ayurveda and Pharmacy , 2013,
Abstract: Kupipakva Rasayana is the most potent preparation which is frequently used by Rasavaidyas. But traditional method of preparation of Kupipakva Rasayana seems to be quite complicated. Time duration, more manpower, more fuel, pollution and other obstacles add to negligence of its preparation. To overcome above obstacles, some alteration in the traditional method has been made without interfering concept behind the tradition. Rasasindura (Mercuric sulphide) was prepared by Modified portable Valukayantra vis-à-vis traditional method where detailed documentation of each and every step of procedure was done. To assess the quality of prepared medicine, both the samples were subjected to same Ayurvedic as well as modern parameters and results were interpreted. The study establishes efficacy and applicability of modified portable valukayantra in the preparation of Rasasindura (Mercuric sulphide).
Evaluation of CNS activity of Bramhi Ghrita
Achliya G,Wadodkar S,Dorle A
Indian Journal of Pharmacology , 2005,
Abstract: OBJECTIVE: To eavaluate the CNS activity of Bramhi Ghrita, a polyherbal formulation containing Bacopa monneri, Evolvulus alsinoids, Acorus calamus, Saussurea lappa and cow′s ghee. MATERIALS AND METHODS: The effect of Bramhi Ghrita on motor coordination, behavior, sleep, convulsions, locomotion and analgesia was evaluated in mice using standard procedures. RESULTS: The formulation exhibited reduced alertness, spontaneous locomotor activity and reactivity. It also antagonized the behavioral effects of d-amphetamine, potentiated the pentobarbitone-induced sleep and increased the pain threshold. Bramhi Ghrita protected mice from maximum electroshock and pentylene tetrazole-induced convulsions.
New spectrophotometric method for simultaneous determination of metoprolol tartarate and hydrochlorthiazide in tablets
Gupta K,Tajne M,Wadodkar S
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: The present work describes a two-wavelength method for simultaneous determination of metoprolol and hydrochlorthiazide in fixed dose combination tablet. The wavelengths selected for method were 257.8 nm, 282.9 nm and 315.0 nm. The absorbance difference at first two wavelengths was used for determination of metoprolol and the latter was used for determination of hydrochlorthiazide. The recovery value for the drugs from the tablet matrix was found to be 100.55% (metoprolol) and 99.97% (comparison with standard) and 98.09% (E1%, 1cm) for hydrochlorthiazide. The method has an advantage that hydrochlorthiazide can be estimated in combination, as there is no interference of metoprolol at 315.0 nm. The method was evaluated statistically for its accuracy and precision.
RP-HPLC method for simultaneous estimation of telmisartan and hydrochlorothiazide in tablet dosage form
Wankhede S,Tajne M,Gupta K,Wadodkar S
Indian Journal of Pharmaceutical Sciences , 2007,
Abstract: The present work describes a validated reverse phase high performance liquid chromatographic method for simultaneous estimation of telmisartan and hydrochlorothiazide in tablet formulation. Chromatography was performed on a ODS Hypersil C18 (25 cmx4.6 mm I.D) column from thermo in isocratic mode with mobile phase containing acetonitrile:0.05 M KH2PO4 pH 3.0 (60:40). The flow rate was 1.0 ml/min and the eluent was monitored at 271 nm. The selected chromatographic conditions were found to effectively separate telmisartan (RT- 5.19 min) and hydrochlorothiazide (RT- 2.97 min). Linearity for telmisartan and hydrochlorothiazide were found in the range of 4.1-20.48 μg/ml and 1.28-6.4 μg/ml, respectively. The proposed method was found to be accurate, precise, reproducible and specific and can be used for simultaneous analysis of these drugs in tablet formulation.
UV Spectrophotometric Method for theEstimation of Itopride Hydrochloride in Pharmaceutical Formulation
K. R. Gupta,R. R. Joshi,R. B. Chawla,S. G. Wadodkar
Journal of Chemistry , 2010, DOI: 10.1155/2010/526891
Abstract:
Behavior of suspending and wetting agents in aqueous environment
Dhawale Shashikant,Wadodkar Sudhir,Dorle Avinash
Asian Journal of Pharmaceutics , 2009,
Abstract: This work describes the changes in viscosity, conductivity, pH, electrical conductivity, dielectric constant, zeta potential, UV, and IR spectra of aqueous solutions/dispersions of sodium carboxy methyl cellulose (CMC), Tween 80, and sodium lauryl sulphate (SLS) during aging at different temperatures. Significant reduction in viscosity ofh sodium CMC occurred during aging studies, while relatively small decrease in viscosity was seen with Tween 80 and SLS. Increment in specific conductivity was seen with aging of excipients. Significant increase of zeta potential was also seen with aging of samples. Concomitant shift in IR spectra of samples was observed with aging at 40°C.
Stability indicating RP-HPLC method for simultaneous determination of pantoprazole sodium and itopride hydrochloride in bulk and capsule
Krishna R. Gupta,Rajesh B. Chawala,Sudhir G. Wadodkar
Orbital : the Electronic Journal of Chemistry , 2011,
Abstract: A stability indicating reversed-phase HPLC method has been developed and subsequently validated for simultaneous estimation of pantoprazole present as pantoprazole sodium sesquihydrate (PSS), and itopride hydrochloride from their combination product. The proposed RP-HPLC method utilizes a Phenomenex C18, 5 μm, 250 mm X 4.6 mm i.d. column, mobile phase consisting of phosphate buffer and acetonitrile in the proportion of 55:45 (v/v) with apparent pH adjusted to 5.0, and UV detection at 289.0 nm using a UV detector. PAN, ITH and their combination drug product were exposed to thermal, photolytic, hydrolytic and oxidative stress conditions, and the stressed samples were analyzed by the proposed method. The described method was linear over a range of 4-20 μg/mL for PAN and 15-75 μg/mL for ITH. The mean recoveries were 100.02 and 99.88 for PAN and ITH, respectively. Chromatographic peak purity data of PAN and ITH indicated no co-eluting peaks with the main peaks of drugs which demonstrated the specificity of assay method for their estimation in presence of degradation products. The proposed method can be useful in the quality control of combination drug products.
Spectrophotometric methods for simultaneous estimation of pantoprazole and itopride hydrochloride in capsules
Krishna R. Gupta,Rajesh B. Chawala,Sudhir G. Wadodkar
Orbital : the Electronic Journal of Chemistry , 2010,
Abstract: Three simple, accurate and economical methods for simultaneous estimation of pantoprazole and itopride hydrochloride in two component solid dosage forms have been developed. The proposed methods employ the application of simultaneous equation method (Method A), absorbance ratio method (Method B) and multicomponent mode of analysis method (Method C). All these methods utilize distilled water as a solvent. In distilled water pantoprazole shows maximum absorbance at a wavelength of 289.0 nm while itopride hydrochloride shows maximum absorbance at a wavelength of 258.0 nm also the drugs show an isoabsorptive point at a wavelength of 270.0 nm. For multicomponent method, sampling wavelengths 289.0 nm, 270.0 nm and 239.5 nm were selected. All these methods showed linearity in the range from 4-20 μg/mL and 15-75 μg/mL for pantoprazole and itopride hydrochloride respectively. The results of analysis have been validated statistically and by recovery studies.
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