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Search Results: 1 - 10 of 2398 matches for " Wadhwa Sanjay "
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Molecular docking of glucosamine-6-phosphate synthase in Rhizopus oryzae
Kamalika Banerjee,Utkarsh Gupta,Sanjay Gupta,Gulshan Wadhwa
Bioinformation , 2011,
Abstract: Recent expansion of immunocompromised population has led to significant rise in zygomycosis caused by filamentous fungus Rhizopus oryzae. Due to emergence of fungal resistance and side-effects of antifungal drugs, there is increased demand for novel drug targets. The current study elucidates molecular interactions of peptide drugs with G-6-P synthase (catalyzing the rate-limiting step of fungal cell wall biosynthetic pathway) of R.oryzae by molecular docking studies. The PDB structures of enzyme in R.oryzae are not known which were predicted using I-TASSER server and validated with PROCHECK. Peptide inhibitors, FMDP and ADGP previously used against enzyme of E.coli (PDBid: 1XFF), were used for docking studies of enzyme in R.oryzae by Schrodinger-Maestro v9.1. To investigate binding between enzyme and inhibitors, Glide and Induced Fit docking were performed. IFD results of 1XFF with FMDP yielded C1, R73, W74, T76, G99 and D123 as the binding sites. C379 and Q427 appear to be vital for binding of R.oryzae enzymes to inhibitors. The comparison results of IFD scores of enzyme in R.oryzae and E.coli (PDBid: 2BPL) yield appreciable score, hinting at the probable effectiveness of inhibitors FMDP and ADGP against R.oryzae, with ADGP showing an improved enzyme affinity. Moreover, the two copies of gene G-6-P synthase due to extensive fungal gene duplication, in R. oryzae eliminating the problem of drug ineffectiveness could act as a potential antifungal drug target in R. oryzae with the application of peptide ligands.
Structured Rehabilitation Exercise Program in Parkinson’s Disease
Srikumar V,Wadhwa Sanjay,Singh U,Yadav SL
Indian Journal of Physical Medicine and Rehabilitation , 2010,
Abstract: Title of the article: A Study of structured rehabilitationexercise program in Parkinson’s diseaseContext: There is a growing need to address rehabilitationissues to supplement medical therapy.Aims: To assess the impact of rehabilitation interventionin the functional status and quality of life in patients withParkinson’s disease.Settings and Design: Prospective follow-up study in ateaching hospitalMaterials and Methods: Twenty-eight cases withParkinson’s Disease on a stable pharmacological regimenand moderately disabled participated in this study. Allpatients were given the same set of exercises. Duringthe first month, patients performed exercises undersupervision at the hospital and rest of the days at home.In the second and third month, patients continued thesame exercises at home. During the fourth month, patientsmaintained their usual level of physical activity butdiscontinued the exercises. All patients were evaluatedat 0, 1, 2, 3 and 4 months. Outcome measures used wereUnified Parkinson’s Disease Rating Scale (UPDRS)version 3.0, Webster step seconds product, andParkinson’s Disease Quality of Life Questionnaire(PDQL)Results: Significant improvements were observed inUPDRS section 1 (Mentation, behavior and mood),sections 2 and 6 (Activities of Daily Living), PDQLsubscales (parkinsonian symptoms, systemic symptomsand social functioning), and Webster step-seconds product.Conclusions: Systematic program of physical therapy isbeneficial in patients suffering from moderately disabledParkinson’s disease. Activities of daily living like dressing,turning in bed and walking respond favorably to exercises.Quality of life improves considerably following exercisesleading to increased social participation
Organisational climate from view point of motivation in district hospital, India  [PDF]
Bhaskar Purohit, Ashok Wadhwa
Health (Health) , 2012, DOI: 10.4236/health.2012.47063
Abstract: Organisational Climate (OC) has been an important topic of research in Organisational Development. There are several frameworks and approaches to study OC. One such framework focuses on the effect of OC on motivation. Although studying OC from viewpoint of motivetion is an important one, there is very limited research in Indian public health system on assessing OC from the view point of motivation. The present study uses a comprehensive framework that focuses on assessing OC from the view point of motivation in a government district hospital. The overall objective of the study was to assess the OC of a District Hospital (DH) from the view point of motivation. A total of 66 staff (all from the same district hospital) participated in the study that included 12 Class I doctor specialists; 14 Class II doctors and 40 Class III staff The data was collected using a validated instrument called Motivational Analysis of Climate (MAO-C). The instrument included six needs or motives and twelve dimensions of organisational climate that were ranked by individuals according to their perception. Based on the ranks, final scores were calculated that reflected the dominant climate (highest score for a particular motive) and backup climates (second highest score for a particular motive). Also a combination of the two motives, dominant and back up motives or climates indicated a particular OC. According to the study, the dominant climate in the organisation was that for Dependency motive while the backup climate for the organisation was for Control motive. According to the literature, both Dependency and Control motives are dysfunctional climates. A high dependency motive indicates that the overall organisational climate is characterized by no initiatives by the people and the employees always look for approval from their seniors; assistance of others in developing oneself; a need to check with others who are more knowledgeable. Similarly high score for control motive indicates that order is maintained in organisation; indicates display of personal power; a desire to stay informed and an urge to monitor events and to take corrective action when needed. When the two motives are combined, the study indicates a dependency-control climate profile which means that the organisational practices are similar to government offices, where subordinates have no say in decision making and they have to follow the established rules of the organisation. Such organisations have clearly laid communication channels controlled from higher authority indicating typical characteristics of a
Highly Efficient, One Pot Synthesis and Oxidation of Hantsch 1,4-Dihydropyridines Mediated by Iodobenzene Diacetate (III) Using Conventional Heating, Ultrasonic and Microwave Irradiation  [PDF]
Khalid Hussain, Deepak Wadhwa
International Journal of Organic Chemistry (IJOC) , 2014, DOI: 10.4236/ijoc.2014.43019
Abstract: A mild, general, convenient, and efficient one-pot synthesis of 4-arylpyridines (4) is described using conventional heating, ultrasound and microwave irradiation. Aryl aldehydes (2) were efficiently condensed with ethylacetoacetate (1) and ammonium acetate in acetonitrile to give dihydropyridine intermediates (4). The latter underwent a smooth Iodobenzene Diacetate (III) mediated aromatization reaction in the same pot to afford 4-arylpyridines (4) in good to excellent yields.
An Empirical Examination of Efficiency Theory of Mergers in Emerging Market India  [PDF]
Kavita Wadhwa, Sudhakara Reddy Syamala
Theoretical Economics Letters (TEL) , 2015, DOI: 10.4236/tel.2015.56088
Abstract: The “inconclusive” existing literature on long-term horizon studies of mergers is the motivation of this paper to reexamine the post-merger performance and explore the reasons of unsatisfactory performance. We test efficiency theory of mergers by examining the industry adjusted operating performance of mergers. Unlike the existing literature which examines the operating performance of mergers at end level (ROA or ROE), we not only examine the operating performance at end level but also analyze the performance at each stage of operation i.e. material, labor, overheads, tax, interest and sales. We do not find synergy creation at the end level (i.e. ROA level). However, we observe synergy creation at tax and interest level and synergy destruction at labor and overheads level. The performance of different categories of mergers which are group/non-group mergers, related/unrelated mergers and BIFR/non-BIFR mergers is also examined. Factors explaining the post-merger profitability, efficiency and cash flows are also examined.
Financial Crisis and International Portfolio Diversification: A Principal Component Analysis Approach  [PDF]
Sudhakara Reddy Syamala, Kavita Wadhwa
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.62038
Abstract: The present study examines the co-movement of selected world market stock indices in order to analyze the potential gains that Indian investors can achieve when they diversify their portfolio into international markets. The sample consists of a mix of different categories of world markets such as the matured markets like the USA, Japan, and UK, emerging markets like India, Singapore, South Korea, and Thailand with an inclusion of other world markets to cover more or less all the markets of the world. We examine the co-movement using principal component analysis which is useful in terms of stability of factors and it is unlikely that factor stability can be observed over longer periods. We examine the co-movement for a period of 15 years from 2000-2015. The results here suggest that there was a different pattern in the world markets before and after the financial crisis and the best portfolio for an Indian investor is Germany, Malaysia, Jakarta, Mexico, and Israel would appropriate.
A Research Study on Mobile Internet Protocol Wireless Network
Hitesh Wadhwa
International Journal of Advances in Engineering Sciences , 2012,
Abstract: This Paper presents the way to implement a test bed for the measurement of various parameters that might affect wireless network performance and to validate results obtained from the simulator environment to that of real networking environment. This validation is of great importance to correctly predict current and future uses of the Internet technology in wireless domain. This validation will also help to make recommendations on research and standardization tasks to improve acceptance of Internet network and transport layer protocols in wireless environments.
Memory less Non Linear System Model
Hitesh Wadhwa
International Journal of Advances in Engineering Sciences , 2011,
Abstract: This Paper presents a methodology for the design of analog circuits. Under this methodology, the ports of all circuit blocks are bidirectional. The stability of circuits designed following this methodology can be determined by local, rather than global,analysis. If the circuit blocks follow a certain design discipline, they can be connected in nearly arbitrary configurations while maintaining stability. This methodology may be applied to designing circuits that solve several classes of problems. In particular, it is applied to designing a small circuit that can build a model of a memory less nonlinear system, and to predistort to linearize this system. First, this document shows how this methodology can be used to solve basic con-strained optimization problems in analog circuits. Given a set of constraint equations, it shows how to build a circuit that will solve that set of equations. This circuit is sufficiently small that it can be used for simple analog processing in basic analog circuits; for instance, it may be used to set optimal bias currents for another circuit. Next, this Paper shows how to use this methodology to build a circuit that can be used to determine the parameters of a model of a system through observation of the system’s behavior. This circuit can, for instance, be used to monitor and model the nonlinearity of the power output stage of an amplifier. Given this model, a symmetric, matched circuit can predistort to compensate for the nonlinearity. These circuits are small enough that they can be used as blocks for other analog circuits, particularly in places where digital processing is impossible due to size and cost constraints.
Quantitative Stereology: The Use of Camera Lucida for Counting Neurons by Physical Disector Method in Chick Brainstem Auditory Nuclei
Wadhwa S
Journal of Postgraduate Medicine , 2003,
Two Photon Physics at LEP
Maneesh Wadhwa
Physics , 1999,
Abstract: LEP offers an excellent opportunity to measure two photon processes over a large kinematical range and thus study the complex nature of the photon. This article reviews the experimental status of ``Two Photon Physics'' at LEP. The recent results on resonances, multi-hadron production and photon structure functions are discussed
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