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Search Results: 1 - 10 of 55220 matches for " WU Tian "
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The Reconstruction Strategies of Vrisa, Greece after the 2017 Earthquake  [PDF]
Fangning Wu, Yinsheng Tian
World Journal of Engineering and Technology (WJET) , 2018, DOI: 10.4236/wjet.2018.62B003
Abstract:
This paper focuses on a small Greek village named Vrisa and a specific condition of Lesbos as the arrival island for hundreds of thousands of refugees, aiming to reconsider places in state of emergency and think of flexible future reconstruction strategies which are able to adapt to the new unpredictable conditions of post-disaster. After the 2017 earthquake, the buildings in Vrisa were marked with red, yellow and green which shows different levels of damage. Also, there are some regulations to restrict the fa?ade, square meter, decoration and funding of rebuilding. By analyzing the characteristics of Vrisa village before earthquake and situation after earthquake, we came up with three reconstruction strategies from different aspects to find solutions. Meanwhile, this paper hopes to provide a reference and suggestions for similar cases of post-earthquake reconstruction.
Application of Neural Network to Game Algorithm  [PDF]
Ying Tian, Sangkee Min, Qinge Wu
Journal of Computer and Communications (JCC) , 2018, DOI: 10.4236/jcc.2018.62001
Abstract: Intelligent was very important for command decision model, and it was also the key to improve the quality of simulation training and combat experiment. The decision-making content was more complex in the implementation of tasks and the nature of the problem was different, so the demand for intelligence was high. To solve better the problem, this paper presented a game method and established a game neural network model. The model had been successfully applied in the classification experiment of winning rate between chess game, which had good theoretical significance and application value.
Research on Policy Regulation and Realization Path of Ningxia’s Construction of All-for-One Tourism Demonstration Zone  [PDF]
Di Tian, Meifan Wu, Mu Zhang
Modern Economy (ME) , 2018, DOI: 10.4236/me.2018.99097
Abstract: Located at the key spot of the construction of the Silk Road Economic Belt, Ningxia Hui Autonomous Region has abundant natural and cultural resources with relatively small area and small population, and tourism here plays an important role in local economic development. As China vigorously promoted the construction of tourism throughout the nation, the local government actively responded to the call of the state and successfully became the second state-level all-for-one tourism demonstration zone on a province basis, and finally achieved some decent results. In order to summarize the experience on tourism policy of Ningxia, by introducing Nvivo implementation analysis tool, this paper analyzes and summarizes a series of policy documents for the construction of demonstration zone in Ningxia. According to the specific requirements in the Guideline on the Development of All-for-One Tourism released by the State Council, the article encodes the specific policy measures for Ningxia’s development and establishes a node system, pointing out that Ningxia’s policy measures are consistent with the ones formulated at the national level. On this basis, taking the Xixia District of Yinchuan in Ningxia Hui Autonomous Region as an example, the paper analyzes its specific measures and effects of developing regional tourism, and discusses the policy regulation and implementation path that means taking planning and guidance seriously, emphasizing concrete implementation, promoting industrial integration, and paying close attention to tourism supervision.
Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche
Tian Li,Yaojiong Wu
Bone Marrow Research , 2011, DOI: 10.1155/2011/353878
Abstract: Hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are both adult stem cells residing in the bone marrow. MSCs interact with HSCs, they stimulate and enhance the proliferation of HSCs by secreting regulatory molecules and cytokines, providing a specialized microenvironment for controlling the process of hematopoiesis. In this paper we discuss how MSCs contribute to HSC niche, maintain the stemness and proliferation of HSCs, and support HSC transplantation. 1. Introduction Hematopoietic stem cells (HSCs) are rare cells residing in the bone marrow (BM; 1 in 104 to 1 in 108 of BM nucleated cells), and they are progenitors that become progressively restricted to several or single lineages. These progenitors yield blood precursors devoted to unilineage differentiation and the production of mature blood cells, including red blood cells, megakaryocytes, myeloid cells (monocyte/macrophage and neutrophil), and lymphocytes [1, 2]. CD34 surface antigen (CD34+) is commonly used as a marker to identify and quantify the population of progenitor cells [3], according to which, sorting HSCs from BM, peripheral blood (PB), and umbilical cord (UC)/placenta blood is relatively simple and practical [2, 4–6]. Human HSCs are known to exhibit CD34+, Thy1+, CD38lo/?, Ckit?/lo, CD105+, and Lin? phenotype. However, there is no general agreement on the association between any combination of these antigenic properties and function of stem cells [3, 6]. HSCs depend on their microenvironment, the niche, for regulating self-renewal and differentiation [7]. For instance, the disruption of BMP pathway can increase the numbers of osteoblasts and HSCs [8, 9], and the chemokine CXCL12 regulates the cyclical release and the migration of HSCs [10, 11]. Activation of β-catenin enforces HSCs enter cell cycle, thus leading to exhaustion of the long-term stem cell pool [12–14]. These findings suggest that signaling pathways and cellular interactions regulate the BM niche for HSCs. Besides, hypoxia regulate hematopoiesis in BM by maintaining important HSC functions and the interplay between HSCs and neighboring cells [15, 16]. Plating studies indicate that mesenchymal stem cells (MSCs) are present as a rare population of cells in the BM. They represent approximately 0.001% to 0.01% of the nucleated cells, about 10-fold less abundant than HSCs, but MSCs can be readily grown in culture [17]. Though predominantly residing in the BM, MSCs also present similar but not identical features in many other tissues such as blood, placenta, dental pulp, and adipose tissue. MSCs have the
A Bayesian Algorithm for Functional Mapping of Dynamic Complex Traits
Tian Liu,Rongling Wu
Algorithms , 2009, DOI: 10.3390/a2020667
Abstract: Functional mapping of dynamic traits measured in a longitudinal study was originally derived within the maximum likelihood (ML) context and implemented with the EM algorithm. Although ML-based functional mapping possesses many favorable statistical properties in parameter estimation, it may be computationally intractable for analyzing longitudinal data with high dimensions and high measurement errors. In this article, we derive a general functional mapping framework for quantitative trait locus mapping of dynamic traits within the Bayesian paradigm. Markov chain Monte Carlo techniques were implemented for functional mapping to estimate biologically and statistically sensible parameters that model the structures of time-dependent genetic effects and covariance matrix. The Bayesian approach is useful to handle difficulties in constructing confidence intervals as well as the identifiability problem, enhancing the statistical inference of functional mapping. We have undertaken simulation studies to investigate the statistical behavior of Bayesian-based functional mapping and used a real example with F2 mice to validate the utilization and usefulness of the model.
Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors
Sun Tian, Wu Jianhua
International Journal of Biological Sciences , 2010,
Abstract: Proprotein convertases are enzymes that proteolytically cleave protein precursors in the secretory pathway to yield functional proteins. Seven mammalian subtilisin/Kex2p-like proprotein convertases have been identified: furin, PC1, PC2, PC4, PACE4, PC5 and PC7. The binding pockets of all seven proprotein convertases are evolutionarily conserved and highly similar. Among the seven proprotein convertases, the furin cleavage site motif has recently been characterized as a 20-residue motif that includes one core region P6-P2′ inside the furin binding pocket. This study extended this information by examining the 3D structural environment of the furin binding pocket surrounding the core region P6-P2′ of furin substrates. The physical properties of mutations in the binding pockets of the other six mammalian proprotein convertases were compared. The results suggest that: 1) mutations at two positions, Glu230 and Glu257, change the overall density of the negative charge of the binding pockets, and govern the substrate specificities of mammalian proprotein convertases; 2) two proprotein convertases (PC1 and PC2) may have reduced sensitivity for positively charged residues at substrate position P5 or P6, whereas the substrate specificities of three proprotein convertases (furin, PACE4, and PC5) are similar to each other. This finding led to a novel design of a short peptide pattern for small molecule inhibitors: [K/R]-X-V-X-K-R. Compared with the widely used small molecule dec-RVKR-cmk that inhibits all seven proprotein convertases, a finely-tuned derivative of the short peptide pattern [K/R]-X-V-X-K-R may have the potential to more effectively inhibit five of the proprotein convertases (furin, PC4, PACE4, PC5 and PC7) compared to the remaining two (PC1 and PC2). The results not only provide insights into the molecular evolution of enzyme function in the proprotein convertase family, but will also aid the study of the functional redundancy of proprotein convertases and the development of therapeutic applications.
Timing Acquisition with Noisy Template for Ultra-Wideband Communications in Dense Multipath
Zhi Tian,Lin Wu
EURASIP Journal on Advances in Signal Processing , 2005, DOI: 10.1155/asp.2005.439
Abstract: Timing acquisition is critical to enabling the potential of ultra-wideband (UWB) radios in high-speed, short-range indoor wireless networking. An effective timing acquisition method should not only operate at a low sampling rate to reduce implementation complexity and synchronization time, but also be able to collect sufficient signal energy in order to operate in a reasonable transmit SNR regime. Energy capture for time-hopping impulse-radio transmissions in dense multipath is particularly challenging during the synchronization phase, in the absence of reliable channel and timing information. In this paper, we develop an efficient sampling strategy for correlation-based receivers to accomplish adequate energy capture at a low cost, using a noisy correlation template constructed directly from the received waveform. Merging our sampling operation based on noisy template with low-complexity timing acquisition schemes, we derive enhanced cyclostationarity-based blind synchronizers, as well as data-aided maximum likelihood timing offset estimators, all operating at a low frame rate. Both analysis and simulations confirm evident improvement in timing performance when using our noisy template, which makes our low-complexity timing acquisition algorithms attractive for practical UWB systems operating in dense multipath.
Thermodynamics of Black Holes from Equipartition of Energy and Holography
Yu Tian,Xiaoning Wu
Physics , 2010, DOI: 10.1103/PhysRevD.81.104013
Abstract: A gravitational potential in the relativistic case is introduced as an alternative to Wald's potential used by Verlinde, which reproduces the familiar entropy/area relation S=A/4 (in the natural units) when Verlinde's idea is applied to the black hole case. Upon using the equipartition rule, the correct form of the Komar mass (energy) can also be obtained, which leads to the Einstein equations. It is explicitly shown that our entropy formula agrees with Verlinde's entropy variation formula in spherical cases. The stationary space-times, especially the Kerr-Newman black hole, are then discussed, where it is shown that the equipartition rule involves the reduced mass, instead of the ADM mass, on the horizon of the black hole.
Optimization of clear liquid fermentation condition for ethanol production from Canna edulis Kerl  [PDF]
Ying Shen, Qing-li Tang, Tian-Xiang Wu
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.22019
Abstract: In this paper, clear liquid fermentation condition for ethanol production from Canna edulis Kerl with orthogonal design was studied. We have studied five factors that influenced clear liquid fermentation condition for ethanol production from Canna edulis Kerl by the single-factor test. The five factors were α-amylase amount, glu-coamylase amount, pH, nitrogen and auxiliary materials amount. Selected the best amounts of α-amylase, glucoamylase, pH, nitrogen source and auxiliary materials by means of the singe- factors test. And then, we used the Orthogonal test to optimize the fermentation process. The study showed that the best fermentation condi-tions were α-amylase amount 7 u/g C.eduli, glu-coamylase amount 145u/g C. edulis, pH 4.4 and the amount of urea 0.08%, 1% of rice bran as auxiliary materials. The rate of alcohol which was produced by the best fermentation conditions is 21.5% that increased by 1.3% than the rate of alcohol by the single-factor test.
Preparation of N, N, N′, N′-tetrakis-(2-benzimidazolylmethyl)-1,2-ethanediamine and crystal assemblies of the relative complexes  [PDF]
Shanling Tong, Yahong Wu, Zhaoyong Tian, Yan Yan
Open Journal of Inorganic Chemistry (OJIC) , 2012, DOI: 10.4236/ojic.2012.24011
Abstract: N, N, N′, N′-tetrakis-(2-benzimidazolylmethyl)-1, 2-ethanediamine(TBIMEDA), was prepared by reaction of ethylenediamine tetra-acetic acid disodium salt(EDTA) with 1, 2-diaminobenzene in a refluxed glycol solution, and furthermore, three allomeric complexes[(MIITBIMEDA) SO4·5H2O, M = Cd, Co, Ni] were selfassembled by solvothermal method based on reaction of this ligand with the relative sulfates respectively. These allomeric complexes were characterized by elemental analysis and IR spectroscopy and their crystal structures were determined by single crystal X-ray structural analysis. In the crystal architecture of these complexes, every metal(II) ion is chelated by one neutral TBIMEDA ligand to form an octahedral core with configuration of five heterocyclic rings (five- member ring). These cores then were linked to- gether by multi hydrogen bond interactions with sul- fate ions and water molecules to construct their 3D crystal architectures.
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