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Search Results: 1 - 10 of 5754 matches for " WR Miller "
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Evolution of aromatase inhibitors as an endocrine treatment for breast cancer
WR Miller
Breast Cancer Research , 2006, DOI: 10.1186/bcr1546
Predicting response/resistance to endocrine therapy for breast cancer
WR Miller, TJ Anderson, D Evans, A Krause, JM Dixon
Breast Cancer Research , 2005, DOI: 10.1186/bcr1056
Abstract: All patients had histologically confirmed breast cancer and were treated for 3–4 months with either tamoxifen or an aromatase inhibitor (anastrozole, exemestane or letrozole). Core or excisional tumour biopsies were taken before and at the end of treatment (and at 10–14 days in certain studies). Oestrogen receptors (ER), progestogen receptors and c-erbB1 and c-erbB2 were measured by immunohistochemistry. Microarray analysis was performed on tumour RNA extracted and amplified before hybridization on Affymetrix HG_U133A GeneChips for microarray analysis.Steroid hormone receptor status highly influences the response to all endocrine therapies, negative tumours failing to respond and response being more likely with increasing levels of ER and the concomitant presence of PgR. Conversely, tumour overexpression of c-erbB2 (and c-erbB1) is associated with resistance to tamoxifen but not aromatase inhibitors. While these receptors are helpful in identifying groups of tumours with differing sensitivity to endocrine therapy, they fail to predict accurately in individual cases. To address this deficiency, in Edinburgh we have looked for early genetic changes (at 10–14 days) that occur with treatment and might be associated with subsequent response to the aromatase inhibitor letrozole. Clinical response data were available for 43 cases, of which 33 (77%) were classified as responders (>50% reduction in tumour volume) and 30 (70%) displayed evidence of pathological response. No gene changed substantially with treatment in all cases; however, there was consistent upregulation of three genes and downregulation of 65 genes in 50 of the cases. Based on clustering techniques, it was possible to identify highly consistent changes in gene expression with treatment, which allowed tumours to be subdivided into groups showing distinct patterns of molecular changes. While the change in expression of any single gene failed to correlate with response, significant differences in change of expr
Inverting the organisational pyramid
WR Hendee
Biomedical Imaging and Intervention Journal , 2007, DOI: 10.2349/biij.3.3.e29
Pancreatic Fine Needle Aspiration: To Do or not To Do?
Brugge WR
JOP Journal of the Pancreas , 2004,
A Monte-Carlo algorithm for maximum likelihood estimation of variance components
S Xu, WR Atchley
Genetics Selection Evolution , 1996, DOI: 10.1186/1297-9686-28-4-329
The presence of Fasciola hepatica (Liver-fluke) in humans and cattle from a 4,500 Year old archaeological site in the Saale-Unstrut Valley, Germany
Dittmar, K;Teegen, WR;
Memórias do Instituto Oswaldo Cruz , 2003, DOI: 10.1590/S0074-02762003000900021
Abstract: during an excavation of a site of the corded ware culture in the saale-unstrut-valley (ca. 3000 bc) in germany, a soil sample from the pelvis of a human skeleton was studied under palaeoparasitological aspects. eggs of the trematode fasciola hepatica and of the nematode genus capillaria were found. this is the first case of a direct association of a f. hepatica-infestation to both a prehistoric human skeleton and domesticated animal remains. sheep and cattle bones were present at the same site and f. hepatica eggs were found in bovine samples. this strongly points toward an existing infection cycle, involving humans as a final host.
Further notes on the natural history of the South American pepper frog, Leptodactylus labyrinthicus (Spix, 1824) (Anura, Leptodactylidae)
Silva, WR.;Giaretta, AA.;
Brazilian Journal of Biology , 2008, DOI: 10.1590/S1519-69842008000200024
Abstract: leptodactylus labyrinthicus tadpoles reach a large size in the nest through consumption of trophic eggs. we previously suggested that the trophic eggs are laid just after amplexus has finished, but our new data do not support this hypothesis. we also present further details on the natural history of the species with regard to breeding activity, spawning site, retreats and the ability of tadpoles in preying upon fully-growth heterospecific tadpoles. we also show that the tadpoles are mainly nocturnal and take diurnal refuges. we collected the data in brazil in three localities within the cerrado biome. we examined burrows used by l. labyrinthicus males, verified if females still contained mature eggs just after released from amplexus, and tested the ability of tadpoles in preying fully-growth heterospecific tadpoles. field observations and experiments were conducted on tadpole activity time, hiding behaviour and level of susceptibility to predation by the bird leaf-scrapers in four sheltering situations. reproduction could start before the first rains; this may be advantageous by allowing the tadpoles to exploit eggs of other frogs. we found one floating nest built in a temporary pool. the nest of the species is normally circumscribed in an excavated basin beside the water body. adult males were found during the day with their head-out of the entrance of underwater burrows, which were perforations through dense root mats beside calling/spawning sites. probably, these burrows in permanently water-filled soil are actively excavated by males. females released all their eggs during the amplexus, so trophic eggs are not produced by the currently-accepted mechanism. fully-grown heterospecific tadpoles were not preyed upon by l. labyrinthicus tadpoles, which can prey only slow-moving newly hatched ones. field tadpoles took shelter under mud/dead leaves during daylight and became exposed on the bottom at night. free-ranging leaf-scrapers removed dead leaves from a pool with
RX Herculink Elite renal stent system: a review of its use for the treatment of renal artery stenosis
Colyer Jr, WR
Medical Devices: Evidence and Research , 2012, DOI: http://dx.doi.org/10.2147/MDER.S25150
Abstract: culink Elite renal stent system: a review of its use for the treatment of renal artery stenosis Review (1632) Total Article Views Authors: Colyer Jr, WR Published Date August 2012 Volume 2012:5 Pages 67 - 73 DOI: http://dx.doi.org/10.2147/MDER.S25150 Received: 28 March 2012 Accepted: 13 May 2012 Published: 01 August 2012 William R Colyer Jr Division of Cardiovascular Medicine, University of Toledo Medical Center, Toledo, OH, USA Abstract: The management of renal artery stenosis (RAS) remains controversial. While some evidence suggests that treatment with stent placement is beneficial, randomized trials have failed to demonstrate a significant benefit. Ongoing clinical trials should help to better define the role for stenting of RAS while avoiding limitations seen with earlier trials. When it comes to stenting for RAS, several stents have been used; however, many stents which have been used previously and which are still being used are biliary stents that are used “off-label.” These stents have typically come onto the market through the 510(k) pathway. To date, a total of five stents have been approved by the United States Food and Drug Administration for use in the renal arteries. Of the five stents that have received approval, the Bridge Extra Support (Medtronic CardioVascular, Santa Rosa, CA) and the Palmaz (Cordis Corporation, Bridgewater, NJ) stents are no longer available. Currently, the Express SD (Boston Scientific, Natick, MA), Formula (Cook Medical, Bloomington, IN), and Herculink Elite (Abbott Vascular, Santa Clara, CA) stents are Food and Drug Administration approved and available for use. The Herculink Elite is the most recently approved of the renal stents, having received approval in late 2011. The Herculink Elite stent is the only cobalt chromium stent approved for use in the renal arteries. Although trial data are limited and direct comparisons among renal stents is not possible, the Herculink Elite stent has demonstrated good performance. Additionally, the design of the Herculink Elite offers some advantages that may translate into improved outcomes.
Flowering dynamics, nectar secretion and insect visitation of Phacelia campanularia A. Gray
Anna Wróblewska
Acta Agrobotanica , 2010, DOI: 10.5586/aa.2010.004
Abstract: In the years 2004-2006, flowering dynamics and nectar secretion of Phacelia campanularia A. Gray flowers as well as the insect visitation rate were studied in the climatic conditions of Lublin, Poland. The flowering of phacelia started in the middle of June and lasted for 1.5 up to 2 months. Full bloom occurred between the third and fifth week of the flowering period of this taxon. For the study period, the average weight of nectar produced by 10 flowers was 75.64 mg, weight of sugars 11.31 mg, while their concentration in the nectar was 20.2%. Among the entomofauna foraging on the flowers of phacelia, honey bees were predominant, with their proportion among the pollinators accounting for 84.8%.
Response of Fuchsia hybrida cuttings to flurprimidol and naphthaleneacetic acid application
Katarzyna Wróblewska
Acta Agrobotanica , 2013, DOI: 10.5586/aa.2013.002
Abstract: Auxins are the only compounds used in commercial plant propagation to stimulate rooting, although efforts have been made to find other efficient compounds. Another group of rooting promoters could be plant growth retardants (PGRs) which act as inhibitors of gibberellin synthesis. The aim of the experiment was to determine the effect of flurprimidol and naphthalene-1-acetic acid (NAA) applied by quick-dip method on rooting and development of Fuchsia hybrida 'Swingtime' cuttings and their subsequent growth. Anatomical analysis of the rooting process was also done. Flurprimidol and NAA did not influence the percentage of rooted fuchsia cuttings but increased the number of adventitious roots. Both compounds were involved in earlier formation of root primordia. Flurprimidol and NAA, used simultaneously or separately, increased the number and length of axillary shoots of fuchsia cuttings. The effect of flurprimidol on the number of roots and shoots was stronger than that of NAA, but diminished after transplanting the rooted cuttings. The influence of flurprimidol on axillary shoot length was weaker as its concentration increased.
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