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Search Results: 1 - 10 of 4859 matches for " WONG JS "
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Acute drug induced hepatitis secondary to a weight loss product purchased over the internet
Deepak Joshi, Tim JS Cross, Voi Wong
Nutrition Journal , 2007, DOI: 10.1186/1475-2891-6-13
Abstract: A 20-year old woman presented with a two day history of abdominal pain, vomiting and jaundice. There were no identifiable risk factors for chronic liver disease. Liver function tests demonstrated an acute hepatitis (aminoaspartate transaminase 1230 IU/L). A chronic liver disease screen was negative. The patient had started a weight loss product (Pro-Lean), purchased over the internet two weeks prior to presentation. The patient was treated conservatively, and improved. The sequence of events suggests an acute hepatitis caused by an herbal weight loss product.This case report highlights the dangers of weight loss products available to the public over the internet, and the importance of asking specifically about alternative medicines in patients who present with an acute hepatitis.Obesity is increasingly recognised as a medical problem [1]. Many people now seek alternative methods of weight loss, in particular weight reduction products, some of which are available over the internet. The potential dangers of these products are often not known. The authors describe a case of acute hepatitis in a 20 year old woman caused by such a product purchased over the internet.A 20-year-old woman presented with a two-day history of right upper quadrant pain, vomiting and jaundice. She did not drink alcohol and her only regular medication was the oral contraceptive pill that she had taken for many years. There was no history of recent foreign travel. There had also been no recent use of paracetamol, non steroidal anti-inflammatory drugs (NSAIDs), anti-biotics, or recreational drugs. She denied the use of intravenous drugs. On examination, she was icteric, with epigastric tenderness but no palpable organomegaly. There was no hepatic encephalopathy, nor stigmata of chronic liver disease. The full blood count was normal; white cell count 7.4 109/L (NR 4–11), platelets 200 109/L (NR 150–400), haemoglobin 15.9 g/dl (NR 11–13). Urea and electrolytes and coagulation studies were also norma
RISK FACTORS FOR DIABETIC RETINOPATHY IN DIABETICS SCREENED USING FUNDUS PHOTOGRAPHY AT A PRIMARY HEALTH CARE SETTING IN EAST MALAYSIA
MALLIKA PS,LEE PY,CHEAH WL,WONG JS
Malaysian Family Physician , 2011,
Abstract: Introduction: This study reports on the prevalence of diabetic retinopathy (DR) and risk factors among diabetic patients, who underwent fundus photography screening in a primary care setting of Borneo Islands, East Malaysia. We aimed to explore the preliminary data to help in the planning of more effective preventive strategies of DR at the primary health care setting. Materials and Methods: A cross-sectional study on 738 known diabetic patients aged 19-82 years was conducted in 2004. Eye examination consists of visual acuity testing followed by fundus photography for DR assessment. The fundus pictures were reviewed by a family physician and an ophthalmologist. Fundus photographs were graded as having no DR, NPDR, PDR and maculopathy. The data of other parameters was retrieved from patient’s record. Bi-variate and multivariate analysis was used toelucidate the factors associated with DR. Results: Any DR was detected in 23.7% (95% CI=21 to 27%) of the patients and 3.2% had proliferative DR. The risk factors associated with any DR was duration of DM (OR =2.5, CI=1.6 to 3.9 for duration of five to 10 years when compared to <5 years)and lower BMI (OR=1.8, CI=1.1 to 3.0). Moderate visual loss was associated with DR (OR=2.1, CI=1.2 to 3.7). Conclusions: This study confirms associations of DR with diabetic duration, body mass index and visual loss. Our data provide preliminary findings to help to improve the screening and preventive strategies of DR at the primary health care setting.
Perioperative and rehabilitation outcome after lower-limb amputation in elderly Chinese patients in Hong Kong.
Leung HB,Wong WC,Wu FC,Guerin JS
Journal of Orthopaedic Surgery , 2004,
Abstract: PURPOSE. Major amputation of the lower limb is considered the last resort when limb salvage is impossible. The aim of this study is to determine the morbidity, mortality, and rehabilitation outcome of patients that underwent a lower-limb amputation. METHODS. A retrospective cohort study was conducted among 100 elderly patients who underwent a total of 120 lower-limb amputations in a regional hospital in Hong Kong from 1996 to 2001. RESULTS. The mean age of the amputees was 77.9 years; 58 were female. 95% of the amputations were performed because of infection with or without vascular compromise; 55 transfemoral and 60 transtibial amputations contributed 96% of the case mix. Some 43% of patients experienced early complications and 12% required re-amputation. The early (30-day) mortality rate was 15%. Only 55% of the amputees survived after 4 years. A 44% return-home rate was achieved. However, only 11% of the amputees could walk without help from other people. Although prostheses were issued to 42% of the survivors, compliance was only 53%; 24% of the survivors lost their remaining leg within 2 years. CONCLUSION. The outcome of major lower-extremity amputation remains poor. Efforts should be made to retain these limbs. When it is proven impossible, one should strive to preserve the knee joint whenever feasible.
Endothelial cell counts after Descemet’s stripping automated endothelial keratoplasty versus penetrating keratoplasty in Asian eyes
Ang M,Mehta JS,Anshu A,Wong HK
Clinical Ophthalmology , 2012,
Abstract: Marcus Ang1,2, Jodhbir S Mehta1–4, Arundhati Anshu1,2, Hon Kiat Wong5, Hla M Htoon2, Donald Tan1–31Singapore National Eye Centre, 2Singapore Eye Research Institute, 3Department of Ophthalmology, National University Health Systems, 4Department of Clinical Sciences, Duke-NUS Graduate Medical School, 5Department of Ophthalmology, Tan Tock Seng Hospital, SingaporeBackground: The purpose of this study was to compare endothelial cell counts after Descemet’s stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty in Asian eyes.Methods: This was a retrospective study of patients from our prospective Singapore Corneal Transplant Study cohort who received corneal transplantation in 2006–2008. We compared eyes that underwent DSAEK or penetrating keratoplasty for Fuchs’ endothelial dystrophy or pseudophakic and aphakic bullous keratopathy. Clinical data, and donor and recipient characteristics were recorded. Of 241 patients who met our inclusion criteria, 68 underwent DSAEK and 173 underwent penetrating keratoplasty. The main outcome measure was endothelial cell loss at 1 year. Secondary outcome measures were graft survival and visual outcomes at 1-year follow-up.Results: There were no significant differences in baseline characteristics of patients between the treatment groups. Percent endothelial cell loss at 1-year follow-up was greater in penetrating keratoplasty eyes (40.9% ± 2.9%) compared with DSAEK eyes (22.4% ± 2.3%; P < 0.001). DSAEK-treated eyes had significantly superior uncorrected visual acuity (mean difference = 0.42 ± 0.0059; P < 0.001) and best spectacle-corrected visual acuity (mean difference = 0.14 ± 0.032; P < 0.001) as compared with penetrating keratoplasty-treated eyes. Penetrating keratoplasty-treated eyes had worse astigmatism as compared with DSAEK-treated eyes (-3.0 ± 2.1 versus -1.7 ± 0.8; P < 0.001). Graft survival at 1 year was comparable in both groups, ie, 66/68 (97.0%) DSAEK-treated eyes versus 158/173 (92.0%) of penetrating keratoplasty-treated eyes had clear grafts (P = 0.479).Conclusion: We report lower percent endothelial cell loss comparing DSAEK and penetrating keratoplasty at 1-year follow-up in Asian eyes, with comparable graft survival rates in both groups.Keywords: Descemet’s stripping automated endothelial keratoplasty, endothelial cell count, penetrating keratoplasty
Seasonal effects of influenza on mortality in a subtropical city
Lin Yang, Chit Wong, King Chan, Patsy Chau, Chun Ou, Kwok Chan, JS Malik Peiris
BMC Infectious Diseases , 2009, DOI: 10.1186/1471-2334-9-133
Abstract: A time-varying coefficient Poisson regression model was fitted to the weekly numbers of mortality of Hong Kong from 1996 to 2002. Excess risks associated with influenza were calculated to assess the seasonal effects of influenza.We demonstrated that the effects of influenza were higher in winter and late spring/early summer than other seasons. The two-peak pattern of seasonal effects of influenza was found for cardio-respiratory disease and sub-categories pneumonia and influenza, chronic obstructive pulmonary disease, cerebrovascular diseases and ischemic heart disease as well as for all-cause deaths.The results provide insight into the possibility that seasonal factors may have impact on virulence of influenza besides their effects on virus transmission. The results warrant further studies into the mechanisms behind the seasonal effect of influenza.The impact of influenza on mortality has been well established in the temperate regions, but only recently has such impact been documented in tropical and subtropical regions [1,2]. Unlike in the cool temperate regions where influenza activity shows a distinctive seasonality with a well-defined influenza epidemic occurring almost every winter [3], in the warm tropics and subtropics seasonal patterns of virus activity are more diffuse, sometimes showing two influenza epidemics annually but with influenza viruses being isolated throughout the year [4].Although influenza can be active in most time of the year, the upsurge of influenza viruses is not always followed by increased mortality [1]. We hypothesize that there are temporal variations in the effects of influenza on mortality. Such temporal variations are likely to exhibit a seasonal pattern because of seasonal variations in virus virulence and host susceptibility. Virulence of virus strains could be regulated through interaction between herd immunity, introduction of na?ve individuals, and ability of virus to shed and to generate new strains [5]. The frequent genetic
Endothelial cell counts after Descemet’s stripping automated endothelial keratoplasty versus penetrating keratoplasty in Asian eyes
Ang M, Mehta JS, Anshu A, Wong HK, Htoon HM, Tan D
Clinical Ophthalmology , 2012, DOI: http://dx.doi.org/10.2147/OPTH.S26343
Abstract: dothelial cell counts after Descemet’s stripping automated endothelial keratoplasty versus penetrating keratoplasty in Asian eyes Original Research (2181) Total Article Views Authors: Ang M, Mehta JS, Anshu A, Wong HK, Htoon HM, Tan D Published Date April 2012 Volume 2012:6 Pages 537 - 544 DOI: http://dx.doi.org/10.2147/OPTH.S26343 Received: 13 February 2012 Accepted: 06 March 2012 Published: 03 April 2012 Marcus Ang1,2, Jodhbir S Mehta1–4, Arundhati Anshu1,2, Hon Kiat Wong5, Hla M Htoon2, Donald Tan1–3 1Singapore National Eye Centre, 2Singapore Eye Research Institute, 3Department of Ophthalmology, National University Health Systems, 4Department of Clinical Sciences, Duke-NUS Graduate Medical School, 5Department of Ophthalmology, Tan Tock Seng Hospital, Singapore Background: The purpose of this study was to compare endothelial cell counts after Descemet’s stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty in Asian eyes. Methods: This was a retrospective study of patients from our prospective Singapore Corneal Transplant Study cohort who received corneal transplantation in 2006–2008. We compared eyes that underwent DSAEK or penetrating keratoplasty for Fuchs’ endothelial dystrophy or pseudophakic and aphakic bullous keratopathy. Clinical data, and donor and recipient characteristics were recorded. Of 241 patients who met our inclusion criteria, 68 underwent DSAEK and 173 underwent penetrating keratoplasty. The main outcome measure was endothelial cell loss at 1 year. Secondary outcome measures were graft survival and visual outcomes at 1-year follow-up. Results: There were no significant differences in baseline characteristics of patients between the treatment groups. Percent endothelial cell loss at 1-year follow-up was greater in penetrating keratoplasty eyes (40.9% ± 2.9%) compared with DSAEK eyes (22.4% ± 2.3%; P < 0.001). DSAEK-treated eyes had significantly superior uncorrected visual acuity (mean difference = 0.42 ± 0.0059; P < 0.001) and best spectacle-corrected visual acuity (mean difference = 0.14 ± 0.032; P < 0.001) as compared with penetrating keratoplasty-treated eyes. Penetrating keratoplasty-treated eyes had worse astigmatism as compared with DSAEK-treated eyes (-3.0 ± 2.1 versus -1.7 ± 0.8; P < 0.001). Graft survival at 1 year was comparable in both groups, ie, 66/68 (97.0%) DSAEK-treated eyes versus 158/173 (92.0%) of penetrating keratoplasty-treated eyes had clear grafts (P = 0.479). Conclusion: We report lower percent endothelial cell loss comparing DSAEK and penetrating keratoplasty at 1-year follow-up in Asian eyes, with comparable graft survival rates in both groups.
Effect modification of environmental factors on influenza-associated mortality: a time-series study in two Chinese cities
Lin Yang, Ping Chen, Jian He, King Chan, Chun Ou, Ai Deng, JS Malik Peiris, Chit Wong
BMC Infectious Diseases , 2011, DOI: 10.1186/1471-2334-11-342
Abstract: We applied a Poisson regression model to the mortality data of two Chinese metropolitan cities located within the subtropical zone, to calculate the influenza associated excess mortality risks during the periods with different levels of temperature and humidity.The results showed that high absolute humidity (measured by vapor pressure) was significantly (p < 0.05) associated with increased risks of all-cause and cardiorespiratory deaths, but not with increased risks of pneumonia and influenza deaths. The association between absolute humidity and mortality risks was found consistent among the two cities. An increasing pattern of influenza associated mortality risks was also found across the strata of low to high relative humidity, but the results were less consistent for temperature.These findings highlight the need for people with chronic cardiovascular and respiratory diseases to take extra caution against influenza during hot and humid days in the subtropics and tropics.Influenza used to be considered as a "cold" disease as it usually returns every cold winter in temperate countries. However, recent studies have shown that influenza can be active throughout the year in the warm tropics and subtropics and the disease burden of influenza there can be as heavy as that in temperate climates [1-4]. It has been proposed that influenza seasonality is driven by complicated interactions between antigenic drifts of virus strains, environmental factors, host susceptibility and behavior changes [5-7]. Among these potential factors, environmental factors including temperature and relative humidity have been most thoroughly explored by laboratory and observational studies [8,9]. Recent studies raised a hypothesis that absolute humidity is one of drivers for influenza seasonality in temperate regions [10,11], but the mechanism behind various seasonal patterns of influenza outbreaks under different climates remains unclear.Given the association of environmental factors with both
Resistance of livestock to viruses: mechanisms and strategies for genetic engineering
JS Gavora
Genetics Selection Evolution , 1996, DOI: 10.1186/1297-9686-28-5-385
Abstract:
Menstrual disturbances
JS Bagratee
Continuing Medical Education , 2004,
Abstract:
risk factors for hypertension among urban males in mombasa kenya
JS Salehmohamed
Dar Es Salaam Medical Students' Journal , 2008,
Abstract: OBJECTIVE To assess socio-cultural factors associated with hypertension among adult males of Mombasa in Kenya. MATERIALS AND METHODS: A community based cross-sectional study was done in Mombasa Old Town area, whereby males aged 15 yrs and above attending mosque after prayers were randomly requested to participate in the study. Data was collected using structured English questionnaires. Hypertension (HT) risk factors were assessed, followed by physical examination for obesity anthropometric measurements and blood pressure measurements. Questionnaires were coded and data entered in a computer and analyzed by epi info 2002 statistical computer program. RESULTS: The Prevalence of Hypertension in the population was found to be 6.7%, increase in age and smoking were found to be a predisposing risk factor for HT. Smokers had significant risk ratio of 4 in acquiring HT. It was also noted that Chewing of Miraa and Drinking alcohol had no significant association as a risk predisposing to HT. Although many alcohol consumers had HT. Occupation was not significantly associated with HT. The study unveiled that physical exercise had protective effect there by decreasing the risk of having HT. High Body Mass index (BMI) and Weight to Hip ration (WHR) was a predisposing risk factor for having HT. CONCLUSION & RECOMMENDATIONS Doing physical exercise was found to have protective association towards HT. It has been also noted that those people who had hypertension and were on regular medication were relatively better, thus physicians should intervene as early as possible so as to block the natural history of this debilitating disease.
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