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Search Results: 1 - 10 of 120158 matches for " WANG BaoDi "
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U-Pb zircon dating of Early Paleozoic gabbro from the Nantinghe ophiolite in the Changning-Menglian suture zone and its geological implication
BaoDi Wang,LiQuan Wang,GuiTang Pan,FuGuang Yin,DongBing Wang,Yuan Tang
Chinese Science Bulletin , 2013, DOI: 10.1007/s11434-012-5481-8
Abstract: The Nantinghe ophiolite is located in the northern part of the Changning-Menglian suture zone in southeast Tibet. It is composed of meta-peridotite, cumulative gabbro, meta-gabbro, plagioclase amphibolite and meta-basalt. Zircon U-Pb dating of the cumulative gabbro gives concordant ages of 473.0±3.8 Ma and 443.6±4.0 Ma respectively, indicating the early and late episodes of mafic magmatisms during the Paleo-Tethys oceanic rifting. The 16 LA-ICPMS zircon U-Pb analyses of meta-gabbro yield a weight mean age of 439±2.4 Ma. The gabbro shows relatively low contents of SiO2 (46.46%–52.11%), TiO2 (0.96%–1.14%) and K2O (0.48%–0.75%). Its trace element distribution patterns are partly similar to those of the mid-ocean ridge basalts, and part is depleted in high field strength elements such as Nb, Ta, Zr, Hf and Ti. These features suggest that the mafic rocks were probably formed in a MORB-like or backarc rift basin setting. The zircon U-Pb age of gabbro is consistent with a late crystallization age of the cumulative gabbro from the Nantinghe ophiolite, suggesting that the Paleo-Tethys oceanic basin was opened during 444–439 Ma, possibly as a backarc basin. It is the first precise age which defines the formation time of the early Paleozoic ophiolite in the Changning-Menglian suture zone. These geochronological and geochemical characteristics of the Nantinghe ophiolite are consistent with those from the Guoganjianianshan and Taoxinghu of the Longmu Co-Shuanghu suture in the Qiangtang region. Thus, we suggest that the both Changning-Menglian and Longmu Co-Shuanghu sutures were probably transformed from the relic oceanic crust of the uniform Paleo-Tethys, which likely represents the original and main Paleo-Tethys oceanic basin.
TAGCNA: A Method to Identify Significant Consensus Events of Copy Number Alterations in Cancer
Xiguo Yuan, Junying Zhang, Liying Yang, Shengli Zhang, Baodi Chen, Yaojun Geng, Yue Wang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041082
Abstract: Somatic copy number alteration (CNA) is a common phenomenon in cancer genome. Distinguishing significant consensus events (SCEs) from random background CNAs in a set of subjects has been proven to be a valuable tool to study cancer. In order to identify SCEs with an acceptable type I error rate, better computational approaches should be developed based on reasonable statistics and null distributions. In this article, we propose a new approach named TAGCNA for identifying SCEs in somatic CNAs that may encompass cancer driver genes. TAGCNA employs a peel-off permutation scheme to generate a reasonable null distribution based on a prior step of selecting tag CNA markers from the genome being considered. We demonstrate the statistical power of TAGCNA on simulated ground truth data, and validate its applicability using two publicly available cancer datasets: lung and prostate adenocarcinoma. TAGCNA identifies SCEs that are known to be involved with proto-oncogenes (e.g. EGFR, CDK4) and tumor suppressor genes (e.g. CDKN2A, CDKN2B), and provides many additional SCEs with potential biological relevance in these data. TAGCNA can be used to analyze the significance of CNAs in various cancers. It is implemented in R and is freely available at http://tagcna.sourceforge.net/.
Genesis of the Guanfang copper deposit in the Yunxian-Jinggu volcanic arc, western Yunnan: Evidences from fluid inclusions and geochronology


岩石学报 , 2013,
Abstract: The Guanfang copper deposit is located in the north part of Yunxian-Jinggu volcanic arc. Disseminated Cu ores and veinlets are hosted in the Xiaodingxi Formation almond-shaped basalt, basaltic breccia and associated fractures. We first report a precise zircon U-Pb age of 234.3±0.8Ma of the basalt from the Xiaodingxi Formation. This age indicates that the Xiaodingxi Formation is Middle Triassic, different with previously accepted of Late Triassic. Petrography, microthermometry and Laster Raman spectra studies on fluid inclusions in quartz and calcite indicate that at least two mineralizing episodes occurred in the Guanfang Cu deposit: the volcanic-subvolcanic hydrothermal mineralization during Middle Triassic and the groundwater hydrothermal (possibly genozoic) overprinting. In combination with the evolution history of the Yunxian-jinggu volcanic arc, we conclude that the Middle Triassic Xiaodingxi basalt and Manghuai rhyolite formed bimodal volcanic rock assemblage. The Guanfang Cu deposit occurs in the mafic volcanic rocks in rift basin with marine-continent-alternating sedimentary conditions. It has VHMS features in the early mineralization stage. Due to lack "brine pool", the place that hydrothermal ore-forming fluids accumulation, the Guangfang Cu deposit only occurs veinlet, networks and breccia bodies in volcanic path at the deposit bottom but no massive stratiformed ore bodies at the surface. The deposit overprinted by groundwater hydrothermal fluids at the late mineralization stage.
Hsp90 Is Involved in Apoptosis of Candida albicans by Regulating the Calcineurin-Caspase Apoptotic Pathway
BaoDi Dai, Yan Wang, DeDong Li, Yi Xu, RongMei Liang, LanXue Zhao, YongBing Cao, JianHui Jia, YuanYing Jiang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045109
Abstract: Candida albicans is the most common human fungal pathogen. Recent evidence has revealed the occurrence of apoptosis in C. albicans that is inducible by environmental stresses such as hydrogen peroxide, acetic acid, and amphotericin B. Apoptosis is regulated by the calcineurin-caspase pathway in C. albicans, and calcineurin is under the control of Hsp90 in echinocandin resistance. However, the role of Hsp90 in apoptosis of C. albicans remains unclear. In this study, we investigated the role of Hsp90 in apoptosis of C. albicans by using an Hsp90-compromised strain tetO-HSP90/hsp90 and found that upon apoptotic stimuli, including hydrogen peroxide, acetic acid or amphotericin B treatment, less apoptosis occurred, less ROS was produced, and more cells survived in the Hsp90-compromised strain compared with the Hsp90/Hsp90 wild-type strain. In addition, Hsp90-compromised cells were defective in up-regulating caspase-encoding gene CaMCA1 expression and activating caspase activity upon the apoptotic stimuli. Investigations on the relationship between Hsp90 and calcineurin revealed that activation of calcineurin could up-regulate apoptosis but could not further down-regulate apoptosis in Hsp90-compromised cells, indicating that calcineurin was downstream of Hsp90. Hsp90 inhibitor geldanamycin (GdA) could further decrease the apoptosis in calcineurin-pathway-defect strains, indicating that compromising Hsp90 function had a stronger effect than compromising calcineurin function on apoptosis. Collectively, this study demonstrated that compromised Hsp90 reduced apoptosis in C. albicans, partially through downregulating the calcineurin-caspase pathway.
Origin of the Miocene Bugasi Group volcanic rocks in the Cuoqin County,Western Tibetan Plateau

CHEN JianLin,XU JiFeng,KANG ZhiQiang,WANG BaoDi,
,] 许继峰 康志强[,] 王保弟[,]

岩石学报 , 2006,
Abstract: 通常认为青藏高原新生代钾质、超钾质岩浆源于地幔,但最近的一些研究显示一些钾质火山岩也可以起源于下地壳.青藏高原西部措勤县中新世布嘎寺组火山岩是一套钾质到超钾质的岩石,根据化学组成可以将它们分成中酸性和中基性两组火山岩,它们都属于钾玄岩系列.其中中酸性组火山岩具有一些类似于埃达克质熔体的成分特征,它们可能是拉萨地块下地壳相对富钾的镁铁质物质部分熔融的产物;中基性组火山岩可能起源于一个含金云母的地幔源区,或者是来自该地幔的基性岩浆的分异产物.对中酸性组火山岩高精度的氩-氩同位素定年获得其坪年龄为15.5Ma,证实布嘎寺组火山岩喷发在晚中新世.结合布嘎寺组火山岩的年龄、化学组成和区域构造以及岩浆组合,我们初步认为布嘎寺组火山岩可能与15~20Ma左右构造伸展活动产生的南北向地堑系统有关.
Geochemical comparison of Paleogene high-Mg potassic volcanic rocks in Sanjiang area and interior Tibetan Plateau: Compositional difference of the mantle sources

CHEN JianLin,XU JiFeng,WANG BaoDi,KANG ZhiQiang,

岩石学报 , 2010,
Abstract: “三江”地区和青藏高原内部广泛分布有新生代早第三纪高镁钾质岩(MgO>6%,K2O/Na2O>1),通常认为它们应起源于地幔源区,虽然它们均有着富钾、富集LILE和亏损HFSE的共同特征,并在形成时代上有着一致性,但青藏高原这些在不同区域的早第三纪火山岩在地球化学特征有显著的差异。“三江”地区同高原内部高镁钾质岩相比具有明显高的εNd(t) 值,指示前者起源于一个相对亏损的富集地幔源区。青藏高原早第三纪高镁钾质岩可能源于与古俯冲环境相联系的富集地幔源区,但不同地区的富集物质和地幔源区矿物组成以及形成深度却是各不同。青藏高原内部高镁钾质岩的形成可能与高原腹部始新世下地壳的拆沉有关;而“三江”地区早第三纪高镁钾质岩可能与发生在50~40Ma北向俯冲的特提斯大洋板片断离有关。同时早第三纪特提斯大洋板片的北向俯冲和断离对“三江”地区在该时期的成矿物质的富集和成矿过程有着重要的贡献。
Study of mineral exsolution on the Songduo eclogites in Tibet

GUO Qian,ZHAO WenXi,CHEN JianLin,WANG BaoDi,

岩石学报 , 2012,
Abstract: A lot exsolution structures have been observed in the Songduo eclogites, southern Tibet. EDS analyzing in the EPMA shows that the exsolutions in garnet are rutile, and the exsolutions in omphacite are a K-rich mineral and quartz. The calculation of the garnet-omphacite-phengite geobarothermometer shows that the peak-metamorphic P-T conditions of the Songduo eclogites are close to the transformation line between quartz-coesite. Thus, the exsolutions of minerals indicate that the Songduo eclogites likely experienced UHP metamorphism, which provides an important evidence for formation P-T conditions of the Songduo eclogites.
Chronology, geochemistry and petrogenesis of Deqin granodiorite body in the middle section of Jiangda-Weixi arc

ZHANG WanPing,WANG LiQuan,WANG BaoDi,WANG DongBing,DAI Jie,LIU Wei,

岩石学报 , 2011,
Abstract: 本文对江达-维西火山岩浆弧德钦岩体的寄主岩石——花岗闪长岩及其镁铁质微粒包体(MME)——闪长岩进行了详细研究。二者LA-ICPMS锆石U-Pb年龄分别为254.6±1.8Ma和253.5±1.6Ma,二者形成时代一致。地球化学研究结果表明,花岗闪长岩富K2O和Na2O,且K2O>Na2O,富Al2O3,A/CNK平均为0.96;闪长岩富K2O和Na2O,但K2O2O,富Al2O3和MgO,A/CNK平均为0.72;花岗闪长岩的稀土总量低于闪长岩,二者轻重稀土分馏明显,配分曲线为右倾的轻稀土富集型;二者均富集大离子亲石元素而亏损高场强元素Nb、Ta等;二者均具有相对较高的Mg#(58.8~65.8),并具有相对较高的相容元素Cr、Ni含量(花岗闪长岩平均值分别为115×10-6和31.6×10-6,闪长岩平均值分别为398×10-6和98.2×10-6;花岗闪长岩和闪长岩176Hf/177Hf的平均值分别为0.282383和0.282287,二者εHf(t)平均值分别为-8.3和-11.8,反映了二者属于I型花岗岩,可能为岩浆混合作用的产物。地球化学特征及Hf同位素组成一致显示岩浆来源于地壳的部分熔融,伴有不同比例的地幔物质加入,形成于弧陆碰撞-后碰撞的构造背景,暗示金沙江结合带在~255Ma已经进入了弧陆碰撞-后碰撞的地质时期。
Geochemical differences between the subduction-and collisional-type ore-bearing porphyric rocks

CHEN JianLin,XU JiFeng,REN JiangBo,WANG BaoDi,YU HongXia,

岩石学报 , 2011,
Abstract: Porphyry Cu-Mo-Au deposits occur not only in an arc setting, but also in a collisional belt. These ore-bearing porphyries in different tectonic settings have distinctly different geochemistry in trace elements, implying that they have different compositions in source or dynamic mechanisms. Comparing with collisional-type ore-bearing porphyries, the subduction-type rocks have obviously high HREE and Y concentrations, low Sr/Y, (La/Yb)N and (Dy/Yb)N ratios, suggesting that their source are mainly consisted of amphibole but less or no garnet. Although some of subduction-type ore-bearing porphyric rocks have somewhat adakitic geochemical signature, most samples show characteristics similar to the normal arc volcanic rocks, which are likely the product of mantle wedge, metasomatically enriched during slab subduction, through MASH (melting-assimilation-storage-homogenization) process. The collisional-type ore-bearing porphyric rocks clearly have characteristics of typical adakites, which be likely related to the earlier episodes of subduction in their source. The geochemistry of major and trace elements of ore-bearing porphyric rocks in Pulang-Xuejipin is similar to that of the subduction-type. They are likely the products by partial melting of metasomatized mantle wedge by subduction fluid or sediment, trigged by slab break-off of westward-subduction of Ganzi-Litang Ocean, instead of by direct partial melt of an oceanic slab.
The zoning structure of clinopyroxene phenocrysts in the Miocene sodium analcime (nepheline) phonolite in Mibale area, Tibet: Implications for the magmatic and tectonic evolution

ZHAO WenXia,YU LiFang,CHEN JianLin,GUO Qian,WANG BaoDi,

岩石学报 , 2011,
Abstract: Sodium analcime (nepheline) phonolites in Mibale area of Tibetan Plateau contain abundant clinopyroxene phenocrysts which show the normal, reverse or oscillatory zoning patterns. The normal zones increase in FeO, Na2O, Al2O3 and TiO2 but decrease in Mg#, MgO, Cr2O3 from core to rim, which indicates the normal magmatic evolution of fractional crystallization. The reverse zone have increasing Mg#, MgO and Cr2O3 but decreasing FeO, Na2O and Al2O3, indicating that the sodium analcime (nepheline) phonolite had been mixed or contaminated by the ultra-potassic or potassic magmas, and that both phonolite and potassic-rich rocks might have different parental magmas. The clinopyroxenes with oscillatory zones were probably the result of multi-stage magmatic mixing since that Na2O, Al2O3, TiO2 and Cr2O3 vary between normal and reverse zone clinopyroxenes as well as Mg# within the range of the phenocryst and the matrix clinopyroxenes. The peralkaline sodium magmas erupted at 13~12Ma in the area, corresponding to a temporary tectonic transformation, which suggests a typical intracontinental extensional setting.
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