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Search Results: 1 - 10 of 640885 matches for " W.K.B.K.M. Fernando "
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The Toxic Laundry Detergent Powder ‘Prinso’ Is Gaining Notoriety Amongst Villagers For Deliberate Self- Poisoning In And Around The Matara District
M.A.A.K. Munasinghe,W.K.B.K.M. Fernando
Sri Lanka Journal of Critical Care , 2009,
Abstract: ntroduction: The washing powder ‘Prinso' consists of 2 sachets, one containing pink crystals and the other white granules which has become a popular agent amongst the youth for self poisoning.Objectives: To document clinical and biochemical features of ‘prinso' poisoning. To analyze the chemical constituents of prinso. Patients and methods: We present a series of 7 patients who were admitted to General hospital Matara following ‘Prinso' poisoning, from 01.06 2006 to 01.10.2007. We chemically analyzed the two sachets in faculty of science university of Ruhuna.Results: The male: female ratio was 3:4.Out of the 7 patients, 1 patient developed acute renal failure.Conclusion: The readily available household product ‘Prinso' has come to recognition in the array of poisons responsible for deliberate self poisoning among young with a preponderance among females ingesting it in the southern province of Sri Lanka.
The impact of seminal zinc and fructose concentration on human sperm characteristic
Amidu, N.,Owiredu, W.K.B.A.,Bekoe, M.A.T.,Quaye, L.
Journal of Medical and Biomedical Sciences , 2012,
Abstract: This study assessed the association between the estimated fructose and zinc concentration and various seminal characteristics. The study participants include 90 male subjects visiting the Komfo Anokye Teaching Hospital between January and July, 2010 for semen analysis as part of routine fertility investigations prior to treatment. Seminal fructose concentration was significantly lower when the normozoospermic group was compared to the oligozoospermic group (P < .0001) and in the normozoospermic group compared to the azoospermic group (P = 0.0096). A comparison be-tween the oligospermic group and the azoospermic group gave no statistically significant differ-ence. Fructose correlated positively with volume (r = 0.36, P < 0.0001) and head defect (r = 0.07, P > 0.05) and negatively with count (r = -0.21, P < 0.05). Zinc correlated negatively with volume (r = -0.09) and head defect (r = -0.20) and positively with motility (r = 0.18), count (r = 0.15) and tail de-fect (r = 0.11). Seminal fructose and zinc concentrations correlated negatively (r = -0.26, P < 0.05). The role of seminal fructose concentration does not only lie in the assessment of seminal vesicle dysfunction but in conjunction with other seminal properties could give a useful indication of male reproductive function whilst seminal zinc concentration might not be most appropriate for the as-sessment of male reproductive dysfunction.
The Prevalence of Autoimmune Diabetes Among Diabetes Mellitus Patients in Kumasi, Ghana
M.T. Agyei-Frempong,F.V.K. Titty,W.K.B.A. Owiredu,B.A. Eghan
Pakistan Journal of Biological Sciences , 2008,
Abstract: This study investigate the occurrence and the prevalence of autoantibodies and the metabolic characteristics of autoimmune and antibody-negative type 2, diabetes in recently diagnosed diabetes mellitus patients in Kumasi, Ghana. This study involved a total of 120 recently diagnosed (< 1 year) Ghanaian diabetes mellitus patients (17 insulin-requiring and 103 non insulin-requiring) and 60 controls. A standardized questionnaire was used. Blood pressure and anthropometric measurements were taken. Fasting glucose, lipid and lipoprotein concentrations were measured by enzymatic methods and HbA1C levels by agglutination test. Serum insulin level and autoantibodies (ICA, GAD ab and IAA) were analyzed by enzyme-linked immunosorbent assay (ELISA). Out of the 17 insulin-requiring, six were positive for either GAD ab or ICA or both. Out of the 103 non insulin-requiring, 16.5% were positive for ICA and /or GAD ab and/or IAA. The prevalence of Latent Auto-immune Diabetes of Adults (LADA) in the non-insulin requiring and in the total diabetic patients, were 13.5 and 11.7%, respectively. The prevalence of autoimmune type 1 diabetes in the studied population was 7.5% and that of autoimmune diabetes in the total diabetic population was 19.2%. Autoimmune and autoantibody-negative type 2, diabetes did not differ (p = ns) in the mean values of clinical and metabolic parameters, except hypertension, central obesity and HbA1C values. Autoimmune diabetes occurs in recently diagnosed diabetic patients in Ghana at prevalence comparable to that in developed countries. Both ICA and GAD ab tests are required to identify autoimmune diabetes.
Serum Lipid Profile of Breast Cancer Patients
W.K.B.A. Owiredu,S. Donkor,B. Wiafe Addai,N. Amidu
Pakistan Journal of Biological Sciences , 2009,
Abstract: The purpose of this study was to carry out a comparative study to investigate the effect of lipid profile, oestradiol and obesity on the risk of a woman developing breast cancer. This study was carried out at the Komfo Anokye Teaching Hospital (KATH), Peace and Love Hospital, Oduom, Kumasi and Redeemed Clinic, Nima, Accra between May 2002 and March 2003. In this study, 200 consented women comprising 100 breast cancer patients (43 pre- and 57 post-menopausal) and 100 controls (45 pre- and 55 post-menopausal) with similar age range (25 to 80 years) were assessed for lipid profile, oestradiol and BMI. There was a significant increase in Body Mass Index (BMI) (p = 0.011), Total Cholesterol (TC) (p<0.001), triglyceride (p = 0.026) and low density lipoprotein (LDL-cholesterol) (p = 0.001) of the breast cancer patients compared to the controls. With the exception of oestradiol (EST) that decreased, the lipid profile generally increased with age in both subjects and controls with the subjects having a much higher value than the corresponding control. There was also a significant positive correlation between BMI and TC (r2 = 0.022; p = 0.002) and also between BMI and LDL-cholesterol (r2 = 0.031; p = 0.0003). Apart from EST and LDL-cholesterol that were increased significantly only in the postmenopausal phase in comparison to the controls, BMI, TC and TG were increased in both pre-menopausal and post menopausal phases with HDL-cholesterol remaining unchanged. This study confirms the association between dyslipidaemia, BMI and increased breast cancer risk.
Antidepressant-Like Effects of an Ethanolic Extract of Sphenocentrum jollyanum Pierre Roots in Mice
E. Woode,N. Amidu,W.K.B.A. Owiredu,E. Boakye-Gyasi
International Journal of Pharmacology , 2009,
Abstract: In the present study, the effect of an ethanolic extract of the roots of the plant in two animal models of depression the Forced Swimming Test (FST) and Tail Suspension Test (TST) has been reported. The extract (100-1000 mg kg-1; p.o.), dose-dependently reduced the duration of immobility in both the FST (ED50: 296.20 ± 53.97 mg kg-1) and TST (203.90 ± 39.01 mg kg-1).The effect of the extract was 20-50 times less potent than imipramime and fluoxetine which were used as standards. Pretreatment with α-methydopa (400 mg kg-1; 3 h; p.o.) attenuated the anti-immobility effects of imipramime but not SJE and fluoxetine. Similarly, pretreatment with reserpine (1 mg kg-1; 24 h; s.c.) abolished the effect of imipramime and partially the effects of SJE but not fluoxetine. A concomitant treatment with α-methyldopa and reserpine attenuated the effects of all but fluoxetine. The extract, imipramime and fluoxetine did not modify motor performance on the rotarod test at all doses tested. Putting all together, present results suggest that SJE has antidepressant-like effects in the model employed and may possibly exert its effects by modifying monoamine transport and/or metabolism.
Precision and Accuracy of Three Blood Glucose Meters: Accu-Chek Advantage, One Touch Horizon and Sensocard
W.K.B.A. Owiredu,G. Amegatcher,N. Amidu
Journal of Medical Sciences , 2009,
Abstract: This study evaluated the accuracy and precision associated with the use of three popular alternative-site blood glucose monitors, Accu-chek Advantage, Onetouch Horizon and Sensocard, using forearm venous blood samples and capillary blood samples. The study was conducted from January to March, 2009 at the Komfo Anokye Teaching Hospital, Kumasi. One hundred and ninety consenting subjects were included in the study. The blood glucose levels were analyzed on glucose meters; Accu-chek Advantage, Sensocard and Onetouch Horizon by finger stick, using amperometry Technology. At the same time venous blood glucose was analyzed using the WHO reference Glucose Oxidase Method (GOD). The mean value generated by the WHO reference method (7.91±0.35) was not significantly different (p = 0.2816) from that produced by the Accu-chek Advantage (8.46±0.36), Sensocard (7.72±0.35; p = 0.7028) and Onetouch Horizon (7.97±0.35; p = 0.9044). Bland-Altman analysis indicates that Onetouch Horizon and Accu-chek Advantage have the tendency of overestimating blood glucose with a bias of -0.1 and -0.5, respectively. Sensocard could under-estimate with a bias of 0.2. In terms of rating, while all the glucose meters gave precisions at about the same level (i.e., 1.0), Onetouch Horizon is generating the closest value to the reference method with a difference between mean of -0.06, followed by Sensocard of 0.19 and Accu-chek Advantage with a value of -0.55. The precision of the Accu-chek Advantage, Onetouch Horizon and Sensocard for blood glucose monitoring from about 3.1-33.3 mmol L-1 is good. However, the Accu-chek Advantage has the tendency to overestimate at the hypoglycaemic levels. The Accu-chek Advantage is capable of estimating both capillary and venous blood glucose to the same level of accuracy. The Onetouch Horizon and Sensocard are however incapable of efficiently estimating venous blood glucose.
Prevalence of metabolic syndrome among Psychiatric Patients in the Kumasi Metropolis, Ghana
Owiredu, W.K.B.A.,Osei, O.,Amidu, N.,Appiah-Poku, J.
Journal of Medical and Biomedical Sciences , 2012,
Abstract: This cross-sectional study seeks to find the prevalence of the metabolic syndrome (MetS), its indi-vidual components and oxidative stress in psychiatric patients on antipsychotic medication com-pared to newly diagnosed patients attending the Psychiatric Department of the Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana, between February 2009 and July 2010. A total of 200 psychiatric patients comprising 100 newly diagnosed antipsychotic-na ve patients and 100 patients on antipsychotic medication were sampled for the study. MetS was diagnosed using the World Health Organization (WHO), International Diabetes Federation (IDF) and the National Choles-terol Education Programme, Adult Treatment Panel III (NCEP ATP III) criteria. The overall prevalence of MetS was 11.5%, 13.5% and 15.5% using NCEP ATP III, WHO and IDF criteria re-spectively. The prevalence was significantly higher among psychiatric patients on treatment as compared to treatment-na ve group using NCEP ATP III (21.0% vs. 2.0%; p < 0.0001) and IDF (29.0% vs. 2.0%; p < 0.0001) criteria but not WHO (13.0% vs. 14.0%; p = 0.8372). These overall prev-alence rates were higher compared to the general Ghanaian population prevalence rates of 3.9%, 2.2% and 7.8% determined with the NCEP ATP III, WHO and IDF criteria respectively. Regular monitoring of metabolic parameters should be considered as a standard part of their medical care.
The Impact of Blood Glucose and Cholesterol Levels on the Manifestation of Psychiatric Disorders
W.K.B.A. Owiredu,J. Appiah-Poku,F. Adusei-Poku,N. Amidu
Pakistan Journal of Biological Sciences , 2009,
Abstract: This study examined possible association of fasting glucose, and lipid abnormalities in psychiatric patients on conventional antipsychotic medications. A total of 305 subjects were used for the study, comprising 203 clinically diagnosed psychiatric patients and 102 non-psychiatric subjects used as control at the psychiatric clinic at Komfo Anokye Teaching Hospital (KATH). Questionnaires were administered, blood pressure and anthropometric measurements undertaken. Fasting blood samples were taken for glucose and total cholesterol. The patients included those treated with conventional antipsychotic agents. It was noted, that there were higher rates of diabetes (22.17%) and lipid abnormalities (42.43%) with lower rate of hypertension (5.91%) and obesity (5.91%) across the sample as compared to control. This finding suggests that the high prevalence of diabetes and lipid abnormalities, in a young, psychiatrically ill population makes the case for aggressive screening.
Residual Risk of Transmission of Hepatitis B Virus through Blood Transfusion in Ghana: Evaluation of the performance of Rapid Immunochromatographic Assay with Enzyme Linked Immuno-sorbent Assay
Owiredu, W.K.B.A.,Osei-Yeboah, J.,Amidu, N.,Laing, E.F.
Journal of Medical and Biomedical Sciences , 2012,
Abstract: Blood transfusion necessitates screening of transmissible infectious pathogens such as hepatitis B virus (HBV) to curtail post transfusion risk of infection. The study re-examined this approach by evaluating the efficiency of solely testing for hepatitis B surface antigen (HbsAg) marker for blood transfusion, the efficacy of the various immunochromatographic assays in the screening process and the residual risk of hepatitis B viral transmission through transfusion in Ghana. A convenient purposive sampling technique was used in selecting ten hospitals, from each of the 10 regions. A total of 480 aliquots of blood were collected anonymously, from blood already tested for HbsAg with immunochromatographic assay in the blood banks of the chosen facilities and declared nega-tive. Plasma from the blood was obtained through centrifugation, separated into well labeled micro-tubes and transported in cold boxes to the Molecular Medicine Department-KNUST. The samples were then re-examined for all six hepatitis B virus (HBV) (HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc and IgM anti-HBc) serological markers using ELISA assay. When a total of 480 plasma samples from the blood banks of the ten chosen facilities were re-examined with the ELISA assay, 39(8.13%) samples reacted positive for HBsAg, 60(12.5%) reacted for Anti-HBs, 13(2.71%) reacted for HBeAg, 51(10.63%) for Anti-HBe and 329(68.54%) reacted positively for Anti-HBc. None of the samples reacted positive for IgM anti-HBc. The estimated sero-prevalence for all HBV serological markers is 76.67% whereas the estimated residual risk of HBV infection through blood transfusion caused by the use of immunochromatographic methods in the screening of blood for transfusion was 8.47%(5.98% - 10.94% at 95% CI). An additional risk of 3.10%(1.54% - 4.62% at 95% CI) of HBV infection through transfusion was also estimated for the non-testing of other HBV infectious sero-logical markers. The total residual risk for transfusion transmitted HBV was 11.16%(8.34% - 13.95% at 95% CI). The study revealed that neither the kits in use nor the testing strategy in place now is adequate to prevent transmission of hepatitis B virus through transfusion in Ghana due to the high residual risk of transmission of HBV. There is therefore an urgent need for a sustainable quality control system on the screening of HBsAg in blood for donation in Ghana.
The Prevalence of the Metabolic Syndrome Among Ghanaian Pregnancy-Induced Hypertensive Patients Using the World Health Organisation and the National Cholesterol Education Program III Criteria
C.A. Turpin,L. Ahenkorah,W.K.B.A. Owiredu,E.F. Laing
Journal of Medical Sciences , 2008,
Abstract: The aim of this study was to determine the risk factors among Ghanaian women with Pregnancy-Induced Hypertension (PIH). Thirty women with preeclampsia, seventy with gestational hypertension and fifty normotensive pregnant women (controls) in the second half of pregnancy were recruited for this study. There was a significant increase in the prevalence of metabolic syndrome among the PIH subjects as compared to the normotensive pregnant women (controls) using the National Cholesterol Education Program (NCEPIII) and World Health Organisation criteria. Ghanaian women presenting with PIH are very prone to the development of the metabolic syndrome, thus the indices must be screened for during antenatal care.
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