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Search Results: 1 - 10 of 84507 matches for " W. McFarland "
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Neutrino Scattering in a Magnetic Field
K. S. McFarland,A. C. Melissinos,N. V. Mikheev,W. W. Repko
Physics , 2001, DOI: 10.1063/1.1374980
Abstract: Motivated by the evidence for a finite neutrino mass we examine anew the interaction of neutrinos in a magnetic field. We present the rate for radiative scattering for both massless and massive neutrinos in the standard model and give the corresponding numerical estimates. We also consider the effects arising from a possible neutrino magnetic moment.
Teaching English to the medical profession. Developing communication skills and bringing humanities to medicine
Jonathan McFarland
Panace@ : Revista de Medicina, Lenguaje y Traducción , 2009,
Abstract: This is a personal account of teaching English for medical purposes (EMP), explaining my interest in helping health professionals in Majorca improve their English. My main aim has been to enable them to communicate both orally at medical conferences and in written form for journals. The article explains how the teaching has been a twofold experience, with the professionals explaining their different specialities, while I have provided them with the necessary linguistic tools. Presentations have been integral to this, with humanities in medicine being a theme underlying the entire approach. The article concludes with a small section on the future of English in a medical context. ------------------------------------------------------- Ense ar inglés a los médicos: desarrollo de las habilidades de comunicación y acercamiento de las humanidades a la medicina. Este es un relato personal de mi experiencia en la ense anza de inglés con fines médicos (IFM), en el que explico mi interés en ayudar a los profesionales sanitarios de Mallorca a mejorar su nivel de inglés. Mi objetivo principal ha sido capacitarlos para que pudieran comunicarse verbalmente en conferencias médicas y por escrito en las publicaciones correspondientes. Doy cuenta en él de la dualidad de la experiencia adquirida durante la ense anza, en la que los profesionales explicaban sus distintas especializaciones mientras yo les proporcionaba las herramientas lingüísticas necesarias. Las presentaciones han sido un elemento crítico del proceso, y las humanidades médicas un tema subyacente al enfoque integral del proyecto. El artículo finaliza con una peque a sección acerca del futuro del inglés en el contexto médico.
Examination of the role of magnetic resonance imaging in multiple sclerosis: A problem-orientated approach
McFarland Henry
Annals of Indian Academy of Neurology , 2009,
Abstract: Magnetic Resonance Imaging (MRI) has brought in several benefits to the study of Multiple Sclerosis (MS). It provides accurate measurement of disease activity, facilitates precise diagnosis, and aid in the assessment of newer therapies. The imaging guidelines for MS are broadly divided in to approaches for imaging patients with suspected MS or clinically isolated syndromes (CIS) or for monitoring patients with established MS. In this review, the technical aspects of MR imaging for MS are briefly discussed. The imaging process need to capture the twin aspects of acute MS viz. the autoimmune acute inflammatory process and the neurodegenerative process. Gadolinium enhanced MRI can identify acute inflammatory lesions precisely. The commonly applied MRI marker of disease progression is brain atrophy. Whole brain magnetization Transfer Ratio (MTR) and Magnetic Resonance Spectroscopy (MRS) are two other techniques use to monitor disease progression. A variety of imaging techniques such as Double Inversion Recovery (DIR), Spoiled Gradient Recalled (SPGR) acquisition, and Fluid Attenuated Inversion Recovery (FLAIR) have been utilized to study the cortical changes in MS. MRI is now extensively used in the Phase I, II and III clinical trials of new therapies. As the technical aspects of MRI advance rapidly, and higher field strengths become available, it is hoped that the impact of MRI on our understanding of MS will be even more profound in the next decade.
Neutrino Interactions
Kevin McFarland
Physics , 2008,
Abstract: This manuscript summarizes a series of three lectures on interactions of neutrinos . The lectures begin with a pedagogical foundation and then explore topics of interest to current and future neutrino oscillation and cross-section experiments.
Quality of life for veterans and servicemembers with major traumatic limb loss from Vietnam and OIF/OEF conflicts
Richard A. Epstein, PhD,Allen W. Heinemann, PhD,Lynne V. McFarland, PhD
Journal of Rehabilitation Research and Development , 2010,
Abstract: The goals of rehabilitation after major limb loss include not only functional restoration but also a return to a high quality of life (QOL). Few studies have identified which factors are associated with QOL in veterans and servicemembers with combat-associated major limb loss. We enrolled Vietnam and Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) veterans and servicemembers in a national survey on prostheticdevice use. In the Vietnam group, multivariate analysis found multiple limb loss (adjusted odds ratio [aOR] = 3.1, 95% confidence interval [CI] = 1.57–6.02) and satisfaction with currentprostheses (aOR = 1.2, 95% CI = 1.05–1.38) are associated with better overall QOL, while a higher amputation impact rank (aOR = 0.66, 95% CI = 0.59–0.74) and depression (aOR = 0.21, 95% CI = 0.08–0.54) are associated with worse overall QOL. In the OIF/OEF group, three factors are significantly associated with worse overall QOL: combat-associated head injury (aOR = 0.78, 95% CI = 0.61–0.99), combat-associated injury to the nonamputatedlimb (aOR = 0.71, 95% CI = 0.57–0.88), and assistanceneeded in daily living (aOR = 0.12, 95% CI = 0.02–0.72). Improving satisfaction with prosthetic devices, improving mentalhealth care, and treating other combat-associated injuries may significantly improve the overall QOL for these veterans and servicemembers.
HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures
Adam Pickard?,Simon S. McDade?,Marie McFarland,W. Glenn McCluggage?,Cosette M. Wheeler?,Dennis J. McCance
PLOS Pathogens , 2015, DOI: 10.1371/journal.ppat.1004988
Abstract: Cervical cancer is a multi-stage disease caused by human papillomaviruses (HPV) infection of cervical epithelial cells, but the mechanisms regulating disease progression are not clearly defined. Using 3-dimensional organotypic cultures, we demonstrate that HPV16 E6 and E7 proteins alter the secretome of primary human keratinocytes resulting in local epithelial invasion. Mechanistically, absence of the IGF-binding protein 2 (IGFBP2) caused increases in IGFI/II signalling and through crosstalk with KGF/FGFR2b/AKT, cell invasion. Repression of IGFBP2 is mediated by histone deacetylation at the IGFBP2 promoter and was reversed by treatment with histone deacetylase (HDAC) inhibitors. Our in vitro findings were confirmed in 50 invasive cancers and 79 cervical intra-epithelial neoplastic lesions caused by HPV16 infection, where IGFBP2 levels were reduced with increasing disease severity. In summary, the loss of IGFBP2 is associated with progression of premalignant disease, and sensitises cells to pro-invasive IGF signalling, and together with stromal derived factors promotes epithelial invasion.
Size-exclusion chromatography can identify faster-associating protein complexes and evaluate design strategies
Chad L Mayer, W Kalani Snyder, Monika A Swietlicka, Andrew D VanSchoiack, Chad R Austin, Benjamin J McFarland
BMC Research Notes , 2009, DOI: 10.1186/1756-0500-2-135
Abstract: Small-zone size-exclusion chromatography (SEC) detected persistent high-affinity MICA mutant-NKG2D complexes in solution as early-eluting peaks. The SEC binding assay used standard protein purification instrumentation to evaluate complex stability, qualitatively paralleled the SPR results, and successfully discriminated among complexes that differed only in on-rates. We used the SEC binding assay, along with SPR, to assess the results of a follow-up design strategy targeting the non-interfacial redesigned region. Both SEC and SPR agreed that these mutations did not enhance affinity as much as previous mutants. When the SEC binding assay was run in 1 M urea, only the highest affinity complex was detected.This SEC binding assay provides a correlation with SPR results for protein complex affinities, detecting changes in complex on-rates, and tunable to lower sensitivity with 1 M urea. The SEC binding assay is complementary to other protein design evaluation methods, can be adapted to the undergraduate research laboratory, and may provide additional structural information about changes in hydrodynamic radii from elution times. Our assay allowed us to conclude that further alteration of MICA at non-contacting residues is unlikely to further enhance NKG2D affinity.Several protein design algorithms have been produced over the past decade for rationally altering and optimizing the cores of proteins, protein-ligand interfaces, and protein-protein interfaces for structural and therapeutic application [1], including RosettaDesign [2]. Protein design schemes require a step for screening a set of candidate proteins. Size-exclusion chromatography (SEC) is an option for design evaluation if a protein's size is changed significantly or a larger, high-affinity protein-protein complex is formed. For protein-protein complexes, the SEC column can be saturated with protein for a large-zone assay [3], or a small plug of protein can be injected onto a column for a small-zone assay [4,5].
Cost Analysis of a Nucleic Acid Amplification Test in the Diagnosis of Pulmonary Tuberculosis at an Urban Hospital with a High Prevalence of TB/HIV
Max W. Adelman, Ekaterina Kurbatova, Yun F. Wang, Michael K. Leonard, Nancy White, Deborah A. McFarland, Henry M. Blumberg
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0100649
Abstract: Introduction The Centers for Disease Control and Prevention has recommended using a nucleic acid amplification test (NAAT) for diagnosing pulmonary tuberculosis (TB) but there is a lack of data on NAAT cost-effectiveness. Methods We conducted a prospective cohort study that included all patients with an AFB smear-positive respiratory specimen at Grady Memorial Hospital in Atlanta, GA, USA between January 2002 and June 2008. We determined the sensitivity, specificity, and positive and negative predictive value of a commercially available and FDA-approved NAAT (amplified MTD, Gen-Probe) compared to the gold standard of culture. A cost analysis was performed and included costs related to laboratory tests, hospital charges, anti-TB medications, and contact investigations. Average cost per patient was calculated under two conditions: (1) using a NAAT on all AFB smear-postive respiratory specimens and (2) not using a NAAT. One-way sensitivity analyses were conducted to determine sensitivity of cost difference to reasonable ranges of model inputs. Results During a 6 1/2 year study period, there were 1,009 patients with an AFB smear-positive respiratory specimen at our public urban hospital. We found the NAAT to be highly sensitive (99.6%) and specific (99.1%) on AFB smear-positive specimens compared to culture. Overall, the positive predictive value (PPV) of an AFB smear-positive respiratory specimen for culture-confirmed TB was 27%. The PPV of an AFB smear-positive respiratory specimen for culture-confirmed TB was significantly higher for HIV-uninfected persons compared to those who were HIV-seropositive (152/271 [56%] vs. 85/445 [19%]; RR = 2.94, 95% CI 2.36–3.65, p<0.001). The cost savings of using the NAAT was $2,003 per AFB smear-positive case. Conclusions Routine use of the NAAT on AFB smear-positive respiratory specimens was highly cost-saving in our setting at a U.S. urban public hospital with a high prevalence of TB and HIV because of the low PPV of an AFB smear for culture-confirmed TB.
Evidence of Rapid Optical Variability In Selected Narrow-Line Seyfert 1 Galaxies
H. R. Miller,E. C. Ferrara,J. P. McFarland,J. W. Wilson,A. B. Daya,R. E. Fried
Physics , 2000, DOI: 10.1016/S1387-6473(00)00094-4
Abstract: We present the first results of a search for the presence of rapid optical variability in a sample of five Narrow-Line Seyfert 1 galaxies. We find clear evidence of rapid variability for IRAS 13224-3809 with variations occurring on time scales of an hour. However, the results are less conclusive for the other four sources in our sample, Markarian 766, PG 1244+026, PG 1404+226 and Arakelian 564. While there are several instances among these latter objects where there is a hint that variability may be present, IRAS 13224-3809 provides the only conclusive evidence of rapid optical variability detected to date.
Quantum beat spectroscopy: stimulated emission probe of hyperfine quantum beats in the atomic Cs 8p $^{2}P_{3/2}$ level
S. B. Bayram,P. Arndt,O. I. Popov,C. Guney,W. P. Boyle,M. D. Havey,J. McFarland
Physics , 2014, DOI: 10.1103/PhysRevA.90.062510
Abstract: Measurements of hyperfine polarization quantum beats are used determine the magnetic dipole (A) and electric quadrupole (B) coupling constants in the excited atomic Cs 8p level. The experimental approach is a novel combination of pulsed optical pumping and time-delayed stimulated emission probing of the excited level. From the measured evolution of the atomic linear polarization degree as a function of probe delay time, we determine the hyperfine coupling constants A = 7.42(6) MHz and B = 0.14(29) MHz.
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