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Search Results: 1 - 10 of 198 matches for " Vyberg Mogens "
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Small duct autoimmune sclerosing cholangitis and Crohn colitis in a 10-year-old child. A case report and review of the literature
Erling Larsen, Allan Bayat, Mogens Vyberg
Diagnostic Pathology , 2012, DOI: 10.1186/1746-1596-7-100
Abstract: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1418596609736470 webciteImmune-mediated liver diseases fall into two broad categories, those with a hepatitic predominance: autoimmune hepatitis (AIH), and those with a predominance of cholestatic features: primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). AIH is characterized by elevated serum aminotransferases, hypergammaglobulinaemia (primarily immunoglobulin G), circulating autoantibodies (primarily antinuclear antibodies (ANA) and smooth muscle cell antibodies (SMA)) and interface hepatitis on liver biopsy specimen, while markedly elevated serum alkaline phosphatase (ALP), circulating antimitochondrial antibodies (AMA), or biliary changes on liver biopsy specimen are normally not present [1]. In contrast, PBC and PSC are characterized by cholestatic biochemistry, occurrence of AMA (PBC only), and histological biliary changes such as granulomatous cholangitis (PBC only) or fibroobliterative cholangitis (mainly PSC), leading to ductopenia and biliary cirrhosis. However, PBC and PSC may also reveal features of AIH, which are sufficiently pronounced to qualify for so-called overlap syndromes, even though there are no established definitions for these [2]. A scoring system established by the International Autoimmune Hepatitis Group (IAIHG) for research purposes [1] has been widely used in the clinical practise to classify patients as having “definite AIH”, “probable AIH” or “not AIH”. The scoring system is, however, not directly applicable for overlap syndromes.The AIH/PSC overlap syndrome, also designated autoimmune sclerosing cholangitis (AISC) is occasionally seen in adults [2-4], but more often occur in children, where up to about 50% of patients presenting with AIH reveal radiological features of cholangiopathy [5]. Even among AIH patients with normal cholangiogram, histological biliary changes have been found in about 30% [5]. In other
Adipose tissue arachidonic acid content is associated with the expression of 5-lipoxygenase in atherosclerotic plaques
Nielsen Michael S,Gr?nholdt Marie-Louise M,Vyberg Mogens,Overvad Kim
Lipids in Health and Disease , 2013, DOI: 10.1186/1476-511x-12-7
Abstract: Background The content of arachidonic acid in adipose tissue is positively associated with the risk of myocardial infarction, whereas the content of eicosapentaenoic acid in adipose tissue has been reported to be negatively associated with the risk of myocardial infarction. Both arachidonic acid and eicosapentaenoic acid are substrates for the synthesis of pro-inflammatory leukotrienes and leukotrienes derived from eicosapentaenoic acid are generally much less potent. In this study we hypothesized that a high content of arachidonic acid in adipose tissue would reflect a high formation of arachidonic acid derived leukotrienes and a high expression of 5-lipoxygenase in atherosclerotic plaques. Likewise, we hypothesized that a high content of eicosapentaenoic acid in adipose tissue would reflect a low formation of arachidonic acid derived leukotrienes and a low expression of 5-lipoxygenase in plaques. Methods In a cross sectional study we included 45 consecutive subjects undergoing femoral thrombendarterectomy. The expression of 5-lipoxygenase in plaques was assessed by a semi-automated image analysis computer programme after immunohistochemical staining with mono-clonal 5-lipoxygenase antibodies. Leukotriene B4 and cysteinyl leukotriene formation from stimulated femoral artery plaques was quantified using ELISA methods. The fatty acid content of adipose tissue biopsies from the thigh was analyzed using gas chromatography. Associations between variables were assessed by Pearson correlations and were further explored in a multivariable linear regression model adjusting for potential confounders. Results A high content of arachidonic acid in adipose tissue was associated with a higher expression of 5-lipoxygenase in plaques (r = 0.32, p = 0.03), but no significant associations with leukotriene B4 (r = 0.22, p = 0.14) and cysteinyl leukotriene (r = 0.11, p = 0.46) formation was seen. No significant associations were found between the content of eicosapentaenoic acid in adipose tissue and 5-lipoxygenase expression or leukotriene formation in plaque. Conclusions Adipose tissue arachidonic acid contents correlated positively with the expression of 5-lipoxygenase in plaques. This association might represent a causal link between adipose tissue arachidonic acid and the risk of myocardial infarction but confirmatory studies are needed.
On-demand sedation with propofol for colonoscopy—A prospective pilot study of the influence on short-term memory, psychomotor function and postural stability*  [PDF]
Mogens R?rb?k Madsen
Open Journal of Clinical Diagnostics (OJCD) , 2013, DOI: 10.4236/ojcd.2013.33023
Abstract: Background: After sedated colonoscopy, patients are discharged on the basis of their subjective judgment that they have recovered, corroborated by the nursing staff. The aim of this study was to assess objectively whether patients were in fact fully recovered at the time of discharge, and to demonstrate whether the methods of testing applied could detect any influence of sedation on short-term memory, psychomotor function and postural stability. Methods: Twenty-two patients were investigated. At the beginning of the procedure, a defined bolus of propofol/alfentanil was given intravenously. During the procedure, an additional bolus was injected one or more times as requested by the patient. After colonoscopy, the patients stayed in the recovery room until the patients judged that they had recovered completely, which was also the judgement of the nursing staff at that time. Before colonoscopy and again before discharge, tests were performed of short-term memory, psychomotor function and postural stability (balance). Results: A positive correlation was found between the duration of colonoscopy and the amount of sedative given (p < 0.03). No differences in short-term memory or postural control were found when measurements obtained before and after colonoscopy were compared. Reaction time was prolonged significantly after colonoscopy (p < 0.01), which was mainly due to prolongation of perception time (p < 0.003). No correlation was found between the observed reduction in psychomotor function and the amount of sedative given. Conclusions: The introduction of ultrashort-acting sedative and hypnotic agents has facilitated out-patient colonoscopy. However, although they feel that they have recovered fully, some patients are still affected by the sedative at the time of discharge, as demonstrated by tests of short-term memory, reaction time and postural stability.
Fri ter. Om de italienske lokalradioer
Mogens Schmidt
Massekultur & Medier , 1981,
Abstract: Fri ter. Om de italienske lokalradioer
Gerd Z. Nordst m: Bildspr k och bildanalys
Mogens Schmidt
Massekultur & Medier , 1984,
Abstract:
Hvad vi kan l re, er ikke til at b re. Om de italianske networks
Mogens Schmidt
Massekultur & Medier , 1983,
Abstract: Hvad vi kan l re, er ikke til at b re. Om de italianske networks
Erlend Hovland (red.): Vestens musikkhistorie. Fra 1600 til v r tid. Oslo: Cappelen Damm, 2012. Erlend Hovland (red.): Vestens musikkhistorie. Fra 1600 til v r tid. Oslo: Cappelen Damm, 2012.
Mogens Christensen
InFormation : Nordic Journal of Art and Research , 2012, DOI: 10.7577/information.v1i2.410
Abstract:
Surrounding Risks
Mogens Steffensen
Risks , 2013, DOI: 10.3390/risks1010043
Abstract: Research in insurance and finance was always intersecting although they were originally and generally viewed as separate disciplines. Insurance is about transferring risks between parties such that the burdens of risks are borne by those who can. This makes insurance transactions a beneficial activity for the society. It calls on detection, modelling, valuation, and controlling of risks. One of the main sources of control is diversification of risks and in that respect it becomes an issue in itself to clarify diversifiability of risks. However, many diversifiable risks are not, by nature or by contract design, separable from non-diversifiable risks that are, on the other hand, sometimes traded in financial markets and sometimes not. A key observation is that the economic risk came before the insurance contract: Mother earth destroys and kills incidentally and mercilessly, but the uncertainty of economic consequences can be more or less cleverly distributed by the introduction of an insurance market.
Pricing American Options Using Transition Probabilities: A Dynamical Systems Approach  [PDF]
Rocio Elizondo, Pablo Padilla, Mogens Bladt
Open Journal of Statistics (OJS) , 2015, DOI: 10.4236/ojs.2015.56056
Abstract:

We give a new way to price American options by using Samuelson’s formula. We first obtain the option price corresponding to a European option at time t, weighing it by the probability that the underlying asset takes the value S at time t. We then use Samuelson’s formula with this factor which is given by the solution of the Fokker-Planck (Kolmogorov) equation for the transition probability density. The main advantage of this approach is that we can systematically introduce the effect of macroeconomic factors. If a macroeconomic framework is given by a dynamical system in the form of a set of ordinary differential equations we only have to solve a partial differential equation for the transition probability density. In this context, we verify, for the sake of consistency, that this formula coincides with the Black-Scholes model and compare several numerical implementations.

Immunological Links to Nonspecific Effects of DTwP and BCG Vaccines on Infant Mortality
Mogens Helweg Claesson
Journal of Tropical Medicine , 2011, DOI: 10.1155/2011/706304
Abstract: A number of mainly observational studies suggest that many African females below the age of one year die each year from the nonspecific effects of vaccination with diphtheria-tetanus toxoids and killed (whole-cell) Bordetella pertussis (DTwP). In contrast, similar studies suggest that many African females and males may have their lives saved each year by the nonspecific immunological benefits of Bacillus Calmette-Guerin (BCG) vaccination. From an immunological point of view, we hypothesise that the adverse effects of DTwP vaccine may occur because of the Th2-polarising effect of the aluminium phosphate adjuvant in the vaccine and because intramuscular administration of the vaccine may cause chronic inflammation at the site of injection. However, the Th1-polarising effect of BCG is likely to be beneficial. Sexual dimorphism affecting immune functions and vitamin A supplementation may influence both the deleterious and beneficial nonspecific effects of immunisation. 1. Background The paper discusses the immunology behind the reported nonspecific effects of DTwP and BCG vaccination: increased childhood mortality rates after DTwP and decreased mortality rates after BCG vaccination given during the course of the WHO recommended vaccine programs implemented in Guinea-Bissau and other low-income countries [1, 2]. Both the detrimental and the beneficial effects of vaccination are strongest in females [3–7]. We speculate here that vaccine-induced changes in innate and adaptive immunity may play a role. 2. DTwP Vaccine According to the WHO recommendations children in low-income countries are vaccinated against diphtheria, tetanus, and pertussis at 6, 10, and 14 weeks of age. Most countries use a whole-cell Bordetella pertussis vaccine. A typical DTwP vaccine dose (0.5?mL) from the Serum Institute of India contains diphtheria toxoid (25?Lf), tetanus toxoid (5?Lf), and pertussis toxoid (4?IU), aluminium phosphate (1.5?mg), and a preservative, thiomersal (0.01%). Aluminium phosphate acts primarily as an antigen-adsorbing and Th2-polarizing adjuvant [8]. Intramuscular vaccine injection results in a palpable sore induration at the site of injection in 70% of children. In 9% of the children the induration lasts 4 weeks and there is a significant correlation between local reactivity and fever (J. Agergaard, personal communication). 3. Increased Mortality after DTwP Vaccination The major causes of death in general among children in Guinea-Bissau are related to gastrointestinal infections with diarrhoea and dehydration, pneumonia and septicaemia, whereas the risk of death
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