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Search Results: 1 - 10 of 8486 matches for " Vladimir Shvarts "
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Epilepsy, Antiseizure Therapy, and Sleep Cycle Parameters
Vladimir Shvarts,Steve Chung
Epilepsy Research and Treatment , 2013, DOI: 10.1155/2013/670682
Abstract: A reciprocal relationship exists between sleep and epilepsy. The quality of sleep is affected by the presence and frequency of seizures, type of antiepileptic therapy utilized, and coexisting primary sleep disorders. Daytime somnolence is one of the most common adverse effects of antiepileptic therapy, with specific pharmacologic agents exhibiting a unique influence on components of sleep architecture. The newer generation of antiseizure drugs demonstrates improved sleep efficiency, greater stabilization of sleep architecture, prolongation of REM sleep duration, and increased quality of life measures. The emerging field of chronoepileptology explores the relationship between seizures and circadian rhythms, aiming for targeted use of antiseizure therapies to maximize therapeutic effects and minimize the adverse events experienced by the patients. 1. Introduction Although the complex relationship between sleep and epilepsy has not been fully elucidated, it is well known that sleep disturbance provokes seizures and that seizure activity may influence the quality of sleep. In addition, antiepileptic drugs (AEDs) that are commonly used for seizure treatment affect sleep quality and architecture. Some AEDs tend to cause sleepiness or drowsiness while others can lead to insomnia. Sleep is an essential physiologic state that influences restorative and memory consolidating functions [1]. As previously recognized, the relationship between epilepsy and sleep disturbance is likely multifactorial: the direct effect of seizures, adverse events due to AED therapy, presence of psychiatric comorbidity, and coexisting sleep disorders all have the potential to contribute to alteration of sleep architecture and the subjective quality of sleep. Accordingly, one would expect that lack of sound sleep would significantly impact neurocognitive and psychological function, especially in patients treated with AEDs for their seizures. It is important for clinicians to understand the proclivity of a specific AED to affect the quality of sleep in order to guide epilepsy therapy and prevent disturbance of a patients’ nocturnal recovery. This review systematically evaluates the currently available literature, elucidating the effect of antiepileptic drug therapy upon the sleep cycle. A search of relevant primary research and review articles was performed utilizing the PubMed database. 2. Epilepsy and Sleep Sleep is classically divided into REM and non-REM phases as defined by the parameters of electroencephalography, respiration, eye movement, and electromyography. The non-REM phase
Asymptotic self-similar solutions with a characteristic time-scale
Eli Waxman,Dov Shvarts
Physics , 2010, DOI: 10.1088/0004-637X/721/2/1928
Abstract: For a wide variety of initial and boundary conditions, adiabatic one dimensional flows of an ideal gas approach self-similar behavior when the characteristic length scale over which the flow takes place, $R$, diverges or tends to zero. It is commonly assumed that self-similarity is approached since in the $R\to\infty(0)$ limit the flow becomes independent of any characteristic length or time scales. In this case the flow fields $f(r,t)$ must be of the form $f(r,t)=t^{\alpha_f}F(r/R)$ with $R\propto(\pm t)^\alpha$. We show that requiring the asymptotic flow to be independent only of characteristic length scales imply a more general form of self-similar solutions, $f(r,t)=R^{\delta_f}F(r/R)$ with $\dot{R}\propto R^\delta$, which includes the exponential ($\delta=1$) solutions, $R\propto e^{t/\tau}$. We demonstrate that the latter, less restrictive, requirement is the physically relevant one by showing that the asymptotic behavior of accelerating blast-waves, driven by the release of energy at the center of a cold gas sphere of initial density $\rho\propto r^{-\omega}$, changes its character at large $\omega$: The flow is described by $0\le\delta<1$, $R\propto t^{1/(1-\delta)}$, solutions for $\omega<\omega_c$, by $\delta>1$ solutions with $R\propto (-t)^{1/(\delta-1)}$ diverging at finite time ($t=0$) for $\omega>\omega_c$, and by exponential solutions for $\omega=\omega_c$ ($\omega_c$ depends on the adiabatic index of the gas, $\omega_c\sim8$ for $4/3<\gamma<5/3$). The properties of the new solutions obtained here for $\omega\ge\omega_c$ are analyzed, and self-similar solutions describing the $t>0$ behavior for $\omega>\omega_c$ are also derived.
Anemic syndrome in hospitalized patients with ischemic heart disease: inflammation marker or factor of pathogenesis?
Suvorova S.A.,Parkhonyuk Е.М.,Shvarts Yu.G.
Saratov Journal of Medical Scientific Research , 2010,
Abstract: The article presents the research results on the correlation between anemic syndrome and main risk factors in hospitalized patients with different forms of cardiovascular pathologies. This category of patients is characterized by more severe arterial hypertension and low level of total cholesterol in blood. It has been revealed that anemia in patients with CVD (cardiovascular diseases) is not only associated with unfavorable prognosis, but also becomes a marker of peculiarities in mechanism of disease development indicating the severity of inflammatory component
Early thyroid gland dysfunction and biorhythmic activity disturbance in patients with cardiovascular pathology and atrial fibrillation
Baurina Yu.O.,Mayskova Е.А.,Shvarts Yu.G.
Saratov Journal of Medical Scientific Research , 2012,
Abstract: The review deals with the problem of combined pathology of the thyroid gland and cardiovascular system, the state of thyroid homeostasis in atrial fibrillation. The main mechanisms of action of thyroid hormones on the heart and blood vessels, particularly changes in the cardiovascular system with hypo-or hyperthyroidism; the possibility of substitution therapy in subclinical disease have been presented in the article. Characteristics of daily rhythmic activity of thyroid gland in normal and various pathological conditions with persistent and paroxysmal atrial fibrillation have been considered.
Control of anticoagulant therapy and quality of life of patients with atrial fibrillation (review)
Artanova E.L.,Shvarts Y.G.
Saratov Journal of Medical Scientific Research , 2012,
Abstract: The review presents the published data on the relevance of the problem of thromboembolic complications in atrial fibrillation, the peculiarities of anticoagulant therapy for this disease. The relationship of clinical characteristics of patients with anticoagulant dose adjustment algorithms has been described. The problem of ethical issues of out of clinical trials patients and the dynamics of their quality of life against the background of long-term use of anticoagulant have been considered.
The Influence of Israel Health Insurance Law on the Negev Bedouin Population — A Survey Study
Mohammed Morad,Shifra Shvarts,Joav Merrick,Jeffrey Borkan
The Scientific World Journal , 2006, DOI: 10.1100/tsw.2006.06
Abstract:
The Use of Developmental Rehabilitation Services. Comparison between Bedouins and Jews in the South of Israel
Hasia Lubetzky,Shifra Shvarts,Joav Merrick,Gideon Vardi
The Scientific World Journal , 2004, DOI: 10.1100/tsw.2004.18
Abstract:
Anemic syndrome in patients with ischemic heart disease and chronic heart failure (review)
Kaluta Т.Yu.,Suvorova S.A.,Shvarts Y.G.
Saratov Journal of Medical Scientific Research , 2011,
Abstract: Anemic syndrome of different severity often accompanies ischemic heart disease (IHD) and chronic heart failure (CHF). Anemia has association with unfavorable prognosis in patients with all forms of CVD — acute and chronic. In this article the authors summarize a literature review of English articles dedicated to the problem of anemia and ischemic heart disease (IHD) and the results of original research on the relationship between anemic syndrome and prognosis in the hospitalized patients with IHD and chronic heart failure (CHF). Anemia is frequently observed in patients with CHF, and evidence suggests that anemia might be associated with an increased mortality in both systolic and diastolic chronic heart failure (CHF), morbidity and rate of hospitalization in CHF patients. Moreover, CHF itself could be involved in the pathogenesis of anemia. Early studies suggested a pathogenic role of inflammation mediators. The normalization of hemoglobin concentration by EPO and iron supply in patients with CHF and chronic renal insufficiency results in improved exercise capacity by increasing oxygen delivery and improving cardiac function. However, there is limited information concerning the association of hemoglobin concentration and new onset of clinically recognized coronary artery disease, and lack of information about the effect of anemia treatment on prognosis of acute forms of IHD
Clinical and laboratory peculiarities of acute myocardial infarction after chronic tonsillitis
Dzhukaeva Kh.R.,Shvarts Y.G.
Saratov Journal of Medical Scientific Research , 2012,
Abstract: Aim: The definition of the relationship of clinical and laboratory features of acute myocardial infarction depending on the suffering of chronic tonsillitis. Materials and methods. The study included 54 patients with acute myocardial infarction suffering for 1-2 days. The collection of the anamnesis, assessment of clinical factors, inspection of the palatine tonsils, clinical and biochemical blood tests have been done. Markers of myocardial necrosis, an electrocardiogram with calculation of a dispersion of interval QT, echocardiogram have been taken into account. Results. 45 of 54 patients reported the symptoms of chronic tonsillitis in their lifetime. At 17 patients the previous diagnosis of chronic tonsillitis has been made, in 6 of them bilateral tonsillectomy was held. All of the patients were divided into 2 groups: 1 with proven chronic tonsillitis (17 patients) and 2 — the others (37 patients). At patients with chronic tonsillitis substantially more developed acute heart failure at sick this group glucose of the blood at receipt was higher than in 2 groups (p=0,004), given distinction was independent of presence of diabetes. According to the echocardiography 1 group of patients determined course-diastolic dimensions of the right ventricle increase in comparison with 2 groups (p=0,01). Conclusion. In patients with chronic tonsillitis more severe course of acute myocardial infarction has been determined, which became evident in the relatively high values of blood glucose on admission. The frequent development of congestive heart failure, and increase of the course-diastolic dimensions of the right ventricle have been also revealed.
Weak Interaction and the Nature of Virtual Particles  [PDF]
Vladimir Konushko
Journal of Modern Physics (JMP) , 2011, DOI: 10.4236/jmp.2011.22009
Abstract: The granular structure of space, the nature of virtual particles and the unity of physical interactions are under study. The mass of an elementary cell in the Universe is determined, as a whole, with the physical meaning of the renormalization procedure changing in this case.
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