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Search Results: 1 - 10 of 8543 matches for " Vladimir Cerny "
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Sublingual microcirculatio
Vladimir Cerny
Applied Cardiopulmonary Pathophysiology , 2012,
Abstract: Microcirculation plays a crucial role in the interaction between blood and tissue both in physiological and pathophysiological states. Orthogonal polarization spectral (OPS) and Side stream dark field (SDF) imaging are relatively new noninvasive methods that allow the investigation of mucosal sites, especially sublingual area, particularly in critically ill patients. OPS imaging has been validated against conventional capillary microscopy, results demonstrated that OPS images provided similar values for RBC-velocity and capillary diameter as those measured by conventional capillary microscopy. Despite some limitations, sublingual microcirculation has been considered as a possible surrogate measure for splanchnic blood flow. There are several areas in human medicine, where observation of sublingual microcirculatory bed has been carried out – different kinds of shock, cardiac arrest, effect of various treatments, drugs and extreme physiological conditions as well. Early detection of microvascular abnormality seems to be a key factor to start early therapeutic intervention in order to reverse microvascular dysfunction, to maintain efficient microvascular flow and to contribute to better clinical outcome. In experimental setting, observing sublingual microcirculation is an important part of any research focused on the role of microcirculation during various diseases models and to assess effect of different treatment modalities on microcirculation.
Energy, Entropy, Information, and Intelligence
Vladimir Cerny
Physics , 2012,
Abstract: The paper presents a lightweight discussion of relations between energy, entropy, information, and intelligence, based on an analysis of the energy needed for computation.
Orthogonal Polarization Spectral (OPS)/Sidestream dark field (SDF) imaging: a new method for the observation of the microcirculation in pediatrics
Marketa Stanclova,Zdenek Kokstein,Vladimir Cerny
Applied Cardiopulmonary Pathophysiology , 2012,
Abstract: Microcirculation plays an important role both in physiological and pathophysiological states. Early recognition of changes in microcirculation is crucial for starting early therapeutic intervention and reversing the organ failure. Orthogonal polarization spectral (OPS) and Sidestream dark field imaging (SDF) are relatively new noninvasive methods that allow direct visualisation of the microcirculation at the bedside and analysis using semi-quantitative scores. In human medicine, these optical devices have been so far carried out in critically ill adult patients (sepsis, shock, cardiac arrest etc.). To date, only a few medical papers have been published on the use of the technique in children, in particular in preterm neonates. Although it has been the sublingual region commonly used for the observation in adults, the most frequently used site for assessment in newborns is the skin or buccal mucosa. The studies published on the use of OPS/SDF imaging in the newborns show them as a potentially important addition to hemodynamic monitoring in neonatal intensive care.
Generating heavy particles with energy and momentum conservation
Michal Meres,Ivan Melo,Boris Tomasik,Vladimir Balek,Vladimir Cerny
Physics , 2011, DOI: 10.1016/j.cpc.2011.06.015
Abstract: We propose a novel algorithm, called REGGAE, for the generation of momenta of a given sample of particle masses, evenly distributed in Lorentz invariant phase space and obeying energy and momentum conservation. In comparison to other existing algorithms, REGGAE is designed for the use in multiparticle production in hadronic and nuclear collisions where many hadrons are produced and a large part of the available energy is stored in the form of their masses. The algorithm uses a loop simulating multiple collisions which lead to production of configurations with reasonably large weights.
Imaging of the sublingual microcirculation in elderly patients – a pilot study
Islam Saleh Abdo,Zdenek Turek,Renata Parizkova,Vladimir Cerny
Applied Cardiopulmonary Pathophysiology , 2012,
Abstract: Demographic changes, i. e. worldwide increase in older population, require to direct research efforts to age-relevant topics. The present article focuses on microcirculation in elderly patients. Sidestream dark field (SDF) imaging, a relatively new technology, allows direct visualization of mucosal microcirculation and imaging of surface layers of solid organs using a handheld microscopical camera probe. Our study aimed at assessing sublingual microcirculation in elderly patients using this new SDF technology in order to identify and compare changes across different age groups. The study results suggest that even in healthy individuals microvascular flow index (MFI) and functional capillary density (FCD) change significantly during the process of aging.
The endocannabinoid system in sepsis – a potential target to improve microcirculation?
Christian Lehmann,Mandana Kianian,Juan Zhou,Vladimir Cerny
Signa Vitae , 2011,
Abstract: During the last decade, research has identified the endocannabinoid system (ECS) as a key regulator of essential physiological functions, including the regulation of microvascular and immune function. Indeed, increasing evidence now suggests that release of endocannabinoids and activation of cannabinoid receptors occurs during sepsis and that manipulation of the ECS may represent an important therapeutic target to improve microcirculation in sepsis. In this review, the pharmacology and physiology of the ECS and the involvement of cannabinoids, cannabinoid receptors and non-CB1R/CB2R pathways related to ECS activation will be described. This information will increase our comprehension of the role of lipid signaling pathways in sepsis and may lead to the identification of new drug targets for the treatment of impaired microcirculation.
The Effect of Nitrogen Ion Implantation on the Surface Properties of Ti6Al4V Alloy Coated by a Carbon Nanolayer
Petr Vlcak,Frantisek Cerny,Zdenek Weiss,Stanislav Danis,Josef Sepitka,Zdenek Tolde,Vladimir Jech
Journal of Nanomaterials , 2013, DOI: 10.1155/2013/475758
Abstract: The ion beam assisted deposition (IBAD) method was chosen for preparing a carbon thin film with a mixing area on a substrate of Ti6Al4V titanium alloy. Nitrogen ions with energy 90?keV were used. These form a broad ion beam mixing area at the interface between the carbon film and the substrate. We investigated the chemical composition by the glow discharge optical emission spectroscopy (GD-OES) method and the phases by the X-ray diffraction (XRD) method. The measured concentration profiles indicate the mixing of the carbon film into the substrate, which may have an effect on increasing the adhesion of the deposited film. The nanohardness and the coefficient of friction were measured. We found that the modified samples had a markedly lower coefficient of friction even after damage to the carbon film, and they also had higher nanohardness than the unmodified samples. The increased nanohardness is attributed to the newly created phases that arose with ion implantation of nitrogen ions. 1. Introduction Titanium and titanium alloys have many applications. They are used in the aerospace industry and in biomedical engineering. However, the components of titanium alloys show unsatisfactory tribological properties [1]. The tribological properties of Ti6Al4V titanium alloy have received huge attention worldwide. Many methods and concepts for modifying the coating to reduce the coefficient of friction and the wear rate have been applied. It is known that carbon-based coatings can exhibit a very low coefficient of friction and that their application on a substrate may result in a multiple increase in its working life [2–4]. Due to the high internal stress, these coatings have low adhesion to many substrates [5, 6]. We therefore investigated various deposition techniques and the parameters of these techniques that influence not only the adhesion but also other properties of carbon-based layers [7–9]. In our work, the ion beam assisted deposition (IBAD) method was chosen for modifying the surface properties of the titanium alloy. A carbon coating a few tens nanometers in thickness was applied to a Ti6Al4V alloy substrate. Subsequent ion bombardment by nitrogen ions with energy 90?keV was aimed at mixing the coating and substrate atoms and hardening the surface area. The parameters of the preparation process were proposed in such a way that the resulting model of the mixed area would have a decreasing concentration towards the substrate. The aim was to investigate the effect of the deposition parameters on the penetration depth of the mixed and implanted atoms and on
Pre-perihelion photometric behavior of comet C/2012 S1 (ISON) and its future prospect
Cerny Jakub
Physics , 2013,
Abstract: Comet C/2012 S1 (ISON) shows strange photometric behavior compared to many past comets. Shortly after its discovery, majority of astronomers expected its surviving until perihelion passage. Unprecedented evolution of its photometric parameters nearly 2 AU from Sun, pushed this comet under survival line defined by formula of John. E. Bortle, where ~70% comets in his analysis disintegrated. However comparison with photometric behavior of group of past disintegrated comets showing large differences and ISON doesn't seems to be typical member of this group. In other hand, compared to surviving, dynamically new comets which were observed far away from Sun and survived its perihelion passage, ISON showing peculiar gradual decrease of its activity, probably caused by exhaustion of active fractions of its nucleus.
Unexpected fading of comet C/2003 T4 (LINEAR) and disintegration of C/2012 S1 (ISON)
Jakub Cerny
Physics , 2014,
Abstract: Comet C/2003 T4 (LINEAR) exhibit a large asymmetry in brightness before and after perihelion, when it became much fainter. Large non-gravitational forces shows that mass of nucleus doesn't exceed 2.51*10^11 kg, which is nearly double than previously disintegrated comets C/2012 S1 (ISON) and C/1999 S4 (LINEAR). Amount of water mass loss of C/2003 T4 in interval between 70 days before to 60 after perihelion, was nearly 3.16(+/- 0.60)*10^10 kg or >13 % of total nucleus mass and >21 % for C/2012 S1, which is much larger than value >7 % previously stated for C/1999 S4.
Acute hepatitis associated with the use of natural product camu-camu  [PDF]
Raffaela Bertoli, Luca Mazzuchelli, Andreas Cerny
Open Journal of Gastroenterology (OJGas) , 2013, DOI: 10.4236/ojgas.2013.33035
Abstract: A 45-year-old previously healthy caucasian man was admitted for pruritus, scleral icterus and dark urine. The patient was reported to have taken a spoon of a preparation containing camu-camu (myrciaria dubia) a day. He took no other drugs and did not drink alcohol or use illicit substance. Laboratory studies reveiled an elevated aspartate transaminase of 403 U/L, and alanine transaminase of 1185 U/L, alkalinephosphatase of 335 U/L, gamma glutamyl transpeptidase of 300 U/L, and elevated total bilirubin of 142 μmol/L. His complete blood count was normal. Tests for viral, metabolic or autoimmune causes of liver injury were negative. Liver biopsy demonstrated centrilobular hepatocellular damage was compatible with drug toxicity which was not of very recent origin. Clinical and laboratory signs of liver injury gradually improved and the patient was discharged. Myrciaria dubia is used as a dietary supplement with antioxidant properties. To our knowledge, this is the first report of liver injury probably related to use of camu-camu. Exclusion of other causes and the histological diagnosis were compatible with drug toxicity render camu-camu which was most likely as the cause of acute heaptitis most likely. It is important to increase the awareness of both clinicians and patients about the potential dangers of herbal remedies in absence of reliable studies of clinical efficacy and benefit-risk assessment.
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