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Search Results: 1 - 10 of 88219 matches for " Vlad I. Valtchinov "
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DNA Dynamics Is Likely to Be a Factor in the Genomic Nucleotide Repeats Expansions Related to Diseases
Boian S. Alexandrov,Vlad I. Valtchinov,Ludmil B. Alexandrov,Vladimir Gelev,Yossi Dagon,Jonathan Bock,Isaac S. Kohane,Kim ?. Rasmussen,Alan R. Bishop,Anny Usheva
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019800
Abstract: Trinucleotiderepeats sequences (TRS) represent a common type of genomic DNA motif whose expansion is associated with a large number of human diseases. The driving molecular mechanisms of the TRS ongoing dynamic expansion across generations and within tissues and its influence on genomic DNA functions are not well understood. Here we report results for a novel and notable collective breathing behavior of genomic DNA of tandem TRS, leading to propensity for large local DNA transient openings at physiological temperature. Our Langevin molecular dynamics (LMD) and Markov Chain Monte Carlo (MCMC) simulations demonstrate that the patterns of openings of various TRSs depend specifically on their length. The collective propensity for DNA strand separation of repeated sequences serves as a precursor for outsized intermediate bubble states independently of the G/C-content. We report that repeats have the potential to interfere with the binding of transcription factors to their consensus sequence by altered DNA breathing dynamics in proximity of the binding sites. These observations might influence ongoing attempts to use LMD and MCMC simulations for TRS–related modeling of genomic DNA functionality in elucidating the common denominators of the dynamic TRS expansion mutation with potential therapeutic applications.
Two-Body Correlations and the Underlying Phase Transitions in Bilayers
V. I. Valtchinov,G. Kalman,K. Blagoev
Physics , 1997,
Abstract: The pair correlation functions for a bilayer system of classical electrons has been calculated through a two-component HNC formalism. The results show changes in the structure of the correlation functions as the interlayer distance is increased from zero to about twice the Wigner-Seitz radius. These changes are indicative of structural phase transitions which are expected to take place in the crystallized phase and whose short range orders the liquid phases emulate.
Phases in Strongly Coupled Electronic Bilayer Liquids
V. I. Valtchinov,G. Kalman,K. Blagoev
Physics , 1997, DOI: 10.1103/PhysRevE.56.4351
Abstract: The strongly correlated liquid state of a bilayer of charged particles has been studied via the HNC calculation of the two-body functions. We report the first time emergence of a series of structural phases, identified through the behavior of the two-body functions.
Collective Modes in Strongly Coupled Elecronic Bilayer Liquids
G. Kalman,V. Valtchinov,K. I. Golden
Physics , 2000, DOI: 10.1103/PhysRevLett.82.3124
Abstract: We present the first reliable calculation of the collective mode structure of a strongly coupled electronic bilayer. The calculation is based on a classical model through the $3^{rd}$ frequency-moment-sum-rule preserving Quasi Localized Charge Approximation, using the recently calculated Hypernetted Chain pair correlation functions. The spectrum shows an energy gap at $k=0$ and the absence of a previously conjectured dynamical instability.
Stimulation of Striking Roots at the Cuttings of Laurel Tree (Laurus nobilis) with the Aid of Bioactive Substances of the Radistim Type
Mariana VLAD,I. VLAD
Notulae Botanicae Horti Agrobotanici Cluj-Napoca , 2008,
Abstract: The laurel tree was first appraised as a decorative plant because of its persistent, glossy and agreeably nuanced leaves , as well as by its small yellow flowers grouped in panicles of an attractive aspect. This paper followed the effect of radistim on striking roots at the cuttings of Laurus nobilis, observing a considerably increase of the rate of striking roots as well as an enhancement of the quality of the rooting process proved through the number of roots per cutting. The stimulation of the laurel tree cuttings root striking with the aid of the bio-stimulators of the radistim 2 type ensures a superior vegetation potential for the newly formed plants. The work method elaborated at the glass houses complex of Oradea, may contribute to the extension of the laurel tree as a culture in Romania.
Current-voltage characteristics of a tunnel junction with resonant centers
T. Ivanov,V. Valtchinov
Physics , 1994, DOI: 10.1103/PhysRevB.50.5721
Abstract: We calculate the I-V characteristics of a tunnel junction containing impurities in the barrier. We consider the indirect resonant tunneling involving the impurities. The Coulomb repulsion energy $E_c$ between two electrons with opposite spins simultaneously residing on the impurity is introduced by an Anderson Hamiltonian. At low temperatures $T \ll E_c$ the I-V characteristic is linear in $V$ both for $VE_c$ and changes slope at $V=E_c$. This behavior reflects the energy spectrum of the impurity electrons - the finite value of the charging energy $E_c$. At $T \sim E_c$ the junction reveals an ohmic-like behavior as a result of the smearing out of the charging effects by the thermal fluctuations.
Numerical Analysis of the Dynamic Behavior of a High Power Salient Pole Synchronous Machine by using a Corrected Model
Advances in Electrical and Computer Engineering , 2012, DOI: 10.4316/aece.2012.01016
Abstract: In the paper is shown that, by using the circuit theory which operates with lumped parameters, it is possible to derive mathematical models of a high power salient pole synchronous machine (SPSM), that can take into account the basic processes of the machine. It offers results regarding the electromagnetic and mechanical stresses for a given practical application. The quantitative determinations were performed on an 8000 kW synchronous motor. The results of quantitative determinations are of essential interest in the designing stage, for dynamic characteristics and parameters derivation and for constructive solutions to be chosen.
Review of analytical treatments of barrier-type problems in plasma theory
F. Spineanu,M. Vlad,K. Itoh,S. -I. Itoh
Physics , 2003,
Abstract: We review the analytical methods of solving the stochastic equations for barrier-type dynamical behavior in plasma systems. The path-integral approach is examined as a particularly efficient method of determination of the statistical properties.
Notes on a possible phenomenology of internal transport barriers in tokamak
F. Spineanu,M. Vlad,K. Itoh,S. -I. Itoh
Physics , 2003,
Abstract: We propose a new phenomenology of the generation of internal transport barriers, based on the exact periodic solution of the Flierl-Petvishvili equation. We examine the stability of this solution and compare the late stages of the flow with the ensemble of vortices.
Fast Automatic Video Retrieval using Web Images
Xintong Han,Bharat Singh,Vlad I. Morariu,Larry S. Davis
Computer Science , 2015,
Abstract: We describe a real-time video retrieval framework based on short text input in which weakly labelled training samples from the web are obtained, after the query is known. Concept discovery methods in such a setting train hundreds of detectors at test time and apply them to every frame in the video database. Hence, they are not practical for use in a text based video retrieval setting. We show that an efficient visual representation for a new query can be constructed on-line that enables matching against the test set in real-time. We evaluate a few combinations of encoding, pooling, and matching schemes that are efficient and find that such a system can be built with surprisingly simple and well-known components. We are not only able to construct and apply query models in real-time, but with the help of a re-ranking scheme, we also outperform state-of-the-art methods by a significant margin.
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