Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2020 ( 1 )

2019 ( 174 )

2018 ( 1212 )

2017 ( 1076 )

Custom range...

Search Results: 1 - 10 of 79887 matches for " Vivian Chen "
All listed articles are free for downloading (OA Articles)
Page 1 /79887
Display every page Item
Progress Monitoring Measures: The Interaction of Clinician Initial Motivation with Selection and Maintenance Issues  [PDF]
Megan Knoll, Gabriela Ionita, Jann Tomaro, Vivian Chen, Marilyn Fitzpatrick
Psychology (PSYCH) , 2016, DOI: 10.4236/psych.2016.73046

The use of Progress Monitoring (PM) measures has been shown to improve outcomes in therapy for clients who do not follow the normal trajectory of improvement. In addition to improved outcomes, there are several other documented benefits of PM that may motivate clinicians to use PM. Research has examined the broader field of selecting mental health care quality assessment tools and a review of the literature has pointed to the importance of considering motivation for assessment when selecting a measure. However, how motivation influences the selection or maintained usage of PM measures has not been studied. This study examined initial motivation as well as measure selection and continuing use of PM. Consensual Qualitative Research methodology was applied to characterize how clinicians (n = 25) started, selected, and maintained use of PM measures and how initial motivation related to measure selection and continued use. Regardless of initial motivation, convenience and effectiveness emerged as important when selecting and continuing to use a measure. Results are compared to current frameworks for selecting mental health- care quality indicators. Our results suggest that PM measures need to strike a balance, emphasizing convenience as well as efficacy in order to improve clinical uptake and adherence.

Identifying Where the Values Come from IT-Innovations in Health and Social Care  [PDF]
Vivian Vimarlund, Sabine Koch
Intelligent Information Management (IIM) , 2012, DOI: 10.4236/iim.2012.425042
Abstract: Studies aimed to capture the effects of IT-innovations in health and social care have shown that there is a gap between expected and factual outcomes. Many decision makers feel the need to articulate an ideal end-state for their organiza-tions. Striking the balance between novelty and believability of such an ideal end-state is often tricky and they become neither satisfied with the ideal not the visioning. In this study, we explore the contribution of IT-innovations to health and social care. The results showed that coherence between context and IT-innovation is important to capture effects and outcomes. Being coherent rather than visionary contributes to identify where you are, as an organization, and to capture effects and outcomes that “make sense” in the context in question. The paper makes an exposition from the model building, algorithm design to performance analysis and contributes to the academic prosperity in Intelligent In-formation Management The knowledge generated is expected to provide input when identifying goals that IT-investments are supposed to achieve.
Views on Creativity, Environmental Sustainability and Their Integrated Development  [PDF]
Vivian M. Y. Cheng
Creative Education (CE) , 2018, DOI: 10.4236/ce.2018.95054
Abstract: In the modern paradigm of sustainability, the role of creativity is of growing significance. No literature was found to have explored the relationship of creativity and environmental sustainability, in the perspective of university students. It is unsure—how our university students perceive them, especially for students of different backgrounds. This study aims at investigating the views of university students on human creativity (HC) and environmental sustainability (ES), and how these two views might affect their supportiveness and understanding of HC-ES integrated development. Case studies of four university students were conducted. They were carefully chosen in an education university of Hong Kong, a place where east-west culture meets. The Self-determination Theory and the Four-C Creativity Model were adopted to frame this study and to analyze its data. Two rounds of interview were conducted with interview scripts transcribed for content analysis. Results showed that the university students hold quite diverse views on HC, ES and HC-ES relationships. The students with general creativity training and/or authentic experiences in ES/HC were found to adopt a little-C and mini-C creativity conception and a self-determined ES approach, which subsequently bought a greater support to HC-ES integrated development/education. Based on the present findings, creativity training is recommended to environmental or sustainability programme in university education. Adopted the case study method, the present research has finally revealed the complexity of this seemingly simple issue, and paves the way for future creative environmental development and its research studies.
Bezielle Selectively Targets Mitochondria of Cancer Cells to Inhibit Glycolysis and OXPHOS
Vivian Chen, Richard E. Staub, Sylvia Fong, Mary Tagliaferri, Isaac Cohen, Emma Shtivelman
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030300
Abstract: Bezielle (BZL101) is a candidate oral drug that has shown promising efficacy and excellent safety in the early phase clinical trials for advanced breast cancer. Bezielle is an aqueous extract from the herb Scutellaria barbata. We have reported previously that Bezielle was selectively cytotoxic to cancer cells while sparing non-transformed cells. In tumor, but not in non-transformed cells, Bezielle induced generation of ROS and severe DNA damage followed by hyperactivation of PARP, depletion of the cellular ATP and NAD, and inhibition of glycolysis. We show here that tumor cells' mitochondria are the primary source of reactive oxygen species induced by Bezielle. Treatment with Bezielle induces progressively higher levels of mitochondrial superoxide as well as peroxide-type ROS. Inhibition of mitochondrial respiration prevents generation of both types of ROS and protects cells from Bezielle-induced death. In addition to glycolysis, Bezielle inhibits oxidative phosphorylation in tumor cells and depletes mitochondrial reserve capacity depriving cells of the ability to produce ATP. Tumor cells lacking functional mitochondria maintain glycolytic activity in presence of Bezielle thus supporting the hypothesis that mitochondria are the primary target of Bezielle. The metabolic effects of Bezielle towards normal cells are not significant, in agreement with the low levels of oxidative damage that Bezielle inflicts on them. Bezielle is therefore a drug that selectively targets cancer cell mitochondria, and is distinguished from other such drugs by its ability to induce not only inhibition of OXPHOS but also of glycolysis. This study provides a better understanding of the mechanism of Bezielle's cytotoxicity, and the basis of its selectivity towards cancer cells.
Identification and Analysis of the Active Phytochemicals from the Anti-Cancer Botanical Extract Bezielle
Vivian Chen, Richard E. Staub, Scott Baggett, Ramesh Chimmani, Mary Tagliaferri, Isaac Cohen, Emma Shtivelman
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030107
Abstract: Bezielle is a botanical extract that has selective anti-tumor activity, and has shown a promising efficacy in the early phases of clinical testing. Bezielle inhibits mitochondrial respiration and induces reactive oxygen species (ROS) in mitochondria of tumor cells but not in non-transformed cells. The generation of high ROS in tumor cells leads to heavy DNA damage and hyper-activation of PARP, followed by the inhibition of glycolysis. Bezielle therefore belongs to a group of drugs that target tumor cell mitochondria, but its cytotoxicity involves inhibition of both cellular energy producing pathways. We found that the cytotoxic activity of the Bezielle extract in vitro co-purified with a defined fraction containing multiple flavonoids. We have isolated several of these Bezielle flavonoids, and examined their possible roles in the selective anti-tumor cytotoxicity of Bezielle. Our results support the hypothesis that a major Scutellaria flavonoid, scutellarein, possesses many if not all of the biologically relevant properties of the total extract. Like Bezielle, scutellarein induced increasing levels of ROS of mitochondrial origin, progressive DNA damage, protein oxidation, depletion of reduced glutathione and ATP, and suppression of both OXPHOS and glycolysis. Like Bezielle, scutellarein was selectively cytotoxic towards cancer cells. Carthamidin, a flavonone found in Bezielle, also induced DNA damage and oxidative cell death. Two well known plant flavonoids, apigenin and luteolin, had limited and not selective cytotoxicity that did not depend on their pro-oxidant activities. We also provide evidence that the cytotoxicity of scutellarein was increased when other Bezielle flavonoids, not necessarily highly cytotoxic or selective on their own, were present. This indicates that the activity of total Bezielle extract might depend on a combination of several different compounds present within it.
Can public report cards affect consumer’s private learning of quality? An evaluation of the impact of Florida hospital report cards on acute myocardial infarction patient admission patterns  [PDF]
Vivian Y. Wu, Pai Liu
Health (Health) , 2013, DOI: 10.4236/health.2013.512297

The empirical literature on hospital report cards typically assumes that report card cannot interact with consumer’s private learning. This study examines the impact of the implementation of FL hospital quality reporting system in late 2004 on hospital admission patterns using a pre-post difference-in-difference design. The estimation model allows for the possibility that report-card learning may interact with non-report-card learning. The study sample is comprised of all patients admitted to any FL hospital between 2000 and 2008 with a principal diagnosis of acute myocardial infarction (AMI). We find that hospital admission patterns for AMI patients did not respond to report card information. However, we find evidence consistent with the possibility that the implementation of a report card system may stimulate consumers (either patients or physicians) to seek higher quality hospitals through private information channels.


El arte como objeto cultural elitista: Apuntes para una reflexión sobre las gramáticas de recepción estéticas y los procesos de interacción humana y social que se desprenden a partir de ellas
Romeu, Vivian;
Andamios , 2006,
Abstract: through the nicole everaert's model of artistic communication, this paper gets into trouble the negative influence of mediatics reception grammatics on the artistic communication reception. the goal is propose the artistic communication as the concret issue for the solution of human conflict and social interactions. two conclusions are made of this: 1) the negative influence of the mediatics reception grammatics, in terms of sense structures, and 2) the misreading of considerer art as a massive product, because for one angle, this enphazies its elitism, and for the other art is devalue as a real issue for social interactions and healthy social transformation.
Arte, ética y socialización: Una manera de entender la estética pragmática en las coordenadas postmodernas
Romeu, Vivian;
Andamios , 2008,
Abstract: this article presents a reflexion on the social function of contemporary artistic practices. the work takes, initially, a position on postmodernism and also reviews the principal philosophical positions that allow us to assert a pragmatic proposal about the aesthetic proposal. by means of the critical analysis of these proposals, the author indicates the aspects that could be taken into account to elaborate a view that allows us to think about the inmanent relations between art and ethics, which is oriented in this work through the concepts of "dialogue", "knowledge" and "aesthetic experience".
Frontier topics in gold chemistry
Vivian Yam
Gold Bulletin , 2009, DOI: 10.1007/BF03214898
S?o Paulo em Perspectiva , 2001, DOI: 10.1590/S0102-88392001000200005
Abstract: a cultura popular analisada a partir da concep??o dos folcloristas e dos membros do centro popular de cultura, colocando em cena os termos tradi??o e transforma??o, considerados antag?nicos por ambas as tendências e envolvidos pela quest?o nacional, amplamente discutida pelas ciências sociais durante todo o século xx
Page 1 /79887
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.