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Search Results: 1 - 10 of 139371 matches for " Vishal K. Doshi "
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Variation in MSRA Modifies Risk of Neonatal Intestinal Obstruction in Cystic Fibrosis
Lindsay B. Henderson,Vishal K. Doshi,Scott M. Blackman,Kathleen M. Naughton,Rhonda G. Pace,Jackob Moskovitz,Michael R. Knowles,Peter R. Durie,Mitchell L. Drumm,Garry R. Cutting
PLOS Genetics , 2012, DOI: 10.1371/journal.pgen.1002580
Abstract: Meconium ileus (MI), a life-threatening intestinal obstruction due to meconium with abnormal protein content, occurs in approximately 15 percent of neonates with cystic fibrosis (CF). Analysis of twins with CF demonstrates that MI is a highly heritable trait, indicating that genetic modifiers are largely responsible for this complication. Here, we performed regional family-based association analysis of a locus that had previously been linked to MI and found that SNP haplotypes 5′ to and within the MSRA gene were associated with MI (P = 1.99×10?5 to 1.08×10?6; Bonferroni P = 0.057 to 3.1×10?3). The haplotype with the lowest P value showed association with MI in an independent sample of 1,335 unrelated CF patients (OR = 0.72, 95% CI [0.53–0.98], P = 0.04). Intestinal obstruction at the time of weaning was decreased in CF mice with Msra null alleles compared to those with wild-type Msra resulting in significant improvement in survival (P = 1.2×10?4). Similar levels of goblet cell hyperplasia were observed in the ilea of the Cftr?/? and Cftr?/?Msra?/? mice. Modulation of MSRA, an antioxidant shown to preserve the activity of enzymes, may influence proteolysis in the developing intestine of the CF fetus, thereby altering the incidence of obstruction in the newborn period. Identification of MSRA as a modifier of MI provides new insight into the biologic mechanism of neonatal intestinal obstruction caused by loss of CFTR function.
A novel approach for e-payment using virtual password system
Vishal Vadgama,Bhavin Tanti,Chirag Modi,Nishant Doshi
Computer Science , 2012,
Abstract: In today's world of E-Commerce everything comes online like Music, E-Books, Shopping all most everything is online. If you are using some service or buying things online then you have to pay for that. For that you have to do Net Banking or you have to use Credit card which will do online payment for you. In today's environment when everything is online, the service you are using for E-Payment must be secure and you must protect your banking information like debit card or credit card information from possible threat of hacking. There were lots way to threat like Key logger, Forgery Detection, Phishing, Shoulder surfing. Therefore, we reveal our actual information of Bank and Credit Card then there will be a chance to lose data and same credit card and hackers can use banking information for malicious purpose. In this paper we discuss available E-Payment protocols, examine its advantages and delimitation's and shows that there are steel needs to design a more secure E-Payment protocol. The suggested protocol is based on using hash function and using dynamic or virtual password, which protects your banking or credit card information from possible threat of hacking when doing online transactions.
Simulation of Runoff and Sediment Yield for a Himalayan Watershed Using SWAT Model  [PDF]
Sanjay K. Jain, Jaivir Tyagi, Vishal Singh
Journal of Water Resource and Protection (JWARP) , 2010, DOI: 10.4236/jwarp.2010.23031
Abstract: Watershed is considered to be the ideal unit for management of the natural resources. Extraction of water-shed parameters using Remote Sensing and Geographical Information System (GIS) and use of mathematical models is the current trend for hydrologic evaluation of watersheds. The Soil and Water Assessment Tool (SWAT) having an interface with ArcView GIS software (AVSWAT2000/X) was selected for the estimation of runoff and sediment yield from an area of Suni to Kasol, an intermediate watershed of Satluj river, located in Western Himalayan region. The model was calibrated for the years 1993 & 1994 and validated with the observed runoff and sediment yield for the years 1995, 1996 and 1997. The performance of the model was evaluated using statistical and graphical methods to assess the capability of the model in simulating the run-off and sediment yield from the study area. The coefficient of determination (R2) for the daily and monthly runoff was obtained as 0.53 and 0.90 respectively for the calibration period and 0.33 and 0.62 respectively for the validation period. The R2 value in estimating the daily and monthly sediment yield during calibration was computed as 0.33 and 0.38 respectively. The R2 for daily and monthly sediment yield values for 1995 to 1997 was observed to be 0.26 and 0.47.
Analysis of the Impact of P-Ratio on BER, Q-Factor and OSNR of Radio over Fiber (RoF) System  [PDF]
Vishal Sharma, Amarpal Singh, Ajay K. Sharma
Optics and Photonics Journal (OPJ) , 2011, DOI: 10.4236/opj.2011.14029
Abstract: The impact of p-ratio i.e. ratio of carrier power to total received RF power at control office (CO) on Bit error rate (BER), Q- performance parameter and Optical signal noise ratio (OSNR) of RoF communication system is theoretically analyzed using angular full-linewidth at half maximum (FWHM) of Lorentzian shape for the RF oscillator in this paper. As reduction in Laser linewidth improves the performance of RoF system, the RF oscillator linewidth at FWHM also plays an important role in improving the performance of RoF system.
Role of reactive nitrogen species in male infertility
Doshi Sejal B,Khullar Karishma,Sharma Rakesh K,Agarwal Ashok
Reproductive Biology and Endocrinology , 2012, DOI: 10.1186/1477-7827-10-109
Abstract: Reactive nitrogen species (RNS) is a subset of free oxygen radicals called reactive oxygen species (ROS). Physiological levels of ROS are necessary to maintain the reproductive functions such as cell signaling, tight junction regulation, production of hormones, capacitation, acrosomal reaction, sperm motility, and zona pellucida binding. However, an excess of RNS can adversely affect reproductive potential by causing testicular dysfunction, decreased gonadotropin secretion, and abnormal semen parameters. Because such levels of RNS have been demonstrated in males with fertility problems and routine semen analysis has not been able to accurately predict IVF outcomes, it is imperative that novel strategies be developed in order to both assess and treat oxidative stress. This article describes both physiological and pathological roles of this unique subset of ROS.
Fatal air embolism following retroperitoneal air insufflation (a case report).
Ravichandran R,Doshi P,Chawla K,Acharya V
Journal of Postgraduate Medicine , 1983,
Mechanical Behaviour and Fracture Mechanics of Praseodymium Modified Lead Titanate Ceramics Prepared by Solid-State Reaction Route
Vishal Singh,Shivani Suri,K. K. Bamzai
Journal of Ceramics , 2013, DOI: 10.1155/2013/280605
Abstract: The praseodymium modified lead titanate ceramics with composition where = 0.04, 0.06, 0.08, and 0.10 prepared by solid-state reaction technique were subjected to indentation induced hardness testing method. The indentations were induced in the applied load ranging from 0.245?N to 4.90?N. The microhardness varies nonlinearly with load and was best explained by the concept of Newtonian resistance pressure as proposed by Hays and Kendall’s law. Crack propagation, fracture toughness ( ), brittleness index ( ), and yield strength ( ) were studied to understand the effect of Pr content on various mechanical parameters. The load independent values were found to increase with the increase in praseodymium content. 1. Introduction Ceramics are generally associated with distinctive problems, some uniquely beneficial and restrictive which determine the materials utilities, among these are hardness, brittleness, and fracture toughness. The measured hardness of a brittle material as determined by conventional tests (Vickers, Knoop, Rockwell, etc.) is a measure of materials resistance to deformation, densification, displacement and fracture. Conventional hardness measurements, which depend on size of an indentation resulting from an applied load, are load independent. This is especially noticeable at lower indentation loads where most measurements are made in order to avoid experimental problems associated with fracture. Local fracture around and under an indentation can affect the depth of penetration or size of the indentation and thus can be considered an intrinsic part of the indentation process. Fracture can also create practical difficulties in making hardness measurements because cracking at indentation corners or fragmentation can hamper hardness measurements. The degree of fracture at indentations in ceramics is load dependent. Low loads are associated with deformation while fracture is conspicuously more prominent at high loads. Microindentation technology has been used for the measurements of fracture toughness of ceramic materials by Evans and Charles [1]. Generally, the dielectric, piezoelectric, elastic, and mechanical behavior of ferroelectric ceramics depend in a complex way on microstructural parameters such as porosity, grain size, and grain boundary effects. The properties of ferroelectric ceramics are also very sensitive to temperature, to stress and strain, to frequency, and so forth. Lead titanate (PbTiO3) is well known as a perovskites type ferroelectric material with a high Curie point ( ) of 490°C. A phase transition from the paraelectric
The Effects of Interferential Stimulation on Pain and Motion after Shoulder Surgery: A Prospective Randomized Study  [PDF]
Vishal Mehta
Surgical Science (SS) , 2015, DOI: 10.4236/ss.2015.610067
Abstract: Purpose: The purpose of this study is to determine the effects of interferential stimulation on pain and motion after shoulder surgery. Study Design: Randomized Controlled Trial. Methods: 102 patients undergoing arthroscopic rotator cuff repair or labral repair were prospectively randomized to receive either an interferential stimulation unit immediately after surgery (STIM) or not to receive the unit (NO-STIM). Each patient was measured for the range of motion (ROM) in forward flexion (FF), abduction (ABD), internal rotation (IR) and external rotation (ER). These measurements were taken prior to surgery and at the 6 weeks post-operative time point. Visual Analogue Scale (VAS) scores (0 - 10) and the amount of narcotic taken (standardized to 10 mg equivalents of hydrocodone) were measured and compared between the two groups at 2 days and 4 weeks post-operatively. 51 patients were excluded due to failure to document VAS scores and medication usage, lack of follow-up at the 6 weeks post-operative time point or hospitalization after surgery. This left 27 patients in the STIM group and 24 patients in the NO-STIM group. Results: No difference was found in the amount of narcotic taken after 2 days (STIM 14.37 ± 1.02, NO-STIM 15.88 ± 1.22, p = 0.34) or after 4 weeks (STIM 45.32 ± 4.36, NO-STIM 48.96 ± 5.50, p = 0.60). No difference in mean VAS scores were found at 2 days (STIM 5.56 ± 0.53, NO-STIM 4.63 ± 0.57, p = 0.24) or 4 weeks (STIM 1.68 ± 0.39, NO-STIM 1.38 ± 0.34, p = 0.57). At 6 weeks post-operatively, a difference was found in ER (STIM 62.5 ± 4.09, NO-STIM 50.4 ± 4.09, p = 0.04), and no differences found in FF (STIM 134.2 ± 5.29, NO-STIM 133.3 ± 4.85, p = 0.60), ABD (STIM 124.8 ± 6.22, NO-STIM 119.6 ± 5.42, p = 0.53) or IR (STIM 60.0 ± 3.69, NO-STIM 55.9 ± 3.03, p = 0.39). A post-hoc power analysis performed using an á = 0.05 revealed the study to be 90% powered to identify a difference of one narcotic equivalent between groups and 90% powered to identify a 0.3 difference in VAS scores. Conclusions: The use of an interferential stimulator in the immediate post-operative period had no effect on pain or narcotic usage following arthroscopic rotator cuff repair or labral repair. External rotation was significantly greater in the interferential stimulator group while no differences were found in other motion parameters.
Earthworms: Charles Darwin’s ‘Unheralded Soldiers of Mankind’: Protective & Productive for Man & Environment  [PDF]
Rajiv K. Sinha, Krunal Chauhan, Dalsukh Valani, Vinod Chandran, Brijal Kiran Soni, Vishal Patel
Journal of Environmental Protection (JEP) , 2010, DOI: 10.4236/jep.2010.13030
Abstract: Earthworms promises to provide cheaper solutions to several social, economic and environmental problems plaguing the human society. Earthworms can safely manage all municipal and industrial organic wastes including sewage sludge and divert them from ending up in the landfills. Their body work as a ‘biofilter’ and they can ‘purify’ and also ‘disinfect’ and ‘detoxify’ municipal and several industrial wastewater. They reduce the BOD & COD loads and the TDSS of wastewater significantly. They can even remove the EDCs (endocrine disrupting chemicals) from sewage which is not removed by the conventional sewage treatments plants. Earthworms can bio-accumulate and bio-transform many chemical contaminants including heavy metals and organic pollutants in soil and clean-up the contaminated lands for re-development. Earthworms restore & improve soil fertility by their secretions (growth hormones) and excreta (vermicast with beneficial soil microbes) & boost ‘crop productivity’. They have potential to replace the environmentally destructive chemical fertilizers from farm production. The ‘protein rich’ earthworm biomass is being used for production of ‘nutritive feed materials’ for fishery, dairy & poultry industries. They are also being used as ‘raw materials’ for rubber, lubricant and detergent industries. The bioactive compounds isolated from earthworms are finding new uses in production of ‘life saving medicines’ for cardiovascular diseases and cancer cure.
Synthesis of Cu(II), Ni(II), Co(II), and Mn(II) Complexes with Ciprofloxacin and Their Evaluation of Antimicrobial, Antioxidant and Anti-Tubercular Activity  [PDF]
Ketan S. Patel, Jiten C. Patel, Hitesh R. Dholariya, Vishal K. Patel, Kanuprasad D. Patel
Open Journal of Metal (OJMetal) , 2012, DOI: 10.4236/ojmetal.2012.23008
Abstract: Co(II), Ni(II), Cu(II) and Mn(II) complexes synthesized by reflux of 6-bromo-3-(3-(4-chlorophenyl)acryloyl)-2H- chromen-2-one, Ciprofloxacin and various transition metal. 1H, 13C, IR and ESI Mass confirm the formation of ligand. The metal complexes were characterized on the basis of various spectroscopic techniques like IR studies and elemental analysis while the geometry of complexes was octahedral which is confirmed by electronic spectra and thermogravimetric analysis. The compounds were subjected to antimicrobial, antioxidant and anti-tubercular activity screening using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. Mn(II) complex has shown significant antifungal activity with an MIC of 6.25 μg/ml while Cu(II) complex is noticeable for antibacterial activity at the same concentration. Anti-TB activity of the ligand has enhanced on complexation with Ni(II) and Co(II) ions. While Ni(II) complex shows superior antioxidant activity than other complexes.
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