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Search Results: 1 - 10 of 190 matches for " Viroj Wiwaniikit "
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A note on the prothrombin time abnormality in the patients with amebic liver abscess
Viroj Wiwaniikit,Nattakarn Suwansaksri,Jamsai Suwansaksri
Online Journal of Health & Allied Sciences , 2006,
Abstract: Amebic liver abscess is reported worldwide and can present with a a wide spectrum of clinical manifetations. Similar to the other liver diseases, the prothrombin time abnormality can be seen in the patients with amebic liver abscess. We retrospectively studied the prothrombin times among 30 Thai hospitalized patients with amebic liver abscesses and did not find any correlation between the prothrombin time and any other studied manifestation
Nurse-led Telephone Follow-up Diabetes Mellitus - Letter to the editor
Turkish Journal of Endocrinology and Metabolism , 2010,
Abstract: Editor, I read the recent publication by nar et al. with a great interest [1]. nar et al. concluded that “a nurse telephone intervention may improve glycemic parameters as well as diet, exercise, and medication adherence [1]”. I have some questions on this work. First, there might be selection bias on the included case in this work since there is no procedure for preventing it. Second, there is no confirmation that there is no interobserver variation in telephoning technique and outcome measurement. Third, there are also other factors, rather than a few period telephone conversations, that can result in the diabetic control outcome in the patients. Indeed, this limitation is reported in a previous similar work by Bowles [2].
Maternal C-Reactive Protein for Detection of Chorioamnionitis: an Appraisal
Viroj Wiwanitkit
Infectious Diseases in Obstetrics and Gynecology , 2005, DOI: 10.1080/10647440500068321
Abstract: Premature delivery is still a significant problem in obstetrics, and chorioamnionitis is an unwelcome complication. C-reactive protein (CRP) is a circulating marker of low-grade inflammation and the role of its measurement in clinical practice remains unclear for many conditions. It has been claimed that estimation of CRP is helpful in the diagnosis of chorioamnionitis, and this study aims to appraise such claims. Following review of the literature, six reports were recruited for further metanalysis, including 466 cases. The overall prevalence of chorioamnionitis was 41% (191/466). The overall diagnostic activity showed sensitivity, specificity, false-positives and false-negatives of 72.8%, 76.4%, 23.6% and 27.2%, respectively. Therefore, we can conclude that estimation of maternal CRP is not helpful in the detection of chorioamnionitis, compared with standard investigations.
Molecular Structure of Human Transferrin – Transferrin Receptor Complex
Viroj Wiwanitkit
International Journal of Molecular Sciences , 2006, DOI: 10.3390/i7070197
Abstract: Transferrin receptor (TfR) is a glycoprotein mediating the entry of ferrictransferrin (Tf) from the extracellular compartment into the cells. TfR are present on thesurface of many cell types but they are most abundant on cells active in hemoglobinsynthesis. However, the knowledge on the complex, recombination, between Tf and sTfR islimited. Here, the author performs an analysis to study the molecular structure of human Tf- sTfR complex. The output 3D molecular structure from the combination between Tf andTfR is derived. The property as well as geometry of the derived complex was also presented.
New anti-neoplastic drug test using in vitro model: what to be concern?
Viroj Wiwanitkit
DARU Journal of Pharmaceutical Sciences , 2012, DOI: 10.1186/2008-2231-20-65
Abstract: Considering the present in vitro cell culture study for new anti-neoplastic agent, several facts should be discussed. First, as already noted, the observation on the drug study is derived from abnormal transformed cells which usually passed several biomedical modification and sub-culture process. This cannot directly and totally imply the normal cells and non transformed, non sub-cultured cancerous cells. To refer for effectiveness and safety for further human study or usage must be careful.Second, in vitro model cannot include any biotransformation that might occur in vivo. Drug distribution, drug elimination and interference from other biochemical substances in human body are all not studied in the vitro test. Third, it should be noted that several new anti-neoplastic alternative are developed with advanced biomedical engineering technology [4], such as recombinant protein technology and nanopharmacology. Since the medical society still has few information on the side effect of those new substances (new recombinants, new nanomaterials, etc.). The complete study on the toxicological effect is required. For the new nano-anti-neoplastic drug, the drug in vitro might totally not reflect the actual action in human body. Since the nanomaterial is highly sensitive, it might aggregate to form larger molecule in vivo or it might interact with several substances, especially for proteins, in human body. For sure, if such scenario occur, the change in pharmacological and toxicological properties is possible. The development of new drug test system for nanomaterial – based anti-neoplastic drug is required and the test must be performed within certified nanotechnology laboratory. Fourth, it must be repeatedly noted that anti-neoplastic agent is chemical hazardous. The safety concern should be for not only the patients but also on the medical personnel who develop and perform drug test. The safety of the practitioners seems to be the forgotten issue. Finally, the new alternative
A note on clinical presentations of amebic liver abscess: an overview from 62 Thai patients
Viroj Wiwanitkit
BMC Family Practice , 2002, DOI: 10.1186/1471-2296-3-13
Abstract: A retrospective case review was carried out for 62 Thai patients who had been diagnosed with amebic liver abscess. Clinical information was collected, including symptoms and signs, location and number of abscesses. The Anti HIV serology laboratory investigation was also reviewed.According to our study, the common clinical symptoms and signs are abdominal pain (85.5 %), fever and chills (74.2 %), and abdominal tenderness (69.4 %). The location of the abscess was predominantly in the right lobe (74.2 %), and most of patients had a single abscess (77.4 %). Similar trends in clinical presentations were observed in both Anti HIV seropositive and Anti HIV seronegative subjects.In conclusion, the clinical presentations of our amebic liver abscess patients were similar to those in previous reports. A similarity to those in the pyogenic liver abscess patients can be observed. Nevertheless, we could not detect important significant differences in the clinical presentations between Anti HIV seropositive and Anti HIV seronegative groups of patients.Significant differences exist in the prevalence of most gastroenterological emergencies in tropical countries compared with temperate countries [1]. Both ethnic and environmental, often clearly defined geographically, factors are relevant. Amebiasis is a widespread parasitic disease caused by Entamoeba histolytica. This protozoan organism is the third leading parasitic cause of death in the developing world and is an important health risk to travelers in endemic areas [2]. Amebiasis most commonly results in asymptomatic colonization of the gastrointestinal tract, but some patients may develop intestinal invasive disease or extraintestinal disease. The most common extraintestinal manifestation is that of a liver abscess [2]. This infection is common throughout the world and can be associated with life-threatening consequences [2-5].Concerning the amebic liver abscess, the pathogenic organism is carried through the blood to the liver w
High serum alkaline phosphatase levels, a study in 181 Thai adult hospitalized patients
Viroj Wiwanitkit
BMC Family Practice , 2001, DOI: 10.1186/1471-2296-2-2
Abstract: A review was made of medical records of inpatients with high ALP level above 1000 IU/L in King Chulalongkorn Memorial Hospital, Thailand from January 1999 to December 1999. Excluded were cases of (a) patients who have bone involvements with malignancies, (b) pediatric patients younger than 15 years old and c) HIV-seropositive patients.A total of 181 hospitalized patients with eligible medical records were identified (96 males and 85 females, mean age 49.4 ± 16.1 years). Their ALP levels ranging from 1,001 to 3,067 IU/L, these patients were divided into four groups.High serum ALP levels in hospitalized patients were commonly found in three major groups having obstructive biliary diseases, infiltrative liver disease and sepsis. The study results were in accordance with previous reports in developed countries. Nonetheless, cholangiocarcionoma and some tropical diseases unique to our setting were also detected in these cases. where there was a marked elevation of serum ALP.Alkaline phosphatase (ALP; EC comprises a group of enzymes that catalyze the hydrolysis of phosphate esters in an alkaline environment, generating an organic radical and inorganic phosphate.[1] Like other enzymes, this enzyme has many isoenzymes. In healthy adults, this enzyme is mainly derived from the liver, bones and in lesser amounts from intestines, placenta, kidneys and leukocytes.[2]An increase in serum ALP levels is frequently associated with a variety of diseases. Such disorders as extrahepatic bile obstruction, intrahepatic cholestasis, infiltrative liver disease and hepatitis are mentioned. Unfortunately, the elevation of ALP less than three times the normal level is considered non specific and insufficient to provide a definite diagnosis. [3]Markedly elevated serum ALP, hyperalkalinephosphatasemia, is seen predominantly with more specific disorders, including, malignant biliary obstruction, primary biliary cirrhosis, primary sclerosing cholangitis, hepatic lymphoma and sarcoidosis
Intestinal parasitic infections in Thai HIV-infected patients with different immunity status
Viroj Wiwanitkit
BMC Gastroenterology , 2001, DOI: 10.1186/1471-230x-1-3
Abstract: A study of stool samples from 60 Thai HIV-infected patients with different immune status was performed at King Chulalongkorn Memorial Hospital, Thailand. Each patient was examined for CD4 count and screened for diarrheal symptoms.The prevalence of intestinal parasitic infection among the HIV-infected patients in this study was 50 %. Non- opportunistic intestinal parasite infections such as hookworms, Opisthorchis viverrini and Ascaris lumbricoides were commonly found in HIV-infected people regardless of immune status with or without diarrheal symptoms. Opportunistic intestinal parasites such as Cryptosporidium, Isospora belli, Microsporidia and Strongyloides stercoralis infection were significantly more frequent in the low immunity group with diarrhea.Therefore, opportunistic intestinal parasite infection should be suspected in any HIV infected patient with advanced disease presenting with diarrhea. The importance of tropical epidemic non-opportunistic intestinal parasite infections among HIV-infected patients should not be neglected.Human immunodeficiency virus (HIV) infection, a worldwide infection, is a serious problem in the present day. A high rate of infection is found in many regions of the world, including the Southeast Asia. In Thailand, a tropical country in Southeast Asia, HIV infection is a major problem, like in other regional countries. It has been estimated that a million people are infected with HIV infection in Thailand [1]. And it also the possibly higher undetected HIV infection in the community.One of the major health problems among HIV seropositive patients is superimposed infection due to the defect of immunity. Furthermore, intestinal parasite infection, which is also one of the basic health problems in tropical region [2], is common in these patients.In this study, a cross sectional study to document the prevalence of intestinal parasitic infection in Thai HIV- infected patients with different immune status was performed.This study was perfor
Types and frequency of preanalytical mistakes in the first Thai ISO 9002:1994 certified clinical laboratory, a 6 – month monitoring
Viroj Wiwanitkit
BMC Clinical Pathology , 2001, DOI: 10.1186/1472-6890-1-5
Abstract: In this study, we evaluated the frequency and types of preanalytical mistakes found in our laboratory, by monitoring specimens requested for laboratory analyses from both in-patient and out-patient divisions for 6 months.Among a total of 935,896 specimens for 941,902 analyses, 1,048 findings were confirmed as preanalytical mistakes; this was a relative frequency of 0.11 % (1,048/935,896). A total of 1,240 mistakes were identified during the study period. Comparing the preanalytical mistakes to other mistakes in the laboratory process monitored in the same setting and period, the distribution of mistakes was: preanalytical 84.52 % (1,048 mistakes), analytical 4.35 % (54 mistakes), and postanalytical 11.13 % (138 mistakes). Of 1,048 preanalytical mistakes, 998 (95.2%) originated in the care units. All preanalytical mistakes, except for 12 (1.15 %) relating to the laboratory barcode reading machine, were due to human error.Most mistakes occurred before samples were analysed, either during sampling or preparation for analysis. This suggests that co-operation with clinicians and personnel outside the laboratory is still the key to improvement of laboratory quality.Quality is the heart in management of all laboratories. Due to the good governance concepts, accountability of the whole laboratory process is the main focus of current concern in laboratory medicine. Due to the laboratory quality cycle, reliability cannot be achieved in a clinical laboratory through the control of accuracy in the analytical phase of testing process alone. There should be a certification on the whole laboratory, but not on single analytical process. Precision and accuracy of analyses are not only determined by the analytical procedure but also by preanalytical factors, such as contamination and loss during sampling and sample preparation. Under the broad umbrella of the preanalytical phase can be included requesting test, specimen collection, handling and processing in the process before comple
The usefulness of case reports in managing emerging infectious disease
Viroj Wiwanitkit
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-194
Abstract: The case report is a specific kind of publication in the medical literature. This specific kind of article is seldom seen in other non-medical literature. The case report is usually a short article describing "an interesting case" in medicine [1]. This might be a new medical condition, a new diagnostic approach, a new treatment or a new disease. In general, case reports usually describe a specific group of medical disorders including metabolic diseases, malignancies, infections and genetic disorders.Case reports on infection have a long history. Some case reports can be found in the ancient literature. A good example is the description of a condition that is believed to be "malaria" in the papyrus [2]. In ancient Chinese and Egyptian papers, a condition that is believed to be "syphilis" is also recorded [3]. Hence, there is no doubt that infection has been focused on by physicians and medical scientists for many centuries.Concerning the nature of case reports on infection, a variety of reports can be seen. For example, reports can be on new disease, a rare disease, a new diagnostic tool or a new treatment. An interesting type of case report is that of an emerging infectious disease. By definition, an emerging infectious disease is a condition of outbreak or epidemic of an infection [4]. This can be a newly detected disease or the reemergence of an old disease. Emerging infectious disease is a condition that needs urgent management, and it is a public health focus.In the early emerging phase or in a small outbreak, the case reports are usually the first documents on those problems. A good example is the first case report from Mexico on the influenza of 2009 or swine flu before the present pandemic [5]. This outbreak report brought global attention to the possible emergence of this new serious infection [5]. Later, the infection became a pandemic around the world. Hundreds of publications on swine flu were published following this first case report. Of interest, the f
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