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Search Results: 1 - 10 of 21974 matches for " Vipin Kumar Garg "
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Anti-Inflammatory Activity of Aqueous Extract of Cynodon dactylon
Vipin Kumar Garg,Sarvesh Kumar Paliwal
International Journal of Pharmacology , 2011,
Abstract: Whole plant of Cynodon dactylon is traditionally used to treat painful and inflammatory conditions. We have undertaken this study, since no detailed scientific study was available regarding the anti-inflammatory activity of Cynodon dactylon. In the present study, anti-inflammatory activity of aqueous extract of Cynodon dactylon at different doses was studied using carrageenan, serotonin, histamine and dextran induced rat paw edema and cotton pellet method. The study was carried out in three different doses levels of 200, 400 and 600 mg kg-1 orally. The aqueous extract of Cynodon dactylon was found to be safe at all the doses used and there was no mortality up to the dose of 4000 mg kg-1 of extract when administered orally. Cynodon dactylon showed significant anti-inflammatory activities in all models studied. The extract was found to reduce significantly (p<0.001) the formation of edema induced by carrageenan, serotonin, histamine and dextran after 3 and 5 h. Also, it produced maximum 46.40% inhibition in dry weight cotton pellet formation at a dose of 600 mg kg-1 as compared to 46.27% inhibition produced by Indomethacin. The standard drug used was Indomethacin (10 mg kg-1). The preliminary phytochemical screening has revealed the presence of glycosides and flavonoids in the aqueous extract. The presence of flavonoids might be responsible for its anti-inflammatory activity. Results support the traditional use of the plant in the treatment of inflammatory conditions.
Terrestrial Ecosystem Carbon Fluxes Predicted from MODIS Satellite Data and Large-Scale Disturbance Modeling  [PDF]
Christopher Potter, Steven Klooster, Vanessa Genovese, Cyrus Hiatt, Shyam Boriah, Vipin Kumar, Varun Mithal, Ashish Garg
International Journal of Geosciences (IJG) , 2012, DOI: 10.4236/ijg.2012.33050
Abstract: The CASA (Carnegie-Ames-Stanford) ecosystem model based on satellite greenness observations has been used to estimate monthly carbon fluxes in terrestrial ecosystems from 2000 to 2009. The CASA model was driven by NASA Moderate Resolution Imaging Spectroradiometer (MODIS) vegetation cover properties and large-scale (1-km resolution) disturbance events detected in biweekly time series data. This modeling framework has been implemented to estimate historical as well as current monthly patterns in plant carbon fixation, living biomass increments, and long-term decay of woody (slash) pools before, during, and after land cover disturbance events. Results showed that CASA model predictions closely followed the seasonal timing of Ameriflux tower measurements. At a global level, predicting net ecosystem production (NEP) flux for atmospheric CO2 from 2000 through 2005 showed a roughly balanced terrestrial biosphere carbon cycle. Beginning in 2006, global NEP fluxes became increasingly imbalanced, starting from -0.9 Pg C yr-1 to the largest negative (total net terrestrial source) flux of -2.2 Pg C yr-1 in 2009. In addition, the global sum of CO2 emissions from forest disturbance and biomass burning for 2009 was predicted at 0.51 Pg C yr-1. These results demonstrate the potential to monitor and validate terrestrial carbon fluxes using NASA satellite data as inputs to ecosystem models.
Anti-Infl ammatory Activity of Aqueous Extract of Beta Vulgaris L.
Swati Jain,Vipin Kumar Garg,Pramod Kumar Sharma
Journal of Basic and Clinical Pharmacy , 2011,
Abstract: The present study deals with the investigation of phytochemically evaluated aqueous extract of leaves of Beta vulgaris for its anti-inflammatory activity. The anti-inflammatory activity was evaluated by carrageenan induced rat paw oedema method for acute inflammation and cotton pellet granuloma method for chronic inflammation. The standard drug used was indomethacin (10 mg/kg) for both themodels. In both methods, aqueous extract at a dose level of 1000 mg/kg has shown significant activity which is comparable to that of the standard.
Khushbu pandey*,Pramod Kumar Sharma,Vipin Kumar Garg,Sambhu Charan Mondal
Pharmacie Globale : International Journal of Comprehensive Pharmacy , 2011,
Abstract: Insulin-dependent type 1 diabetes is an autoimmune disease mediated by T lymphocytes recognizing pancreatic islet cell antigens. Glutamic acid decarboxylase 65 (GAD-65) appears to be an important auto antigen in this type of disease. However, T cells from both patients with type 1 diabetes and healthy subjects vigorously proliferate in response to GAD-65 stimulation ex-vivo, leading us to postulate that the critical event in the onset of human diabetes is the activation of auto reactive T cells. Thus, it was investigated, whether GAD-65 reactive T cells in patients with diabetes functioned as previously activated memory T cells, no longer requiring a second, co-stimulatory signal for clone expansion. We found that in patients with new-onset type 1diabetes, GAD-65-reactive T cells were strikingly less dependent on CD-28 and B7-1 co-stimulation to enter into cell cycle and proliferate than were equivalent cells derived from healthy controls. The hypothesis reveals that these auto reactive T cells have been activated in-vivo and have differentiated into memory cells, suggesting a pathogenic role in type 1 diabetes. In addition, it was observed that different effects with selective blockade of either B7-1 or B7-2 molecules; B7-1 appears to deliver a negative signal by engaging CTLA-4, while B7-2 engagement of CD-28 up regulates T cell proliferation and cytokine secretion.
Object-Oriented Database Connectivity for Hand Held Devices  [PDF]
Vipin Saxena, Santosh Kumar
Journal of Software Engineering and Applications (JSEA) , 2012, DOI: 10.4236/jsea.2012.55037
Abstract: Due to the lack of representation of an object-oriented database on hand-held devices, the present work describes an approach to send the information in the form of an object-oriented database on hand-held devices. A smart phone is selected as a hand-held device and connectivity between the object-oriented databases has been established by the use of the object-oriented programming language C#.Net. For modeling purpose, Unified Modeling Language (UML) is used to specify a UML Class Model and Sequence diagram. A concept of star schema is also used to represent the object-oriented database.
Object Oriented Query Response Time for UML Models  [PDF]
Vipin Saxena, Santosh Kumar
Journal of Software Engineering and Applications (JSEA) , 2012, DOI: 10.4236/jsea.2012.57059
Abstract: Nowadays, the size of database of any business organization is increasing and many of the companies are shifted the old structured database into the object oriented database. Due to increase of size of database complexity of database is increasing therefore, it is necessary to optimize the object oriented query response time from the complex object oriented database. In the present paper, a real case study of Life Insurance Corporation of India is taken and sample object oriented database is designed by the use of SQL Server 2008. A UML model is designed for computing the object oriented query response time. Table and graph are also represented for the computed records in five runs.
Impact of Coupling and Cohesion in Object-Oriented Technology  [PDF]
Vipin Saxena, Santosh Kumar
Journal of Software Engineering and Applications (JSEA) , 2012, DOI: 10.4236/jsea.2012.59079
Abstract: The interaction between the classes or within the classes shows the complexity of the design. For one smaller problem, there may be more than one software design but who will be the best; depends on the complexity level of software design. Therefore, coupling and cohesion which shows the interlinking of classes and strength of classes; control the complexity of the design. The best software object oriented design is based upon the low coupling and high cohesion level. In the present work, a real case study of Life Insurance policy for handicapped person is demonstrated through the UML Class Diagram; coupling and cohesion levels are measured and results are demonstrated in the form of tables.
Mobile Based Electricity Bill Deposit System through UML  [PDF]
Pawan Kumar Chaurasia, Vipin Saxena
Journal of Software Engineering and Applications (JSEA) , 2011, DOI: 10.4236/jsea.2011.43021
Abstract: The present paper deals with a model design through Unified Modeling Language (UML) for a mobile based elec-tricity bill deposit system. Due to complex life style of people this model is proposed in the form of UML Class, Sequence and Use Case diagrams. For implementation of proposed model, a real case study of Uttar Pradesh Electricity Bill deposit System is considered. By the use of this model, one can display the status of deposited electricity bill on a hand held mobile device system.
Vipin Kumar
International Journal of Computer Science and Management Studies , 2012,
Abstract: The purpose of the security architecture blueprint is to bring focus to the key areas of concern for the enterprise, highlighting decision criteria and context for each domain. Since security is a system property it can be difficult for Enterprise Security groups toseparate the disparate concerns that exist at different system layers and to understand their role in the system as a whole. Computers and Information technology has impacted every aspect of modern life and business. It’s use for decision making andcontrolling important operations without human supervision have made its entry in both public and private sectors.
Natural Remedies against Multi-Drug Resistant Mycobacterium tuberculosis  [PDF]
Ramesh Pandit, Pawan Kumar Singh, Vipin Kumar
Journal of Tuberculosis Research (JTR) , 2015, DOI: 10.4236/jtr.2015.34024
Abstract: Tuberculosis (TB), caused by Mycobacterium tuberculosis is an infectious deadly disease and the treatment of which is one of the most severe challenges at the global level. Currently more than 20 chemical medications are described for the treatment of TB. Regardless of availability of several drugs to treat TB, the causative agent, M. tuberculosis is nowadays getting resistant toward the conventional drugs and leading to conditions known as Multidrug-resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB). This situation has terrified the global health community and raised a demand for new anti-tuberculosis drugs. Medicinal plants have been used to cure different common as well as lethal diseases by ancient civilizations due to its virtue of variety of chemical compounds which may have some important remedial properties. The aim of the present review is to focus the anti-tubercular medicinal plants native to India as well as the plants effective against MDR or XDR-TB across the globe. In the present review, we have addressed 25 medicinal plants for TB and 16 plants effective against MDR-TB testified from India and 23 herbal plants described for MDR-TB across the world during 2011-2015. These herbal plants can serve as promising candidates for developing novel medications to combat multidrug resistant M. tuberculosis.
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